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1. 发明授权

US08471099B2 Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics 有权
标题翻译：由此编码的核苷酸序列和多肽可用于修饰植物特征
公开(公告)号：US08471099B2
公开(公告)日：2013-06-25
申请号：US12615920
申请日：2009-11-10
申请人： Richard Schneeberger , Emilio Margolles-Clark , Gerard Magpantay
发明人： Richard Schneeberger , Emilio Margolles-Clark , Gerard Magpantay
IPC分类号： C12N15/82 , C12N15/87
CPC分类号： C12N15/8243 , C07K14/415
摘要： Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased nitrogen use efficiency. The present invention further relates to nucleotide sequences and the use of those nucleotide sequences in the genetic-engineering of plants to display enhanced nitrogen assimilatory and utilization capacities, grow larger, more efficiently or rapidly, and/or have enriched nitrogen contents in vegetative and/or reproductive plant parts and/or increased biomass. More particularly, this invention relates to producing transgenic plants engineered to have altered expression of key components in the nitrogen assimilation and utilization pathways. The engineered plants may be productively cultivated under conditions of low nitrogen fertilizer input or in nitrogen poor soils. Alternatively, the engineered plants may be used to achieve faster growing or maturing crops, higher crop yields and/or more nutritious products under ideal cultivation conditions.
摘要翻译：描述了分离的多核苷酸和由此编码的多肽，以及这些产物用于制备具有增加的氮利用效率的转基因植物的用途。本发明还涉及核苷酸序列和这些核苷酸序列在植物遗传工程中的用途，以显示增强的氮同化和利用能力，增长更大，更有效或快速，和/或在营养和/ 或生殖植物部分和/或增加的生物量。更具体地说，本发明涉及生产工程改造为在氮同化和利用途径中改变关键成分表达的转基因植物。工程植物可以在低氮肥输入条件下或在氮肥不足的土壤中有效栽培。或者，工程植物可以用于在理想的栽培条件下实现更快的生长或成熟的作物，更高的作物产量和/或更有营养的产品。

2. 发明申请

US20110065675A1 AZO DYE RELATED SMALL MOLECULE MODULATORS OF PROTEIN-PROTEIN INTERACTIONS 审中-公开
标题翻译： AZO DYE相关小分子蛋白质蛋白质相互作用的调节剂
公开(公告)号：US20110065675A1
公开(公告)日：2011-03-17
申请号：US12991079
申请日：2009-05-05
申请人： Peter Buchwald , Emilio Margolles-Clark , Norma S. Kenyon , Camillo Ricordi
发明人： Peter Buchwald , Emilio Margolles-Clark , Norma S. Kenyon , Camillo Ricordi
IPC分类号： A61K31/655 , A61K31/185 , C12N5/071 , A61P35/00 , A61P3/10 , A61P29/00 , A61P19/04 , A61P3/00 , A61P17/00 , A61P17/06 , A61P37/02 , A61P37/06 , A61P25/28 , A61P9/10
CPC分类号： A61K31/517
摘要： Azo dyes and suramin-related small molecules are effective in inhibiting the CD40/CD154 protein-protein interaction, an important co-stimulatory interaction involved in the activation of immune responses mediated by T- and B-cells. The compounds were found to be active as indicated by their IC50 values both in a cell-free binding assay and in the inhibition of CD154-induced B-cell proliferation assay. The compounds may be used as therapeutic compounds for treatment of diseases and disorders related to immune or inflammatory responses. Methods of inhibiting the CD40/CD154 protein-protein interaction and treating diseases and disorders related to immune or inflammatory responses are described.
摘要翻译：偶氮染料和苏拉明相关的小分子在抑制CD40 / CD154蛋白质 - 蛋白质相互作用中是有效的，这是参与由T细胞和B细胞介导的免疫应答活化的重要的共刺激相互作用。发现这些化合物在无细胞结合测定和抑制CD154诱导的B细胞增殖测定中的IC 50值都是活性的。该化合物可用作治疗与免疫或炎症反应有关的疾病和病症的治疗化合物。描述了抑制CD40 / CD154蛋白质相互作用和治疗与免疫或炎症反应相关的疾病和病症的方法。

3. 发明申请

US20070042387A1 Promoter, promoter control elements, and combinations, and uses thereof 失效
公开(公告)号：US20070042387A1
公开(公告)日：2007-02-22
申请号：US11172703
申请日：2005-06-30
申请人： Roger Pennell , Kenneth Feldmann , Yu-Ping Lu , Yiwen Fang , Shing Kwok , Van-Dinh Dang , Zhihong Cook , Jack Okamuro , Nestor Apuya , Richard Schneeberger , Emilio Margolles-Clark , Edward Kiegle , Leonard Medrano
发明人： Roger Pennell , Kenneth Feldmann , Yu-Ping Lu , Yiwen Fang , Shing Kwok , Van-Dinh Dang , Zhihong Cook , Jack Okamuro , Nestor Apuya , Richard Schneeberger , Emilio Margolles-Clark , Edward Kiegle , Leonard Medrano
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06
CPC分类号： C12N15/8216 , C12N15/8225 , C12N15/8226 , C12N15/8227 , C12N15/8229 , C12N15/823 , C12N15/8233 , C12N15/8234 , C12N15/8237
摘要： The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.

4. 发明申请

US20090070892A1 PROMOTER, PROMOTER CONTROL ELEMENTS AND COMBINATIONS AND USES THEREOF 审中-公开
标题翻译：促销者，促销者控制元素及其组合及其用途
公开(公告)号：US20090070892A1
公开(公告)日：2009-03-12
申请号：US11855117
申请日：2007-09-13
申请人： Emilio Margolles CLARK , Richard Schneeberger
发明人： Emilio Margolles CLARK , Richard Schneeberger
IPC分类号： A01H1/00 , C07H21/00 , C12N15/63 , A01H5/00 , C12Q1/68 , C12N5/04 , C12N15/82
CPC分类号： C12N15/8261 , C12N15/8238 , C12N15/8271 , Y02A40/146
摘要： The present invention is directed to nitrogen responsive promoter sequences and promoter control elements, polynucleotide constructs comprising the nitrogen responsive promoters and control elements and methods of identifying the nitrogen responsive promoters, control elements, or fragments thereof. The invention further relates to the use of the present nitrogen responsive promoters or promoter control elements to modulate transcript levels.
摘要翻译：本发明涉及氮响应启动子序列和启动子控制元件，包含氮应答启动子和控制元件的多核苷酸构建体和识别氮应答启动子，控制元件或其片段的方法。本发明还涉及本发明的氮应答启动子或启动子控制元件用于调节转录水平的用途。

5. 发明申请

US20060137034A1 Modulating plant nitrogen levels 失效
标题翻译：调节植物氮含量
公开(公告)号：US20060137034A1
公开(公告)日：2006-06-22
申请号：US11292951
申请日：2005-12-02
申请人： Richard Schneeberger , Emilio Margolles-Clark , Joon-Hyun Park , Boris Jankowski , Steven Bobzin
发明人： Richard Schneeberger , Emilio Margolles-Clark , Joon-Hyun Park , Boris Jankowski , Steven Bobzin
IPC分类号： A01H5/00 , C12N15/82 , A01H1/00
CPC分类号： C12N15/8261 , C12N15/8251 , Y02A40/146
摘要： Methods and materials for modulating (e.g., increasing or decreasing) nitrogen levels in plants are disclosed. For example, nucleic acids encoding nitrogen-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Plants and plant products having increased nitrogen levels are also disclosed.
摘要翻译：公开了用于调节（例如增加或减少）植物中氮水平的方法和材料。例如，公开了编码氮调节多肽的核酸以及使用这些核酸来转化植物细胞的方法。还公开了具有增加的氮水平的植物和植物产品。

6. 发明申请

US20060107346A1 Promoter, promoter control elements, and combinations, and uses thereof 失效
标题翻译：启动子，启动子控制元件及其组合及其用途
公开(公告)号：US20060107346A1
公开(公告)日：2006-05-18
申请号：US11234633
申请日：2005-09-22
申请人： Richard Schneeberger , Emilio Margolles-Clark
发明人： Richard Schneeberger , Emilio Margolles-Clark
IPC分类号： A01H1/00 , C12Q1/68 , C07H21/04 , C12N15/82 , C12N5/04
CPC分类号： C12N15/8261 , C12N15/8238 , C12N15/8271 , Y02A40/146
摘要： The present invention is directed to nitrogen responsive promoter sequences and promoter control elements, polynucleotide constructs comprising the nitrogen responsive promoters and control elements and methods of identifying the nitrogen responsive promoters, control elements, or fragments thereof. The invention further relates to the use of the present nitrogen responsive promoters or promoter control elements to modulate transcript levels.
摘要翻译：本发明涉及氮响应启动子序列和启动子控制元件，包含氮应答启动子和控制元件的多核苷酸构建体和识别氮应答启动子，控制元件或其片段的方法。本发明还涉及本发明的氮应答启动子或启动子控制元件用于调节转录水平的用途。

7. 发明申请

US20110041208A1 PROMOTER, PROMOTER CONTROL ELEMENTS, AND COMBINATIONS, AND USES THEREOF 审中-公开
公开(公告)号：US20110041208A1
公开(公告)日：2011-02-17
申请号：US12891689
申请日：2010-09-27
申请人： Roger PENNELL , Kenneth A. Feldmann , Yu-Ping Lu , Yiwen Fang , Shing Kwok , Van-Dinh Dang , Zhihong Cook , Jack Okamuro , Nestor Apuya , Richard Schneeberger , Emilio Margolles-Clark , Edward A. Kiegle , Leonard Medrano
发明人： Roger PENNELL , Kenneth A. Feldmann , Yu-Ping Lu , Yiwen Fang , Shing Kwok , Van-Dinh Dang , Zhihong Cook , Jack Okamuro , Nestor Apuya , Richard Schneeberger , Emilio Margolles-Clark , Edward A. Kiegle , Leonard Medrano
IPC分类号： A01H1/00 , C07H21/04 , C12N15/63 , C12N5/10 , A01H5/00
CPC分类号： C12N15/8216 , C12N15/8225 , C12N15/8226 , C12N15/8227 , C12N15/8229 , C12N15/823 , C12N15/8233 , C12N15/8234 , C12N15/8237
摘要： The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.

8. 发明授权

US07696409B2 Nucleotide sequences and polypeptides encoded thereby useful for modifying nitrogen use efficiency characteristics in plants 有权
标题翻译：编码的核苷酸序列和多肽可用于修饰植物中的氮利用效率特征
公开(公告)号：US07696409B2
公开(公告)日：2010-04-13
申请号：US11114963
申请日：2005-04-25
申请人： Richard Schneeberger , Emilio Margolles-Clark , Gerard Magpantay
发明人： Richard Schneeberger , Emilio Margolles-Clark , Gerard Magpantay
IPC分类号： C12N15/82 , C12N15/87
CPC分类号： C12N15/8243 , C07K14/415
摘要： Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased nitrogen use efficiency. The present invention further relates to nucleotide sequences and the use of those nucleotide sequences in the genetic-engineering of plants to display enhanced nitrogen assimilatory and utilization capacities, grow larger, more efficiently or rapidly, and/or have enriched nitrogen contents in vegetative and/or reproductive plant parts and/or increased biomass. More particularly, this invention relates to producing transgenic plants engineered to have altered expression of key components in the nitrogen assimilation and utilization pathways. The engineered plants may be productively cultivated under conditions of low nitrogen fertilizer input or in nitrogen poor soils. Alternatively, the engineered plants may be used to achieve faster growing or maturing crops, higher crop yields and/or more nutritious products under ideal cultivation conditions.
摘要翻译：描述了分离的多核苷酸和由此编码的多肽，以及这些产物用于制备具有增加的氮利用效率的转基因植物的用途。本发明还涉及核苷酸序列和这些核苷酸序列在植物遗传工程中的用途，以显示增强的氮同化和利用能力，增长更大，更有效或快速，和/或在营养和/ 或生殖植物部分和/或增加的生物量。更具体地说，本发明涉及生产工程改造为在氮同化和利用途径中改变关键成分表达的转基因植物。工程植物可以在低氮肥输入条件下或在氮肥不足的土壤中有效栽培。或者，工程植物可以用于在理想的栽培条件下实现更快的生长或成熟的作物，更高的作物产量和/或更有营养的产品。

9. 发明授权

US07335510B2 Modulating plant nitrogen levels 失效
标题翻译：调节植物氮含量
公开(公告)号：US07335510B2
公开(公告)日：2008-02-26
申请号：US11292951
申请日：2005-12-02
申请人： Richard Schneeberger , Emilio Margolles-Clark , Joon-Hyun Park , Boris Jankowski , Steven Craig Bobzin
发明人： Richard Schneeberger , Emilio Margolles-Clark , Joon-Hyun Park , Boris Jankowski , Steven Craig Bobzin
IPC分类号： A01H5/00 , A01H1/00 , C12N15/82 , C12N15/87
CPC分类号： C12N15/8261 , C12N15/8251 , Y02A40/146
摘要： Methods and materials for modulating (e.g., increasing or decreasing) nitrogen levels in plants are disclosed. For example, nucleic acids encoding nitrogen-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Plants and plant products having increased nitrogen levels are also disclosed.
摘要翻译：公开了用于调节（例如增加或减少）植物中氮水平的方法和材料。例如，公开了编码氮调节多肽的核酸以及使用这些核酸来转化植物细胞的方法。还公开了具有增加的氮水平的植物和植物产品。

10. 发明授权

US07329797B2 Modulating plant carbon levels 失效
标题翻译：调节植物碳水平
公开(公告)号：US07329797B2
公开(公告)日：2008-02-12
申请号：US11296657
申请日：2005-12-06
申请人： Richard Schneeberger , Emilio Margolles-Clark , Joon-Hyun Park , Boris Jankowski , Steven Craig Bobzin
发明人： Richard Schneeberger , Emilio Margolles-Clark , Joon-Hyun Park , Boris Jankowski , Steven Craig Bobzin
IPC分类号： A01H1/00 , C07H21/04 , C07K14/415 , C12N15/29
CPC分类号： C12N15/8242 , C12N15/8243 , C12N15/8245 , C12N15/8251 , C12N15/8261 , Y02A40/146
摘要： Methods and materials for modulating (e.g., increasing or decreasing) carbon levels in plants are disclosed. For example, nucleic acids encoding carbon-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased carbon levels.
摘要翻译：公开了用于调节（例如增加或减少）植物中碳水平的方法和材料。例如，公开了编码碳调节多肽的核酸以及使用这种核酸转化植物细胞的方法。还公开了具有增加的碳水平的植物。

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