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1. 发明申请

US20140021065A1 DEVICE AND METHOD FOR MEASURING BIOMARKERS 审中-公开
标题翻译：用于测量生物标记的装置和方法
公开(公告)号：US20140021065A1
公开(公告)日：2014-01-23
申请号：US13988091
申请日：2011-11-18
申请人： Justyna Wiedemair , Wouter Olthuis , Albert Van Den Berg
发明人： Justyna Wiedemair , Wouter Olthuis , Albert Van Den Berg
IPC分类号： G01N27/404
CPC分类号： G01N27/4045 , A61B5/082 , A61B5/097 , A61B2010/0087 , G01N33/497
摘要： The invention relates to a device for the measurement of hydrogen peroxide and optionally other biomarkers in a gaseous mixture, and in particular to a microfabricated device. The device comprises hydrogen peroxide capturing means and an electromechanical sensor comprising a sensing element in direct contact with the capturing means. The device further comprises means to measure the potential of the sensing element and/or the current through it as a result of a changing hydrogen peroxide concentration in the gaseous mixture. The device also comprises cooling/heating means for cooling and/or heating the capturing means. The device is preferably applied for online measurement of the hydrogen peroxide content in exhaled air.
摘要翻译：本发明涉及一种用于测量气体混合物中过氧化氢和任选的其它生物标志物的装置，特别涉及一种微加工装置。该装置包括过氧化氢捕获装置和包括与捕获装置直接接触的感测元件的机电传感器。该装置还包括由于气体混合物中过氧化氢浓度变化而测量感测元件的电位和/或通过它的电流的装置。该装置还包括用于冷却和/或加热捕获装置的冷却/加热装置。该装置优选用于在线测量呼出空气中的过氧化氢含量。

2. 发明申请

US20050227405A1 Method for producing a hybrid organic silicon field effect transistor structure 审中-公开
标题翻译：混合有机硅场效应晶体管结构的制造方法
公开(公告)号：US20050227405A1
公开(公告)日：2005-10-13
申请号：US10514347
申请日：2003-05-19
申请人： Ernst Jan Sudholter , Alexander Sieval , Han Zuilhof , Louis Cornelia De Smet , Gerben Visser , Wouter Olthuis , Piet Bergveld , E.J. Faber
发明人： Ernst Jan Sudholter , Alexander Sieval , Han Zuilhof , Louis Cornelia De Smet , Gerben Visser , Wouter Olthuis , Piet Bergveld , E.J. Faber
IPC分类号： G01N27/414 , H01L29/78 , H01L51/40 , H01L21/00 , H01L21/336
CPC分类号： G01N27/414
摘要： The invention relates to a method for producing a hybrid organic silicon field effect transistor structure, comprising the steps of: i) providing a group IV element based semiconductor substrate provided with a source region, gate region and drain region, having at least in the gate region a surface with hydrogen terminated group IV elements; and ii) covering at least the gate region with an organic monolayer by covalently reacting monolayer forming molecules with terminated hydrogen of the group IV elements at the surface, which monolayer forming molecules comprise a proximal terminated hydrogen reactive group and a spacer group and to a hybrid organic silicon field effect transistor structure as obtainable with the method.
摘要翻译：本发明涉及一种用于制造混合有机硅场效应晶体管结构的方法，包括以下步骤：i）提供具有至少在栅极中的源极区，栅极区和漏极区的基于IV族元素的半导体衬底区域具有氢端基IV族元素的表面; 和ii）通过使单层形成分子与表面上的IV族元素的终止氢共价反应，至少覆盖具有有机单层的栅区，所述单层形成分子包含近端封端的氢反应性基团和间隔基团，并且与混合物有机硅场效应晶体管结构可用该方法获得。

3. 发明授权

US06463312B1 Microdialysis-probe integrated with a si-chip 失效
标题翻译：微透析探针与si芯片集成
公开(公告)号：US06463312B1
公开(公告)日：2002-10-08
申请号：US09601873
申请日：2000-09-12
申请人： Piet Bergveld , Sebastian Bohm , Wouter Olthuis
发明人： Piet Bergveld , Sebastian Bohm , Wouter Olthuis
IPC分类号： A61B505
CPC分类号： A61B5/14528
摘要： Microdialysis device (10), comprising at least a probe (1) provided with an inlet (2) and an outlet (3) for bringing a perfusion fluid into contact with a bodily fluid in a part of a living organism and causing constituents from this fluid to be taken up by this perfusion fluid, whereby the perfusion fluid is enriched to dialysate, wherein the outlet (3) is integrally received in a silicon chip (5) and debouches in a first fluid channel (6) formed in this silicon chip (5) and wherein further at least one analysis means, for instance an ISFET (17, 18), for analysing constituents of the bodily fluid taken up by the perfusion fluid is integrally received in the silicon chip (5) in a manner such that dialysate flowing from the outlet (3) comes into contact with said analysis means in the first fluid channel (6), and wherein the silicon chip (5) is further optionally provided with pumping means (50) or dosing means.
摘要翻译：微透析装置（10）包括至少一个设置有入口（2）和出口（3）的探针（1），用于使灌注流体与生物体的一部分中的体液接触并引起来自该生物体的成分流体被该灌注流体吸收，从而使灌注流体富集成透析液，其中出口（3）整体地容纳在硅芯片（5）中，并且在形成于该硅芯片中的第一流体通道（6）中脱模（5），并且其中另外至少一个分析装置，例如用于分析由灌注流体吸收的体液的成分的ISFET（17,18）以这样的方式被一体地接收在硅芯片（5）中：从出口（3）流出的透析液与第一流体通道（6）中的分析装置接触，并且其中硅芯片（5）还可选地设置有泵送装置（50）或给料装置。

4. 发明申请

US20100031730A1 DEVICE FOR MEASURING THE AMMONIA CONTENT IN A GAS MIXTURE 审中-公开
标题翻译：用于测量气体混合物中的氨含量的装置
公开(公告)号：US20100031730A1
公开(公告)日：2010-02-11
申请号：US12513890
申请日：2007-11-09
申请人： Iris Van Uitert , Wouter Olthuis , Albert Van Den Berg
发明人： Iris Van Uitert , Wouter Olthuis , Albert Van Den Berg
IPC分类号： G01N33/497 , G01F1/00
CPC分类号： G01N33/497 , A61B5/082
摘要： The invention relates to a device for measuring the ammonia content in a gas mixture. The device comprises at least one inlet and one outlet for the gas mixture, between which is situated an ammonia measuring system connected thereto. The device also comprises first regulating means for regulating the gas mixture flow through the inlet, and second means which are adapted such that they allow a measurement of the ammonia content which is substantially independent of the gas mixture flow rate. The device is preferably applied for measuring the ammonia content in exhaled air.
摘要翻译：本发明涉及一种用于测量气体混合物中氨含量的装置。该装置包括用于气体混合物的至少一个入口和一个出口，两个出口与其连接的氨测量系统之间。该装置还包括用于调节通过入口的气体混合物流的第一调节装置和适于使得它们能够测量基本上与气体混合物流速无关的氨含量的第二装置。该装置优选用于测量呼出空气中的氨含量。

5. 发明授权

US06520010B1 System and methods for characterizing a liquid 失效
标题翻译：用于表征液体的系统和方法
公开(公告)号：US06520010B1
公开(公告)日：2003-02-18
申请号：US09368822
申请日：1999-08-05
申请人： Piet Bergveld , Gerardus Rudolph Langereis , Wouter Olthuis
发明人： Piet Bergveld , Gerardus Rudolph Langereis , Wouter Olthuis
IPC分类号： G01F168
CPC分类号： G01N27/06
摘要： A system for characterizing a liquid comprises a sensor for providing an electrical output signal depending on a characteristic of the liquid, and a processing unit for processing the output signal of the sensor to obtain characterizing data of the liquid. The sensor is made as a single sensor/actuator device and can be connected in a plurality of manners to the processing unit. In at least some of these connecting manners the processing unit is adapted to actuate the sensor/actuator device and to process the output signal of the sensor/actuator device to obtain different characterizing data of the liquid.
摘要翻译：用于表征液体的系统包括用于根据液体的特性提供电输出信号的传感器，以及用于处理传感器的输出信号以获得液体的特征数据的处理单元。该传感器被制成单个传感器/致动器装置，并且可以以多种方式连接到处理单元。在这些连接方式中的至少一些中，处理单元适于致动传感器/致动器装置并且处理传感器/致动器装置的输出信号以获得液体的不同特性数据。

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