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1. 发明申请

US20060191086A1 Toothbrush employing acoustic waveguide 审中-公开
标题翻译：牙刷采用声波导
公开(公告)号：US20060191086A1
公开(公告)日：2006-08-31
申请号：US11416852
申请日：2006-05-03
申请人： Pierre Mourad , James McInnes , George Barrett , David Ballard , Gerald Brewer , Frederick Bennett
发明人： Pierre Mourad , James McInnes , George Barrett , David Ballard , Gerald Brewer , Frederick Bennett
IPC分类号： A61C17/22
CPC分类号： A46B15/0002 , A46B15/0028 , A46B2200/1066 , A61C17/20 , A61C17/3481
摘要： A power toothbrush (10) is disclosed having a handle (15), battery (12), ultrasonic drive circuit (14), motor (16), control unit (18), and toothbrush head (20). The toothbrush head includes bristles (26) and a waveguide (24) that is operatively connected to an ultrasonic transducer (22). The waveguide facilitates the transmission of acoustic energy into the dental fluid to achieve improved cleaning and stain removal and improved cleaning in interproximal and subgingival regions. In one embodiment an ultrasound transducer module (30) includes a plurality of piezoelectric elements (32, 34) that may be mechanically connected in series, and electrically connected in parallel. One or more contacts (36) connect the elements, and a waveguide structure (50). An impedance matching layer (38) may be provided between the waveguide and the ultrasonic transducer module. The waveguide may be formed from an relatively soft material, for example, a polymer having a hardness between 10 and 65 Shore A.
摘要翻译：公开了具有手柄（15），电池（12），超声波驱动电路（14），马达（16），控制单元（18）和牙刷头（20）的动力牙刷（10）。牙刷头包括刷毛（26）和可操作地连接到超声换能器（22）的波导（24）。波导有助于将声能传输到牙科液体中，以实现改善的清洁和污渍去除以及改善邻近和龈下区域的清洁。在一个实施例中，超声换能器模块（30）包括多个压电元件（32,34），其可以串联机械连接并并联电连接。一个或多个触点（36）连接元件和波导结构（50）。可以在波导和超声换能器模块之间设置阻抗匹配层（38）。波导可以由相对柔软的材料形成，例如硬度在10和65肖氏A之间的聚合物。

2. 发明申请

US20050015009A1 Systems and methods for determining intracranial pressure non-invasively and acoustic transducer assemblies for use in such systems 有权
标题翻译：用于确定在这种系统中使用的非侵入性和声学换能器组件的颅内压的系统和方法
公开(公告)号：US20050015009A1
公开(公告)日：2005-01-20
申请号：US10861197
申请日：2004-06-03
申请人： Pierre Mourad , Brandt Mohr , Michel Kliot , Robert Frederickson , R. Thompson , Jason Seawall
发明人： Pierre Mourad , Brandt Mohr , Michel Kliot , Robert Frederickson , R. Thompson , Jason Seawall
IPC分类号： A61B5/03 , A61B8/00 , A61B8/04 , A61B8/06 , A61B8/08 , A61B8/14
CPC分类号： A61B5/031 , A61B5/0051 , A61B5/4064 , A61B5/415 , A61B5/418 , A61B5/4824 , A61B5/7267 , A61B8/00 , A61B8/04 , A61B8/065 , A61B8/08 , A61B8/0808 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/488
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.
摘要翻译：提供了基于可以使用非侵入性或微创技术测量的参数来确定ICP的系统和方法，其中使用非线性关系来基于一个或多个可变输入来确定ICP。第一可变输入涉及颅血管和/或血流的一种或多种性质，例如来自具有在颅血管上训练的焦点的声学换能器的声学后向散射，颅血管中的流速等。另外的变量，例如动脉血压（ABP）可以与与颅血管的一种或多种性质（例如大脑中动脉（MCA）的流速）相关的第一可变输入组合使用，以便使用非线性关系。基于它们的声学特性和对于区域的声学扫描来定位目标区域的方法和系统也基于声学特性识别目标区域，以及声源和/或检测器在期望的目标区域上的自动聚焦也是提供。描述了声学换能器组件。

3. 发明申请

US20070016031A1 Systems and methods for making noninvasive assessments of cardiac tissue and parameters 有权
标题翻译：用于进行心脏组织和参数的无创评估的系统和方法
公开(公告)号：US20070016031A1
公开(公告)日：2007-01-18
申请号：US11395437
申请日：2006-03-31
申请人： Pierre Mourad , Michel Kliot , Rex Patterson , Alec Rooke
发明人： Pierre Mourad , Michel Kliot , Rex Patterson , Alec Rooke
IPC分类号： A61B8/00
CPC分类号： A61B8/065 , A61B5/0048 , A61B5/031 , A61B5/4519 , A61B5/4824 , A61B5/4869 , A61B6/503 , A61B6/504 , A61B8/00 , A61B8/04 , A61B8/08 , A61B8/0808 , A61B8/0883 , A61B8/0891 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/485 , A61B8/488
摘要： Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
摘要翻译：公开了使用超声技术非心脏评估心脏组织特性和心脏参数的系统和方法。心肌组织刚度，张力，应变，应变速率等的测定可用于评估心肌收缩力，心肌缺血和梗死，心室充盈和心房压力以及舒张功能。公开了诸如超声波之类的声学技术来采集与内在组织位移有关的数据的非侵入式系统。还公开了其中使用超声技术来声学刺激或触诊靶心脏组织或诱导与心脏组织特性和/或心脏参数相关的心脏组织部位的应答的非侵入性系统。

4. 发明申请

US20060100530A1 Systems and methods for non-invasive detection and monitoring of cardiac and blood parameters 审中-公开
标题翻译：用于非侵入性检测和监测心脏和血液参数的系统和方法
公开(公告)号：US20060100530A1
公开(公告)日：2006-05-11
申请号：US11234914
申请日：2005-09-26
申请人： Michel Kliot , Robert Frederickson , Kamran Forghani , Pierre Mourad
发明人： Michel Kliot , Robert Frederickson , Kamran Forghani , Pierre Mourad
IPC分类号： A61B5/02
CPC分类号： A61B8/06 , A61B5/0002 , A61B5/0205 , A61B5/08 , A61B5/145 , A61B5/681 , A61B5/6814 , A61B5/6822 , A61B5/6828 , A61B5/6831 , A61B8/04 , A61B8/0816 , A61B8/4472 , A61B8/485 , A61B8/543 , A61B8/56 , A61B8/58
摘要： Methods and systems for long term monitoring of one or more physiological parameters such as respiration, heart rate, body temperature, electrical heart activity, blood oxygenation, blood flow velocity, blood pressure, intracranial pressure, the presence of emboli in the blood stream and electrical brain activity are provided. Data is acquired non-invasively using ambulatory data acquisition techniques.
摘要翻译：用于长期监测一种或多种生理参数的方法和系统，例如呼吸，心率，体温，电心脏活动，血氧饱和度，血流速度，血压，颅内压，血液中血栓和电气的存在提供大脑活动。使用流动数据采集技术非侵入性地获取数据。

5. 发明申请

US20060079773A1 Systems and methods for making non-invasive physiological assessments by detecting induced acoustic emissions 审中-公开
标题翻译：通过检测诱发的声发射进行非侵入性生理评估的系统和方法
公开(公告)号：US20060079773A1
公开(公告)日：2006-04-13
申请号：US11050993
申请日：2005-02-04
申请人： Pierre Mourad , Michel Kliot , Robert Frederickson
发明人： Pierre Mourad , Michel Kliot , Robert Frederickson
IPC分类号： A61B8/00
CPC分类号： A61B5/031 , A61B5/0051 , A61B5/4058 , A61B5/4064 , A61B5/415 , A61B5/418 , A61B8/04 , A61B8/08 , A61B8/0808 , A61B8/485 , A61B8/488
摘要： Systems and methods for assessing a physiological parameter of a target tissue wherein a pulse of focused ultrasound is applied to a target tissue site thereby inducing oscillation of the target tissue. By these systems and methods, a property of an acoustic signal emitted from the oscillating target tissue is measured and related to a physiological property of the tissue. Specific applications for systems and methods of the present invention include the assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.
摘要翻译：用于评估目标组织的生理参数的系统和方法，其中聚焦超声的脉冲被施加到目标组织位置，从而引起靶组织的振荡。通过这些系统和方法，测量从振荡目标组织发射的声信号的特性并与组织的生理特性相关。本发明的系统和方法的具体应用包括评估和监测颅内压（ICP），动脉血压（ABP），CNS自动调节状态，血管痉挛，中风，局部水肿，感染和血管，以及诊断和监测其特征在于组织性质的物理变化的疾病和病症。

6. 发明申请

US20050136102A1 Enhanced transport using membrane disruptive agents 有权
标题翻译：增强运输使用膜破坏剂
公开(公告)号：US20050136102A1
公开(公告)日：2005-06-23
申请号：US10857626
申请日：2004-05-28
申请人： Allan Hoffman , Patrick Stayton , Oliver Press , Niren Murthy , Chantal Reed , Lawrence Crum , Pierre Mourad , Tyrone Porter
发明人： Allan Hoffman , Patrick Stayton , Oliver Press , Niren Murthy , Chantal Reed , Lawrence Crum , Pierre Mourad , Tyrone Porter
IPC分类号： A61K47/32 , A61K9/00 , A61K31/7105 , A61K31/711 , A61K41/00 , A61K47/42 , A61K47/48 , A61N1/30 , A61K9/70
CPC分类号： A61K47/481 , A61K41/0028 , A61K41/0047 , A61K47/48376 , A61K47/6801
摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.
摘要翻译：描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。待递送的药剂可以是治疗和/或诊断剂。还可以与破坏剂一起使用增强交付如超声，离子层析和/或电穿孔的处理。

7. 发明申请

US20050091770A1 Toothbrush employing an acoustic waveguide 有权
标题翻译：使用声波导的牙刷
公开(公告)号：US20050091770A1
公开(公告)日：2005-05-05
申请号：US10981735
申请日：2004-11-03
申请人： Pierre Mourad , Francis Olson , Roger Thompson , Jason Seawall
发明人： Pierre Mourad , Francis Olson , Roger Thompson , Jason Seawall
IPC分类号： A46B15/00 , A61C20060101 , A61C17/20 , A61C17/22 , A61C17/34
CPC分类号： A46B15/0002 , A46B15/0028 , A46B2200/1066 , A61C17/20 , A61C17/3481
摘要： A power toothbrush (10) is disclosed having a handle (15) containing a rechargeable battery (12), an ultrasonic drive circuit (14), a sonic component (16) such as a motor, and a control unit (18). The handle is connected to a toothbrush head (20) preferably having a plurality of bristles (26) and an ultrasonic transducer (22) that is operatively connected to a waveguide (24) that extends from the toothbrush head generally adjacent the bristles. The waveguide facilitates the transmission of acoustic energy into the dental fluid. It is contemplated that the waveguide may be utilized in manual or power toothbrushes, and in a combination without the sonic component, or in a combination without the ultrasonic transducer. Toothbrushes disclosed herein achieve improved plaque and stain removal from the teeth as well as interproximal and subgingival regions, while enhancing the user experience, massaging the gums, and stimulating dental tissue.
摘要翻译：公开了一种电动牙刷（10），其具有包含可再充电电池（12）的手柄（15），超声波驱动电路（14），诸如电动机的声音部件（16）和控制单元（18）。手柄连接到优选地具有多个刷毛（26）的牙刷头（20）和可操作地连接到从牙刷头大致相邻于刷毛延伸的波导（24）的超声波换能器（22）。波导有助于将声能传输到牙科液体中。可以想到，波导可以用于手动或动力牙刷，并且在没有声音部件的情况下组合，或者在没有超声换能器的情况下组合。本文公开的牙刷实现了从牙齿以及邻间和龈下区域改进的斑块和污渍去除，同时增强了使用者体验，按摩牙龈和刺激牙齿组织。

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