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1. 发明授权

US5656661A Dihydrobenzofuran and related compounds useful as anti-inflammatory agents 失效
标题翻译：二氢苯并呋喃及相关化合物可用作抗炎剂
公开(公告)号：US5656661A
公开(公告)日：1997-08-12
申请号：US481727
申请日：1995-06-07
申请人： Michael Wiard Scherz , Randall Stryker Matthews
发明人： Michael Wiard Scherz , Randall Stryker Matthews
IPC分类号： C07D307/79 , C07D333/54 , A61K31/34
CPC分类号： C07D307/79 , C07D333/54
摘要： A compound having the structure: ##STR1## wherein (a) X is oxygen or sulfur;(b) each Y is independently hydrogen or unsubstituted straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms,. or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms;(c) Z is hydrogen or unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl, having from 3 to about 10 atoms other than hydrogen;(d) W is straight, branched or cyclic alkyl or aryl, unsubstituted or substituted, saturated or mono- or di-unsaturated with double bonds except that no terminal carbon atom of W is part of a double bond; W having from 1 to about 15 atoms other than hydrogen;pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
摘要翻译：具有以下结构的化合物：其中（a）X是氧或硫; （b）每个Y独立地为氢或未取代的具有1至约3个碳原子的直链，支链或环烷基。或两个Y键合以形成具有3至约7个碳原子的烷基环; （c）Z为氢或未取代的支链或环状烷基，或未取代或烷基取代的苯基，具有除氢以外的3至约10个原子; （d）W是直链，支链或环状的烷基或芳基，未取代或取代的，饱和的或单或二不饱和的双键，除了W的末端碳原子不是双键的一部分; W具有除氢以外的1至约15个原子; 包含这些化合物的药物组合物，以及使用这些化合物治疗炎症或疼痛的方法。

2. 发明授权

US5674891A Dihydrobenzothiophene compounds useful as anti-inflammatory agents 失效
标题翻译：用作抗炎剂的二氢苯并噻吩化合物
公开(公告)号：US5674891A
公开(公告)日：1997-10-07
申请号：US481726
申请日：1995-06-07
申请人： Michael Wiard Scherz , Randall Stryker Matthews
发明人： Michael Wiard Scherz , Randall Stryker Matthews
IPC分类号： C07D307/79 , C07D333/54 , A61K31/38
CPC分类号： C07D307/79 , C07D333/54
摘要： A compound having the structure: ##STR1## wherein (a) X is oxygen or sulfur; (b) each Y is independently hydrogen or unsubstituted straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; (c) Z is hydrogen or unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl, having from 3 to about 10 atoms other than hydrogen; (d) W is straight, branched or cyclic alkyl or aryl, unsubstituted or substituted, saturated or mono- or di-unsaturated with double bonds except that no terminal carbon atom of W is part of a double bond; W having from 1 to about 15 atoms other than hydrogen; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
摘要翻译：具有以下结构的化合物：其中（a）X是氧或硫; （b）每个Y独立地为氢或未取代的具有1至约3个碳原子的直链，支链或环状烷基，或两个Y键合以形成具有3至约7个碳原子的烷基环; （c）Z为氢或未取代的支链或环状烷基，或未取代或烷基取代的苯基，具有除氢以外的3至约10个原子; （d）W是直链，支链或环状的烷基或芳基，未取代或取代的，饱和的或单或二不饱和的双键，除了W的末端碳原子不是双键的一部分; W具有除氢以外的1至约15个原子; 包含这些化合物的药物组合物，以及使用这些化合物治疗炎症或疼痛的方法。

3. 发明授权

US5684002A Dihydorbenzofuran and related compounds useful as anti-inflammatory agents 失效
标题翻译：二氢苯并呋喃和相关化合物可用作抗炎剂
公开(公告)号：US5684002A
公开(公告)日：1997-11-04
申请号：US486876
申请日：1995-06-07
申请人： Michael Wiard Scherz , John Michael Janusz
发明人： Michael Wiard Scherz , John Michael Janusz
IPC分类号： C07D333/52 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61P25/04 , A61P29/00 , C07D307/79 , C07D333/54
CPC分类号： C07D307/79 , C07D333/54
摘要： A compound having the structure: ##STR1## wherein (a) W is --C(X')--NRR' or --NR--C(X')R'; (b) X and X' are independently O or S; (c) each Y is independently hydrogen or straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; (d) Z is unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl or benzyl, Z having from 3 to about 10 atoms other than hydrogen; (e) R and R' are each independently selected from hydrogen, hydroxy straight, branched or substituted alkyl having from 1 to about 6 carbon atoms, and cyclic alkyl having from 3 to about 7 carbon atoms; unsubstituted or substituted aryl, heteroaryl or heterocyclic groups; or R and R' are bonded together to form a ring having from from 3 to about 8 atoms wherein about 1 to about 4 atoms may be heteroatoms; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
摘要翻译：具有以下结构的化合物：其中（a）W是-C（X'）-NRR'或-NR-C（X'）R'; （b）X和X'独立地为O或S; （c）每个Y独立地为氢或具有1至约3个碳原子的直链，支链或环状烷基，或两个Y键合以形成具有3至约7个碳原子的烷基环; （d）Z是未取代的支链或环状烷基，或未取代的或烷基取代的苯基或苄基，Z具有除氢以外的3至约10个原子; （e）R和R'各自独立地选自氢，具有1至约6个碳原子的羟基直链，支链或取代的烷基和具有3至约7个碳原子的环状烷基; 未取代或取代的芳基，杂芳基或杂环基团; 或R和R'键合在一起形成具有3至约8个原子的环，其中约1至约4个原子可以是杂原子; 包含这些化合物的药物组合物，以及使用这些化合物治疗炎症或疼痛的方法。

4. 发明授权

US5684041A Dihydrobenzofuran and related compounds useful as anti-inflammatory agents 失效
标题翻译：二氢苯并呋喃及相关化合物可用作抗炎剂
公开(公告)号：US5684041A
公开(公告)日：1997-11-04
申请号：US595158
申请日：1996-02-01
申请人： Michael Wiard Scherz
发明人： Michael Wiard Scherz
IPC分类号： A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/382 , A61P19/02 , A61P29/00 , A61P43/00 , C07D307/79 , C07D333/54 , C07D335/06 , C07D337/08
CPC分类号： C07D307/79 , A61K31/343 , C07D333/54
摘要： A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO.sub.2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from 3 to about 7 atoms; (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (e) W is O or S; and (f) R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, straight, branched or cyclic alkyl having from 1 to 10 carbon atoms, aryl, heterocyclyl, heteroaryl, hydroxy, or alkoxy; or R1, R2 or R3 may be bonded to form one or more rings each ring having from 3 to about 7 atoms wherein from 1 to 3 atoms may be heteroatoms. pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
摘要翻译：具有以下结构的化合物：其中（a）n为1至约3; （b）X选自由O，S，SO或SO 2组成的组; （c）Y独立地为氢或具有1至约4个碳原子的直链，支链或环状烷基，或Y连接在一起形成具有3至约7个原子的烷基环; （d）Z是氢或具有除氢以外的3至约10个原子的直链，支链或环状烷基; （e）W为O或S; 和（f）R 1，R 2和R 3独立地为氢，具有1至10个碳原子的直链，支链或环状烷基，芳基，杂环基，杂芳基，羟基或烷氧基; 或者R 1，R 2或R 3可以键合以形成一个或多个环，每个环具有3至约7个原子，其中1至3个原子可以是杂原子。包含这些化合物的药物组合物，以及使用这些化合物治疗炎症或疼痛的方法。

5. 发明授权

US5672620A Dihydrobenzofuran and related compounds useful as anti-inflammatory agents 失效
标题翻译：二氢苯并呋喃及相关化合物可用作抗炎剂
公开(公告)号：US5672620A
公开(公告)日：1997-09-30
申请号：US595086
申请日：1996-02-01
申请人： Michael Wiard Scherz , Laurence Ichih Wu
发明人： Michael Wiard Scherz , Laurence Ichih Wu
IPC分类号： C07D333/54 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/4178 , A61P19/02 , A61P29/00 , A61P43/00 , C07D307/79 , C07D335/06 , C07D337/08 , C07D405/06
CPC分类号： C07D307/79 , C07D405/06
摘要： A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from 3 to about 7 atoms; (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (e) W is hydrogen or straight, branched or cyclic alkyl, aryl, hydroxy or alkoxy; and (f) R.sub.1 and R.sub.2 are independently hydrogen or straight, branched or cyclic alkyl having from one to 10 carbon atoms, aryl, heterocyclyl, heteroaryl, hydroxy, or alkoxy; or R.sub.1 and R.sub.2 are bonded together to form a ring having from from 3 to about 7 atoms wherein one to three atoms may be heteroatoms. pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
摘要翻译：具有以下结构的化合物：其中（a）n为1至约3; （b）X选自O，S，SO或SO 2; （c）Y独立地为氢或具有1至约4个碳原子的直链，支链或环状烷基，或Y连接在一起形成具有3至约7个原子的烷基环; （d）Z是氢或具有除氢以外的3至约10个原子的直链，支链或环状烷基; （e）W是氢或直链，支链或环状烷基，芳基，羟基或烷氧基; 和（f）R 1和R 2独立地是氢或具有1至10个碳原子的直链，支链或环状烷基，芳基，杂环基，杂芳基，羟基或烷氧基; 或者R 1和R 2结合在一起形成具有3-约7个原子的环，其中一至三个原子可以是杂原子。包含这些化合物的药物组合物，以及使用这些化合物治疗炎症或疼痛的方法。

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