专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08377897B2 Compositions and methods for non-parenteral delivery of oligonucleotides 有权
公开(公告)号：US08377897B2
公开(公告)日：2013-02-19
申请号：US11237063
申请日：2005-09-28
申请人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
发明人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： A61K48/0008 , A61K9/0014 , A61K9/0031 , A61K9/107 , A61K9/1075 , A61K38/00 , A61K47/12 , A61K47/28 , A61K48/00 , A61K48/0025 , A61K48/0041 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3527 , C12N2310/3525
摘要： The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed herein include, for systemic delivery, emulsion and microemulsion formulations for a variety of applications and oral dosage formulations. It has also surprisingly been discovered that oligonucleotides may be locally delivered to colonic sites by rectal enemas and suppositories in simple solutions, e.g., neat or in saline. Such pharmaceutical compositions of oligonucleotides may further include one or more penetration enhancers for the transport of oligonucleotides and other nucleic acids across mucosal membranes. The compositions and methods of the invention are utilized to effect the oral, buccal, rectal or vaginal administration of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic, palliative or prophylactic purposes.

2. 发明授权

US6083923A Liposomal oligonucleotide compositions for modulating RAS gene expression 失效
标题翻译：用于调节RAS基因表达的脂质体寡核苷酸组合物
公开(公告)号：US6083923A
公开(公告)日：2000-07-04
申请号：US961469
申请日：1997-10-31
申请人： Gregory E. Hardee , Richard S. Geary , Arthur Levin , Michael V. Templin , Randy Howard , Rahul C. Mehta
发明人： Gregory E. Hardee , Richard S. Geary , Arthur Levin , Michael V. Templin , Randy Howard , Rahul C. Mehta
IPC分类号： A61K9/127 , A61K38/00 , C07H21/00 , C12N15/113 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/11
CPC分类号： C12N15/1135 , A61K9/1271 , C07H21/00 , A61K38/00 , A61K9/127 , C12N2310/341
摘要： Pharmaceutical compositions comprising sterically stabilized liposomes containing antisense oligonucleotides are provided for the modulation of expression of the human ras gene in both the normal (wildtype) and activated (mutant) forms.
摘要翻译：提供包含含有反义寡核苷酸的空间稳定的脂质体的药物组合物用于在正常（野生型）和活化（突变体）形式中调节人ras基因的表达。

3. 发明授权

US08168600B2 Compositions and methods for topical delivery of oligonucleotides 有权
标题翻译：用于局部递送寡核苷酸的组合物和方法
公开(公告)号：US08168600B2
公开(公告)日：2012-05-01
申请号：US11112451
申请日：2005-04-21
申请人： Sujatha Dokka , Scott Cooper , Susan Kelly , Gregory E. Hardee , James G. Karras
发明人： Sujatha Dokka , Scott Cooper , Susan Kelly , Gregory E. Hardee , James G. Karras
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： A61K8/606 , A61K9/0014 , A61K9/127 , A61K47/14 , A61K48/0075 , A61Q7/02 , C12N15/87 , Y02A50/401
摘要： The present invention relates to compositions and methods which enhance the delivery of nucleic acids and other nucleosidic moieties via topical routes of administration. The invention relates to the use of an aqueous solution to preferentially deliver nucleic acids preferentially to hair follicles. The invention relates to a method of inhibiting hair growth comprising administration of a nucleic acid preferentially to a hair follicle.
摘要翻译：本发明涉及通过局部施用途径增强核酸和其它核苷部分的递送的组合物和方法。本发明涉及水溶液优先将核酸优先递送至毛囊的用途。本发明涉及一种抑制毛发生长的方法，包括将核酸优先施用于毛囊。

4. 发明申请

US20090326045A1 COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF OLIGONUCLEOTIDES 失效
标题翻译：用于局部输送寡核苷酸的组合物和方法
公开(公告)号：US20090326045A1
公开(公告)日：2009-12-31
申请号：US12545778
申请日：2009-08-21
申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
发明人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
IPC分类号： A61K31/7088 , A61P35/00
CPC分类号： A61K48/0008 , A61K48/0025 , A61K48/0041 , A61K48/0075
摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
摘要翻译：本发明涉及通过局部施用途径增强寡核苷酸和其它核苷部分的递送的组合物和方法。优选的组合物包括用于将这些部分递送到动物中用于调查，治疗或预防目的的皮肤和/或表皮组织的脂质体或渗透增强剂。

5. 发明授权

US06747014B2 Compositions and methods for non-parenteral delivery of oligonucleotides 失效
标题翻译：用于非肠胃外递送寡核苷酸的组合物和方法
公开(公告)号：US06747014B2
公开(公告)日：2004-06-08
申请号：US10029598
申请日：2001-12-21
申请人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
发明人： Ching-Leou Teng , Phillip Dan Cook , Lloyd Tillman , Gregory E. Hardee , David J. Ecker , Muthiah Manoharan
IPC分类号： A61K3170
CPC分类号： A61K48/0075 , A61K9/0014 , A61K9/0019 , A61K47/12 , A61K47/28 , A61K48/00 , C07H21/00 , Y10S514/946
摘要： The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed herein include, for systemic delivery, emulsion and microemulsion formulations for a variety of applications and oral dosage formulations. It has also surprisingly been discovered that oligonucleotides may be locally delivered to colonic sites by rectal enemas and suppositories in simple solutions, e.g., neat or in saline. Such pharmaceutical compositions of oligonucleotides may further include one or more penetration enhancers for the transport of oligonucleotides and other nucleic acids across mucosal membranes. The compositions and methods of the invention are utilized to effect the oral, buccal, rectal or vaginal administration of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic, palliative or prophylactic purposes.
摘要翻译：本发明涉及通过非肠胃外给药途径增强寡核苷酸和核酸的局部和全身摄取和递送的组合物和方法。包含本文公开的寡核苷酸的药物组合物包括用于全身递送的乳液和微乳液制剂用于各种应用和口服剂型。还令人惊讶地发现，可以用简单的溶液，例如纯的或盐水，通过直肠灌肠剂和栓剂将寡核苷酸局部递送至结肠部位。寡核苷酸的这种药物组合物可以进一步包括一种或多种用于将寡核苷酸和其它核酸转移穿过粘膜的渗透增强剂。本发明的组合物和方法用于对动物进行口服，口腔，直肠或阴道施用反义寡核苷酸，以调节动物中基因在调查，治疗，姑息或预防目的中的表达。

6. 发明授权

US5721359A Crystalline ceftiofur free acid 失效
标题翻译：结晶头孢噻呋游离酸
公开(公告)号：US5721359A
公开(公告)日：1998-02-24
申请号：US549821
申请日：1995-09-11
申请人： Michael J. Dunn , Michael S. Bergren , Gregory E. Hardee , Kenneth Paul Shephard , Robert S. Chao , Jeffrey L. Havens
发明人： Michael J. Dunn , Michael S. Bergren , Gregory E. Hardee , Kenneth Paul Shephard , Robert S. Chao , Jeffrey L. Havens
IPC分类号： C07D501/26 , A61K31/545 , A61K31/546 , A61P31/12 , C07D501/00 , C07D501/36
CPC分类号： C07D501/00 , A61K31/545
摘要： Anhydrous and crystalline free acid form of the cephalosporin antiobiotic ceftiofur, processes for its manufacture, and pharmaceutical composition containing it are provided. ##STR1##
摘要翻译： PCT No.PCT / US94 / 01862 Sec。 371 1995年9月11日第 102（e）1995年9月11日PCT PCT 1994年3月7日PCT公布。公开号WO94 / 20505 PCT 日期1994年9月15日提供无头和结晶游离酸形式的头孢菌素抗生素头孢噻呋，其制备方法和含有它的药物组合物。

7. 发明申请

US20110256217A1 PULSATILE RELEASE COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL DRUG ABSORPTION 审中-公开
标题翻译：弹性释放组合物和增强吸入药物的方法
公开(公告)号：US20110256217A1
公开(公告)日：2011-10-20
申请号：US12485675
申请日：2009-06-16
申请人： Susan Weinbach , Lloyd G. Tillman , Richard S. Geary , Gregory E. Hardee
发明人： Susan Weinbach , Lloyd G. Tillman , Richard S. Geary , Gregory E. Hardee
IPC分类号： A61K9/14 , A61K31/712 , A61K9/22 , A61K9/28 , A61K31/7088 , A61K9/52
CPC分类号： A61K9/4808 , A61K9/4891
摘要： Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second population of carrier particles comprising a penetration enhancer and a delayed release coating or matrix. This penetration enhancer is released at a second location in the intestine downstream from the first location and enhances absorption of the drug when it reaches the second location.
摘要翻译：延迟口服药物制剂和增强肠吸收药物的方法。所述制剂包含第一载体颗粒群，其包含在肠中的第一位置释放的药物和渗透增强剂，以及包含渗透促进剂和延迟释放包衣或基质的第二种载体颗粒。这种渗透增强剂在第一位置下游的肠道的第二位置释放，并且当药物到达第二位置时增强药物的吸收。

8. 发明申请

US20110213014A1 COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF OLIGONUCLEOTIDES 审中-公开
标题翻译：用于局部输送寡核苷酸的组合物和方法
公开(公告)号：US20110213014A1
公开(公告)日：2011-09-01
申请号：US13107131
申请日：2011-05-13
申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
发明人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
IPC分类号： A61K31/7088 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： A61K48/0008 , A61K48/0025 , A61K48/0041 , A61K48/0075
摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
摘要翻译：本发明涉及通过局部施用途径增强寡核苷酸和其它核苷部分的递送的组合物和方法。优选的组合物包括用于将这些部分递送到动物中用于调查，治疗或预防目的的皮肤和/或表皮组织的脂质体或渗透增强剂。

9. 发明授权

US07964579B2 Compositions and methods for topical delivery of oligonucleotides 失效
标题翻译：用于局部递送寡核苷酸的组合物和方法
公开(公告)号：US07964579B2
公开(公告)日：2011-06-21
申请号：US12545778
申请日：2009-08-21
申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
发明人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
IPC分类号： C07H21/02 , C07H21/04 , A61K31/70 , C12Q1/68
CPC分类号： A61K48/0008 , A61K48/0025 , A61K48/0041 , A61K48/0075
摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
摘要翻译：本发明涉及通过局部施用途径增强寡核苷酸和其它核苷部分的递送的组合物和方法。优选的组合物包括用于将这些部分递送到动物中用于调查，治疗或预防目的的皮肤和/或表皮组织的脂质体或渗透增强剂。

10. 发明授权

US06841539B1 Compositions and methods for topical delivery of oligonucleotides 失效
标题翻译：用于局部递送寡核苷酸的组合物和方法
公开(公告)号：US06841539B1
公开(公告)日：2005-01-11
申请号：US09315294
申请日：1999-05-20
申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
发明人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
IPC分类号： C12N15/09 , A61K9/107 , A61K31/7088 , A61K31/7125 , A61K47/12 , A61K47/24 , A61K47/38 , A61K48/00 , C07H21/04 , C12Q1/68
CPC分类号： A61K48/0008 , A61K48/0025 , A61K48/0041 , A61K48/0075
摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
摘要翻译：本发明涉及通过局部施用途径增强寡核苷酸和其它核苷部分的递送的组合物和方法。优选的组合物包括用于将这些部分递送到动物中用于调查，治疗或预防目的的皮肤和/或表皮组织的脂质体或渗透增强剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式