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1. 发明授权

US07998188B2 Compliant blood vessel graft 有权
标题翻译：符合血管移植
公开(公告)号：US07998188B2
公开(公告)日：2011-08-16
申请号：US11797648
申请日：2007-05-04
申请人： Peter Paul Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
发明人： Peter Paul Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
IPC分类号： A61F2/06
CPC分类号： A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
摘要： Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
摘要翻译：提供支架和使用支架的方法。本发明的支架为设置在其内的血管段提供外部支撑结构，其中支架能够以模仿动脉的顺应性的方式弹性径向扩张。支架可以由形成的针织或编织网形成，以便提供所需的顺应性。提供具有支架和设置在其内的静脉段的静脉移植物，其中移植物能够模拟动脉的顺应性。提供了选择小型化支架的方法和使用本发明的支架在缩小和平滑方面的方法。提供了用包括本发明的支架的静脉移植物代替动脉的一部分的方法。提供了使用本发明的支架在静脉移植物中减少植入静脉段内膜增生的方法。

2. 发明授权

US08187319B2 Porous synthetic vascular grafts with oriented ingrowth channels 失效
标题翻译：具有定向向内生长通道的多孔合成血管移植物
公开(公告)号：US08187319B2
公开(公告)日：2012-05-29
申请号：US12780098
申请日：2010-05-14
申请人： Peter Paul Zilla , Deon Bezuidenhout
发明人： Peter Paul Zilla , Deon Bezuidenhout
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2250/0031 , A61L27/18 , A61L27/507 , B29C47/0004 , B29C47/0014 , B29C47/0023 , B29C47/20 , B29C53/587 , B29C53/665 , B29K2075/00 , B29K2105/045 , B29K2105/06 , B29K2105/101 , B29L2031/7534 , C08L75/04
摘要： A vascular prosthesis is constructed from a structure having interconnected, helically oriented channel-porosity to allow oriented ingrowth of connective tissue into a wall of the prosthesis. The prosthesis can have a small internal diameter of 6 mm or less. Several different methods can be used to produce the prosthesis, including a fiber winding and extraction technique, a melt extrusion technique, and a particle and fiber extraction technique using either a layered method or a continuous method. Furthermore, mechanical properties of prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.
摘要翻译：血管假体由具有相互连接的螺旋形取向的通道孔隙的结构构成，以允许结缔组织的定向向内生长进入假体的壁。假体可以具有6mm或更小的小内径。可以使用几种不同的方法来生产假体，包括纤维缠绕和提取技术，熔体挤出技术以及使用分层方法或连续方法的颗粒和纤维提取技术。此外，假体的机械性能与主体容器的机械性能相匹配，从而克服了柔顺性失配的问题。

3. 发明授权

US07033388B2 Porous synthetic vascular grafts with oriented ingrowth channels 失效
公开(公告)号：US07033388B2
公开(公告)日：2006-04-25
申请号：US10187522
申请日：2002-07-02
申请人： Peter Paul Zilla , Deon Bezuidenhout
发明人： Peter Paul Zilla , Deon Bezuidenhout
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2250/0031 , A61L27/18 , A61L27/507 , B29C47/0004 , B29C47/0014 , B29C47/0023 , B29C47/20 , B29C53/587 , B29C53/665 , B29K2075/00 , B29K2105/045 , B29K2105/06 , B29K2105/101 , B29L2031/7534 , C08L75/04
摘要： A vascular prosthesis is constructed from a structure having interconnected, helically oriented channel-porosity to allow oriented ingrowth of connective tissue into a wall of the prosthesis. The prosthesis can have a small internal diameter of 6 mm or less. Several different methods can be used to produce the prosthesis, including a fiber winding and extraction technique, a melt extrusion technique, and a particle and fiber extraction technique using either a layered method or a continuous method. Furthermore, mechanical properties of the prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.

4. 发明授权

US06616699B2 Foam-type vascular prosthesis with well-defined angio-permissive open porosity 失效
公开(公告)号：US06616699B2
公开(公告)日：2003-09-09
申请号：US09757527
申请日：2001-01-09
申请人： Peter Paul Zilla , Deon Bezuidenhout
发明人： Peter Paul Zilla , Deon Bezuidenhout
IPC分类号： A61F224
CPC分类号： A61F2/06 , A61F2/0077 , A61L27/507 , A61L27/56 , A61L27/18 , C08L75/04
摘要： A vascular prosthesis is constructed from a well-defined pore structure to allow uninterrupted ingrowth of connective tissue into a wall of the prosthesis. Several different methods can be used to produce the prosthesis, including a vacuum impregnation technique, a paste molding technique, a paste extrusion technique, a dip coating technique, and a melt extrusion technique. Furthermore, mechanical properties of the prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.

5. 发明授权

US06673108B2 Transmural concentric multilayer ingrowth matrix within well-defined porosity 失效
标题翻译：透明同心多层向内生长矩阵在明确孔隙度内
公开(公告)号：US06673108B2
公开(公告)日：2004-01-06
申请号：US10142957
申请日：2002-05-10
申请人： Peter Paul Zilla , Deon Bezuidenhout , Theresa Yvonne Dower
发明人： Peter Paul Zilla , Deon Bezuidenhout , Theresa Yvonne Dower
IPC分类号： A61F206
CPC分类号： A61L27/56 , A61L27/22 , A61L31/043 , A61L31/146
摘要： A multilayer ingrowth matrix is constructed within well-defined porosity of a prosthetic material. The matrix consists of either proteinaceous or synthetic layers or gradients, or a combination of proteinaceous and synthetic layers or gradients. Each layer within the matrix is designed to achieve a specific function, such as facilitation of ingrowth of a particular cell type or release of a particular growth factor. The well-defined porosity is in the form of either helically oriented, interconnected transmural ingrowth channels, or a porous wall structure containing uniformly shaped pores (i.e. voids) in a very narrow size range, or a combination of channels and pores. This invention allows for uninterrupted ingrowth of connective tissue into walls of a synthetic graft prosthesis made from the prosthetic material. Furthermore, this invention can produce small diameter prostheses having an internal diameter of 6 mm or less.
摘要翻译：多层向内生长基质被构造在假体材料的明确孔隙度内。基质由蛋白质或合成层或梯度组成，或蛋白质和合成层或梯度的组合。设计基质内的每个层以实现特定功能，例如促进特定细胞类型的向内生长或特定生长因子的释放。明确定义的孔隙度是螺旋取向的，互连的透壁向内生长通道或包含非常窄尺寸范围内的均匀形状的孔（即空隙）或通道和孔的组合的多孔壁结构的形式。本发明允许结缔组织向假体材料制成的合成移植假体的壁中不间断地向内延伸。此外，本发明可以制造内径为6mm以下的小直径假体。

6. 发明授权

US06540780B1 Porous synthetic vascular grafts with oriented ingrowth channels 失效
公开(公告)号：US06540780B1
公开(公告)日：2003-04-01
申请号：US09434071
申请日：1999-11-05
申请人： Peter Paul Zilla , Deon Bezuidenhout
发明人： Peter Paul Zilla , Deon Bezuidenhout
IPC分类号： A61F206
CPC分类号： A61F2/06 , A61F2250/0031 , A61L27/18 , A61L27/507 , B29C47/0004 , B29C47/0014 , B29C47/0023 , B29C47/20 , B29C53/587 , B29C53/665 , B29K2075/00 , B29K2105/045 , B29K2105/06 , B29K2105/101 , B29L2031/7534 , C08L75/04
摘要： A vascular prosthesis is constructed from a structure having interconnected, helically oriented channel-porosity to allow oriented ingrowth of connective tissue into a wall of the prosthesis. The prosthesis can have a small internal diameter of 6 mm or less. Several different methods can be used to produce the prosthesis, including a fiber winding and extraction technique, a melt extrusion technique, and a particle and fiber extraction technique using either a layered method or a continuous method. Furthermore, mechanical properties of the prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.

7. 发明授权

US06702848B1 Foam-type vascular prosthesis with well-defined anclio-permissive open porosity 失效
公开(公告)号：US06702848B1
公开(公告)日：2004-03-09
申请号：US09434649
申请日：1999-11-05
申请人： Peter Paul Zilla , Deon Bezuidenhout
发明人： Peter Paul Zilla , Deon Bezuidenhout
IPC分类号： A61F206
CPC分类号： A61F2/06 , A61F2/0077 , A61L27/507 , A61L27/56 , A61L27/18 , C08L75/04
摘要： A vascular prosthesis is constructed from a well-defined pore structure to allow uninterrupted ingrowth of connective tissue into a wall of the prosthesis. Several different methods can be used to produce the prosthesis, including a vacuum impregnation technique, a paste molding technique, a paste extrusion technique, a dip coating technique, and a melt extrusion technique. Furthermore, mechanical properties of the prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.

8. 发明申请

US20120059447A1 Stent Deployment Device 有权
标题翻译：支架部署装置
公开(公告)号：US20120059447A1
公开(公告)日：2012-03-08
申请号：US13123380
申请日：2009-10-08
申请人： Peter Paul Zilla , Deon Bezuidenhout , David Franklyn Williams
发明人： Peter Paul Zilla , Deon Bezuidenhout , David Franklyn Williams
IPC分类号： A61F2/84
CPC分类号： A61F2/2433 , A61F2/243 , A61F2/95 , A61M2025/1097
摘要： A stent deployment device (1) over which a stent (2) is securable for the purpose of delivery into an operative position in a human body is provided. The device comprises a plurality of elongate wings (16), each of which has a length consistent with the length of a stent to be deployed using the deployment device, the wings being arranged circumferentially about a central body (10) which extends from, and is operable through, a catheter (14). The wings are movable between a radially withdrawn delivery position and expanded positions in which they are displaced radially outwards of the body. A flow path (105) is defined internally of the wings in the expanded positions thereof and a temporary valve (68) is provided in such flow path to permit the flow of blood though the flow path predominantly in one direction. An inflatable annular balloon (80) is preferably provided over the wings to cause final expansion of the stent. Locator arms (40) are deployable from the body to assist in locating the body within a natural heart valve (101).
摘要翻译：提供了一种支架展开装置（1），支架（2）在该支架展开装置（1）上可固定以便输送到人体内的操作位置。该装置包括多个细长翼片（16），每个翼片具有与使用展开装置展开的支架的长度一致的长度，翼部围绕中心体（10）周向地布置，中心体（10）从可通过导管（14）操作。翼可在径向拉出的输送位置和膨胀位置之间移动，在该位置中它们径向向外移动。流动路径（105）在其扩展位置中的翼部的内部限定，并且在该流动路径中设置临时阀（68），以允许主要沿一个方向通过流动路径流动血液。可膨胀的环形气囊（80）优选地设置在机翼上方以引起支架的最终膨胀。定位臂（40）可从身体展开以帮助将身体定位在天然心脏瓣膜（101）内。

9. 发明申请

US20110213454A1 Porous Synthetic Vascular Grafts with Oriented Ingrowth Channels 失效
标题翻译：多孔合成血管移植物具有定向增殖通道
公开(公告)号：US20110213454A1
公开(公告)日：2011-09-01
申请号：US12780098
申请日：2010-05-14
申请人： Peter Paul Zilla , Deon Bezuidenhout
发明人： Peter Paul Zilla , Deon Bezuidenhout
IPC分类号： A61F2/82 , A61F2/24 , B29C41/02
CPC分类号： A61F2/06 , A61F2250/0031 , A61L27/18 , A61L27/507 , B29C47/0004 , B29C47/0014 , B29C47/0023 , B29C47/20 , B29C53/587 , B29C53/665 , B29K2075/00 , B29K2105/045 , B29K2105/06 , B29K2105/101 , B29L2031/7534 , C08L75/04
摘要： A vascular prosthesis is constructed from a structure having interconnected, helically oriented channel-porosity to allow oriented ingrowth of connective tissue into a wall of the prosthesis. The prosthesis can have a small internal diameter of 6 mm or less. Several different methods can be used to produce the prosthesis, including a fiber winding and extraction technique, a melt extrusion technique, and a particle and fiber extraction technique using either a layered method or a continuous method. Furthermore, mechanical properties of prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.
摘要翻译：血管假体由具有相互连接的螺旋形取向的通道孔隙的结构构成，以允许结缔组织的定向向内生长进入假体的壁。假体可以具有6mm或更小的小内径。可以使用几种不同的方法来生产假体，包括纤维缠绕和提取技术，熔体挤出技术以及使用分层方法或连续方法的颗粒和纤维提取技术。此外，假体的机械性能与主体容器的机械性能相匹配，从而克服了柔顺性失配的问题。

10. 发明授权

US07632306B2 Foam-type vascular prosthesis with well-defined angio-permissive open porosity 失效
标题翻译：泡沫型血管假体具有明确的血管容许开放孔隙度
公开(公告)号：US07632306B2
公开(公告)日：2009-12-15
申请号：US10612082
申请日：2003-07-02
申请人： Peter Paul Zilla , Deon Bezuidenhout
发明人： Peter Paul Zilla , Deon Bezuidenhout
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/0077 , A61L27/507 , A61L27/56 , A61L27/18 , C08L75/04
摘要： A vascular prosthesis is constructed from a well-defined pore structure to allow uninterrupted ingrowth of connective tissue into a wall of the prosthesis. Several different methods can be used to produce the prosthesis, including a vacuum impregnation technique, a paste molding technique, a paste extrusion technique, a dip coating technique, and a melt extrusion technique. Furthermore, mechanical properties of the prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.
摘要翻译：血管假体由明确的孔结构构造，以允许连续组织的不间断向内生长进入假体的壁。可以使用几种不同的方法来生产假体，包括真空浸渍技术，糊模技术，糊挤技术，浸涂技术和熔体挤出技术。此外，假体的机械性能与主体容器的机械性能相匹配，从而克服顺应性失配的问题。

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