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1. 发明授权

US08479728B2 Effective delivery of nanoparticles and micrometer-sized pharmaceutical aerosols to the lung through enhanced condensational growth 有权
标题翻译：通过增强冷凝生长，将纳米颗粒和微米级药物气溶胶有效递送到肺
公开(公告)号：US08479728B2
公开(公告)日：2013-07-09
申请号：US12866869
申请日：2009-02-18
申请人： Philip Worth Longest , Jinxiang Xi , Michael Hindle
发明人： Philip Worth Longest , Jinxiang Xi , Michael Hindle
IPC分类号： A61M16/10 , A61M15/00 , A61M16/00 , F23D11/00 , F23D14/02
CPC分类号： A61M11/041 , A61M11/042 , A61M15/0003 , A61M2016/0021 , A61M2016/0039 , A61M2205/0244 , A61M2205/07 , A61M2205/3653 , A61M2205/8206
摘要： Methods and devices for inhalation therapy to deliver and embed (deposit) particles less than about 1 μm in diameter in the lung. High humidity treatment of the lungs causes condensational growth in particle size upon entering the lungs. Increased particle size is conducive to particle embedment (deposition) in deep lung tissue or at a specific targeted lung region.
摘要翻译：用于吸入治疗以在肺中输送和沉积直径小于约1um的颗粒的方法和装置。肺的高湿度治疗在进入肺部时会导致粒度的凝结生长。增加的粒度有助于深层肺组织或特定靶向肺部区域的颗粒嵌入（沉积）。

2. 发明申请

US20110056492A1 EFFECTIVE DELIVERY OF NANOPARTICLES AND MICROMETER-SIZED PHARMACEUTICAL AEROSOLS TO THE LUNG THROUGH ENHANCED CONDENSATIONAL GROWTH 有权
标题翻译：通过增强的凝血生长有效地将纳米颗粒和微小尺寸的药物气雾剂提供给肺
公开(公告)号：US20110056492A1
公开(公告)日：2011-03-10
申请号：US12866869
申请日：2009-02-18
申请人： Philip Worth Longest , Jinxiang Xi , Michael Hindle
发明人： Philip Worth Longest , Jinxiang Xi , Michael Hindle
IPC分类号： A61M16/10 , A61K9/12 , A61K9/14 , A61P11/00
CPC分类号： A61M11/041 , A61M11/042 , A61M15/0003 , A61M2016/0021 , A61M2016/0039 , A61M2205/0244 , A61M2205/07 , A61M2205/3653 , A61M2205/8206
摘要： Methods and devices for inhalation therapy to deliver and embed (deposit) particles less than about 1 μm in diameter in the lung. High humidity treatment of the lungs causes condensational growth in particle size upon entering the lungs. Increased particle size is conducive to particle embedment (deposition) in deep lung tissue or at a specific targeted lung region.
摘要翻译：用于吸入治疗以在肺中输送和沉积直径小于约1μm的颗粒的方法和装置。肺的高湿度治疗在进入肺部时会导致粒度的凝结生长。增加的粒度有助于深层肺组织或特定靶向肺部区域的颗粒嵌入（沉积）。

3. 发明申请

US20120251594A1 Delivery of Submicrometer and Nanometer Aerosols to the Lungs Using Hygroscopic Excipients or Dual Stream Nasal Delivery 有权
标题翻译：使用吸湿辅助剂或双流鼻输送将亚微米和纳米气溶胶递送至肺部
公开(公告)号：US20120251594A1
公开(公告)日：2012-10-04
申请号：US13503927
申请日：2010-11-09
申请人： Philip Worth Longest , Michael Hindle
发明人： Philip Worth Longest , Michael Hindle
IPC分类号： A61K9/12 , A61K38/23 , A61K31/58 , A61K31/137 , A61K47/10 , A61K31/5513 , A61K31/7088 , A61P11/00 , A61P23/00 , A61P11/06 , A61P29/00 , A61P25/24 , A61P25/00 , A61P31/12 , A61P31/04 , A61P31/10 , A61P35/00 , A61M11/00 , A61K38/02
CPC分类号： A61K31/137 , A61K9/008 , A61K9/12 , A61K9/5115 , A61K9/5123 , A61K31/58 , A61M11/00 , A61M11/001 , A61M11/005 , A61M15/00 , A61M15/009 , A61M15/08 , A61M16/0057 , A61M16/0666 , A61M16/0875 , A61M16/109 , A61M16/12 , A61M16/147 , A61M16/16 , A61M16/20 , A61M2202/0208 , A61M2202/064
摘要： Pharmaceutically engineered aerosols (e.g. submicrometer and nano-particles and droplets) containing a hygroscopic growth excipient or agent are employed to improve the delivery of respiratory aerosols to the lung. Inclusion of the hygroscopic agent results in near zero depositional loss in the nose-mouth-throat regions and near 100% deposition of the aerosol in the lung. Targeting of the aerosol to specific lung depths is also possible. In addition, methods and apparatuses for delivering aerosols to the lung are provided. The aerosol is delivered to one nostril of a patient while a relatively high humidity gaseous carrier is delivered to the other nostril, resulting in post-nasopharyngeal growth of the aerosol to a size that promotes deposition in the lung.
摘要翻译：使用含有吸湿生长赋形剂或药剂的药学设计的气溶胶（例如亚微米和纳米颗粒和液滴）来改善呼吸性气溶胶向肺的递送。包含吸湿剂导致鼻口喉部区域附近的沉积损失接近零，并且在肺中近100％的气溶胶沉积。将气溶胶靶向特定肺深度也是可能的。此外，还提供了将气溶胶递送到肺的方法和装置。气雾剂被输送到患者的一个鼻孔，而相对高湿度的气体载体被递送到另一个鼻孔，导致气溶胶的鼻后生长到促进肺中沉积的尺寸。

4. 发明授权

US09433588B2 Delivery of submicrometer and nanometer aerosols to the lungs using hygroscopic excipients or dual stream nasal delivery 有权
标题翻译：使用吸湿性赋形剂或双流鼻输送将亚微米和纳米气溶胶递送至肺
公开(公告)号：US09433588B2
公开(公告)日：2016-09-06
申请号：US13503927
申请日：2010-11-09
申请人： Philip Worth Longest , Michael Hindle
发明人： Philip Worth Longest , Michael Hindle
IPC分类号： A61K31/137 , A61K31/58 , A61K31/5513 , A61K31/7088 , A61K38/02 , A61K9/00 , A61K9/12 , A61K9/51 , A61M16/06 , A61M16/16 , A61M16/10 , A61M16/14 , A61M15/08 , A61M16/00 , A61M16/08 , A61M11/00 , A61M15/00 , A61M16/12 , A61M16/20
CPC分类号： A61K31/137 , A61K9/008 , A61K9/12 , A61K9/5115 , A61K9/5123 , A61K31/58 , A61M11/00 , A61M11/001 , A61M11/005 , A61M15/00 , A61M15/009 , A61M15/08 , A61M16/0057 , A61M16/0666 , A61M16/0875 , A61M16/109 , A61M16/12 , A61M16/147 , A61M16/16 , A61M16/20 , A61M2202/0208 , A61M2202/064
摘要： Pharmaceutically engineered aerosols (e.g. submicrometer and nano-particles and droplets) containing a hygroscopic growth excipient or agent are employed to improve the delivery of respiratory aerosols to the lung. Inclusion of the hygroscopic agent results in near zero depositional loss in the nose-mouth-throat regions and near 100% deposition of the aerosol in the lung. Targeting of the aerosol to specific lung depths is also possible. In addition, methods and apparatuses for delivering aerosols to the lung are provided. The aerosol is delivered to one nostril of a patient while a relatively high humidity gaseous carrier is delivered to the other nostril, resulting in post-nasopharyngeal growth of the aerosol to a size that promotes deposition in the lung.
摘要翻译：使用含有吸湿生长赋形剂或药剂的药学设计的气溶胶（例如亚微米和纳米颗粒和液滴）来改善呼吸性气溶胶向肺的递送。包含吸湿剂导致鼻口喉部区域附近的沉积损失接近零，并且在肺中近100％的气溶胶沉积。将气溶胶靶向特定肺深度也是可能的。此外，还提供了将气溶胶递送到肺的方法和装置。气雾剂被输送到患者的一个鼻孔，而相对高湿度的气体载体被递送到另一个鼻孔，导致气溶胶的鼻后生长到促进肺中沉积的尺寸。

5. 发明申请

US20150007817A1 SYSTEMS, DEVICES, AND METHODS FOR CHANGING THERAPEUTIC AEROSOL SIZE AND IMPROVING EFFICIENCY OF VENTILATION AND AEROSOL DRUG DELIVERY 有权
标题翻译：用于改变治疗气囊尺寸的系统，装置和方法以及提高通气和喷雾药物输送的效率
公开(公告)号：US20150007817A1
公开(公告)日：2015-01-08
申请号：US14325667
申请日：2014-07-08
申请人： Philip Worth Longest , Michael Hindle
发明人： Philip Worth Longest , Michael Hindle
IPC分类号： A61M16/10 , A61M16/08 , A61M15/00 , A61M16/06 , A61M16/00 , A61M16/14
CPC分类号： A61M16/1085 , A61M15/0086 , A61M15/009 , A61M16/0066 , A61M16/0069 , A61M16/04 , A61M16/06 , A61M16/0666 , A61M16/0833 , A61M16/1095 , A61M16/12 , A61M16/14 , A61M16/16 , A61M2016/0024 , A61M2202/064 , A61M2205/3653
摘要： A mixer-heater device provides controllable reduction in aerosol droplet size. Additionally, an intermittent delivery mode for administering an aerosol to a patient may take into account patient expiration and reduce aerosol losses without prolonging treatment time. Depositional losses in aerosol delivery systems may be reduced by streamlining the three dimensional geometry of conduits which change stream direction or flow path diameter. Ventilation systems may also benefit from streamlined components, in particular Y-connectors, with resulting advantages such as reduced rebreathed CO2.
摘要翻译：混合器加热器装置提供气溶胶液滴尺寸的可控减小。此外，用于向患者施用气雾剂的间歇递送模式可以考虑到患者呼气并且减少气雾剂损失而不延长治疗时间。气溶胶输送系统中的沉积损失可以通过简化改变流动方向或流路直径的导管的三维几何形状来减少。通风系统还可以受益于流线型部件，特别是Y型连接器，具有诸如减少二氧化碳的优点。

6. 发明授权

US07128067B2 Method and apparatus for generating an aerosol 有权
标题翻译：用于产生气溶胶的方法和装置
公开(公告)号：US07128067B2
公开(公告)日：2006-10-31
申请号：US10394654
申请日：2003-03-24
申请人： Peter R. Byron , Michael Hindle
发明人： Peter R. Byron , Michael Hindle
IPC分类号： A61M15/00 , H05B3/00 , B67D5/62
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M16/109 , A61M2016/0024 , A61M2205/8206
摘要： An aerosol is formed by supplying a material in liquid form to a flow passage and heating the flow passage such that the material volatizes and expands out of an open end of the flow passage. The volatized material combines with ambient air such that volatized material condenses to form the aerosol. An apparatus and method for generating such an aerosol are disclosed wherein the apparatus may include an electrically conductive sleeve at an open end of the flow passage, an electrically conductive flow passage and/or a spacer chamber. The volatilized material may contain a volatilized solute and vehicle such that the resulting aerosol particle sizes of the solute and the vehicle are either different or the same.
摘要翻译：通过将液体形式的材料供应到流动通道并加热流动通道使得材料从流动通道的开放端部挥发和膨胀而形成气溶胶。挥发的材料与环境空气结合，使得挥发的物质冷凝形成气溶胶。公开了一种用于产生这种气溶胶的装置和方法，其中所述装置可包括在所述流动通道的开口端处的导电套管，导电流动通道和/或间隔室。挥发的物质可以含有挥发的溶质和载体，使得所得到的溶质和载体的气溶胶颗粒尺寸是不同的或相同的。

7. 发明授权

US06701922B2 Mouthpiece entrainment airflow control for aerosol generators 有权
标题翻译：用于气溶胶发生器的气嘴夹带气流控制
公开(公告)号：US06701922B2
公开(公告)日：2004-03-09
申请号：US10022739
申请日：2001-12-20
申请人： Michael Hindle , Peter R. Byron , John N. Hong
发明人： Michael Hindle , Peter R. Byron , John N. Hong
IPC分类号： A61M1600
CPC分类号： A61M11/041 , A61M11/001 , A61M11/007 , A61M11/042 , A61M15/00 , A61M2205/8206
摘要： An aerosol generator includes a housing, a heater and a mouthpiece wherein the heater volatilizes liquid material within a flow passage and forms an aerosol in the mouthpiece. Mixing ambient air with the vaporized liquid material controls a droplet size of the aerosol. The ambient air can be directed into the mouthpiece by at least one air passageway in an airflow entrainment control member. The at least one air passageway provides a desired volume and/or velocity of ambient air entering into the mouthpiece thereby achieving a desired droplet size distribution of an aerosol. In an alternative arrangement, a funnel shaped airflow entrainment control member includes a narrow end proximate the outlet end of the flow passage. A cone angle of the funnel-shaped member can be selected to provide a desired volume of ambient air which mixes with the vaporized liquid material and achieves a desired aerosol droplet size distribution.
摘要翻译：气雾发生器包括壳体，加热器和吸嘴，其中加热器使流动通道内的液体材料挥发并且在接口管中形成气溶胶。将环境空气与蒸发的液体材料混合控制气溶胶的液滴尺寸。环境空气可以通过气流夹带控制构件中的至少一个空气通道引导到接口管中。至少一个空气通道提供进入到吸嘴中的环境空气的期望体积和/或速度，从而实现气溶胶的期望的液滴尺寸分布。在另一种布置中，漏斗形气流夹带控制构件包括靠近流动通道的出口端的窄端。可以选择漏斗形构件的锥角以提供与气化液体材料混合并达到所需气溶胶滴尺寸分布的期望体积的环境空气。

8. 发明授权

US06883516B2 Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution 有权
标题翻译：用于产生具有预定和/或基本上单分散的粒度分布的气溶胶的方法
公开(公告)号：US06883516B2
公开(公告)日：2005-04-26
申请号：US09981739
申请日：2001-10-19
申请人： Michael Hindle , Peter R. Byron , Rajiv Gupta
发明人： Michael Hindle , Peter R. Byron , Rajiv Gupta
IPC分类号： A61K9/72 , A61K9/00 , A61K9/12 , A61K31/573 , A61K31/58 , A61K47/10 , A61M5/00 , A61M11/00 , A61M11/04 , A61M15/00 , A61M16/00 , A61M16/10 , A61P11/00 , B67D7/80
CPC分类号： A61K9/007 , A61K9/0073 , A61M11/007 , A61M11/041 , A61M11/042 , A61M16/109 , A61M2016/0024 , A61M2205/8206
摘要： A method is provided for generating an aerosol. The method includes preparing a solution formed of a first component in a liquid component such that after volatilization of the liquid component by passing the solution through a flow passage while heating the solution, an aerosol is formed having a predetermined particle size distribution of the first component, wherein the solution is prepared such that the amount of the first component therein is sufficient to achieve the predetermined particle size distribution of the first component. The method also includes passing the solution through the flow passage while heating the solution to a temperature sufficient to volatilize the liquid component, wherein the flow passage comprises an outlet through which the first component and the volatilized liquid component flow, and wherein an aerosol is formed.
摘要翻译：提供了一种产生气溶胶的方法。该方法包括制备由液体组分中的第一组分形成的溶液，使得在加热溶液的同时通过使溶液通过流动通道使液体组分挥发，形成具有预定的第一组分的粒度分布的气溶胶其中制备溶液使得其中的第一组分的量足以实现第一组分的预定的粒度分布。该方法还包括使溶液通过流动通道，同时将溶液加热到足以挥发液体组分的温度，其中流动通道包括第一组分和挥发的液体组分流过的出口，并且其中形成气溶胶。

9. 发明授权

US07683029B2 Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin 有权
标题翻译：含有胰岛素和烟雾发生装置的液体气溶胶制剂和产生气雾化胰岛素的方法
公开(公告)号：US07683029B2
公开(公告)日：2010-03-23
申请号：US10829945
申请日：2004-04-23
申请人： Michael Hindle , Kenneth A. Cox
发明人： Michael Hindle , Kenneth A. Cox
IPC分类号： A61K38/28 , A61M15/00
CPC分类号： A61K9/007 , A61K38/28 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/0065 , A61M15/008 , A61M15/02 , A61M15/025 , A61M2016/0039 , A61M2205/8206 , A61M2205/8237
摘要： Liquid aerosol formulations for generating aerosolized insulin include insulin and at least one high volatility carrier which protects the insulin from thermal degradation during vaporization of the carrier. The carrier can be a mixture of ethanol and water and the liquid aerosol formulation can be propellant free. An aerosol generating device generates the aerosolized insulin by passing the liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor which entrains insulin particles which mix with air to form an aerosol. The insulin particles can be dry insulin particles produced by a hand held inhaler. By controlling the concentration of the insulin in the formulation, the size of the flow passage and/or the amount of heat which heats the flow passage, the aerosol can be provided with a selected mass median aerodynamic diameter of 1 to 3 μm or less than 1 μm so as to be delivered to a targeted portion of the lung using the inhaler.
摘要翻译：用于产生气雾化胰岛素的液体气溶胶制剂包括胰岛素和至少一种高挥发性载体，其保护胰岛素在载体蒸发期间的热降解。载体可以是乙醇和水的混合物，液体气溶胶制剂可以不含推进剂。烟雾发生装置通过使液体气溶胶制剂通过加热的流动通道将液体转化成蒸气，该蒸气夹带与空气混合以形成气溶胶的胰岛素颗粒，产生雾化的胰岛素。胰岛素颗粒可以是由手持式吸入器产生的干性胰岛素颗粒。通过控制制剂中胰岛素的浓度，流路的尺寸和/或加热流道的热量，气溶胶可以具有1至3μm或更小的选定质量中值空气动力学直径使用吸入器将其输送到肺的目标部分。

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