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1. 发明授权

US06463312B1 Microdialysis-probe integrated with a si-chip 失效
标题翻译：微透析探针与si芯片集成
公开(公告)号：US06463312B1
公开(公告)日：2002-10-08
申请号：US09601873
申请日：2000-09-12
申请人： Piet Bergveld , Sebastian Bohm , Wouter Olthuis
发明人： Piet Bergveld , Sebastian Bohm , Wouter Olthuis
IPC分类号： A61B505
CPC分类号： A61B5/14528
摘要： Microdialysis device (10), comprising at least a probe (1) provided with an inlet (2) and an outlet (3) for bringing a perfusion fluid into contact with a bodily fluid in a part of a living organism and causing constituents from this fluid to be taken up by this perfusion fluid, whereby the perfusion fluid is enriched to dialysate, wherein the outlet (3) is integrally received in a silicon chip (5) and debouches in a first fluid channel (6) formed in this silicon chip (5) and wherein further at least one analysis means, for instance an ISFET (17, 18), for analysing constituents of the bodily fluid taken up by the perfusion fluid is integrally received in the silicon chip (5) in a manner such that dialysate flowing from the outlet (3) comes into contact with said analysis means in the first fluid channel (6), and wherein the silicon chip (5) is further optionally provided with pumping means (50) or dosing means.
摘要翻译：微透析装置（10）包括至少一个设置有入口（2）和出口（3）的探针（1），用于使灌注流体与生物体的一部分中的体液接触并引起来自该生物体的成分流体被该灌注流体吸收，从而使灌注流体富集成透析液，其中出口（3）整体地容纳在硅芯片（5）中，并且在形成于该硅芯片中的第一流体通道（6）中脱模（5），并且其中另外至少一个分析装置，例如用于分析由灌注流体吸收的体液的成分的ISFET（17,18）以这样的方式被一体地接收在硅芯片（5）中：从出口（3）流出的透析液与第一流体通道（6）中的分析装置接触，并且其中硅芯片（5）还可选地设置有泵送装置（50）或给料装置。

2. 发明授权

US06520010B1 System and methods for characterizing a liquid 失效
标题翻译：用于表征液体的系统和方法
公开(公告)号：US06520010B1
公开(公告)日：2003-02-18
申请号：US09368822
申请日：1999-08-05
申请人： Piet Bergveld , Gerardus Rudolph Langereis , Wouter Olthuis
发明人： Piet Bergveld , Gerardus Rudolph Langereis , Wouter Olthuis
IPC分类号： G01F168
CPC分类号： G01N27/06
摘要： A system for characterizing a liquid comprises a sensor for providing an electrical output signal depending on a characteristic of the liquid, and a processing unit for processing the output signal of the sensor to obtain characterizing data of the liquid. The sensor is made as a single sensor/actuator device and can be connected in a plurality of manners to the processing unit. In at least some of these connecting manners the processing unit is adapted to actuate the sensor/actuator device and to process the output signal of the sensor/actuator device to obtain different characterizing data of the liquid.
摘要翻译：用于表征液体的系统包括用于根据液体的特性提供电输出信号的传感器，以及用于处理传感器的输出信号以获得液体的特征数据的处理单元。该传感器被制成单个传感器/致动器装置，并且可以以多种方式连接到处理单元。在这些连接方式中的至少一些中，处理单元适于致动传感器/致动器装置并且处理传感器/致动器装置的输出信号以获得液体的不同特性数据。

3. 发明申请

US20050227405A1 Method for producing a hybrid organic silicon field effect transistor structure 审中-公开
标题翻译：混合有机硅场效应晶体管结构的制造方法
公开(公告)号：US20050227405A1
公开(公告)日：2005-10-13
申请号：US10514347
申请日：2003-05-19
申请人： Ernst Jan Sudholter , Alexander Sieval , Han Zuilhof , Louis Cornelia De Smet , Gerben Visser , Wouter Olthuis , Piet Bergveld , E.J. Faber
发明人： Ernst Jan Sudholter , Alexander Sieval , Han Zuilhof , Louis Cornelia De Smet , Gerben Visser , Wouter Olthuis , Piet Bergveld , E.J. Faber
IPC分类号： G01N27/414 , H01L29/78 , H01L51/40 , H01L21/00 , H01L21/336
CPC分类号： G01N27/414
摘要： The invention relates to a method for producing a hybrid organic silicon field effect transistor structure, comprising the steps of: i) providing a group IV element based semiconductor substrate provided with a source region, gate region and drain region, having at least in the gate region a surface with hydrogen terminated group IV elements; and ii) covering at least the gate region with an organic monolayer by covalently reacting monolayer forming molecules with terminated hydrogen of the group IV elements at the surface, which monolayer forming molecules comprise a proximal terminated hydrogen reactive group and a spacer group and to a hybrid organic silicon field effect transistor structure as obtainable with the method.
摘要翻译：本发明涉及一种用于制造混合有机硅场效应晶体管结构的方法，包括以下步骤：i）提供具有至少在栅极中的源极区，栅极区和漏极区的基于IV族元素的半导体衬底区域具有氢端基IV族元素的表面; 和ii）通过使单层形成分子与表面上的IV族元素的终止氢共价反应，至少覆盖具有有机单层的栅区，所述单层形成分子包含近端封端的氢反应性基团和间隔基团，并且与混合物有机硅场效应晶体管结构可用该方法获得。

4. 发明授权

US4910840A Electroacoustic transducer of the so-called "electret" type, and a method of making such a transducer 失效
标题翻译：所谓“驻极体”型的电声换能器，以及制造这种传感器的方法
公开(公告)号：US4910840A
公开(公告)日：1990-03-27
申请号：US385150
申请日：1989-07-26
申请人： Adrianus J. Sprenkels , Piet Bergveld
发明人： Adrianus J. Sprenkels , Piet Bergveld
IPC分类号： H04R19/01
CPC分类号： H04R19/01 , Y10T29/43 , Y10T29/49005
摘要： This invention provides an electroacoustic transducer and a method of making it. The transducer according to the invention comprises a substrate of a semiconductor material with a recessed portion. A membrane is stretched across the recessed portion, which membrane is set in vibration in response to an input signal comprising audio and/or ultrasonorous frequencies. A pair of electrodes is provided, which form a capacitor, and between which an electric field is present. The electrodes are so arranged relatively to the membrane that the capacitance of the capacitor can vary under the influence of vibrations of the membrane, so that acoustic signals are converted into electric signals. A layer of an electrically insulating material functions as a carrier for an electric charge to provide an auxiliary electric field between the electrodes. The transducer is characterized in that the peripheral edge of the substrate, which is raised relatively to the recessed portion, has a set of openings formed in it, each extending through the substrate. The membrane is attached through the openings to the peripheral edge.
摘要翻译：本发明提供一种电声换能器及其制造方法。根据本发明的换能器包括具有凹陷部分的半导体材料的衬底。膜跨过凹部拉伸，该膜响应于包括音频和/或超声频率的输入信号而被设置在振动中。提供一对电极，其形成电容器，并且其间存在电场。这些电极相对于膜布置得如此，电容器的电容可以在膜的振动的影响下变化，从而将声信号转换成电信号。电绝缘材料层用作电荷的载体，以在电极之间提供辅助电场。传感器的特征在于，相对于凹部凸起的衬底的周缘具有形成在其中的一组开口，每个开口延伸穿过衬底。膜通过开口连接到周边边缘。

5. 发明授权

US4908805A Electroacoustic transducer of the so-called "electret" type, and a method of making such a transducer 失效
公开(公告)号：US4908805A
公开(公告)日：1990-03-13
申请号：US263196
申请日：1988-10-27
申请人： Adrianus J. Sprenkels , Piet Bergveld
发明人： Adrianus J. Sprenkels , Piet Bergveld
IPC分类号： H04R19/01
CPC分类号： H04R19/01 , Y10T29/43 , Y10T29/49005
摘要： This invention provides an electroacoustic transducer and a method of making it. The transducer according to the invention comprises a substrate of a semiconductor material with a recessed portion. A membrane is stretched across the recessed portion, which membrane is set in vibration in response to an input signal comprising audio and/or ultrasonorous frequencies. A pair of electrodes is provided, which form a capacitor, and between which an electric field is present. The electrodes are so arranged relatively to the membrane that the capacitance of the capacitor can vary under the influence of vibrations of the membrane, so that acoustic signals are converted into electric signals. A layer of an electrically insulating material functions as a carrier for an electric charge to provide an auxiliary electric field between the electrodes. The transducer is characterized in that the peripheral edge of the substrate, which is raised relatively to the recessed portion, has a set of openings formed in it, each extending through the substrate. The membrane is attached through the openings to the peripheral edge.

6. 发明授权

US4267504A Device for measuring a quantity which influences a field-effect transistor 失效
标题翻译：用于测量影响场效晶体管的量的装置
公开(公告)号：US4267504A
公开(公告)日：1981-05-12
申请号：US86922
申请日：1979-10-22
申请人： Piet Bergveld
发明人： Piet Bergveld
IPC分类号： G01N27/00 , G01N27/06 , G01N27/26 , G01N27/414 , G01R17/00 , G01R19/00 , G01R19/32 , H01L29/78 , G01R27/02
CPC分类号： G01R17/00 , G01N27/4148 , G01R19/0023 , G01R19/32
摘要： A device for measuring a quantity which influences a field-effect transistor which is included in a measuring circuit as a variable resistance. To compensate for temperature-dependent changes of the field-effect transistor, an auxiliary signal, having a frequency located outside the frequency range of the quantity to be measured, is applied to the transistor. The two signals are separated from one another again after having been processed by the measuring circuit.
摘要翻译：一种用于测量影响作为可变电阻的测量电路中包含的场效应晶体管的量的装置。为了补偿场效应晶体管的温度依赖性变化，将具有位于待测量的频率范围之外的频率的辅助信号施加到晶体管。两个信号在被测量电路处理之后又被重新分离。

7. 发明授权

US4534825A Method of making an electrochemical sensing cell 失效
标题翻译：制造电化学传感电池的方法
公开(公告)号：US4534825A
公开(公告)日：1985-08-13
申请号：US587819
申请日：1984-03-09
申请人： Gerrit Koning , Piet Bergveld
发明人： Gerrit Koning , Piet Bergveld
IPC分类号： A61B5/00 , G01N27/28 , G01N27/416 , G01N27/46
CPC分类号： A61B5/14542 , A61B5/1473 , A61B5/1495 , G01N27/28 , G01N27/4163 , G01N27/4165
摘要： An in vivo electrochemical monitoring device is formed by a catheter-like member which terminates in a closed end having a wall with a fixed opening to admit fluid to be tested, such as blood in an artery. An electrochemical sensor, such as an ISFET device for monitoring the concentration of a particular ion in blood, is mounted inside the tube at a fixed location below the opening preferably a larger sensing chamber. An infusion channel in the tube is arranged to flood the sensor with a fluid of known chemical properties so that the sensor output can be calibrated. Under pressure the calibration fluid expels the test fluid out of the tube or chamber via the fixed opening. A method of constructing a suitable chamber on an ISFET wafer is also disclosed.

8. 发明授权

US4478222A Electrochemical sensing apparatus with in situ calibration 失效
标题翻译：具有原位校准的电化学传感装置
公开(公告)号：US4478222A
公开(公告)日：1984-10-23
申请号：US242351
申请日：1981-03-10
申请人： Gerrit Koning , Piet Bergveld
发明人： Gerrit Koning , Piet Bergveld
IPC分类号： A61B5/00 , G01N27/28 , G01N27/416
CPC分类号： A61B5/14542 , A61B5/1473 , A61B5/1495 , G01N27/28 , G01N27/4163 , G01N27/4165
摘要： An in vivo electrochemical monitoring device is formed by a catheter-like member which terminates in a closed end having a wall with a fixed opening to admit fluid to be tested, such as blood in an artery. An electrochemical sensor, such as an ISFET device for monitoring the concentration of a particular ion in blood, is mounted inside the tube at a fixed location below the opening preferably a larger sensing chamber. an infusion channel in the tube is arranged to flood the sensor with a fluid of known chemical properties so that the sensor output can be calibrated. Under pressure the calibration fluid expels the test fluid out of the tube or chamber via the fixed opening. A method of constructing a suitable chamber on an ISFET wafer is also disclosed.
摘要翻译：体内电化学监测装置由导管状构件形成，该导管状构件终止于具有固定开口的壁的封闭端，以允许待测流体例如动脉中的血液。诸如用于监测血液中特定离子的浓度的ISFET装置的电化学传感器安装在管内部位于开口下方的固定位置处，优选地是较大的感测室。管中的输液通道布置成用已知化学特性的流体对传感器进行灌注，从而可以校准传感器输出。在压力下，校准流体经由固定开口将测试流体排出管或室。还公开了在ISFET晶片上构建合适腔室的方法。

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