专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5661134A Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity 失效
标题翻译：用于调节具有高手性纯度的硫代磷酸酯键的Ha-ras或Ki-ras的寡核苷酸
公开(公告)号：US5661134A
公开(公告)日：1997-08-26
申请号：US471966
申请日：1995-06-06
申请人： Phillip Dan Cook , Glenn Hoke
发明人： Phillip Dan Cook , Glenn Hoke
IPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C12N15/10 , C12N15/113 , C12P19/34 , C12Q1/68 , C12Q1/70 , A61K31/70
CPC分类号： A61K31/70 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N15/10 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N9/0069 , C12P19/34 , C12Q1/68 , C12Q1/6813 , C12Q1/6876 , C12Q1/701 , C12Y113/11012 , A61K48/00 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533
摘要： Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis. They are especially well suited as diagnostics, therapeutics, and research reagents in diseases mediated by Ha-ras or Ki-ras.
摘要翻译：提供了包含通过基本上所有的Sp或基本上所有的Rp硫代磷酸酯杂合键连接在一起的核苷单元的序列特异性硫代磷酸酯寡核苷酸。通过酶促或化学合成来制备具有基本上手性纯粹的子宫颈间连接的这种序列特异性硫代磷酸酯寡核苷酸。它们特别适用于由Ha-ras或Ki-ras介导的疾病中的诊断，治疗和研究试剂。

2. 发明授权

US06339066B1 Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate &bgr;I, &bgr;II, &ggr;, &dgr;, &Egr;, &zgr; and &eegr; isoforms of human protein kinase C 失效
标题翻译：具有高手性纯度的硫代磷酸酯键并且调节βI，βII，γ，δ和Egr;和zgr的反义寡核苷酸。和人类蛋白激酶C的同种异构体
公开(公告)号：US06339066B1
公开(公告)日：2002-01-15
申请号：US08829637
申请日：1997-03-31
申请人： C. Frank Bennett , Nicholas M. Dean , Phillip Dan Cook , Glenn Hoke
发明人： C. Frank Bennett , Nicholas M. Dean , Phillip Dan Cook , Glenn Hoke
IPC分类号： C07H2104
CPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N9/12 , C12N15/10 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12P19/34 , C12Q1/68 , C12Q1/6813 , C12Q1/6876 , C12Q1/6883 , C12Q1/701 , C12Q2600/158 , C12Y113/11012 , C12Y207/11013
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with the expression of one or more of the &bgr;I, &bgr;II, &ggr;, &dgr;, &egr;, &zgr; or &eegr; isoforms (isozymes) of protein kinase C (PKC). Oligonucleotides are provided which are targeted to nucleic acids encoding PKC-&bgr;I, PKC-&bgr;II, PKC-&ggr;, PKC-&dgr;, PKC-&egr;, PKC-&zgr; or PKC-&eegr;. Provided herein are oligonucleotides specifically hybridizable with a translation initiation site, 5′-untranslated region, 3′-untranslated region or other targeted region of a &bgr;I, &bgr;II, &ggr;, &dgr;, &egr;, &zgr; or &eegr; isoform of PKC, wherein at least about 75% of the nucleoside units of a given oligonucleotide are joined together by a stereospecific (i.e., Sp or Rp) phosphorothioate 3′ to 5′ linkages. In preferred embodiments, the oligonucleotides of the disclosure additionally contain one or more chemical modifications. Also disclosed are methods of using the oligonucleotides of the invention for modulating the expression of at least one of the &bgr;I, &bgr;II, &ggr;, &dgr;, &egr;, &zgr; or &eegr; isoforms of PKC and for treating animals suffering from disease amenable to therapeutic intervention by modulating the expression of one or more of the &bgr;I, &bgr;II, &ggr;, &dgr;, &egr;, &zgr; or &eegr; isoforms of PKC.
摘要翻译：提供组合物和方法用于治疗和诊断与βI，βII，γ，δ，epsi和zgr中的一种或多种的表达相关的疾病。或蛋白激酶C（PKC）的eta同工型（同工酶）。提供寡核苷酸，其靶向编码PKC-βI，PKC-βII，PKC-γ，PKC-δ，PKC-epsi，PKC- 或PKC-eta。本文提供了与翻译起始位点，5'-非翻译区，3'非翻译区或βI，βII，γ，δ，ε1和zgr的其它目标区域特异性杂交的寡核苷酸。或等位基因型，其中给定寡核苷酸的至少约75％的核苷单位通过立体特异性（即Sp或Rp）硫代磷酸酯3'至5'键连接在一起。在优选的实施方案中，本公开的寡核苷酸另外含有一种或多种化学修饰。还公开了使用本发明的寡核苷酸调节βI，βII，γ，δ，epsi和zgr中至少一种的表达的方法。或eta同种型，并通过调节βI，βII，γ，δ，εi，和zgr中的一种或多种的表达来治疗患有适于治疗性干预的疾病的动物。或PKC的eta同种型。

3. 发明授权

US5654284A Oligonucleotides for modulating RAF kinase having phosphorothioate linkages of high chiral purity 失效
标题翻译：用于调节具有高手性纯度的硫代磷酸酯键的RAF激酶的寡核苷酸
公开(公告)号：US5654284A
公开(公告)日：1997-08-05
申请号：US466692
申请日：1995-06-06
申请人： Phillip Dan Cook , Glenn Hoke
发明人： Phillip Dan Cook , Glenn Hoke
IPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C12N15/10 , C12N15/113 , C12P19/34 , C12Q1/68 , C12Q1/70
CPC分类号： A61K31/70 , C07H19/10 , C07H19/20 , C07H21/00 , C12N15/10 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12P19/34 , C12Q1/6813 , C12Q1/6876 , C12Q1/701
摘要： Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis.
摘要翻译：提供了包含通过基本上所有的Sp或基本上所有的Rp硫代磷酸酯杂合键连接在一起的核苷单元的序列特异性硫代磷酸酯寡核苷酸。通过酶促或化学合成来制备具有基本上手性纯粹的子宫颈间连接的这种序列特异性硫代磷酸酯寡核苷酸。

4. 发明申请

US20090326045A1 COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF OLIGONUCLEOTIDES 失效
标题翻译：用于局部输送寡核苷酸的组合物和方法
公开(公告)号：US20090326045A1
公开(公告)日：2009-12-31
申请号：US12545778
申请日：2009-08-21
申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
发明人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
IPC分类号： A61K31/7088 , A61P35/00
CPC分类号： A61K48/0008 , A61K48/0025 , A61K48/0041 , A61K48/0075
摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
摘要翻译：本发明涉及通过局部施用途径增强寡核苷酸和其它核苷部分的递送的组合物和方法。优选的组合物包括用于将这些部分递送到动物中用于调查，治疗或预防目的的皮肤和/或表皮组织的脂质体或渗透增强剂。

5. 发明授权

US07202224B2 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase 有权
标题翻译：核苷衍生物作为RNA依赖性RNA病毒聚合酶的抑制剂
公开(公告)号：US07202224B2
公开(公告)日：2007-04-10
申请号：US11496338
申请日：2006-07-31
申请人： Anne B. Eldrup , Marija Prhavc , Phillip Dan Cook , Steven S. Carroll , David B. Olsen
发明人： Anne B. Eldrup , Marija Prhavc , Phillip Dan Cook , Steven S. Carroll , David B. Olsen
IPC分类号： A61K31/70 , C07H19/14
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

6. 发明授权

US06893815B1 Nucleobase heterocyclic combinatorialization 失效
标题翻译：核碱基杂环组合
公开(公告)号：US06893815B1
公开(公告)日：2005-05-17
申请号：US08884873
申请日：1997-06-30
申请人： Phillip Dan Cook
发明人： Phillip Dan Cook
IPC分类号： C07B61/00 , C07D473/00 , C07H19/16 , C12Q1/68
CPC分类号： C07D473/00 , C07H19/16 , C40B40/00
摘要： Mixtures of chemical compounds are provided having antibacterial and other utility. The mixtures are formed, preferably in solution phase, from the reaction of a purine or pyrimiding heterocyclic scaffold with a set of related chemical substituients, optionally through employment of a tether moiety. Libraries formed in accordance with the invention have utility per se and are articles of commerce. They can be used to screen for pesticides, drugs and other biologically active compounds.
摘要翻译：提供化合物的混合物具有抗菌和其他效用。混合物优选在溶液相中由嘌呤或嘧啶杂环支架与一组相关的化学取代基的反应形成，任选地通过使用系链部分。根据本发明形成的图书馆本身具有效用，并且是商品。它们可用于筛选农药，药物和其他生物活性化合物。

7. 发明授权

US06811975B2 Phosphorothioate oligonucleotides having modified internucleoside linkages 失效
标题翻译：具有修饰的核苷间键的硫代磷酸酯寡核苷酸
公开(公告)号：US06811975B2
公开(公告)日：2004-11-02
申请号：US09805630
申请日：2001-03-14
申请人： Phillip Dan Cook , Muthiah Manoharan
发明人： Phillip Dan Cook , Muthiah Manoharan
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H19/04
摘要： Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′-terminal internucleoside linkage or the 5′- and 3′-terminal linkages are modified.
摘要翻译：模仿和/或调节野生型核酸活性的新型化合物。通常，化合物是硫代磷酸酯寡核苷酸，其中5'-末端核苷间键或5'-和3'-末端键被修饰。

8. 发明授权

US06756199B1 Peptide nucleic acid combinatorial libraries and improved methods of synthesis 失效
标题翻译：肽核酸组合文库和改进的合成方法
公开(公告)号：US06756199B1
公开(公告)日：2004-06-29
申请号：US08466395
申请日：1995-06-06
申请人： Phillip Dan Cook , John Kiely , Kelly Sprankle
发明人： Phillip Dan Cook , John Kiely , Kelly Sprankle
IPC分类号： C12Q168
CPC分类号： C07K14/003 , B01J2219/00592 , B01J2219/00729 , C07K7/02
摘要： New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid oligomers as well as random sequence peptide nucleic acid oligomers. Further these methods also provide for the incorporation of peptide nucleic acid units or strings of such units with amino acids or strings of amino acids in chimeric peptide nucleic acid-amino acid compounds. Further disclosed are method of making random libraries of peptide nucleic acids using the fully preformed monomers. Chimeric oligomers and libraries of the same are also disclosed.
摘要翻译：公开了用于制备肽核酸低聚结构的新的亚单体合成方法，其提供预定义的序列肽核酸寡聚体以及随机序列肽核酸寡聚体的合成。此外，这些方法还提供了嵌合肽核酸 - 氨基酸化合物中肽核酸单元或这些单元的串与氨基酸或氨基酸序列的结合。进一步公开的是使用完全预制的单体制备肽核酸的随机文库的方法。也公开了嵌合低聚物和其文库。

9. 发明授权

US06747014B2 Compositions and methods for non-parenteral delivery of oligonucleotides 失效
标题翻译：用于非肠胃外递送寡核苷酸的组合物和方法
公开(公告)号：US06747014B2
公开(公告)日：2004-06-08
申请号：US10029598
申请日：2001-12-21
申请人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
发明人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
IPC分类号： A61K3170
CPC分类号： A61K48/0075 , A61K9/0014 , A61K9/0019 , A61K47/12 , A61K47/28 , A61K48/00 , C07H21/00 , Y10S514/946
摘要： The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed herein include, for systemic delivery, emulsion and microemulsion formulations for a variety of applications and oral dosage formulations. It has also surprisingly been discovered that oligonucleotides may be locally delivered to colonic sites by rectal enemas and suppositories in simple solutions, e.g., neat or in saline. Such pharmaceutical compositions of oligonucleotides may further include one or more penetration enhancers for the transport of oligonucleotides and other nucleic acids across mucosal membranes. The compositions and methods of the invention are utilized to effect the oral, buccal, rectal or vaginal administration of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic, palliative or prophylactic purposes.
摘要翻译：本发明涉及通过非肠胃外给药途径增强寡核苷酸和核酸的局部和全身摄取和递送的组合物和方法。包含本文公开的寡核苷酸的药物组合物包括用于全身递送的乳液和微乳液制剂用于各种应用和口服剂型。还令人惊讶地发现，可以用简单的溶液，例如纯的或盐水，通过直肠灌肠剂和栓剂将寡核苷酸局部递送至结肠部位。寡核苷酸的这种药物组合物可以进一步包括一种或多种用于将寡核苷酸和其它核酸转移穿过粘膜的渗透增强剂。本发明的组合物和方法用于对动物进行口服，口腔，直肠或阴道施用反义寡核苷酸，以调节动物中基因在调查，治疗，姑息或预防目的中的表达。

10. 发明授权

US06660466B1 Di-nitrogen heterocycle compositions 有权
标题翻译：二氮杂环组合物
公开(公告)号：US06660466B1
公开(公告)日：2003-12-09
申请号：US09128036
申请日：1998-08-03
申请人： Phillip Dan Cook , Pei-Pei Kung , Andrew Mamoru Kawasaki
发明人： Phillip Dan Cook , Pei-Pei Kung , Andrew Mamoru Kawasaki
IPC分类号： C12Q100
CPC分类号： C07D295/13 , A61K31/495 , A61K31/496 , C07D261/08 , C07D277/82 , C07D295/15 , C40B40/00 , Y02A50/473 , A61K2300/00
摘要： Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.
摘要翻译：制备包含含有至少一个N-间位取代的烷芳基的新型二氮杂环化合物的组合物。本发明的化合物可用作抗细菌剂和其他药剂以及用于制备其它药剂的中间体。此外，本发明的化合物可用作研究试剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式