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1. 发明授权

US07030156B2 Devices and methods for eliminating termite colonies 失效
公开(公告)号：US07030156B2
公开(公告)日：2006-04-18
申请号：US10172855
申请日：2002-06-17
申请人： Philip Frederick Brode, III , Garry Steven Garrett , Leo Timothy Laughlin , Randall Stryker Matthews , Dale Edwin Barker , Daniel James Kinne , Gary Eugene McKibben , Christopher Miles Miller , Timothy Robert Probst
发明人： Philip Frederick Brode, III , Garry Steven Garrett , Leo Timothy Laughlin , Randall Stryker Matthews , Dale Edwin Barker , Daniel James Kinne , Gary Eugene McKibben , Christopher Miles Miller , Timothy Robert Probst
IPC分类号： A01N31/00
CPC分类号： A01M1/2011 , A01M1/026 , A01M2200/011 , A01N25/006 , A01N35/06 , A01N43/16 , C07H9/06 , C07H15/203 , A01N2300/00
摘要： This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.

2. 发明授权

US06969512B2 Devices and methods for eliminating termite colonies 失效
公开(公告)号：US06969512B2
公开(公告)日：2005-11-29
申请号：US10268356
申请日：2002-10-10
申请人： Philip Frederick Brode, III , Garry Steven Garrett , Leo Timothy Laughlin , Randall Stryker Matthews
发明人： Philip Frederick Brode, III , Garry Steven Garrett , Leo Timothy Laughlin , Randall Stryker Matthews
IPC分类号： A01M1/02 , A01M1/20 , A01N20060101 , A01N25/00 , A01N25/02 , A01N25/08 , A01N31/00 , A01N33/02 , A01N35/06 , A01N37/00 , A01N37/06 , A01N43/16 , A01N43/40 , A01N43/54 , A01N43/66 , A01N61/00 , C07H9/06 , C07H15/203 , A01N43/50 , A01N25/34 , A01N43/52
CPC分类号： A01M1/026 , A01M1/2011 , A01M2200/011 , A01N25/006 , A01N35/06 , A01N43/16 , A01N61/00 , C07H9/06 , C07H15/203 , Y10S424/11 , A01N2300/00
摘要： This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.

3. 发明授权

US06716421B2 Devices and methods for eliminating termite colonies 失效
标题翻译：消除白蚁菌落的装置和方法
公开(公告)号：US06716421B2
公开(公告)日：2004-04-06
申请号：US09799184
申请日：2001-03-05
申请人： Philip Frederick Brode, III , Garry Steven Garrett , Leo Timothy Laughlin , Randall Stryker Matthews , Dale Edwin Barker , Daniel James Kinne , Gary Eugene McKibben , Christopher Miles Miller , Timothy Robert Probst
发明人： Philip Frederick Brode, III , Garry Steven Garrett , Leo Timothy Laughlin , Randall Stryker Matthews , Dale Edwin Barker , Daniel James Kinne , Gary Eugene McKibben , Christopher Miles Miller , Timothy Robert Probst
IPC分类号： A01N3100
CPC分类号： A01M1/2011 , A01M1/026 , A01M2200/011 , A01N25/006 , A01N35/06 , A01N43/16 , C07H9/06 , C07H15/203 , Y10S424/11 , A01N2300/00
摘要： This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.
摘要翻译：本发明涉及用于消除白蚁菌落的装置，试剂盒和方法。试剂盒，装置和方法采用灭蚁饵基质，其包含a）选择的杀白蚁剂，使得在白蚁开始摄入杀白蚁剂或诱饵之后约24至约84天内，杀白蚁剂导致约50至约100％的白蚁死亡包含杀白蚁剂的基质，b）含纤维素材料，和c）水。杀螨诱饵基质可用于安装在地下的诱饵站。这些套件适合家庭消费者使用。

4. 发明授权

US07157078B2 Devices and methods for eliminating termite colonies 失效
标题翻译：消除白蚁菌落的装置和方法
公开(公告)号：US07157078B2
公开(公告)日：2007-01-02
申请号：US10770195
申请日：2004-02-02
申请人： Philip Frederick Brode, III , Garry Steven Garren , Leo Timothy Laughlin , Randall Stryker Matthews , Dale Edwin Barker , Daniel James Kinne , Gary Eugene McKibben , Christopher Miles Miller , Timothy Robert Probst
发明人： Philip Frederick Brode, III , Garry Steven Garren , Leo Timothy Laughlin , Randall Stryker Matthews , Dale Edwin Barker , Daniel James Kinne , Gary Eugene McKibben , Christopher Miles Miller , Timothy Robert Probst
IPC分类号： A01N31/00 , A01N33/02 , A01N37/00 , A01N37/02 , A01N37/06 , A01N43/40 , A01N43/54 , A01N43/66 , A01N25/00 , A01N25/02 , A01N25/08
CPC分类号： A01M1/2011 , A01M1/026 , A01M2200/011 , A01N25/006 , A01N35/06 , A01N43/16 , C07H9/06 , C07H15/203 , Y10S424/11 , A01N2300/00
摘要： This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.
摘要翻译：本发明涉及用于消除白蚁菌落的装置，试剂盒和方法。试剂盒，装置和方法采用杀螨诱饵基质，其含有：a）选择的杀白蚁剂，使得在白蚁开始摄入杀白蚁剂或白蚁之后约24至约84天内，杀白蚁剂会导致约50至约100％的白蚁死亡包含杀白蚁剂的诱饵基质，b）含纤维素材料，和c）水。白蚁诱饵基质可用于安装在地下的诱饵站。这些套件适合家庭消费者使用。

5. 发明授权

US5684204A Sulfur containing di-tert-butylphenol compounds useful as anti-inflammatory agents 失效
标题翻译：含有二叔丁基苯酚的硫化合物可用作抗炎剂
公开(公告)号：US5684204A
公开(公告)日：1997-11-04
申请号：US559014
申请日：1995-11-15
申请人： Randall Stryker Matthews
发明人： Randall Stryker Matthews
IPC分类号： A61K31/12 , A61P25/04 , A61P29/00 , A61P37/00 , C07C317/24 , C07C323/22 , C07C317/26
CPC分类号： C07C317/24
摘要： The subject invention relates to compounds having the structure: ##STR1## wherein (a) x is from 1 to 5; (b) y is from 1 to 2; and (c) z is from 0 to 5. The subject invention also relates to the pharmaceutical compositions comprising the above compounds, and methods of treating inflammation using the compounds.
摘要翻译：本发明涉及具有以下结构的化合物：其中（a）x为1至5; （b）y为1至2; 本发明还涉及包含上述化合物的药物组合物和使用该化合物治疗炎症的方法。

6. 发明授权

US5656661A Dihydrobenzofuran and related compounds useful as anti-inflammatory agents 失效
标题翻译：二氢苯并呋喃及相关化合物可用作抗炎剂
公开(公告)号：US5656661A
公开(公告)日：1997-08-12
申请号：US481727
申请日：1995-06-07
申请人： Michael Wiard Scherz , Randall Stryker Matthews
发明人： Michael Wiard Scherz , Randall Stryker Matthews
IPC分类号： C07D307/79 , C07D333/54 , A61K31/34
CPC分类号： C07D307/79 , C07D333/54
摘要： A compound having the structure: ##STR1## wherein (a) X is oxygen or sulfur;(b) each Y is independently hydrogen or unsubstituted straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms,. or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms;(c) Z is hydrogen or unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl, having from 3 to about 10 atoms other than hydrogen;(d) W is straight, branched or cyclic alkyl or aryl, unsubstituted or substituted, saturated or mono- or di-unsaturated with double bonds except that no terminal carbon atom of W is part of a double bond; W having from 1 to about 15 atoms other than hydrogen;pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
摘要翻译：具有以下结构的化合物：其中（a）X是氧或硫; （b）每个Y独立地为氢或未取代的具有1至约3个碳原子的直链，支链或环烷基。或两个Y键合以形成具有3至约7个碳原子的烷基环; （c）Z为氢或未取代的支链或环状烷基，或未取代或烷基取代的苯基，具有除氢以外的3至约10个原子; （d）W是直链，支链或环状的烷基或芳基，未取代或取代的，饱和的或单或二不饱和的双键，除了W的末端碳原子不是双键的一部分; W具有除氢以外的1至约15个原子; 包含这些化合物的药物组合物，以及使用这些化合物治疗炎症或疼痛的方法。

7. 发明授权

US06545038B1 Heterocyclic metalloprotease inhibitors 失效
标题翻译：杂环金属蛋白酶抑制剂
公开(公告)号：US06545038B1
公开(公告)日：2003-04-08
申请号：US09707212
申请日：2000-11-06
申请人： Biswanath De , Stanislaw Pikul , Menyan Cheng , Neil Gregory Almstead , Randall Stryker Matthews , Michael George Natchus , Yetunde Olabisi Taiwo
发明人： Biswanath De , Stanislaw Pikul , Menyan Cheng , Neil Gregory Almstead , Randall Stryker Matthews , Michael George Natchus , Yetunde Olabisi Taiwo
IPC分类号： A61K31675
CPC分类号： C07D265/30 , C07D223/06 , C07D241/04 , C07D241/08 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/12 , Y02P20/582
摘要： The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
摘要翻译：本发明提供了权利要求中描述的式的化合物或其旋光异构体，非对映异构体或对映异构体，或其药学上可接受的盐或可生物水解的酰胺，酯或酰亚胺可用作金属蛋白酶的抑制剂。还公开了药物组合物和使用这些化合物治疗以金属蛋白酶活性为特征的疾病，病症和病症的方法或含有它们的药物组合物。

8. 发明授权

US6166005A Heterocyclic metalloprotease inhibitors 失效
公开(公告)号：US6166005A
公开(公告)日：2000-12-26
申请号：US921953
申请日：1997-08-26
申请人： Biswanath De , Stanislaw Pikul , Menyan Cheng , Neil Gregory Almstead , Randall Stryker Matthews , Michael George Natchus , Yetunde Olabisi Taiwo
发明人： Biswanath De , Stanislaw Pikul , Menyan Cheng , Neil Gregory Almstead , Randall Stryker Matthews , Michael George Natchus , Yetunde Olabisi Taiwo
IPC分类号： C07D243/08 , A61K31/395 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/54 , A61K31/554 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P15/00 , A61P17/02 , A61P17/06 , A61P17/16 , A61P19/02 , A61P19/04 , A61P19/08 , A61P19/10 , A61P27/02 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/02 , A61P39/00 , A61P43/00 , C07D223/06 , C07D241/04 , C07D241/08 , C07D265/30 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , A61K31/55 , C07D28/106
CPC分类号： C07D265/30 , C07D223/06 , C07D241/04 , C07D241/08 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/12 , Y02P20/582
摘要： The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

9. 发明授权

US5674891A Dihydrobenzothiophene compounds useful as anti-inflammatory agents 失效
标题翻译：用作抗炎剂的二氢苯并噻吩化合物
公开(公告)号：US5674891A
公开(公告)日：1997-10-07
申请号：US481726
申请日：1995-06-07
申请人： Michael Wiard Scherz , Randall Stryker Matthews
发明人： Michael Wiard Scherz , Randall Stryker Matthews
IPC分类号： C07D307/79 , C07D333/54 , A61K31/38
CPC分类号： C07D307/79 , C07D333/54
摘要： A compound having the structure: ##STR1## wherein (a) X is oxygen or sulfur; (b) each Y is independently hydrogen or unsubstituted straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; (c) Z is hydrogen or unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl, having from 3 to about 10 atoms other than hydrogen; (d) W is straight, branched or cyclic alkyl or aryl, unsubstituted or substituted, saturated or mono- or di-unsaturated with double bonds except that no terminal carbon atom of W is part of a double bond; W having from 1 to about 15 atoms other than hydrogen; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
摘要翻译：具有以下结构的化合物：其中（a）X是氧或硫; （b）每个Y独立地为氢或未取代的具有1至约3个碳原子的直链，支链或环状烷基，或两个Y键合以形成具有3至约7个碳原子的烷基环; （c）Z为氢或未取代的支链或环状烷基，或未取代或烷基取代的苯基，具有除氢以外的3至约10个原子; （d）W是直链，支链或环状的烷基或芳基，未取代或取代的，饱和的或单或二不饱和的双键，除了W的末端碳原子不是双键的一部分; W具有除氢以外的1至约15个原子; 包含这些化合物的药物组合物，以及使用这些化合物治疗炎症或疼痛的方法。

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