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    • 8. 发明授权
    • Method and apparatus for detecting and quantifying a chemical compound in a fluid flow
    • 用于检测和定量流体流中的化合物的方法和装置
    • US08393195B2
    • 2013-03-12
    • US12669227
    • 2008-06-24
    • Olivier DucreuxFabienne Le PeltierCyril Collado
    • Olivier DucreuxFabienne Le PeltierCyril Collado
    • G01N1/00G01N30/96
    • G01N1/4005G01N1/2214G01N1/2247G01N2001/4011
    • A method and apparatus for capturing a chemical compound, typically an impurity, and for accumulating said chemical compound on a capture mass CAPT included in at least one removable adsorbent cartridge MC over a period exceeding 2 days, with a view to the external chemical analysis thereof. The apparatus ST suitable for capturing at least one chemical compound in a fluid flow for its detection and/or quantification comprise, downstream of said cartridge or cartridges, at least one device for measuring the cumulative flow which has traversed the cartridge or cartridges over a set time period. In a preferred variation of the invention, the capture mass CAPT is fragmented into a plurality of elementary masses CAPTi which allows for the spread of an irreversible adsorption front or the displacement of a chromatographic zone.
    • 为了对其进行外部化学分析,本发明提供了一种用于捕获化合物(通常为杂质)的方法和装置,并且用于在超过2天的时间内将所述化合物累积在包含在至少一个可移除吸附剂盒MC中的捕获质量CAPT 。 适于捕获流体流中的至少一种化学化合物用于其检测和/或定量的装置ST包括在所述药筒或药筒的下游的至少一个装置,用于测量已经穿过药筒或药筒的累积流量 时间段。 在本发明的优选变型中,捕获质量CAPT被分段成多个基本质量CAPTi,其允许不可逆吸附前沿的扩散或色谱区的移位。