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1. 发明申请

US20110065675A1 AZO DYE RELATED SMALL MOLECULE MODULATORS OF PROTEIN-PROTEIN INTERACTIONS 审中-公开
标题翻译： AZO DYE相关小分子蛋白质蛋白质相互作用的调节剂
公开(公告)号：US20110065675A1
公开(公告)日：2011-03-17
申请号：US12991079
申请日：2009-05-05
申请人： Peter Buchwald , Emilio Margolles-Clark , Norma S. Kenyon , Camillo Ricordi
发明人： Peter Buchwald , Emilio Margolles-Clark , Norma S. Kenyon , Camillo Ricordi
IPC分类号： A61K31/655 , A61K31/185 , C12N5/071 , A61P35/00 , A61P3/10 , A61P29/00 , A61P19/04 , A61P3/00 , A61P17/00 , A61P17/06 , A61P37/02 , A61P37/06 , A61P25/28 , A61P9/10
CPC分类号： A61K31/517
摘要： Azo dyes and suramin-related small molecules are effective in inhibiting the CD40/CD154 protein-protein interaction, an important co-stimulatory interaction involved in the activation of immune responses mediated by T- and B-cells. The compounds were found to be active as indicated by their IC50 values both in a cell-free binding assay and in the inhibition of CD154-induced B-cell proliferation assay. The compounds may be used as therapeutic compounds for treatment of diseases and disorders related to immune or inflammatory responses. Methods of inhibiting the CD40/CD154 protein-protein interaction and treating diseases and disorders related to immune or inflammatory responses are described.
摘要翻译：偶氮染料和苏拉明相关的小分子在抑制CD40 / CD154蛋白质 - 蛋白质相互作用中是有效的，这是参与由T细胞和B细胞介导的免疫应答活化的重要的共刺激相互作用。发现这些化合物在无细胞结合测定和抑制CD154诱导的B细胞增殖测定中的IC 50值都是活性的。该化合物可用作治疗与免疫或炎症反应有关的疾病和病症的治疗化合物。描述了抑制CD40 / CD154蛋白质相互作用和治疗与免疫或炎症反应相关的疾病和病症的方法。

2. 发明授权

US6004743A Method and apparatus for bulk enrichment of a population or subpopulation of cells 失效
标题翻译：用于大量富集细胞群体或亚群体的方法和装置
公开(公告)号：US6004743A
公开(公告)日：1999-12-21
申请号：US989124
申请日：1997-12-10
申请人： Norma S. Kenyon , Thomas R. Russell , Camillo Ricordi , Robert K. Zwerner
发明人： Norma S. Kenyon , Thomas R. Russell , Camillo Ricordi , Robert K. Zwerner
IPC分类号： G01N33/53 , C12N5/06 , G01N33/537 , G01N33/543 , G01N33/553 , G01N33/569 , A01N1/02 , G01N33/567
CPC分类号： G01N33/5375 , G01N33/54313 , G01N33/553 , G01N33/56966 , G01N33/56972
摘要： A cell population or subpopulation enrichment procedure for separating undesired populations or subpopulations from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have one or more reactants bound thereto which are specific to and will bind with the selected population or subpopulation to be eliminated from the sample. The particles preferably are mixed with the sample by repeatedly causing the particles to settle through a substantial portion of the sample to bind to the selected population. The particles with the bound selected population to be eliminated then are allowed to preferentially settle in the sample and the supernatant including the enriched population or subpopulation is separated from the particles with the population to be eliminated bound thereto. The enriched population supernatant can then be analyzed, utilized as is, have other populations or subpopulations removed or have additional amounts of remaining cells of the previously eliminated populations removed in additional steps.
摘要翻译：使用相对重的致密颗粒和重力沉降从生物样品中分离不想要的种群或亚群体的细胞群或亚群富集程序。颗粒具有一个或多个与其结合的反应物，其与所选择的群体或子群体特异并将与样品中的氨基酸结合。颗粒优选通过重复使颗粒沉淀通过样品的大部分与样品结合而与样品混合。将具有待排除的结合的选定群体的颗粒允许优先沉淀在样品中，并将包含富集群体或亚群体的上清液与要与其排除的群体结合的颗粒分离。然后可以分析富集的群体上清液，按其他方式使用，除去其他群体或亚群体，或者在额外的步骤中除去先前消除的群体的额外量的剩余细胞。

3. 发明授权

US08702684B2 Therapeutic hybrid implantable devices 有权
标题翻译：治疗性混合植入式装置
公开(公告)号：US08702684B2
公开(公告)日：2014-04-22
申请号：US12524918
申请日：2008-02-01
申请人： Nicholas Bodor , Peter Buchwald , Christopher A. Fraker , Jeffrey Hubbell , Luca Inverardi , Norma Sue Kenyon , Paul Latta , Antonello Pileggi , Cheryl Stabler Anderson , Fabio Grassi , Camillo Ricordi
发明人： Nicholas Bodor , Peter Buchwald , Christopher A. Fraker , Jeffrey Hubbell , Luca Inverardi , Norma Sue Kenyon , Paul Latta , Antonello Pileggi , Cheryl Stabler Anderson , Fabio Grassi , Camillo Ricordi
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61F2/022 , A61K35/39 , A61K38/18 , A61K38/185 , A61K38/1866 , A61K38/19 , A61K38/22 , A61K38/55 , A61M5/14244 , A61M5/14276 , A61M5/1452 , A61M2202/097
摘要： A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.
摘要翻译：用于接收植入的生物材料的装置（10）包括限定相邻空间的机械保护表面（16），用于将介质局部输送到所述空间的组件（26,28），以及泵或缓/缓释储存器结构（14）可操作地联接到组件。该装置可以包括用于设置在所述空间中的附加柱塞体。植入的生物材料可以被包封或非包封。

4. 发明申请

US20100204683A1 THERAPEUTIC HYBRID IMPLANTABLE DEVICES 有权
标题翻译：治疗混合植入式装置
公开(公告)号：US20100204683A1
公开(公告)日：2010-08-12
申请号：US12524918
申请日：2008-02-01
申请人： Nicholas Bodor , Peter Buchwald , Christopher A. Fraker , Jeffrey Hubbell , Luca Inverardi , Norma Sue Kenyon , Paul Latta , Antonello Pileggi , Cheryl Stabler Anderson , Fabio Grassi , Camillo Ricordi
发明人： Nicholas Bodor , Peter Buchwald , Christopher A. Fraker , Jeffrey Hubbell , Luca Inverardi , Norma Sue Kenyon , Paul Latta , Antonello Pileggi , Cheryl Stabler Anderson , Fabio Grassi , Camillo Ricordi
IPC分类号： A61M5/14
CPC分类号： A61F2/022 , A61K35/39 , A61K38/18 , A61K38/185 , A61K38/1866 , A61K38/19 , A61K38/22 , A61K38/55 , A61M5/14244 , A61M5/14276 , A61M5/1452 , A61M2202/097
摘要： A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.
摘要翻译：用于接收植入的生物材料的装置（10）包括限定相邻空间的机械保护表面（16），用于将介质局部输送到所述空间的组件（26,28），以及泵或缓/缓释储存器结构（14）可操作地联接到组件。该装置可以包括用于设置在所述空间中的附加柱塞体。植入的生物材料可以被包封或非包封。

5. 发明公开

US20230160791A1 DEVICE AND METHOD FOR TISSUE PROCESSING 审中-公开
公开(公告)号：US20230160791A1
公开(公告)日：2023-05-25
申请号：US17916969
申请日：2021-04-06
申请人： Camillo Ricordi , Giacomo Lanzoni , University of Miami
发明人： Camillo Ricordi , Giacomo Lanzoni
IPC分类号： G01N1/28
CPC分类号： G01N1/286 , G01N2001/2873
摘要： A tissue processing chamber is disclosed. The tissue processing chamber includes at least one rotary blade housed within a tissue chamber and a drive shaft coupled to the rotary blades. Rotation of the drive shaft rotates the rotary blades and presses a tissue sample through a screen adjacent to the at least one rotary blade, wherein rotation of the at least one rotary blade presses processed tissue through the screen. The tissue processing device also includes a collection chamber coupled to the tissue chamber configured to collect the processed tissue.

6. 发明授权

US11466255B2 Methods and compositions for converting non-endocrine pancreatic tissue into insulin-producing cells 有权
公开(公告)号：US11466255B2
公开(公告)日：2022-10-11
申请号：US15573870
申请日：2016-05-02
申请人： Juan Dominguez-Bendala , Luca Inverardi , Ricardo L. Pastori , Camillo Ricordi
发明人： Juan Dominguez-Bendala , Luca Inverardi , Ricardo L. Pastori , Camillo Ricordi
IPC分类号： A61K38/18 , A61P5/50 , A61P3/10 , C12N5/071 , A61K48/00 , A61K35/39
摘要： Compositions and methods are provided for generating islet-like cell clusters. The methods include culturing a whole non-islet pancreatic cell discard or cells sorted therefrom with an effective amount of a molecule having Bone Morphogenetic Protein (BMP) activity (e.g., a BMP polypeptide). The effective amount of said molecule having BMP activity (e.g., BMP polypeptide) is sufficient to induce the formation of islet-like cell clusters. The methods further include treating or attenuating insulin-deficiency disorders, including type 1 diabetes. In one non-limiting embodiment, an insulin-deficiency disorder in a subject is treated or attenuated by culturing a whole non-islet pancreatic cell discard or cells sorted therefrom with an effective amount of a molecule having BMP activity (e.g., a BMP polypeptide) such that tho formation of islet-like cell clusters occurs. A therapeutically effective amount of the islet-like cell clusters which produce insulin are then transplanted into a subject in need to treat the insulin-deficiency disorder.

7. 发明授权

US07790437B2 Organ transportation device 有权
标题翻译：器官运输装置
公开(公告)号：US07790437B2
公开(公告)日：2010-09-07
申请号：US11610913
申请日：2006-12-14
申请人： Ramon E. Poo , Camillo Ricordi
发明人： Ramon E. Poo , Camillo Ricordi
IPC分类号： A01N1/00 , A01N1/02 , C12M1/00 , C12M3/00
CPC分类号： A01N1/02 , A01N1/0273
摘要： An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.
摘要翻译：器官输送装置包括在器官容器内的流体密封的器官容器和结构，用于与器官容器内的器官接合。提供基座组件，以及用于相对于基座组件旋转器官接合结构和器官的结构。基座组件可以具有马达和电池以在运输期间提供器官容器的旋转。

8. 发明申请

US20080166992A1 MOBILE EMERGENCY ALERT SYSTEM 审中-公开
标题翻译：移动应急报警系统
公开(公告)号：US20080166992A1
公开(公告)日：2008-07-10
申请号：US11938057
申请日：2007-11-09
申请人： Camillo Ricordi , Steven Sikes , Stephen William Anthony Sanders
发明人： Camillo Ricordi , Steven Sikes , Stephen William Anthony Sanders
IPC分类号： H04M11/04 , H04M3/42 , H04Q7/00
CPC分类号： H04M11/04 , A61B5/0002 , A61B5/021 , A61B5/024 , A61B5/14532 , A61B5/1455 , G08B21/0269 , G08B21/0283 , G08B21/0453 , G08B25/002 , G08B25/005 , G08B25/006 , G08B25/08 , H04M1/72538
摘要： A health-related emergency mobile alert system to facilitate communication, care and intervention during critical events. The system communicates with medical monitors, which measure and collect a subject's physiological data and vital signs information. A service provider maintains a database with the subject's medical records and an emergency contact list. When a critical event is detected, a two-way mobile communication device that is configured to communicate with the medical monitor transmits the physiological data and location coordinates of the subject to the service provider, and a conference call with members of the emergency contact list is initiated to help facilitate aid to the subject. The two-way mobile communication device may include a speaker and GPS technology. It may also include self-activating features wherein pre-recorded messages conveying potential dangers are transmitted to the subject when the subject's physiological data and vital signs reflect precarious levels.
摘要翻译：健康相关的紧急移动警报系统，以促进关键事件期间的沟通，关怀和干预。系统与医疗监护仪进行通信，医疗监护仪可测量和收集受试者的生理数据和生命体征信息。服务提供商维护与受试者的医疗记录和紧急联系人列表的数据库。当检测到关键事件时，被配置为与医疗监视器通信的双向移动通信设备将该对象的生理数据和位置坐标发送给服务提供商，并且与紧急联系人列表的成员的电话会议是开始帮助促进对该问题的援助。双向移动通信设备可以包括扬声器和GPS技术。它还可以包括自我激活特征，其中当被摄体的生理数据和生命体征反映不稳定的水平时，传达潜在危险的预先记录的信息被传送给受检者。

9. 发明申请

US20080145833A1 ORGAN TRANSPORTATION DEVICE 有权
标题翻译：有机运输装置
公开(公告)号：US20080145833A1
公开(公告)日：2008-06-19
申请号：US11610913
申请日：2006-12-14
申请人： RAMON E. POO , Camillo Ricordi
发明人： RAMON E. POO , Camillo Ricordi
IPC分类号： A01N1/00 , A01N1/02
CPC分类号： A01N1/02 , A01N1/0273
摘要： An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.
摘要翻译：器官输送装置包括在器官容器内的流体密封的器官容器和结构，用于与器官容器内的器官接合。提供基座组件，以及用于相对于基座组件旋转器官接合结构和器官的结构。基座组件可以具有马达和电池以在运输期间提供器官容器的旋转。

10. 发明申请

US20060121437A1 Organ preservation container and method 有权
标题翻译：器官保鲜容器及方法
公开(公告)号：US20060121437A1
公开(公告)日：2006-06-08
申请号：US11003808
申请日：2004-12-03
申请人： Ramon Poo , Camillo Ricordi
发明人： Ramon Poo , Camillo Ricordi
IPC分类号： A01N1/02 , A01N1/00
CPC分类号： A01N1/02 , A01N1/0263
摘要： An organ preservation container includes a gas impermeable housing for containing an organ. At least two liquids having different densities and forming a liquid-liquid interface are also contained in the housing. A closure for hermetically sealing the housing is provided. A structure is provided within the housing for engaging the organ and for maintaining a portion of the organ at the liquid-liquid interface such that the organ will be maintained partially in both of the liquids. A method for preserving the organ is also described.
摘要翻译：器官保存容器包括用于容纳器官的不透气壳体。至少两种具有不同密度并形成液 - 液界面的液体也包含在壳体中。提供用于密封壳体的封闭件。在壳体内设置有用于接合器官并用于将器官的一部分保持在液 - 液界面处的结构，使得器官部分地保持在两液体中。还描述了保存器官的方法。

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