专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08871241B2 Injectable sustained release delivery devices 有权
标题翻译：可注射持续释放递送装置
公开(公告)号：US08871241B2
公开(公告)日：2014-10-28
申请号：US10714549
申请日：2003-11-13
申请人： Kang-Jye Chou , Hong Guo , Paul Ashton , Robert W. Shimizu , David A. Watson
发明人： Kang-Jye Chou , Hong Guo , Paul Ashton , Robert W. Shimizu , David A. Watson
IPC分类号： A61F2/00 , A61K9/28 , A61K9/00 , A61K31/58 , A61K45/06 , A61K9/24 , A61K31/7072 , A61K9/20
CPC分类号： A61K9/0004 , A61K9/0024 , A61K9/0051 , A61K9/0092 , A61K9/204 , A61K9/2086 , A61K9/209 , A61K9/284 , A61K9/2853 , A61K9/2886 , A61K31/58 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.
摘要翻译：可注射药物递送装置包括含有一种或多种药物的核心和一种或多种聚合物。芯可以被一个或多个聚合物外层（本文中称为“涂层”，“表皮”或“外层”）包围。在某些实施方案中，通过挤出或以其它方式预先形成用于药物核心的聚合物皮肤来形成装置。药物核心可以与皮肤共挤出，或者在皮肤挤出后可以将其插入皮肤中，并可能固化。在其它实施方案中，药物核心可以涂覆有一种或多种聚合物涂层。这些技术可以有效地应用于制造具有广泛的药物制剂和皮肤的装置，其可以选择为以适合于使用标准或非标准的注射剂的形式控制药物核心中的药物的释放速率分布和各种其它性质，标准规格针。该装置可以通过组合至少一种聚合物，至少一种药物和至少一种液体溶剂以形成液体悬浮液或溶液而形成，其中在注射时，这样的悬浮液或溶液在变相下形成凝胶。该配置可以提供长时间的药物的控制释放。

2. 发明授权

US06852106B2 Implantable refillable and ported controlled release drug delivery device 有权
标题翻译：植入式可再充装和移植的控释药物输送装置
公开(公告)号：US06852106B2
公开(公告)日：2005-02-08
申请号：US10013946
申请日：2001-12-13
申请人： David A. Watson , Robert W. Shimizu , Richard LaPorte
发明人： David A. Watson , Robert W. Shimizu , Richard LaPorte
IPC分类号： A61M31/00 , A61K9/22 , A61L31/00 , A61M5/168 , A61M5/42 , A61M39/02 , A61M37/00
CPC分类号： A61M39/0208 , A61M5/16877 , A61M5/427 , A61M2039/0226 , A61M2039/0229 , A61M2210/0693
摘要： An implantable, refillable, rate controlled drug delivery device is disclosed that includes a base structure having at least a first opening and a second opening, the base structure defining a chamber, a septum covering the first opening and configured to substantially prevent leakage from the first opening to an exterior of the device, a drug delivery tube comprising a first and second distal end, wherein the first distal end of the tube communicates with the chamber through the second opening, and at least one rate-limiting permeable membrane disposed across a passage between the base structure and the second distal end of the drug delivery tube, which membrane passively regulates drug delivery. The drug delivery device is used to provide controlled drug delivery to an internal portion of the body and is advantageously leak-proof and does not rely on a pressure differential to drive the drug from the device.
摘要翻译：公开了一种可植入的，可再填充的速率控制的药物输送装置，其包括具有至少第一开口和第二开口的基部结构，所述基部结构限定腔室，覆盖所述第一开口的隔膜，并且构造成基本上防止来自所述第一开口开口到装置的外部，药物输送管包括第一和第二远端，其中管的第一远端通过第二开口与腔室连通，以及至少一个速率限制渗透膜，跨越通道在药物输送管的基部结构和第二远端之间，该膜被动地调节药物递送。药物递送装置用于向身体的内部部分提供受控的药物递送，并且有利地是防漏的，并且不依赖于压力来驱动药物从装置。

3. 发明授权

US06936270B2 Device and method for treating conditions of a joint 有权
标题翻译：用于治疗关节病症的装置和方法
公开(公告)号：US06936270B2
公开(公告)日：2005-08-30
申请号：US10139143
申请日：2002-05-02
申请人： David A. Watson , Thomas J. Smith , Richard Laporte , Jianbing Chen , Paul Ashton
发明人： David A. Watson , Thomas J. Smith , Richard Laporte , Jianbing Chen , Paul Ashton
IPC分类号： A61B17/56 , A61B17/00 , A61B17/064 , A61B17/16 , A61B17/80 , A61B17/82 , A61B17/86 , A61B17/88 , A61F2/30 , A61K9/00 , A61K31/58 , A61K38/00 , A61L31/16 , A61M31/00 , A61P19/02 , A61K2/02
CPC分类号： A61K9/0024 , A61B17/0642 , A61B17/1615 , A61B17/80 , A61B17/82 , A61B17/8615 , A61B17/8877 , A61B17/8886 , A61B2017/00004 , A61B2017/00429 , A61B2017/00955 , A61B2017/0647 , A61B2017/0648 , A61F2/30744 , A61F2002/30673 , A61F2002/30677 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/602 , A61M31/002 , A61M2210/02
摘要： A therapeutically effective compound is locally administered by associating the compound with a piece of orthopedic hardware that is implanted at an appropriate site within a body. The compound is adapted, such as through a sustained release device, to administer an effective dosage continuously over an extended period of time. The compound may be administered, for example, to a joint of a mammal by intraarticularly implanting a sustained release device to deliver the therapeutically effective compound within a synovial capsule of the joint, such that synovial fluid concentration of the compound is greater than plasma concentration of the compound. A wide range of orthopedic hardware, such as bone screws and staples, may be adapted to use in the systems described herein to provide treatment for a variety of medical conditions.
摘要翻译：通过将化合物与植入体内适当部位的整形外科硬件相结合来局部施用治疗有效的化合物。化合物例如通过持续释放装置适于在长时间内连续施用有效剂量。该化合物可以例如通过关节内植入持续释放装置来将哺乳动物的关节施用于在关节的滑膜内递送治疗有效化合物，使得该化合物的滑液浓度大于化合物。诸如骨螺钉和钉钉的各种矫形硬件可适于在本文所述的系统中使用以提供针对各种医疗状况的治疗。

4. 发明授权

US08414524B2 Long nose manipulatable catheter 有权
标题翻译：长鼻可操纵导管
公开(公告)号：US08414524B2
公开(公告)日：2013-04-09
申请号：US11641490
申请日：2006-12-19
申请人： Marc-Alan Levine , Stephen Hebert , Thomas G. Breton , David A. Watson
发明人： Marc-Alan Levine , Stephen Hebert , Thomas G. Breton , David A. Watson
IPC分类号： A61M31/00 , A61M37/00 , A61M25/00
CPC分类号： A61M25/008 , A61M25/0068 , A61M25/0136 , A61M25/0147 , A61M25/10 , A61M2025/015 , A61M2025/1079 , A61M2025/1093
摘要： The long nose manipulatable catheter includes a main lumen, a wire lumen with a push-pull wire therethrough, and a flexible joint region. The catheter section includes a control including a handle and a wire control member engaging the push-pull wire for manipulating the flexible joint region. The push-pull wire may be tapered, having a proximal portion of a first diameter and a smaller diameter distal portion. A coil may be placed around the smaller diameter to prevent buckling of the smaller diameter portion. A strapping coil may also disposed around the outside of the catheter, and an outer covering may be disposed around the strapping coil. An outer covering of a mesh may also be disposed around the distal tip of the catheter.
摘要翻译：长鼻子可操纵导管包括主腔，具有穿过其中的推拉线的丝腔以及柔性关节区。导管部分包括一个控制装置，该控制装置包括把手和一个接合推挽线的线控制件，用于操纵柔性接头区域。推拉线可以是锥形的，具有第一直径的近端部分和较小直径的远端部分。线圈可以放置在较小直径周围以防止较小直径部分的弯曲。捆扎线圈也可以设置在导管的外部周围，并且外覆盖物可以设置在捆扎线圈周围。网的外覆盖物也可以设置在导管的远侧末端周围。

5. 发明授权

US5800376A Burr-hole flow control device 失效
标题翻译：钻孔流量控制装置
公开(公告)号：US5800376A
公开(公告)日：1998-09-01
申请号：US826782
申请日：1997-04-07
申请人： David A. Watson , Paul S. Vaskelis
发明人： David A. Watson , Paul S. Vaskelis
IPC分类号： A61M27/00 , A61F5/00
CPC分类号： A61M27/006
摘要： A surgically implantable flow control device positionable over a burr-hole through a patient's skull is provided for use in shunt systems for controlling the release of entrapped body fluids. The device includes a rigid base including an inlet port and a valve seat which surrounds the inlet port, and a flow control member secured to the base. The flow control member has an asymmetric membrane which is resiliently biased to contact the valve seat in a manner forming a releasible seal therebetween, to provide controlled resistance to proximal-to-distal fluid flow through the device. The membrane includes a septum portion overlying the inlet port and a relatively thin portion responsive to fluid pressure differentials on inlet and outlet sides thereof. A membrane shield overlies an outlet side of the membrane and includes a needle guide aperture in alignment with the septum portion of the membrane and the inlet port.
摘要翻译：提供了一种通过患者颅骨定位在钻孔上方的可手术植入的流量控制装置，用于分流系统中用于控制截留体液的释放。该装置包括刚性基座，其包括入口端口和围绕入口端口的阀座，以及固定到基座的流量控制构件。流动控制构件具有不对称膜，其被弹性地偏压以在其间形成可释放密封的方式接触阀座，以提供对通过该装置的近端至远端流体流动的受控阻力。膜包括覆盖入口端口的隔膜部分和响应于其入口侧和出口侧上的流体压力差的相对较薄的部分。膜屏蔽覆盖膜的出口侧，并且包括与膜的隔膜部分和入口对准的针引导孔。

6. 发明授权

US5662600A Burr-hole flow control device 失效
标题翻译：钻孔流量控制装置
公开(公告)号：US5662600A
公开(公告)日：1997-09-02
申请号：US536651
申请日：1995-09-29
申请人： David A. Watson , Paul S. Vaskelis
发明人： David A. Watson , Paul S. Vaskelis
IPC分类号： A61M27/00 , A61M5/00
CPC分类号： A61M27/006
摘要： A surgically implantable flow control device positionable over a burr-hole through a patient's skull is provided for use in shunt systems for controlling the release of entrapped body fluids. The device includes a rigid base including an inlet port and a valve seat which surrounds the inlet port, and a flow control member secured to the base. The flow control member has an asymmetric membrane which is resiliently biased to contact the valve seat in a manner forming a releasible seal therebetween, to provide controlled resistance to proximal-to-distal fluid flow through the device. The membrane includes a septum portion overlying the inlet port and a relatively thin portion responsive to fluid pressure differentials on inlet and outlet sides thereof. A membrane shield overlies an outlet side of the membrane and includes a needle guide aperture in alignment with the septum portion of the membrane and the inlet port.
摘要翻译：提供了一种通过患者颅骨定位在钻孔上方的可手术植入的流量控制装置，用于分流系统中用于控制截留体液的释放。该装置包括刚性基座，其包括入口端口和围绕入口端口的阀座，以及固定到基座的流量控制构件。流动控制构件具有不对称膜，其被弹性地偏压以在其间形成可释放密封的方式接触阀座，以提供对通过该装置的近端至远端流体流动的受控阻力。膜包括覆盖入口端口的隔膜部分和响应于其入口侧和出口侧上的流体压力差的相对较薄的部分。膜屏蔽覆盖膜的出口侧，并且包括与膜的隔膜部分和入口对准的针引导孔。

7. 发明授权

US5387188A Pulsatile flow-accommodating fluid shunt 失效
标题翻译：脉动流量分流器
公开(公告)号：US5387188A
公开(公告)日：1995-02-07
申请号：US59897
申请日：1993-05-10
申请人： David A. Watson
发明人： David A. Watson
IPC分类号： A61M27/00 , A61M5/00
CPC分类号： A61M27/006
摘要： In a cerebrospinal fluid shunt including a flow control device forming a portion of a fluid conduit, a capacitive element is provided for reducing overdrainage of cerebrospinal fluid due to the pulsatile nature of cerebrospinal fluid flow. The capacitive element includes a reservoir having a base and a housing for the base which cooperatively define a fluid flow pathway through the reservoir. A pair of spaced, substantially parallel, flexible diaphragms form opposite sides of the housing such that each flexible diaphragm has an outer surface which forms an exterior surface of the reservoir, and an inner surface in contact with and subject to pressure variations of cerebrospinal fluid within the reservoir. A raised ring surrounds each diaphragm and forms a recess in which the respective diaphragm is positioned. The capacitive element accommodates the pulsatile nature of cerebrospinal fluid flow between a cerebrospinal fluid source and the flow control valve by varying the fluid capacity of the reservoir.
摘要翻译：在包括形成流体导管的一部分的流量控制装置的脑脊液分流器中，提供电容元件用于由于脑脊液流动的脉动特性而减少脑脊液的过量排出。电容元件包括具有基座和用于基座的壳体的储存器，其协作地限定通过储存器的流体流动路径。一对间隔的基本上平行的柔性隔膜形成壳体的相对侧，使得每个柔性隔膜具有形成储存器外表面的外表面，以及与脑脊液内压力变化接触并受其影响的内表面水库。凸起的环围绕每个隔膜并形成凹槽，相应的隔膜位于该凹槽中。电容元件通过改变储存器的流体容量来适应脑脊液源和流量控制阀之间的脑脊液流的脉动特性。

8. 发明授权

US5137529A Injection port 失效
标题翻译：注射口
公开(公告)号：US5137529A
公开(公告)日：1992-08-11
申请号：US679658
申请日：1991-04-02
申请人： David A. Watson , Mark J. Licata , Alfons Heindl , Edward C. Leicht
发明人： David A. Watson , Mark J. Licata , Alfons Heindl , Edward C. Leicht
IPC分类号： A61M39/02
CPC分类号： A61M39/0208 , A61M2039/0072 , A61M2039/0229 , A61M2039/0241 , A61M2205/32 , Y10S128/12
摘要： A subcutaneously implantable injection port includes an elastomeric outer housing which encloses an easily assemblage multi-piece rigid base structure. An injection chamber is defined between an upper septum, formed integrally with the elastomeric outer housing, and the underlying base structure. The outer housing includes an upper dome and a lower reinforced sheet. The septum, which is formed integrally with the upper dome, includes a septum flange which is compressed, interiorly of the outer housing, between two base members. A filter extends across the injection chamber dividing it into upper and lower portions. A needle guard, provided by one of the base components, prevents contact between a needle inserted into the injection chamber and the filter. An outlet connector integrally formed with one of the base components extends through the outer housing for connecting a catheter or the like, with the lower portion of the injection chamber. In assembling the injection port, a first base member or rigid outer ring is placed adjacent to an interior surface of the elastomeric outer housing. A filter is placed within a second base member and held securely in place thereon by a third base member which provides the needle guard and fits within the second base member in an interference fit. This assembly is pushed into the first base member in a manner compressing the septum flange and creating a fluid-tight injection chamber.
摘要翻译：皮下可植入的注射口包括弹性体外壳，其包围容易组装的多片刚性基底结构。注射室限定在与弹性体外壳一体形成的上隔膜和下面的基础结构之间。外壳包括上穹顶和下加强片。与上部圆顶一体形成的隔膜包括在两个基部构件之间被压缩在外部壳体内部的隔膜凸缘。过滤器延伸穿过注射室，将其分成上部和下部。由一个基本部件提供的针护罩防止插入注射室中的针与过滤器之间的接触。与其中一个基座部件整体形成的出口连接件延伸穿过外壳体，用于连接导管等与注射室的下部。在组装注射口时，第一底部构件或刚性外环邻近弹性体外壳的内表面放置。过滤器放置在第二基座构件内并且通过提供针护罩的第三基座构件牢固地保持在适当位置，并以过盈配合装配在第二基座构件内。该组件以压缩隔膜凸缘并产生流体密封的注射室的方式被推入第一基件。

9. 发明授权

US4969153A Laser tube and power supply 失效
标题翻译：激光管和电源
公开(公告)号：US4969153A
公开(公告)日：1990-11-06
申请号：US365874
申请日：1989-07-24
申请人： Frank A. Leyshon , David A. Watson , Herbert D. McClain
发明人： Frank A. Leyshon , David A. Watson , Herbert D. McClain
IPC分类号： G06K7/10 , H01S3/03 , H01S3/101
CPC分类号： G06K7/10 , H01S3/03
摘要： A laser power supply includes a support member in which is mounted a laser tube for outputting a laser light beam and a printed circuit board containing the power supply circuits. A slidably mounted cover member encloses the support member and the laser tube and includes a pair of lens members for diverging and attenuating the laser light beam. A pair of spring clip members mounted on the support member releasable secure the laser tube to the support member while electrically connecting the laser tube to the printed circuit board.
摘要翻译：激光电源包括支撑构件，其中安装有用于输出激光束的激光管和包含电源电路的印刷电路板。可滑动安装的盖构件包围支撑构件和激光管，并且包括用于发散和衰减激光束的一对透镜构件。安装在支撑构件上的一对弹簧夹构件可释放地将激光管固定到支撑构件，同时将激光管电连接到印刷电路板。

10. 发明申请

US20150273193A1 SHUNT VALVE FOR CONTROLLING SIPHON EFFECT 审中-公开
标题翻译：用于控制SIPHON效果的分流阀
公开(公告)号：US20150273193A1
公开(公告)日：2015-10-01
申请号：US14738438
申请日：2015-06-12
申请人： David A. Watson
发明人： David A. Watson
IPC分类号： A61M27/00
CPC分类号： A61M27/006 , A61B17/00
摘要： An improved shunt valve for the control of hydrocephalus provides for physiological atmospherically-referenced siphon control that is not adversely affected by overlying tissue. The valve includes one or more porous outer anti-fouling membranes to protect the flow control membranes from external mechanical tissue pressure, while permitting free movement of the flow control moveable membranes and permitting positive inlet pressure to regulate flow through the improved fluid shunt valve of the invention. The porous membranes are configured to prevent tissue ingrowth into the membranes pores while allowing adequate fluid flow across so as not to inhibit movement of the movable membrane.
摘要翻译：用于控制脑积水的改进的分流阀提供生理大气参考的虹吸控制，其不受上覆组织的不利影响。该阀包括一个或多个多孔外部防污膜，以保护流量控制膜免受外部机械组织压力，同时允许流动控制可移动膜的自由运动并且允许正入口压力来调节通过改进的流体分流阀发明。多孔膜被配置为防止组织向内生成膜孔，同时允许足够的流体流过，以便不会阻止活动膜的运动。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式