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1. 发明授权

US07799278B2 Microfluidic system for chemical analysis 有权
标题翻译：微流控系统进行化学分析
公开(公告)号：US07799278B2
公开(公告)日：2010-09-21
申请号：US10885471
申请日：2004-07-06
申请人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean René Tabeling
发明人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean René Tabeling
IPC分类号： G01N21/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L3/50273
摘要： A microfluidic system for performing fluid analysis is described having: (a) a submersible housing having a fluid analysis means and a power supply to provide power to said system; and (b) a substrate for receiving a fluid sample, having embedded therein a fluid sample inlet, a reagent inlet, a fluid sample outlet, and a mixing region in fluid communication with the fluid sample inlet, the reagent inlet, and the fluid sample outlet, and wherein the substrate includes a fluid drive means for moving the fluid sample through the substrate, and wherein the substrate interconnects with the housing. At least a portion of the fluid analysis means may be embedded in the substrate.
摘要翻译：描述了一种用于执行流体分析的微流体系统，其具有：（a）具有流体分析装置的潜水壳体和向所述系统提供动力的电源; （b）用于接收流体样品的基板，其中嵌入有流体样品入口，试剂入口，流体样品出口和与流体样品入口，试剂入口和流体样品流体连通的混合区域出口，并且其中所述基板包括用于使所述流体样品通过所述基板移动的流体驱动装置，并且其中所述基板与所述壳体相互连接。流体分析装置的至少一部分可以嵌入衬底中。

2. 发明授权

US07695629B2 Microfluidic separator 失效
标题翻译：微流控分离器
公开(公告)号：US07695629B2
公开(公告)日：2010-04-13
申请号：US12390158
申请日：2009-02-20
申请人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean René Tabeling
发明人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean René Tabeling
IPC分类号： B01D61/00 , B01D63/00
CPC分类号： B01D67/0062 , B01D17/085 , B01D19/0031 , B01D61/18 , B01L3/502753 , B01L2200/0673 , B01L2300/0681 , B01L2300/0864 , B01L2300/161 , B01L2400/0487 , E21B43/38 , E21B47/10 , E21B49/081 , E21B49/10 , G01N1/4005 , G01N33/28 , G01N2001/4016 , Y10T436/25375
摘要： The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.
摘要翻译：本发明提供了用于分离和/或分析感兴趣的流体的方法和装置。根据本发明的原理，使用微流体装置实现流体分析，并且可以在地下环境中实时或接近实时地报告。除了油田应用之外或替代，本发明的原理考虑了在实验室或其他环境中的分离用于生物样品分离和分析化学应用。本发明能够分离微流体装置中的液体 - 液体混合物或乳液而不会结垢。

3. 发明申请

US20090183871A1 MICROFLUIDIC SEPARATOR 失效
标题翻译：微流分离器
公开(公告)号：US20090183871A1
公开(公告)日：2009-07-23
申请号：US12390158
申请日：2009-02-20
申请人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean Rene Tabeling
发明人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean Rene Tabeling
IPC分类号： B01D61/00 , B01D19/00 , B01D61/32 , E21B47/00
CPC分类号： B01D67/0062 , B01D17/085 , B01D19/0031 , B01D61/18 , B01L3/502753 , B01L2200/0673 , B01L2300/0681 , B01L2300/0864 , B01L2300/161 , B01L2400/0487 , E21B43/38 , E21B47/10 , E21B49/081 , E21B49/10 , G01N1/4005 , G01N33/28 , G01N2001/4016 , Y10T436/25375
摘要： The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.
摘要翻译：本发明提供了用于分离和/或分析感兴趣的流体的方法和装置。根据本发明的原理，使用微流体装置实现流体分析，并且可以在地下环境中实时或接近实时地报告。除了油田应用之外或替代，本发明的原理考虑了在实验室或其他环境中的分离用于生物样品分离和分析化学应用。本发明能够分离微流体装置中的液体 - 液体混合物或乳液而不会结垢。

4. 发明申请

US20060008382A1 Microfluidic system for chemical analysis 有权
标题翻译：微流控系统进行化学分析
公开(公告)号：US20060008382A1
公开(公告)日：2006-01-12
申请号：US10885471
申请日：2004-07-06
申请人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald Van Hal , Robert Schroeder , Patrick Tabeling
发明人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald Van Hal , Robert Schroeder , Patrick Tabeling
IPC分类号： G01N21/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L3/50273
摘要： A microfluidic system for performing fluid analysis is described having: (a) a submersible housing having a fluid analysis means and a power supply to provide power to said system; and (b) a substrate for receiving a fluid sample, having embedded therein a fluid sample inlet, a reagent inlet, a fluid sample outlet, and a mixing region in fluid communication with the fluid sample inlet, the reagent inlet, and the fluid sample outlet, and wherein the substrate includes a fluid drive means for moving the fluid sample through the substrate, and wherein the substrate interconnects with the housing. At least a portion of the fluid analysis means may be embedded in the substrate.
摘要翻译：描述了一种用于执行流体分析的微流体系统，其具有：（a）具有流体分析装置的潜水壳体和向所述系统提供动力的电源; （b）用于接收流体样品的基板，其中嵌入有流体样品入口，试剂入口，流体样品出口和与流体样品入口，试剂入口和流体样品流体连通的混合区域出口，并且其中所述基板包括用于使所述流体样品通过所述基板移动的流体驱动装置，并且其中所述基板与所述壳体相互连接。流体分析装置的至少一部分可以嵌入衬底中。

5. 发明授权

US08262909B2 Methods and devices for minimizing membrane fouling for microfluidic separators 有权
标题翻译：用于最小化微流控分离器膜污染的方法和装置
公开(公告)号：US08262909B2
公开(公告)日：2012-09-11
申请号：US12503650
申请日：2009-07-15
申请人： Dan Eugen Angelescu , Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Brian Oliver Clark , Christopher Harrison , Matthew Sullivan , Andreas Hausot , Florence Le Gallic de Kerizouet
发明人： Dan Eugen Angelescu , Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Brian Oliver Clark , Christopher Harrison , Matthew Sullivan , Andreas Hausot , Florence Le Gallic de Kerizouet
IPC分类号： B01D63/00 , B01D11/00
CPC分类号： B01D65/08 , B01D61/18 , B01D67/0062 , B01D2321/2016 , B01L3/502753 , B01L3/502784 , B01L2200/0673 , B01L2300/0627 , B01L2300/0681 , B01L2300/0864 , B01L2300/0877 , B01L2300/161 , B01L2400/0487 , E21B43/38 , E21B49/081 , E21B49/10 , G01N1/4005 , G01N33/28 , G01N2001/4016
摘要： A fluid separation method for performing fluid analysis of an unfiltered fluid. The fluid separation method includes providing a structure with a fluid analyzer and a power supply. Using a substrate for receiving a fluid flow stream of a multiphase mixture through a fluid sample inlet, wherein the substrate interconnects with the structure. Providing a membrane disposed across the fluid sample inlet for separating a fluid of interest from the multiphase mixture, wherein the fluid flow stream of the multiphase mixture has a shear rate that prevents a fouling of the membrane. Finally, the fluid separation method includes the substrate having fabricated channels, such that the fabricated channels are arranged substantially tangent to the fluid stream downstream of the porous membrane.
摘要翻译：一种用于对未过滤流体进行流体分析的流体分离方法。流体分离方法包括提供具有流体分析器和电源的结构。使用基底用于通过流体样品入口接收多相混合物的流体流，其中所述基底与所述结构相互连接。提供跨过流体样品入口设置的膜，用于将感兴趣的流体与多相混合物分离，其中多相混合物的流体流动流具有防止膜结垢的剪切速率。最后，流体分离方法包括具有制造通道的基板，使得所制造的通道基本上与多孔膜下游的流体流相切。

6. 发明申请

US20100012586A1 METHODS AND DEVICES FOR MINIMIZING MEMBRANE FOULING FOR MICROFLUIDIC SEPARATORS 有权
标题翻译：用于微流控隔离膜最小化膜方法和装置
公开(公告)号：US20100012586A1
公开(公告)日：2010-01-21
申请号：US12503650
申请日：2009-07-15
申请人： Dan Eugen Angelescu , Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Brian Oliver Clark , Christopher Harrison , Matthew Sullivan , Andreas Hausot , Florence le Gallic de Kerizouet
发明人： Dan Eugen Angelescu , Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Brian Oliver Clark , Christopher Harrison , Matthew Sullivan , Andreas Hausot , Florence le Gallic de Kerizouet
IPC分类号： B01D61/12
CPC分类号： B01D65/08 , B01D61/18 , B01D67/0062 , B01D2321/2016 , B01L3/502753 , B01L3/502784 , B01L2200/0673 , B01L2300/0627 , B01L2300/0681 , B01L2300/0864 , B01L2300/0877 , B01L2300/161 , B01L2400/0487 , E21B43/38 , E21B49/081 , E21B49/10 , G01N1/4005 , G01N33/28 , G01N2001/4016
摘要： A fluid separation method for performing fluid analysis of an unfiltered fluid. The fluid separation method includes providing a structure with a fluid analyzer and a power supply. Using a substrate for receiving a fluid flow stream of a multiphase mixture through a fluid sample inlet, wherein the substrate interconnects with the structure. Providing a membrane disposed across the fluid sample inlet for separating a fluid of interest from the multiphase mixture, wherein the fluid flow stream of the multiphase mixture has a shear rate that prevents a fouling of the membrane. Finally, the fluid separation method includes the substrate having fabricated channels, such that the fabricated channels are arranged substantially tangent to the fluid stream downstream of the porous membrane.
摘要翻译：一种用于对未过滤流体进行流体分析的流体分离方法。流体分离方法包括提供具有流体分析器和电源的结构。使用基底用于通过流体样品入口接收多相混合物的流体流，其中所述基底与所述结构相互连接。提供跨过流体样品入口设置的膜，用于将感兴趣的流体与多相混合物分离，其中多相混合物的流体流动流具有防止膜结垢的剪切速率。最后，流体分离方法包括具有制造通道的基板，使得所制造的通道基本上与多孔膜下游的流体流相切。

7. 发明申请

US20060008913A1 Microfluidic separator 有权
公开(公告)号：US20060008913A1
公开(公告)日：2006-01-12
申请号：US10935858
申请日：2004-09-08
申请人： Dan Angelescu , Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Brian Clark
发明人： Dan Angelescu , Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Brian Clark
IPC分类号： G01N33/24 , G01N1/18
CPC分类号： B01D67/0062 , B01D17/085 , B01D19/0031 , B01D61/18 , B01L3/502753 , B01L2200/0673 , B01L2300/0681 , B01L2300/0864 , B01L2300/161 , B01L2400/0487 , E21B43/38 , E21B47/10 , E21B49/081 , E21B49/10 , G01N1/4005 , G01N33/28 , G01N2001/4016 , Y10T436/25375
摘要： The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.

8. 发明授权

US07575681B2 Microfluidic separator 有权
标题翻译：微流控分离器
公开(公告)号：US07575681B2
公开(公告)日：2009-08-18
申请号：US10935858
申请日：2004-09-08
申请人： Dan Eugen Angelescu , Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Brian Oliver Clark
发明人： Dan Eugen Angelescu , Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Brian Oliver Clark
IPC分类号： B01D63/00 , B01L11/00
CPC分类号： B01D67/0062 , B01D17/085 , B01D19/0031 , B01D61/18 , B01L3/502753 , B01L2200/0673 , B01L2300/0681 , B01L2300/0864 , B01L2300/161 , B01L2400/0487 , E21B43/38 , E21B47/10 , E21B49/081 , E21B49/10 , G01N1/4005 , G01N33/28 , G01N2001/4016 , Y10T436/25375
摘要： The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.
摘要翻译：本发明提供了用于分离和/或分析感兴趣的流体的方法和装置。根据本发明的原理，使用微流体装置实现流体分析，并且可以在地下环境中实时或接近实时地报告。除了油田应用之外或替代，本发明的原理考虑了在实验室或其他环境中的分离用于生物样品分离和分析化学应用。本发明能够分离微流体装置中的液体 - 液体混合物或乳液而不会结垢。

9. 发明授权

US08319175B2 Nano-tips based gas ionization chamber for neutron detection 有权
标题翻译：基于纳米尖端的气体电离室用于中子检测
公开(公告)号：US08319175B2
公开(公告)日：2012-11-27
申请号：US12872355
申请日：2010-08-31
申请人： Zilu Zhou , Markus Berheide , Felix Chen , Bradley A. Roscoe , Joyce Wong , Martin G. Luling , Olivier Philip
发明人： Zilu Zhou , Markus Berheide , Felix Chen , Bradley A. Roscoe , Joyce Wong , Martin G. Luling , Olivier Philip
IPC分类号： G01V5/04
CPC分类号： G01T1/16 , B82Y15/00 , G01T1/18 , G01T3/008
摘要： Methods and devices relating to a radiation detector comprising of a gas chamber having a cathode plate and a substrate separated by a gap. An array of nano-tips deposited on the substrate that forms an anode structure for electron charge collection. An external power source in communication with the cathode plate and the substrate, wherein the external power source is capable of generating a plurality of regions and each region includes an electric field near each nano-tip of the array of the nano-tips that results in initiating a radiation induced controlled discharge of electrons and ions from at least one gas or at least one gas mixture. Finally, the plurality of regions include multiple generated electric fields near tips of the array of nano-tips such as CNTs, that communicatively create a conductive path between the cathode plate and the substrate, the radiation detector is capable of determining at least one radiation property.
摘要翻译：涉及辐射检测器的方法和装置，包括具有阴极板和由间隙隔开的基板的气室。沉积在衬底上的纳米尖端的阵列，其形成用于电子电荷收集的阳极结构。与阴极板和衬底连通的外部电源，其中外部电源能够产生多个区域，并且每个区域包括纳米尖端阵列的每个纳米尖端附近的电场，导致导致引发辐射诱导的电子和离子从至少一种气体或至少一种气体混合物的受控放电。最后，多个区域包括在诸如CNT之类的纳米尖端阵列的尖端附近的多个产生的电场，其在阴极板和衬底之间通信地形成导电路径，该辐射探测器能够确定至少一个辐射特性。

10. 发明申请

US20120049054A1 NANO-TIPS BASED GAS IONIZATION CHAMBER FOR NEUTRON DETECTION 有权
标题翻译：基于NANO-TIPS的气体离子室进行中子检测
公开(公告)号：US20120049054A1
公开(公告)日：2012-03-01
申请号：US12872355
申请日：2010-08-31
申请人： Zilu Zhou , Markus Berheide , Felix Chen , Bradley A. Roscoe , Joyce Wong , Martin G. Luling , Olivier Philip
发明人： Zilu Zhou , Markus Berheide , Felix Chen , Bradley A. Roscoe , Joyce Wong , Martin G. Luling , Olivier Philip
IPC分类号： G01V5/04 , G01T1/185 , H01J47/00 , G01T3/00 , B82Y99/00 , B82Y15/00
CPC分类号： G01T1/16 , B82Y15/00 , G01T1/18 , G01T3/008
摘要： Methods and devices relating to a radiation detector comprising of a gas chamber having a cathode plate and a substrate separated by a gap. An array of nano-tips deposited on the substrate that forms an anode structure for electron charge collection. An external power source in communication with the cathode plate and the substrate, wherein the external power source is capable of generating a plurality of regions and each region includes an electric field near each nano-tip of the array of the nano-tips that results in initiating a radiation induced controlled discharge of electrons and ions from at least one gas or at least one gas mixture. Finally, the plurality of regions include multiple generated electric fields near tips of the array of nano-tips such as CNTs, that communicatively create a conductive path between the cathode plate and the substrate, the radiation detector is capable of determining at least one radiation property.
摘要翻译：涉及辐射检测器的方法和装置，包括具有阴极板和由间隙隔开的基板的气室。沉积在衬底上的纳米尖端的阵列，其形成用于电子电荷收集的阳极结构。与阴极板和衬底连通的外部电源，其中外部电源能够产生多个区域，并且每个区域包括纳米尖端阵列的每个纳米尖端附近的电场，导致导致引发辐射诱导的电子和离子从至少一种气体或至少一种气体混合物的受控放电。最后，多个区域包括在诸如CNT之类的纳米尖端阵列的尖端附近的多个产生的电场，其在阴极板和衬底之间通信地形成导电路径，该辐射探测器能够确定至少一个辐射特性。

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