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1. 发明申请

US20100278931A1 POROUS SILICON DRUG-ELUTING PARTICLES 有权
标题翻译：多孔硅胶药物颗粒
公开(公告)号：US20100278931A1
公开(公告)日：2010-11-04
申请号：US12773127
申请日：2010-05-04
申请人： Paul Ashton , Hong Guo , Jianbing Chen , Leigh Canham
发明人： Paul Ashton , Hong Guo , Jianbing Chen , Leigh Canham
IPC分类号： A61K9/14 , A61K31/58 , A61P27/02
CPC分类号： A61K31/58 , A61K9/0048 , A61K9/0097
摘要： The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent-permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention. The invention also provides methods of fabricating a drug-eluting particle for releasing therapeutic agents
摘要翻译：本发明提供了可用于递送诊断或治疗剂的可生物降解的药物洗脱颗粒。在某些实施方案中，本发明的药物洗脱颗粒包括可生物降解的多孔硅体，形成在多孔硅体内的储存器，其具有至少一个开口到本体的外部，其中储存器包含治疗剂或诊断剂，以及设置在所述至少一个开口上方的渗透剂的密封件。本发明进一步提供了一种治疗患者以获得所需局部或全身生理或药理作用的方法，包括施用本发明的缓释药物递送颗粒。本发明还提供了制备用于释放治疗剂的药物洗脱颗粒的方法

2. 发明申请

US20090123546A1 Polymer-based, sustained release drug delivery system 审中-公开
标题翻译：基于聚合物的缓释药物递送系统
公开(公告)号：US20090123546A1
公开(公告)日：2009-05-14
申请号：US12082520
申请日：2008-04-11
申请人： Paul Ashton , Jianbing Chen , Hong Guo
发明人： Paul Ashton , Jianbing Chen , Hong Guo
IPC分类号： A61K9/10 , A61K31/513
CPC分类号： A61K47/32 , A61K9/0024 , A61K9/7007 , A61K31/513 , A61K47/34 , A61K47/55 , A61K47/554 , A61L17/005 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61L2300/602
摘要： Disclosed is a sustained release system that includes a polymer and a pharmaceutically active agent dispersed in the polymer. The agent is in granular or particulate form, and has a rate of release from the system that is limited primarily by the rate at which the agent dissolves from the granules into the polymer matrix. Advantageously, the polymer is permeable to the agent and is non-release-rate-limiting with respect to the rate of release of the agent from the polymer.
摘要翻译：公开了一种持续释放系统，其包括分散在聚合物中的聚合物和药物活性剂。试剂是颗粒状或颗粒形式，并且具有主要由试剂从颗粒溶解到聚合物基质中的速率受到系统释放的速率。有利地，聚合物对于试剂是可渗透的，并且相对于试剂从聚合物的释放速率而言是非释放速率限制的。

3. 发明授权

US09023896B2 Porous silicon drug-eluting particles 有权
标题翻译：多孔硅药物洗脱颗粒
公开(公告)号：US09023896B2
公开(公告)日：2015-05-05
申请号：US12773127
申请日：2010-05-04
申请人： Paul Ashton , Hong Guo , Jianbing Chen , Leigh Canham
发明人： Paul Ashton , Hong Guo , Jianbing Chen , Leigh Canham
IPC分类号： A61K47/02 , A61K9/14 , A61K9/00 , A61K31/58
CPC分类号： A61K31/58 , A61K9/0048 , A61K9/0097
摘要： The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent-permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention. The invention also provides methods of fabricating a drug-eluting particle for releasing therapeutic agents.
摘要翻译：本发明提供了可用于递送诊断或治疗剂的可生物降解的药物洗脱颗粒。在某些实施方案中，本发明的药物洗脱颗粒包括可生物降解的多孔硅体，形成在多孔硅体内的储存器，其具有至少一个开口到本体的外部，其中储存器包含治疗剂或诊断剂，以及设置在所述至少一个开口上方的渗透剂的密封件。本发明进一步提供了一种治疗患者以获得所需局部或全身生理或药理作用的方法，包括施用本发明的缓释药物递送颗粒。本发明还提供了制备用于释放治疗剂的药物洗脱颗粒的方法。

4. 发明授权

US08815284B2 Bioerodible sustained release drug delivery systems 有权
标题翻译：生物可降解持续释放药物递送系统
公开(公告)号：US08815284B2
公开(公告)日：2014-08-26
申请号：US10877761
申请日：2004-06-25
申请人： Hong Guo , Jianbing Chen , Dongling Su , Paul Ashton
发明人： Hong Guo , Jianbing Chen , Dongling Su , Paul Ashton
IPC分类号： A61K9/66
CPC分类号： A61K38/385 , A61K9/0019 , A61K9/0024 , A61K9/0051 , A61K9/0092 , A61K9/5031 , A61K31/382 , A61K31/485 , A61K31/542
摘要： The present invention relates to sustained release drug delivery systems, medical devices incorporating said systems, and methods of use and manufacture thereof. The inventive systems feature bioerodible drug delivery devices that include biocompatible solid and biocompatible fluid compositions to achieve desired sustained release drug delivery.
摘要翻译：本发明涉及缓释药物递送系统，包含所述系统的医疗装置及其使用和制造方法。本发明的系统具有包括生物相容性固体和生物相容性流体组合物以实现期望的持续释放药物递送的生物可腐蚀药物递送装置。

5. 发明申请

US20110183944A1 SUSTAINED-RELEASE NSAID/HMG CoA REDUCTASE INHIBITOR COMPOSITIONS 审中-公开
标题翻译：持续释放NSAID / HMG CoA还原酶抑制剂组合物
公开(公告)号：US20110183944A1
公开(公告)日：2011-07-28
申请号：US13015058
申请日：2011-01-27
申请人： Paul Ashton , Hong Guo , Jianbing Chen , Tadeusz Cynkowski , Grazyna Cynkowska
发明人： Paul Ashton , Hong Guo , Jianbing Chen , Tadeusz Cynkowski , Grazyna Cynkowska
IPC分类号： A61K31/635 , A61P25/16 , A61P25/28 , A61P35/00
CPC分类号： A61K31/635
摘要： Compositions for controlled release of one or more therapeutic agents where the composition is essentially free of excipients are disclosed. In particular, compositions comprising a HMG-CoA reductase inhibitor, particularly simvastatin, and a NSAID, such as a COX-2 inhibitor, particularly celecoxib, in which greater than 90% of the weight of the composition is made up of the HMG-CoA reductase inhibitor and NSAID are provided.
摘要翻译：公开了用于控制释放一种或多种治疗剂的组合物，其中组合物基本上不含赋形剂。特别地，包含HMG-CoA还原酶抑制剂，特别是辛伐他汀和NSAID的组合物，例如COX-2抑制剂，特别是塞来昔布，其中大于组合物重量的90％由HMG-CoA组成还原酶抑制剂和NSAID。

6. 发明申请

US20090163457A1 Compositions and methods for delivering a biologically active agent 审中-公开
标题翻译：用于递送生物活性剂的组合物和方法
公开(公告)号：US20090163457A1
公开(公告)日：2009-06-25
申请号：US12315076
申请日：2008-11-26
申请人： Paul Ashton , Jianbing Chen , Hong Guo , Grazyna Cynkowska , Tadeusz Cynkowski
发明人： Paul Ashton , Jianbing Chen , Hong Guo , Grazyna Cynkowska , Tadeusz Cynkowski
IPC分类号： A61K31/58 , A61K31/5365 , A61K31/505 , A61K31/335 , A61K31/24 , C07D265/34 , C07D239/24 , C07D317/10 , C07J53/00 , C07C229/40 , A61P43/00
CPC分类号： A61K31/496 , A61K31/192 , A61K47/55 , A61K2300/00
摘要： The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations. In certain embodiments, the codrugs can be locally administered to deliver the constituent biologically active compound in a sustained-release fashion, reducing systemic concentrations of the biologically active compound.
摘要翻译：本发明涉及具有改进性质的药物，其制备和施用方法，以及配制和施用该制剂作为药物制剂的方法。在某些实施方案中，可以局部施用该组合物以缓释方式递送成分生物活性化合物，从而降低生物活性化合物的全身浓度。

7. 发明申请

US20120045513A1 POLYMER-BASED, SUSTAINED RELEASE DRUG DELIVERY SYSTEM 审中-公开
标题翻译：基于聚合物，持续释放药物递送系统
公开(公告)号：US20120045513A1
公开(公告)日：2012-02-23
申请号：US13228774
申请日：2011-09-09
申请人： Paul Ashton , Jianbing Chen , Hong Guo
发明人： Paul Ashton , Jianbing Chen , Hong Guo
IPC分类号： A61K9/16
CPC分类号： A61K47/32 , A61K9/0024 , A61K9/7007 , A61K31/513 , A61K47/34 , A61K47/55 , A61K47/554 , A61L17/005 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61L2300/602
摘要： Disclosed is a sustained release system that includes a polymer and a pharmaceutically active agent dispersed in the polymer. The agent is in granular or particulate form, and has a rate of release from the system that is limited primarily by the rate at which the agent dissolves from the granules into the polymer matrix. Advantageously, the polymer is permeable to the agent and is non-release-rate-limiting with respect to the rate of release of the agent from the polymer.
摘要翻译：公开了一种持续释放系统，其包括分散在聚合物中的聚合物和药物活性剂。试剂是颗粒状或颗粒形式，并且具有主要由试剂从颗粒溶解到聚合物基质中的速率受到系统释放的速率。有利地，聚合物对于试剂是可渗透的，并且相对于试剂从聚合物的释放速率而言是非释放速率限制的。

8. 发明申请

US20110129541A1 SUSPENSION DELIVERY SYSTEM FOR THE SUSTAINED AND CONTROLLED LOCAL RELEASE OF PHARMACEUTICALS 审中-公开
标题翻译：持续和控制药物局部释放的暂停递送系统
公开(公告)号：US20110129541A1
公开(公告)日：2011-06-02
申请号：US12870618
申请日：2010-08-27
申请人： Jianbing Chen , Hong Guo , Paul Ashton
发明人： Jianbing Chen , Hong Guo , Paul Ashton
IPC分类号： A61K31/485 , A61K9/10 , A61P29/00 , A61P25/04
CPC分类号： A61K9/1652 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/2054 , A61K9/2059
摘要： The invention relates to a novel suspension delivery system for the sustained and controlled release of pharmaceuticals. Methods of preparation and use are also disclosed.
摘要翻译：本发明涉及用于持续和控制释放药物的新型悬浮液输送系统。还公开了制备和使用方法。

9. 发明申请

US20050025834A1 Bioerodible sustained release drug delivery systems 有权
标题翻译：生物可降解持续释放药物递送系统
公开(公告)号：US20050025834A1
公开(公告)日：2005-02-03
申请号：US10877761
申请日：2004-06-25
申请人： Hong Guo , Jianbing Chen , Dongling Su , Paul Ashton
发明人： Hong Guo , Jianbing Chen , Dongling Su , Paul Ashton
IPC分类号： A61K9/00 , A61K9/50 , A61K31/382 , A61K31/485 , A61K31/542 , A61K9/14
CPC分类号： A61K38/385 , A61K9/0019 , A61K9/0024 , A61K9/0051 , A61K9/0092 , A61K9/5031 , A61K31/382 , A61K31/485 , A61K31/542
摘要： The present invention relates to sustained release drug delivery systems, medical devices incorporating said systems, and methods of use and manufacture thereof. The inventive systems feature bioerodible drug delivery devices that include biocompatible solid and biocompatible fluid compositions to achieve desired sustained release drug delivery.
摘要翻译：本发明涉及缓释药物递送系统，包含所述系统的医疗装置及其使用和制造方法。本发明的系统具有包括生物相容性固体和生物相容性流体组合物以实现期望的持续释放药物递送的生物可腐蚀药物递送装置。

10. 发明申请

US20050008695A1 Compositions and methods for delivering a biologically active agent 审中-公开
标题翻译：用于递送生物活性剂的组合物和方法
公开(公告)号：US20050008695A1
公开(公告)日：2005-01-13
申请号：US10850957
申请日：2004-05-21
申请人： Paul Ashton , Jianbing Chen , Hong Guo , Grazyna Cynkowska , Tadeusz Cynkowski
发明人： Paul Ashton , Jianbing Chen , Hong Guo , Grazyna Cynkowska , Tadeusz Cynkowski
IPC分类号： A61K31/192 , A61K31/496 , A61K9/20
CPC分类号： A61K31/496 , A61K31/192 , A61K47/55 , A61K2300/00
摘要： The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations. In certain embodiments, the codrugs can be locally administered to deliver the constituent biologically active compound in a sustained-release fashion, reducing systemic concentrations of the biologically active compound.
摘要翻译：本发明涉及具有改进性质的药物，其制备和施用方法，以及配制和施用该制剂作为药物制剂的方法。在某些实施方案中，可以局部施用该组合物以缓释方式递送成分生物活性化合物，从而降低生物活性化合物的全身浓度。

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