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1. 发明授权

US06701922B2 Mouthpiece entrainment airflow control for aerosol generators 有权
标题翻译：用于气溶胶发生器的气嘴夹带气流控制
公开(公告)号：US06701922B2
公开(公告)日：2004-03-09
申请号：US10022739
申请日：2001-12-20
申请人： Michael Hindle , Peter R. Byron , John N. Hong
发明人： Michael Hindle , Peter R. Byron , John N. Hong
IPC分类号： A61M1600
CPC分类号： A61M11/041 , A61M11/001 , A61M11/007 , A61M11/042 , A61M15/00 , A61M2205/8206
摘要： An aerosol generator includes a housing, a heater and a mouthpiece wherein the heater volatilizes liquid material within a flow passage and forms an aerosol in the mouthpiece. Mixing ambient air with the vaporized liquid material controls a droplet size of the aerosol. The ambient air can be directed into the mouthpiece by at least one air passageway in an airflow entrainment control member. The at least one air passageway provides a desired volume and/or velocity of ambient air entering into the mouthpiece thereby achieving a desired droplet size distribution of an aerosol. In an alternative arrangement, a funnel shaped airflow entrainment control member includes a narrow end proximate the outlet end of the flow passage. A cone angle of the funnel-shaped member can be selected to provide a desired volume of ambient air which mixes with the vaporized liquid material and achieves a desired aerosol droplet size distribution.
摘要翻译：气雾发生器包括壳体，加热器和吸嘴，其中加热器使流动通道内的液体材料挥发并且在接口管中形成气溶胶。将环境空气与蒸发的液体材料混合控制气溶胶的液滴尺寸。环境空气可以通过气流夹带控制构件中的至少一个空气通道引导到接口管中。至少一个空气通道提供进入到吸嘴中的环境空气的期望体积和/或速度，从而实现气溶胶的期望的液滴尺寸分布。在另一种布置中，漏斗形气流夹带控制构件包括靠近流动通道的出口端的窄端。可以选择漏斗形构件的锥角以提供与气化液体材料混合并达到所需气溶胶滴尺寸分布的期望体积的环境空气。

2. 发明授权

US07128067B2 Method and apparatus for generating an aerosol 有权
标题翻译：用于产生气溶胶的方法和装置
公开(公告)号：US07128067B2
公开(公告)日：2006-10-31
申请号：US10394654
申请日：2003-03-24
申请人： Peter R. Byron , Michael Hindle
发明人： Peter R. Byron , Michael Hindle
IPC分类号： A61M15/00 , H05B3/00 , B67D5/62
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M16/109 , A61M2016/0024 , A61M2205/8206
摘要： An aerosol is formed by supplying a material in liquid form to a flow passage and heating the flow passage such that the material volatizes and expands out of an open end of the flow passage. The volatized material combines with ambient air such that volatized material condenses to form the aerosol. An apparatus and method for generating such an aerosol are disclosed wherein the apparatus may include an electrically conductive sleeve at an open end of the flow passage, an electrically conductive flow passage and/or a spacer chamber. The volatilized material may contain a volatilized solute and vehicle such that the resulting aerosol particle sizes of the solute and the vehicle are either different or the same.
摘要翻译：通过将液体形式的材料供应到流动通道并加热流动通道使得材料从流动通道的开放端部挥发和膨胀而形成气溶胶。挥发的材料与环境空气结合，使得挥发的物质冷凝形成气溶胶。公开了一种用于产生这种气溶胶的装置和方法，其中所述装置可包括在所述流动通道的开口端处的导电套管，导电流动通道和/或间隔室。挥发的物质可以含有挥发的溶质和载体，使得所得到的溶质和载体的气溶胶颗粒尺寸是不同的或相同的。

3. 发明授权

US06883516B2 Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution 有权
标题翻译：用于产生具有预定和/或基本上单分散的粒度分布的气溶胶的方法
公开(公告)号：US06883516B2
公开(公告)日：2005-04-26
申请号：US09981739
申请日：2001-10-19
申请人： Michael Hindle , Peter R. Byron , Rajiv Gupta
发明人： Michael Hindle , Peter R. Byron , Rajiv Gupta
IPC分类号： A61K9/72 , A61K9/00 , A61K9/12 , A61K31/573 , A61K31/58 , A61K47/10 , A61M5/00 , A61M11/00 , A61M11/04 , A61M15/00 , A61M16/00 , A61M16/10 , A61P11/00 , B67D7/80
CPC分类号： A61K9/007 , A61K9/0073 , A61M11/007 , A61M11/041 , A61M11/042 , A61M16/109 , A61M2016/0024 , A61M2205/8206
摘要： A method is provided for generating an aerosol. The method includes preparing a solution formed of a first component in a liquid component such that after volatilization of the liquid component by passing the solution through a flow passage while heating the solution, an aerosol is formed having a predetermined particle size distribution of the first component, wherein the solution is prepared such that the amount of the first component therein is sufficient to achieve the predetermined particle size distribution of the first component. The method also includes passing the solution through the flow passage while heating the solution to a temperature sufficient to volatilize the liquid component, wherein the flow passage comprises an outlet through which the first component and the volatilized liquid component flow, and wherein an aerosol is formed.
摘要翻译：提供了一种产生气溶胶的方法。该方法包括制备由液体组分中的第一组分形成的溶液，使得在加热溶液的同时通过使溶液通过流动通道使液体组分挥发，形成具有预定的第一组分的粒度分布的气溶胶其中制备溶液使得其中的第一组分的量足以实现第一组分的预定的粒度分布。该方法还包括使溶液通过流动通道，同时将溶液加热到足以挥发液体组分的温度，其中流动通道包括第一组分和挥发的液体组分流过的出口，并且其中形成气溶胶。

4. 发明授权

US06713048B2 &Dgr;9 tetrahydrocannabinol (&Dgr;9 THC) solution metered dose inhalers and methods of use 有权
标题翻译： Delta9四氢大麻酚（Delta9 THC）溶液计量吸入器和使用方法
公开(公告)号：US06713048B2
公开(公告)日：2004-03-30
申请号：US09944221
申请日：2001-09-04
申请人： Joanne Peart , Peter R. Byron , Aron H. Lichtman , Billy R. Martin
发明人： Joanne Peart , Peter R. Byron , Aron H. Lichtman , Billy R. Martin
IPC分类号： A61L904
CPC分类号： A61K9/008 , A61K31/352
摘要： The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which use, non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.
摘要翻译：本发明提供了通过计量吸入器递送的Delta9-四氢大麻酚（Delta 9C THC）的溶液的治疗制剂。使用非CFC推进剂的配方提供了稳定的气溶胶递送源，用于治疗各种医疗状况，例如：与化疗相关的恶心和呕吐 - 肌肉痉挛; 疼痛; 与艾滋病综合征相关的厌食症，癫痫; 青光眼; 支气管哮喘; 和情绪障碍。

5. 发明授权

US06509005B1 &Dgr;9 Tetrahydrocannabinol (&Dgr;9 THC) solution metered dose inhaler 有权
标题翻译： DELTA9四氢大麻酚（DELTA9 THC）溶液计量吸入器
公开(公告)号：US06509005B1
公开(公告)日：2003-01-21
申请号：US09273766
申请日：1999-03-22
申请人： Joanne Peart , Peter R. Byron , Aron H. Lichtman , Billy R. Martin
发明人： Joanne Peart , Peter R. Byron , Aron H. Lichtman , Billy R. Martin
IPC分类号： A61L904
CPC分类号： A61K9/008 , A61K31/352
摘要： The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which utilize non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy; muscle spasticity; pain; anorexia associated with AIDS wasting syndrome; epilepsy; glaucoma; bronchial asthma; and mood disorders.
摘要翻译：本发明提供了用计量吸入器递送的DELTA9-四氢大麻酚（DELTA9 THC）溶液的治疗剂型。使用非CFC推进剂的配方提供了稳定的气溶胶递送源DELTA9 THC，用于治疗各种医疗状况，例如：与化学疗法相关的恶心和呕吐; 肌肉痉挛疼痛; 与艾滋病综合征相关的厌食症; 癫痫; 青光眼; 支气管哮喘; 和情绪障碍。

6. 发明授权

US5202110A Formulations for delivery of beclomethasone diproprionate by metered dose inhalers containing no chlorofluorocarbon propellants 失效
标题翻译：通过不含氯氟烃推进剂的计量吸入器输送二丙酸倍氯米松的配方
公开(公告)号：US5202110A
公开(公告)日：1993-04-13
申请号：US824030
申请日：1992-01-22
申请人： Richard N. Dalby , Peter R. Byron
发明人： Richard N. Dalby , Peter R. Byron
IPC分类号： A61K9/00 , A61K9/12 , A61K31/57 , A61K31/573 , A61K47/48
CPC分类号： A61K9/008 , A61K31/57 , A61K9/124
摘要： Beclomethasone diproprionate (BDP) forms a clathrate with HCFC-123, dimethyl ether (DME) and HCFC-141b which are less harmful propellants than the CFC propellants currently used in metered dose inhalers (MDIs). The clathrate can be remicronized and suspended for use in an MDI. BDP also is completely dissolved by DME based propellant blends and certain HCFC 123 propellant blends. Using propellant blends which completely dissolve BDP will assure more efficient dosing with an MDI.
摘要翻译：二氯丙酸倍氯米松（BDP）与HCFC-123，二甲醚（DME）和HCFC-141b形成包合物，其比目前用于计量吸入器（MDIs）的CFC推进剂更不利于推进剂。包合物可以被称重并悬浮在MDI中。 BDP也被基于DME的推进剂混合物和某些HCFC 123推进剂混合物完全溶解。使用完全溶解BDP的推进剂混合物将确保更有效地配合MDI。

7. 发明授权

US5182097A Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content 失效
标题翻译：用减少或无氯代内容的计量剂量吸入剂输送药物的配方
公开(公告)号：US5182097A
公开(公告)日：1993-01-26
申请号：US655668
申请日：1991-02-14
申请人： Peter R. Byron , Richard N. Dalby
发明人： Peter R. Byron , Richard N. Dalby
IPC分类号： A61K9/00 , A61K9/12 , A61K31/135 , C07C19/08
CPC分类号： A61K9/008 , A61K9/124 , Y10S514/97
摘要： Aerosol formulations for use in metered dose inhalers are disclosed which include 1,1,1,2-tetrafluoroethane alone and in combination with other compounds as well as various hydrocarbon blends. The density, vapor pressure, flame extension characteristics, dispersability of medicant, dissolvability of surfactant, respirable fraction, and compatibility elastomer seals for the aerosol formulations have been examined. The aerosol formulations are attractive alternatives to chlorofluorocarbon based aerosols since they do not deplete the ozone layer.
摘要翻译：公开了用于计量剂量吸入器的气溶胶制剂，其包括单独的1,1,1,2-四氟乙烷和与其它化合物以及各种烃共混物组合的气溶胶制剂。已经研究了密度，蒸汽压力，火焰延伸特性，药物的分散性，表面活性剂的可溶性，可呼吸部分和气溶胶配方的相容性弹性体密封。气溶胶配方是含氟氯烃气溶胶的有吸引力的替代品，因为它们不会消耗臭氧层。

8. 发明申请

US20090110679A1 Methods and compositions for pulmonary administration of a TNFa inhibitor 审中-公开
标题翻译：用于肺部给予TNFα抑制剂的方法和组合物
公开(公告)号：US20090110679A1
公开(公告)日：2009-04-30
申请号：US12217972
申请日：2008-07-10
申请人： Luk-Chiu Li , Yi Shi , Thomas L. Reiland , Masahiro Sakagami , Katherine Nicholson , Peter R. Byron
发明人： Luk-Chiu Li , Yi Shi , Thomas L. Reiland , Masahiro Sakagami , Katherine Nicholson , Peter R. Byron
IPC分类号： A61K39/395 , A61K39/00 , A61M15/00
CPC分类号： A61K39/39533 , A61K9/0075 , A61K38/1793 , A61K39/3955 , C07K2319/30
摘要： The invention describes methods of pulmonary delivery of a TNFα inhibitor to a subject having a disorder in which TNFα is detrimental, such that the disorder is treated. Also included is a method of achieving systemic circulation of a TNFα inhibitor in a subject comprising administering the TNFα inhibitor to the central lung region or the peripheral lung region of the subject via inhalation, such that systemic circulation of the TNFα inhibitor is achieved.
摘要翻译：本发明描述了将TNFα抑制剂肺部递送给具有TNFalpha有害的病症的受试者的方法，使得该病症得到治疗。还包括在受试者中实现TNFα抑制剂的全身循环的方法，其包括通过吸入将TNFα抑制剂给予受试者的中心肺区域或外周肺部区域，从而实现TNFα抑制剂的全身循环。

9. 发明授权

US6060069A Pulmonary delivery of pharmaceuticals 失效
标题翻译：肺部输送药物
公开(公告)号：US6060069A
公开(公告)日：2000-05-09
申请号：US71578
申请日：1998-05-01
申请人： Malcolm Hill , Peter R. Byron
发明人： Malcolm Hill , Peter R. Byron
IPC分类号： A61K9/00 , A61M15/00 , A61K9/12
CPC分类号： A61K9/0075 , A61M15/0006 , A61M15/0016 , A61M15/0033 , A61M15/0045 , A61M15/0048 , Y10S514/826
摘要： In a method for treating lung diseases, a drug formulation is prepared by combining micronized crystalline beclomethasone dipropionate and lactose. The drug formulation is placed into a dry powder inhaler which provides inhalable drug particles having a mass median diameter of about 0.5-5.8 microns. The inhaler is preferably largely flow rate independent. Drug and lactose particles are separated in the inhaler during inhalation, most desirably via a spinning element. Due to deep deposition, the drug particles persist in the lungs for a surprisingly long duration, increasing the therapeutic effect of each dose. The patient inhales the drug particles with an inspiratory flow rate of about 10-60 liters/minute, to produce a deep lung deposition of inhaled particles.
摘要翻译：在治疗肺部疾病的方法中，通过将微粉化的结晶倍氯米松二丙酸酯和乳糖组合制备药物制剂。将药物制剂置于干粉吸入器中，其提供质量中值直径约为0.5-5.8微米的可吸入药物颗粒。吸入器优选地大体积流量独立。药物和乳糖颗粒在吸入过程中在吸入器中分离，最理想的是通过纺丝元件。由于深沉积，药物颗粒在肺中持续令人惊讶的持续时间，增加了每种剂量的治疗效果。患者以吸气流速约10-60升/分钟吸入药物颗粒，以产生吸入颗粒的深层肺沉积。

10. 发明授权

US5492688A Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent 失效
标题翻译：计量剂量吸入器制剂，其包括适用于臭氧的推进剂HFC 134a和药学上可接受的悬浮剂，增溶剂，润湿剂，乳化剂或润滑剂
公开(公告)号：US5492688A
公开(公告)日：1996-02-20
申请号：US217012
申请日：1994-03-23
申请人： Peter R. Byron , Frank E. Blondino
发明人： Peter R. Byron , Frank E. Blondino
IPC分类号： A61K9/00 , A61K9/12
CPC分类号： A61K9/008 , Y10S514/958
摘要： Metered dose inhaler (MDI) formulations which utilize 1,1,1,2-tetrafluoroethane (HFC 134a) as the sole propellant are made practical by including a polar surfactant such as polyethylene glycol, diethylene glycol monoethyl ether, polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, propoxylated polyethylene glycol, and polyoxyethylene (4) lauryl ether for suspending, solubilizing, wetting and emulsifying the drug constituent and lubricating the valve components of the MDI.
摘要翻译：使用1,1,1,2-四氟乙烷（HFC 134a）作为唯一推进剂的计量吸入器（MDI）制剂通过包括极性表面活性剂如聚乙二醇，二甘醇单乙醚，聚氧乙烯（20）脱水山梨糖醇单月桂酸酯，聚氧乙烯（20）脱水山梨糖醇单油酸酯，丙氧基化聚乙二醇和聚氧乙烯（4）月桂基醚，用于悬浮，增溶，润湿和乳化药物成分并润滑MDI的阀组件。

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