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1. 发明授权

US4983841A Non-invasive inspection 失效
标题翻译：无创检查
公开(公告)号：US4983841A
公开(公告)日：1991-01-08
申请号：US412337
申请日：1989-09-26
申请人： Peter A. E. Stewart , Richard T. Skelton , Martin J. Allen , Joseph Douglas
发明人： Peter A. E. Stewart , Richard T. Skelton , Martin J. Allen , Joseph Douglas
IPC分类号： G01V5/00 , G01N23/04 , G01T1/16 , G01T1/161 , G01T1/29
CPC分类号： G01N23/046 , G01T1/2985 , G01N2223/419
摘要： Residual core material can be detected inside hollow cast articles using positron emission tomography. Positron radio-isotope material is inducted into any residual core material present by immersing a cast article in an aqueous solution of radio-isotope emitter, for example gallium. Absorbed gallium subsequently emits positrons which are annihilated in collisions with electrons emitting two 511 KeV gamma rays in diametrically opposite directions. The emissions are detected and tracked by a PET camera and the resulting images correlated with a sectioned image of the article as a check on the location of detected core material. Initially a low-dose-rate solution for the purpose of merely establishing the presence of core material is used but a second optional process step introduces a more active solution allowing a PET camera to collect sufficient data to image absorbed isotope.
摘要翻译：可以使用正电子发射断层扫描在中空铸造制品内部检测残留芯材。通过将铸造物品浸入放射性同位素发射体（例如镓）的水溶液中，将正电子放射性同位素材料引入存在的任何残余芯材料中。随后，吸收的镓随后发射正电子，这些正电子与沿两个方向相反的方向发射两个511KeV伽马射线的电子发生碰撞。由PET照相机检测和跟踪排放物，并将所得到的图像与文章的分割图像相关联，作为对检测到的核心材料位置的检查。最初仅使用建立核材料存在的低剂量率解决方案，但是第二可选工艺步骤引入了更为有效的解决方案，允许PET相机收集足够的数据来成像吸收的同位素。

2. 发明授权

US5124554A Explosives detector 失效
标题翻译：爆炸物探测器
公开(公告)号：US5124554A
公开(公告)日：1992-06-23
申请号：US656942
申请日：1991-02-19
申请人： Peter H. Fowler , Peter A. E. Stewart , John D. Rogers , Martin J. Allen
发明人： Peter H. Fowler , Peter A. E. Stewart , John D. Rogers , Martin J. Allen
IPC分类号： B64F1/32 , B64F1/36 , G01N23/222 , G01N33/22 , G01V5/00 , G21K5/04 , H05H3/04
CPC分类号： H05H3/04 , B64F1/368 , G01N23/222 , G01V5/0008 , G01V5/0069 , G21K5/04 , G01N2223/0745 , G01N2223/204 , G01N2223/206 , G01N2223/302 , G01N2223/40 , G01N2223/501 , G01N33/22
摘要： Apparatus for non-invasively inspecting an object, such as an item of luggage, for explosives material comprises a multi-channel thermal neutron inspection system having a plurality of neutron irradiation chambers. Simultaneous operation of several channels increases maximum system throughout several times. Each chamber has a lithium neutron source which is stimulated to neutron production by a proton beam. Beam switching magnets are energized by pulsing to divert a common proton beam to each source in turn. The initial beam is generated by a radio frequency quadrupole accelerator. The advantages of this system are very low residual source activity and controllable neutron production thereby minimizing safety hazards. The irradiation chamber may contain several different gamma ray detectors to identify the presence elements present in explosives material. In addition a neutron radiography imaging means may be employed to identify the presence of potential shielding materials.
摘要翻译：用于非侵入性地检查用于爆炸物料的行李物品的装置包括具有多个中子照射室的多通道热中子检查系统。多个通道的同时操作可以在数次内增加最大系统。每个室具有锂中子源，其被质子束刺激到中子产生。光束切换磁体通过脉冲激励，以将公共质子束依次转向每个源。初始波束由射频四极加速器产生。该系统的优点是残留源活性非常低，可控制的中子生产，从而使安全隐患最小化。照射室可以包含几种不同的γ射线检测器，以识别爆炸物质中存在的存在元素。此外，可以使用中子射线成像装置来识别潜在屏蔽材料的存在。

3. 发明授权

US06537792B1 Protein engineering of glucoamylase to increase pH optimum, substrate specificity and thermostability 失效
标题翻译：葡糖淀粉酶的蛋白质工程，以提高pH最佳，底物特异性和热稳定性
公开(公告)号：US06537792B1
公开(公告)日：2003-03-25
申请号：US09236063
申请日：1999-01-22
申请人： Martin J. Allen , Tsuei-Yun Fang , Yuxing Li , Hsuan-Liang Liu , Hsiu-Mei Chen , Pedro Coutinho , Richard Honzatko , Clark Ford
发明人： Martin J. Allen , Tsuei-Yun Fang , Yuxing Li , Hsuan-Liang Liu , Hsiu-Mei Chen , Pedro Coutinho , Richard Honzatko , Clark Ford
IPC分类号： C12N924
CPC分类号： C12N9/2428
摘要： A fungal glucoamylase including a mutation pair Asn20Cys coupled with Ala27Cys forming a disulfide bond between the two members of the pair. The mutation provides increased thermal stability and reduced isomaltose formation to the enzyme. A fungal glucoamylase including a 311-314Loop mutation wherein reduced isomaltose formation is provided by the mutation is also provided. A fungal glucoamylase including a mutation Ser411Ala wherein increased pH optimum and reduced isomaltose formation is provided by the mutation is also provided. Combinations of the mutations in engineered glucoamylases are also provided as are combinations with other glucoamylase mutations that provide increased thermal stability, increased pH optimum and reduced isomaltose froamtion for cumulative improvements in the engineered glucoamylases. Also provided is a fungal glucoamylase including a mutation of Ser30Pro coupled with at least two stabilizing mutations forming a disulfide bond between the two stabilizing members. A fungal glucoamylase including a Ser30Pro/Gly137Ala/311-314 Loop is provided. A fungal glucoamylase including a mutation Ser30Pro/Glu137Ala/Ser411Ala is also provided.
摘要翻译：一种真菌葡糖淀粉酶，其包括与成对的两个成员之间形成二硫键的Ala27Cys偶联的突变对Asn20Cys。该突变提供了增加的热稳定性和减少异黄酮对酶的形成。还提供了包含311-314Loop突变的真菌葡糖淀粉酶，其中通过突变提供了减少的异麦芽糖形成。还提供了包括突变Ser411Ala的真菌葡糖淀粉酶，其中通过突变提供了增加的pH最佳和降低的异麦芽糖形成。还提供了工程化葡糖淀粉酶突变的组合，与其它葡糖淀粉酶突变的组合一起提供，其提供增加的热稳定性，增加的pH最佳值和降低的异麦芽糖减少，用于工程化葡糖淀粉酶的累积改进。还提供了真菌葡糖淀粉酶，其包括Ser30Pro突变与至少两个在两个稳定化合物之间形成二硫键的稳定突变。提供了包含Ser30Pro / Gly137Ala / 311-314环的真菌葡糖淀粉酶。还提供了包含突变Ser30Pro / Glu137Ala / Ser411Ala的真菌葡糖淀粉酶。

4. 发明申请

US20100226925A1 Homogeneous Antibody Populations 审中-公开
标题翻译：均质抗体群体
公开(公告)号：US20100226925A1
公开(公告)日：2010-09-09
申请号：US12678130
申请日：2008-09-11
申请人： Thomas M. Dillon , Pavel Bondarenko , Jette Wypych , Martin J. Allen , Alain Balland , Margaret Speed Ricci , Amy Guo , Wenyan Shen , Jeonghoon Sun , Chris Vezina
发明人： Thomas M. Dillon , Pavel Bondarenko , Jette Wypych , Martin J. Allen , Alain Balland , Margaret Speed Ricci , Amy Guo , Wenyan Shen , Jeonghoon Sun , Chris Vezina
IPC分类号： A61K39/395 , C07K16/18 , C12P21/04 , C07H21/04 , C12N15/74 , C12N5/16 , A61P43/00
CPC分类号： C07K16/245 , C07K16/00 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K2317/53 , C07K2317/56
摘要： The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.
摘要翻译：本发明一般涉及产生增殖和/或回收优选形式的单克隆抗体的方法。更具体地说，本发明涉及消除重组IgG2抗体蛋白的铰链区中二硫键异质性的方法。

5. 发明申请

US20070254338A1 Method for making recombinant protein using complementation dependent DHFR mutants 审中-公开
标题翻译：使用互补依赖性DHFR突变体制备重组蛋白的方法
公开(公告)号：US20070254338A1
公开(公告)日：2007-11-01
申请号：US11789339
申请日：2007-04-24
申请人： R. Guy Caspary , Allison Bianchi , Pauline S. Smidt , Virginia L. Price , Martin J. Allen
发明人： R. Guy Caspary , Allison Bianchi , Pauline S. Smidt , Virginia L. Price , Martin J. Allen
IPC分类号： C12P21/06 , C12N9/06 , C07H21/04 , C12N15/74 , C12N1/21
CPC分类号： C12N9/003 , C12P21/02 , C12Y105/01003
摘要： The present invention relates to compositions and methods for making recombinant heteromeric proteins using a protein complementation assay employing complementation pairs of selectable markers.
摘要翻译：本发明涉及使用使用互补对选择标记的蛋白质互补测定法制备重组异聚蛋白质的组合物和方法。

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