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1. 发明授权

US07026310B2 Heteroaryl derivatives and their use as medicaments 失效
标题翻译：杂芳衍生物及其用作药物
公开(公告)号：US07026310B2
公开(公告)日：2006-04-11
申请号：US11105622
申请日：2005-04-14
申请人： Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
发明人： Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
IPC分类号： C07D403/12 , C07D403/14 , A61K31/55 , A61P35/00
CPC分类号： C07D401/06 , C07D215/50
摘要： The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
摘要翻译：本发明涉及式1的新型喹啉衍生物，其制备方法及其用作药物，特别是用于治疗肿瘤。

2. 发明授权

US06890926B2 Heteroaryl derivatives and their use as medicaments 失效
公开(公告)号：US06890926B2
公开(公告)日：2005-05-10
申请号：US09910141
申请日：2001-07-20
申请人： Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
发明人： Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
IPC分类号： C07D401/06 , A61K31/4709 , A61K31/496 , A61K31/513 , A61K31/53 , A61P35/00 , C07D215/50 , C07D219/04 , C07D473/02 , C07D401/14
CPC分类号： C07D401/06 , C07D215/50
摘要： The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

3. 发明授权

US07056912B2 Heteroaryl derivatives and their use as medicaments 失效
公开(公告)号：US07056912B2
公开(公告)日：2006-06-06
申请号：US10713859
申请日：2003-11-14
申请人： Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
发明人： Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
IPC分类号： C07D401/12 , C07D401/14 , A61K31/551 , A61K31/395 , A61P35/02
CPC分类号： C07D401/06 , C07D215/50
摘要： The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

4. 发明授权

US06936615B2 Heteroaryl derivatives and their use as medicaments 失效
公开(公告)号：US06936615B2
公开(公告)日：2005-08-30
申请号：US10741310
申请日：2003-12-19
申请人： Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
发明人： Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
IPC分类号： C07D401/06 , A61K31/4709 , A61K31/496 , A61K31/513 , A61K31/53 , A61P35/00 , C07D215/50 , C07D219/04 , C07D473/02 , C07D403/12 , A61K31/506 , A61P35/02 , C07D403/14
CPC分类号： C07D401/06 , C07D215/50
摘要： The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

5. 发明授权

US06638935B2 Heteroary1 derivatives and their use as medicaments 失效
标题翻译： Heteroary1衍生物及其作为药物的用途
公开(公告)号：US06638935B2
公开(公告)日：2003-10-28
申请号：US09910139
申请日：2001-07-20
申请人： Peter Emig , Eckhard Günther , Bernhard Kutscher , Bernd Nickel , Jürgen Schmidt , Anita Storch
发明人： Peter Emig , Eckhard Günther , Bernhard Kutscher , Bernd Nickel , Jürgen Schmidt , Anita Storch
IPC分类号： A61K31496
CPC分类号： C07D213/81
摘要： The invention relates to novel pyridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors
摘要翻译：本发明涉及式1的新颖吡啶衍生物，其制备方法及其作为药物的用途，特别是用于治疗肿瘤

6. 发明授权

US07579365B2 Indolyl-3-glyoxylic acid derivatives having antitumor action 失效
标题翻译：具有抗肿瘤作用的吲哚基-3-乙醛酸衍生物
公开(公告)号：US07579365B2
公开(公告)日：2009-08-25
申请号：US10309204
申请日：2002-12-04
申请人： Bernd Nickel , Istvan Szelenyi , Jürgen Schmidt , Peter Emig , Dietmar Reichert , Eckhard Günther , Kay Brune , Guillaume Le Baut
发明人： Bernd Nickel , Istvan Szelenyi , Jürgen Schmidt , Peter Emig , Dietmar Reichert , Eckhard Günther , Kay Brune , Guillaume Le Baut
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： A61K31/496 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/444 , A61K31/4709 , C07D209/14 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
摘要翻译：本发明涉及通式I的N-取代的吲哚-3-乙醛酰胺作为抗肿瘤剂和具有抗肿瘤作用的药物组合物的用途，其特征在于其含有至少一种通式1的化合物，如果也适用于生理上可耐受的酸加成盐或N-氧化物的形式。此外，本发明还包括抗肿瘤剂，其包含根据通式1的一种或多种N-取代的吲哚-3-乙醛酰胺作为活性化合物，以及如果合适的话，其生理上可耐受的酸加成盐，以及如果可能的话，N-氧化物和片剂，包衣片剂，胶囊，输注溶液或安瓿，栓剂，贴剂，可通过吸入，悬浮液，霜剂和软膏使用的粉末制剂的药学上可用的载体和/或稀释剂或辅助物质。

7. 发明授权

US06232327B1 Indolyl-3-glyoxylic acid derivatives having antitumor action 有权
标题翻译：具有抗肿瘤作用的吲哚基-3-乙醛酸衍生物
公开(公告)号：US06232327B1
公开(公告)日：2001-05-15
申请号：US09285058
申请日：1999-04-02
申请人： Bernd Nickel , Istvan Szelenyi , Jürgen Schmidt , Peter Emig , Dietmar Reichert , Eckhard Günther , Kay Brune
发明人： Bernd Nickel , Istvan Szelenyi , Jürgen Schmidt , Peter Emig , Dietmar Reichert , Eckhard Günther , Kay Brune
IPC分类号： A61K31435
CPC分类号： A61K31/496 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/444 , A61K31/4709 , C07D209/14 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
摘要翻译：本发明涉及通式I的N-取代吲哚-3-乙醛酰胺作为抗肿瘤剂，并且具有抗肿瘤作用的药物组合物的用途，其特征在于，如果适用，其含有至少一种通式1的化合物还以生理上可耐受的酸加成盐或N-氧化物的形式。此外，本发明还包括抗肿瘤剂，其包含根据通式1的一种或多种N-取代的吲哚-3-乙醛酰胺作为活性化合物，以及如果合适的话，其生理上可耐受的酸加成盐，以及如果可能的话，N-氧化物和片剂，包衣片剂，胶囊，输注溶液或安瓿，栓剂，贴剂，可通过吸入，悬浮液，霜剂和软膏使用的粉末制剂的药学上可用的载体和/或稀释剂或辅助物质。

8. 发明授权

US09453444B2 Device for distributing fluids in exhaust systems 有权
标题翻译：用于在排气系统中分配流体的装置
公开(公告)号：US09453444B2
公开(公告)日：2016-09-27
申请号：US13976299
申请日：2011-10-27
申请人： Michael Fischer , Michael Müller , Jürgen Schmidt
发明人： Michael Fischer , Michael Müller , Jürgen Schmidt
IPC分类号： F01N3/00 , F01N3/10 , B01F3/04 , B01F5/04 , B01F5/06 , F01N3/20 , F01N3/28 , F01N13/08 , F01N13/18
CPC分类号： F01N3/10 , B01F3/04049 , B01F5/0451 , B01F5/0473 , B01F5/061 , B01F5/0616 , B01F2005/0091 , F01N3/2066 , F01N3/2892 , F01N13/08 , F01N13/1816 , F01N2240/20 , F01N2240/40 , F01N2290/04 , F01N2470/24 , F01N2610/02 , F01N2610/1453 , Y02T10/24
摘要： An apparatus for distributing fluids in an exhaust system of an internal combustion engine. The apparatus includes an injection device, wherein a combination of a plurality of individual measures for achieving a uniform mixing of the fluids with the exhaust gas and a complete vaporizing of the fluids in the exhaust gas is provided. The individual measure comprises at least one of at least one swirl-generating device and at least one mixing apparatus. The individual measure also includes at least one catalyst. The individual measure further includes an injection nozzle of the injection device which is arranged at a predefined spacing from a wall of the exhaust tract.
摘要翻译：一种用于在内燃机的排气系统中分配流体的装置。该装置包括注射装置，其中提供了用于实现流体与废气的均匀混合以及废气中的流体的完全蒸发的多种单独措施的组合。单独的措施包括至少一个涡流产生装置和至少一个混合装置中的至少一个。单独的测量还包括至少一种催化剂。单独的措施还包括喷射装置的喷射喷嘴，喷射装置以与排气通道的壁预定的间隔布置。

9. 发明授权

US09234448B2 Muffler 有权
标题翻译：围巾
公开(公告)号：US09234448B2
公开(公告)日：2016-01-12
申请号：US13814321
申请日：2011-08-02
申请人： Jürgen Schmidt , Michael Herbig
发明人： Jürgen Schmidt , Michael Herbig
IPC分类号： F01N3/02 , F01N5/02 , F01N13/08 , F01N1/00 , F01N5/00 , H01L35/30
CPC分类号： F01N5/00 , F01N1/00 , F01N5/02 , F01N5/025 , F01N2240/02 , F01N2470/02 , H01L35/30 , Y02T10/16
摘要： A muffler for an exhaust gas system of an internal combustion engine, the muffler including a muffler housing, at least one exhaust gas inlet, at least one gas outlet and at least one muffling device arranged in the muffler housing. At least one cooling element arranged in the muffler housing is configured to extract heat energy from the exhaust gas and is arranged in the muffler housing.
摘要翻译：一种用于内燃机的排气系统的消声器，所述消音器包括消音器壳体，至少一个废气入口，至少一个气体出口和布置在所述消声器壳体中的至少一个消音装置。布置在消音器壳体中的至少一个冷却元件构造成从废气中提取热能并且布置在消声器壳体中。

10. 发明授权

US07168447B2 Fluid distribution unit for dividing a stream of fluid into a plurality of partial streams 失效
标题翻译：流体分配单元，用于将流体流分成多个部分流
公开(公告)号：US07168447B2
公开(公告)日：2007-01-30
申请号：US10433039
申请日：2002-01-08
申请人： Oliver Stadel , Jürgen Schmidt , Ulrich Krause
发明人： Oliver Stadel , Jürgen Schmidt , Ulrich Krause
IPC分类号： F16L41/00 , C23C16/00
CPC分类号： C23C16/45574 , C23C16/45563 , C23C16/45572 , Y10T137/2196 , Y10T137/2224 , Y10T137/6579 , Y10T137/85938
摘要： The invention relates to a liquid distribution unit (10, 20) for dividing a liquid current into a plurality of partial currents. Said unit comprises at least one liquid inlet (13, 23) for the supplied liquid current, a plurality of liquid outlets (14; 24) for the partial currents, and a plurality of channels (15, 25) connecting the liquid inlets (13, 23) to the liquid outlets (14, 24). Said unit is characterised in that the channels (15, 25) symmetrically and respectively branch off (16, 26) into upstream channels (15a, 15b, 15c, 15d, 15c; 25a, 25b, 25c, 25d, 25c) and each connection leading from the liquid inlet (13; 23 ) to one of the liquid outlets (14; 24) comprises the same channels (15, 25) and the same branches (16, 26). A liquid distribution device for the divided distributiion of at least two different liquids; comprises a plurality of such liquid distribution units (10, 20) placed flatly on top of each other. One of the liquids is distributed in each liquid distribution unit (10, 20) and the other(s) is/are guided through separate passages (17, 27) in an undistributed manner. One such liquid distribution device can especially be embodied as a device for supplying gases for a CVD coating installation. In this case, at least one liquid distribution unit (10) is provided for a precursor gas optionally having a carrier gas, and at least one other liquid distribution unit (20) is provided for a reactive gas.
摘要翻译：本发明涉及一种用于将液体电流分成多个部分电流的液体分配单元（10,20）。所述单元包括用于供应的液流的至少一个液体入口（13,23），用于部分电流的多个液体出口（14; 24）和连接液体入口（13）的多个通道（15,25），23）连接到液体出口（14,24）。所述单元的特征在于通道（15,25）对称并分别分支（16,26）进入上游通道（15a，15b，15c，15d，15c; 25a，25b，25c ，25d，25c），并且从所述液体入口（13; 23）引导到所述液体出口（14; 24）中的一个的每个连接包括相同的通道（15,25）和相同的分支（16,26）。一种用于分配至少两种不同液体的液体分配装置; 包括彼此平坦地放置的多个这样的液体分配单元（10,20）。其中一个液体分布在每个液体分配单元（10,20）中，另一个液体以未分配的方式被引导通过单独的通道（17,27）。一种这样的液体分配装置可以特别地被实施为用于为CVD涂层设备供应气体的装置。在这种情况下，为任选地具有载气的前体气体提供至少一个液体分配单元（10），并且为反应气体提供至少一个其它液体分配单元（20）。

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