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1. 发明授权

US07214710B2 Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids 失效
标题翻译：化学治疗剂与氧杂烷酸的渗透性，水溶性，无刺激性前药
公开(公告)号：US07214710B2
公开(公告)日：2007-05-08
申请号：US10851096
申请日：2004-05-24
申请人： Peter A. Crooks , Tadeusz Cynkowski , Grazyna Cynkowska , Hong Guo , Paul Ashton
发明人： Peter A. Crooks , Tadeusz Cynkowski , Grazyna Cynkowska , Hong Guo , Paul Ashton
IPC分类号： A61K31/215
CPC分类号： A61K47/542 , A61K47/54
摘要： The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.
摘要翻译：本发明涉及化学治疗剂的前药领域及其应用方法。

2. 发明授权

US06765019B1 Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids 失效
公开(公告)号：US06765019B1
公开(公告)日：2004-07-20
申请号：US09565079
申请日：2000-05-04
申请人： Peter A. Crooks , Tadeusz Cynkowski , Grazyna Cynkowska , Hong Guo , Paul Ashton
发明人： Peter A. Crooks , Tadeusz Cynkowski , Grazyna Cynkowska , Hong Guo , Paul Ashton
IPC分类号： A61K31215
CPC分类号： A61K47/542 , A61K47/54
摘要： The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.

3. 发明申请

US20050008695A1 Compositions and methods for delivering a biologically active agent 审中-公开
标题翻译：用于递送生物活性剂的组合物和方法
公开(公告)号：US20050008695A1
公开(公告)日：2005-01-13
申请号：US10850957
申请日：2004-05-21
申请人： Paul Ashton , Jianbing Chen , Hong Guo , Grazyna Cynkowska , Tadeusz Cynkowski
发明人： Paul Ashton , Jianbing Chen , Hong Guo , Grazyna Cynkowska , Tadeusz Cynkowski
IPC分类号： A61K31/192 , A61K31/496 , A61K9/20
CPC分类号： A61K31/496 , A61K31/192 , A61K47/55 , A61K2300/00
摘要： The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations. In certain embodiments, the codrugs can be locally administered to deliver the constituent biologically active compound in a sustained-release fashion, reducing systemic concentrations of the biologically active compound.
摘要翻译：本发明涉及具有改进性质的药物，其制备和施用方法，以及配制和施用该制剂作为药物制剂的方法。在某些实施方案中，可以局部施用该组合物以缓释方式递送成分生物活性化合物，从而降低生物活性化合物的全身浓度。

4. 发明申请

US20110183944A1 SUSTAINED-RELEASE NSAID/HMG CoA REDUCTASE INHIBITOR COMPOSITIONS 审中-公开
标题翻译：持续释放NSAID / HMG CoA还原酶抑制剂组合物
公开(公告)号：US20110183944A1
公开(公告)日：2011-07-28
申请号：US13015058
申请日：2011-01-27
申请人： Paul Ashton , Hong Guo , Jianbing Chen , Tadeusz Cynkowski , Grazyna Cynkowska
发明人： Paul Ashton , Hong Guo , Jianbing Chen , Tadeusz Cynkowski , Grazyna Cynkowska
IPC分类号： A61K31/635 , A61P25/16 , A61P25/28 , A61P35/00
CPC分类号： A61K31/635
摘要： Compositions for controlled release of one or more therapeutic agents where the composition is essentially free of excipients are disclosed. In particular, compositions comprising a HMG-CoA reductase inhibitor, particularly simvastatin, and a NSAID, such as a COX-2 inhibitor, particularly celecoxib, in which greater than 90% of the weight of the composition is made up of the HMG-CoA reductase inhibitor and NSAID are provided.
摘要翻译：公开了用于控制释放一种或多种治疗剂的组合物，其中组合物基本上不含赋形剂。特别地，包含HMG-CoA还原酶抑制剂，特别是辛伐他汀和NSAID的组合物，例如COX-2抑制剂，特别是塞来昔布，其中大于组合物重量的90％由HMG-CoA组成还原酶抑制剂和NSAID。

5. 发明申请

US20090163457A1 Compositions and methods for delivering a biologically active agent 审中-公开
标题翻译：用于递送生物活性剂的组合物和方法
公开(公告)号：US20090163457A1
公开(公告)日：2009-06-25
申请号：US12315076
申请日：2008-11-26
申请人： Paul Ashton , Jianbing Chen , Hong Guo , Grazyna Cynkowska , Tadeusz Cynkowski
发明人： Paul Ashton , Jianbing Chen , Hong Guo , Grazyna Cynkowska , Tadeusz Cynkowski
IPC分类号： A61K31/58 , A61K31/5365 , A61K31/505 , A61K31/335 , A61K31/24 , C07D265/34 , C07D239/24 , C07D317/10 , C07J53/00 , C07C229/40 , A61P43/00
CPC分类号： A61K31/496 , A61K31/192 , A61K47/55 , A61K2300/00
摘要： The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations. In certain embodiments, the codrugs can be locally administered to deliver the constituent biologically active compound in a sustained-release fashion, reducing systemic concentrations of the biologically active compound.
摘要翻译：本发明涉及具有改进性质的药物，其制备和施用方法，以及配制和施用该制剂作为药物制剂的方法。在某些实施方案中，可以局部施用该组合物以缓释方式递送成分生物活性化合物，从而降低生物活性化合物的全身浓度。

6. 发明申请

US20100119580A1 SUSTAINED RELEASE DRUG DELIVERY DEVICES, METHODS OF USE, AND METHODS OF MANUFACTURING THEREOF 有权
标题翻译：持续释放药物递送装置，使用方法及其制造方法
公开(公告)号：US20100119580A1
公开(公告)日：2010-05-13
申请号：US12689956
申请日：2010-01-19
申请人： Hong Guo , Paul Ashton
发明人： Hong Guo , Paul Ashton
IPC分类号： A61K9/00 , A61K47/32 , A61K38/02 , A61K38/22 , A61K31/58 , A61K31/7064 , A61K31/52 , A61K31/522 , A61K31/7072
CPC分类号： A61K9/20 , A61F9/0017 , A61K9/0051 , A61K9/0092 , A61K9/5089 , A61K31/58 , Y10T29/49888
摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.
摘要翻译：提供了一种用于治疗哺乳动物生物体以获得所需局部或全身生理或药理作用的方法和装置。该方法包括向需要这种治疗的哺乳动物生物体施用持续释放药物递送系统，其中需要释放有效药剂并允许有效药剂以受控的方式通过该装置。该装置包括包含有效试剂的内芯或储存器，封闭储存器的一部分的不可渗透管和在管的端部处的可渗透构件。

7. 发明授权

US06375972B1 Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof 有权
标题翻译：缓释药物递送装置，使用方法及其制造方法
公开(公告)号：US06375972B1
公开(公告)日：2002-04-23
申请号：US09558207
申请日：2000-04-26
申请人： Hong Guo , Paul Ashton
发明人： Hong Guo , Paul Ashton
IPC分类号： A61F900
CPC分类号： A61K9/20 , A61F9/0017 , A61K9/0051 , A61K9/0092 , A61K9/5089 , A61K31/58 , Y10T29/49888
摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.
摘要翻译：提供了一种用于治疗哺乳动物生物体以获得所需局部或全身生理或药理作用的方法和装置。该方法包括向需要这种治疗的哺乳动物生物体施用持续释放药物递送系统，其中需要释放有效药剂并允许有效药剂以受控的方式通过该装置。该装置包括包含有效试剂的内芯或储存器，封闭储存器的一部分的不可渗透管和在管的端部处的可渗透构件。

8. 发明授权

US08871241B2 Injectable sustained release delivery devices 有权
标题翻译：可注射持续释放递送装置
公开(公告)号：US08871241B2
公开(公告)日：2014-10-28
申请号：US10714549
申请日：2003-11-13
申请人： Kang-Jye Chou , Hong Guo , Paul Ashton , Robert W. Shimizu , David A. Watson
发明人： Kang-Jye Chou , Hong Guo , Paul Ashton , Robert W. Shimizu , David A. Watson
IPC分类号： A61F2/00 , A61K9/28 , A61K9/00 , A61K31/58 , A61K45/06 , A61K9/24 , A61K31/7072 , A61K9/20
CPC分类号： A61K9/0004 , A61K9/0024 , A61K9/0051 , A61K9/0092 , A61K9/204 , A61K9/2086 , A61K9/209 , A61K9/284 , A61K9/2853 , A61K9/2886 , A61K31/58 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.
摘要翻译：可注射药物递送装置包括含有一种或多种药物的核心和一种或多种聚合物。芯可以被一个或多个聚合物外层（本文中称为“涂层”，“表皮”或“外层”）包围。在某些实施方案中，通过挤出或以其它方式预先形成用于药物核心的聚合物皮肤来形成装置。药物核心可以与皮肤共挤出，或者在皮肤挤出后可以将其插入皮肤中，并可能固化。在其它实施方案中，药物核心可以涂覆有一种或多种聚合物涂层。这些技术可以有效地应用于制造具有广泛的药物制剂和皮肤的装置，其可以选择为以适合于使用标准或非标准的注射剂的形式控制药物核心中的药物的释放速率分布和各种其它性质，标准规格针。该装置可以通过组合至少一种聚合物，至少一种药物和至少一种液体溶剂以形成液体悬浮液或溶液而形成，其中在注射时，这样的悬浮液或溶液在变相下形成凝胶。该配置可以提供长时间的药物的控制释放。

9. 发明申请

US20100278931A1 POROUS SILICON DRUG-ELUTING PARTICLES 有权
标题翻译：多孔硅胶药物颗粒
公开(公告)号：US20100278931A1
公开(公告)日：2010-11-04
申请号：US12773127
申请日：2010-05-04
申请人： Paul Ashton , Hong Guo , Jianbing Chen , Leigh Canham
发明人： Paul Ashton , Hong Guo , Jianbing Chen , Leigh Canham
IPC分类号： A61K9/14 , A61K31/58 , A61P27/02
CPC分类号： A61K31/58 , A61K9/0048 , A61K9/0097
摘要： The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent-permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention. The invention also provides methods of fabricating a drug-eluting particle for releasing therapeutic agents
摘要翻译：本发明提供了可用于递送诊断或治疗剂的可生物降解的药物洗脱颗粒。在某些实施方案中，本发明的药物洗脱颗粒包括可生物降解的多孔硅体，形成在多孔硅体内的储存器，其具有至少一个开口到本体的外部，其中储存器包含治疗剂或诊断剂，以及设置在所述至少一个开口上方的渗透剂的密封件。本发明进一步提供了一种治疗患者以获得所需局部或全身生理或药理作用的方法，包括施用本发明的缓释药物递送颗粒。本发明还提供了制备用于释放治疗剂的药物洗脱颗粒的方法

10. 发明申请

US20090123546A1 Polymer-based, sustained release drug delivery system 审中-公开
标题翻译：基于聚合物的缓释药物递送系统
公开(公告)号：US20090123546A1
公开(公告)日：2009-05-14
申请号：US12082520
申请日：2008-04-11
申请人： Paul Ashton , Jianbing Chen , Hong Guo
发明人： Paul Ashton , Jianbing Chen , Hong Guo
IPC分类号： A61K9/10 , A61K31/513
CPC分类号： A61K47/32 , A61K9/0024 , A61K9/7007 , A61K31/513 , A61K47/34 , A61K47/55 , A61K47/554 , A61L17/005 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61L2300/602
摘要： Disclosed is a sustained release system that includes a polymer and a pharmaceutically active agent dispersed in the polymer. The agent is in granular or particulate form, and has a rate of release from the system that is limited primarily by the rate at which the agent dissolves from the granules into the polymer matrix. Advantageously, the polymer is permeable to the agent and is non-release-rate-limiting with respect to the rate of release of the agent from the polymer.
摘要翻译：公开了一种持续释放系统，其包括分散在聚合物中的聚合物和药物活性剂。试剂是颗粒状或颗粒形式，并且具有主要由试剂从颗粒溶解到聚合物基质中的速率受到系统释放的速率。有利地，聚合物对于试剂是可渗透的，并且相对于试剂从聚合物的释放速率而言是非释放速率限制的。

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