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1. 发明授权

US4004988A Method of preparing sodium chlorate by electrolysis 失效
标题翻译：电解法制备氯酸钠的方法
公开(公告)号：US4004988A
公开(公告)日：1977-01-25
申请号：US509057
申请日：1974-09-25
申请人： Paul Mollard , Pierre Lakodey
发明人： Paul Mollard , Pierre Lakodey
IPC分类号： C25B1/26
CPC分类号： C25B1/265
摘要： A method for preparing sodium chlorate comprises electrolyzing aqueous sodium chloride in the presence of at least one phosphorus-containing agent for complexing alkaline earth impurities, thereby advantageously extending the periods of uninterrupted satisfactory cell operation at substantially constant applied potential and facilitating the cleaning of electrodes between such periods.
摘要翻译：一种制备氯酸钠的方法包括在至少一种含磷试剂存在下电解氯化钠水溶液以络合碱土金属杂质，从而有利地将不间断的令人满意的电解池操作的时间延长到基本恒定的施加电位，并且有助于电极之间的清洁这样的时期。

2. 发明申请

US20140249332A1 METHODS FOR SELECTIVE OXIDATION OF ALPHA TOCOTRIENOL IN THE PRESENCE OF NON-ALPHA TOCOTRIENOLS 有权
标题翻译：在非ALPHA TOCOTRIENOLS存在下选择性氧化阿托伐他汀的方法
公开(公告)号：US20140249332A1
公开(公告)日：2014-09-04
申请号：US14233734
申请日：2012-07-19
申请人： Paul Mollard
发明人： Paul Mollard
IPC分类号： C07C46/06
CPC分类号： C07C46/06 , C07C403/08 , C07C2601/16 , C07D311/72 , C07C50/28
摘要： A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-tocotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs the non-alpha tocotrienol chromans.
摘要翻译：一种生产α-生育三烯酚醌或其立体异构体的方法，所述方法包括通过用金属盐氧化剂氧化α-生育三烯酚，在非α-生育三烯酚染料色素存在下选择性地将α-生育三烯酚苯并二氢吡喃酮打开至α-生育三烯酚醌金属盐氧化剂/α-生育三烯酚的化学计量比为至少4:1，并且其中所述金属氧化剂按顺序加入添加，以减少可能存在于任何量的非α-生育三烯酚黑色素的氧化起始的α-生育三烯酚色满物质。该方法使用有利于α-生育三烯酚苯并二氢吡喃酮与非α-生育三烯酚染料色素的氧化速率的条件。

3. 发明授权

US4808327A Compositions of particulate magnetic oxides with a defect spinel structure, preparation thereof and application thereof 失效
标题翻译：具有缺陷尖晶石结构的颗粒状磁性氧化物的组合物，其制备方法及其应用
公开(公告)号：US4808327A
公开(公告)日：1989-02-28
申请号：US62609
申请日：1987-06-01
申请人： Abel Rousset , Christiane B. Salvaing , Paul Mollard , Michel Gougeon , Philippe Tailhades
发明人： Abel Rousset , Christiane B. Salvaing , Paul Mollard , Michel Gougeon , Philippe Tailhades
IPC分类号： C01B13/18 , C01G49/00 , G11B5/706 , H01F1/11 , C04B35/26
CPC分类号： G11B5/70642 , C01B13/185 , C01G49/009 , C01P2002/32 , C01P2006/42
摘要： Particulate magnetic oxide compositions based on iron oxide (III) and oxide of at least one bivalent metal selected among cobalt, iron, copper, zinc, magnesium, nickel, manganese and cadmium, characterized in that said compositions contain additionally in the form of an oxide from 0.2 to 5% by weight calculated on the total weight at least one additive or substituent selected among alkali metals, alkaline-earth metals, boron, the elements of columns 3, 4 and 5 of the periodical classification of elements having a molecular mass higher than 26, the transition metals 3d and 4d other than those already mentioned, and the rare earths, with the proviso that when an alkali metal or tin is present, at least another additive or substituent is also present, and in that said compositions have a structure of the lanucar spinel type; the preparation and application thereof are also disclosed.
摘要翻译： PCT No.PCT / FR86 / 00337 Sec。 371日期：1987年6月1日 102（e）日期1987年6月1日PCT提交1986年9月30日PCT公布。公开号WO87 / 02173 日本1987年4月9日。基于氧化铁（III）和选自钴，铁，铜，锌，镁，镍，锰和镉中的至少一种二价金属的氧化物的颗粒状磁性氧化物组合物，其特征在于所述组合物含有另外以0.2至5重量％的氧化物的形式，其总重量计算为选自碱金属，碱土金属，硼中的至少一种添加剂或取代基，定期分类的第3,4和5列的元素的分子量高于26的元素，过渡金属3d和4d以外的已知的稀土元素和稀土元素，条件是当存在碱金属或锡时，还存在至少另一种添加剂或取代基，并且所述组合物具有兰卡尔尖晶石型结构; 还公开了其制备和应用。

4. 发明授权

US09162957B2 Methods for oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols 有权
标题翻译：在非α-生育三烯酚存在下氧化α-生育三烯酚的方法
公开(公告)号：US09162957B2
公开(公告)日：2015-10-20
申请号：US14233734
申请日：2012-07-19
申请人： Paul Mollard
发明人： Paul Mollard
IPC分类号： C07C46/06 , C07D311/72 , C07C403/08
CPC分类号： C07C46/06 , C07C403/08 , C07C2601/16 , C07D311/72 , C07C50/28
摘要： A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-tocotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs. the non-alpha tocotrienol chromans.
摘要翻译：一种生产α-生育三烯酚醌或其立体异构体的方法，所述方法包括通过用金属盐氧化剂氧化α-生育三烯酚，在非α-生育三烯酚染料色素存在下选择性地将α-生育三烯酚苯并二氢吡喃酮打开至α-生育三烯酚醌金属盐氧化剂/α-生育三烯酚的化学计量比为至少4:1，并且其中所述金属氧化剂按顺序加入添加，以减少可能存在于任何量的非α-生育三烯酚黑色素的氧化起始的α-生育三烯酚色满物质。该方法使用有利于α-生育三烯酚色度酮与非α-生育三烯酚染料色素的氧化速率的条件。

5. 发明申请

US20110124679A1 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES 有权
标题翻译：用于治疗氧化应激疾病的2-取代对 - 对 - 喹奴酮衍生物
公开(公告)号：US20110124679A1
公开(公告)日：2011-05-26
申请号：US12919007
申请日：2009-03-04
申请人： Andrew W. Hinman , Kieron E. Wesson , Orion D. Jankowski , Paul Mollard , William D. Shrader , Christpher R. Cornell
发明人： Andrew W. Hinman , Kieron E. Wesson , Orion D. Jankowski , Paul Mollard , William D. Shrader , Christpher R. Cornell
IPC分类号： A61K31/47 , A61K31/445 , A61K31/44 , A61K31/405 , A61K31/40 , A61K31/335 , A61K31/165 , C07D217/00 , C07D211/00 , C07D213/73 , C07D209/04 , C07D209/44 , C07D319/14 , C07C233/00
CPC分类号： C07D295/195 , A61P21/00 , A61P25/00 , C07C45/00 , C07C45/30 , C07C205/34 , C07C233/31 , C07C233/61 , C07C233/76 , C07C235/34 , C07C235/40 , C07C235/78 , C07C255/57 , C07C255/60 , C07C275/22 , C07C275/30 , C07C311/03 , C07C311/16 , C07C311/17 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07D209/08 , C07D211/46 , C07D213/56 , C07D213/75 , C07D213/82 , C07D215/08 , C07D217/06 , C07D295/215 , C07D311/74 , C07D317/66 , C07D319/18 , C07D339/04 , C07C47/575 , C07C47/277
摘要： Methods of treating or suppressing oxidative stress diseases including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases and diseases of aging are disclosed, as well as compounds useful in the methods of the invention, such as 2-substituted-p-quinone derivatives as disclosed herein.
摘要翻译：公开了治疗或抑制包括线粒体疾病，受损能量加工障碍，神经变性疾病和衰老疾病的氧化应激疾病的方法，以及可用于本发明方法的化合物，例如所公开的2-取代对醌衍生物这里。

6. 发明申请

US20050137410A1 Practical, cost-effective synthesis of CoQ10 审中-公开
标题翻译： CoQ10的实用，经济合算
公开(公告)号：US20050137410A1
公开(公告)日：2005-06-23
申请号：US10992270
申请日：2004-11-17
申请人： Bruce Lipshutz , Paul Mollard
发明人： Bruce Lipshutz , Paul Mollard
IPC分类号： B01J31/24 , B01J31/12 , B01J31/16 , B01J31/22 , B01J37/16 , C07B61/00 , C07C43/23 , C07C46/00 , C07C46/06 , C07C46/08 , C07C47/575 , C07C50/28 , C07C309/73 , C07F5/06 , C07C49/237
CPC分类号： C07C47/575 , B01J31/1616 , B01J31/2243 , B01J31/2404 , B01J2231/4205 , B01J2531/0252 , B01J2531/845 , B01J2531/847 , C07C43/23 , C07C46/00 , C07C46/06 , C07C46/08 , C07C309/73 , C07F5/062 , C07C50/28
摘要： The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention.
摘要翻译：本发明提供了一种用于合成泛醌和泛醌类似物的收敛方法。还提供了可用于本发明方法的泛醌及其类似物的前体。

7. 发明授权

US5232617A Process for the preparation of hexaferrites 失效
标题翻译：制备十六烷的方法
公开(公告)号：US5232617A
公开(公告)日：1993-08-03
申请号：US681678
申请日：1991-04-08
申请人： Christian Sarda , Abel Rousset , Paul Mollard
发明人： Christian Sarda , Abel Rousset , Paul Mollard
IPC分类号： C01G49/00 , C01G51/00 , C01G53/00 , G11B5/706 , H01F1/11
CPC分类号： C01G53/006 , C01G49/0036 , C01G49/009 , C01G51/006 , G11B5/70678 , H01F1/11 , C01P2002/52 , C01P2004/10 , C01P2004/22 , C01P2004/50 , C01P2004/54 , C01P2004/62 , C01P2006/12 , C01P2006/42
摘要： A process for preparing hexaferrite particles of the type M'Fe.sub.12 O.sub.19 wherein M' represents principally an alkaline earth metal involves preparing a particulate mixture of a ferrous salt of an organic acid and a salt of an organic acid with at least one metal M', optionally with at least one dopant agent, the particles of the mixture having a size not greater than about 0.5 .mu.m and the said mixture containing a stoichiometric excess of the salt of metal M'. This mixture is heated up to the decomposition of the organic salts and the resulting product is submitted to a thermal treatment at a temperature at least equal to 700.degree. C. but not greater than 1000.degree. C. and is maintained at this temperature for a period of time sufficient to form hexaferrite. After cooling the resulting particles are washed with an aqueous solution of an acid capable of dissolving formed monoferrites of the type M'Fe.sub.2 O.sub.4 to remove them.
摘要翻译：制备M'Fe12O19型六铁素颗粒的方法，其中M'主要表示碱土金属，包括制备有机酸亚铁盐和有机酸盐与至少一种金属M'的颗粒混合物，任选地与至少一种掺杂剂，所述混合物的颗粒的尺寸不大于约0.5μm，并且所述混合物含有化学计量过量的金属M'的盐。将该混合物加热至有机盐的分解，并将所得产物在至少等于700℃但不大于1000℃的温度下进行热处理，并在该温度下保持一段时间的时间足以形成六方铁素体。冷却后，用能够溶解形成的M'Fe 2 O 4型铁素体的酸的水溶液洗涤所得颗粒以除去它们。

8. 发明授权

US4971734A Method of making nuclear fuel pellets, comprising producing and using pourable, frittable powders obtained directly by precipitation of peroxides 失效
标题翻译：制备核燃料颗粒的方法，包括生产和使用直接通过沉淀过氧化物获得的可倾倒的易碎粉末
公开(公告)号：US4971734A
公开(公告)日：1990-11-20
申请号：US377117
申请日：1989-07-10
申请人： Antoine Floreancig , Paul Mollard
发明人： Antoine Floreancig , Paul Mollard
IPC分类号： C01B15/047 , C01F15/00 , C01F17/00 , C01G27/02 , C01G43/01 , C01G56/00 , C04B35/64 , G21C3/62
CPC分类号： C01F17/0043 , C01B15/0475 , C01F15/00 , C01F17/0012 , C01G27/02 , C01G43/01 , C01G56/005 , G21C3/623 , C01P2004/40 , C01P2004/61 , C01P2006/10 , C01P2006/12 , C01P2006/20 , C01P2006/60 , C01P2006/80 , C01P2006/82 , Y02E30/38
摘要： A method of obtaining pellets of MxOy oxide, where M represents one or more elements used to make nuclear fuel pellets, as a means of obtaining very high density fritted pellets directly, i.e. without the intermediate powders being conditioned, comprising starting with a solution of soluble salts of the M elements, and treating them with hydrogen peroxide with the pH kept at from 2 to 2.5, in a continuous fluidized bed reactor comprising at least 3 superposed cylindrical sections of different diameters, the solutions in the central section being agitated vigorously, to obtain a precipitate which is subsequently calcined reduced, pressed then fritted.
摘要翻译：获得M x O y氧化物颗粒的方法，其中M表示用于制造核燃料颗粒的一种或多种元素，作为直接获得非常高密度烧结颗粒的方法，即不调节中间体粉末，包括从可溶性溶液在含有至少3个重叠的不同直径的圆柱形切片的连续流化床反应器中，将pH值保持在2至2.5的过氧化氢处理它们，并将中心部分的溶液剧烈搅拌，至得到沉淀，随后煅烧还原，然后烧结。

9. 发明授权

US4022874A Process for the production of sodium percarbonate 失效
标题翻译：过碳酸钠生产工艺
公开(公告)号：US4022874A
公开(公告)日：1977-05-10
申请号：US487613
申请日：1974-07-11
申请人： Paul Mollard , Louis Mesaros
发明人： Paul Mollard , Louis Mesaros
IPC分类号： C01B15/10
CPC分类号： C01B15/103
摘要： Processes for the preparation of sodium percarbonate having substantially the formula 2Na.sub.2 CO.sub.3.3H.sub.2 O.sub.2, the processes being particularly suited to the use of ordinary sodium carbonate, which processes comprise reacting 60 to 80 percent hydrogen peroxide with sodium carbonate monohydrate or a hydrate of sodium carbonate containing from about 75 to 90 percent sodium carbonate; and products obtained thereby, particularly those percarbonate products having an excellent resistance to shock and attrition and effective densities of 0.61-0.92 g/cm.sup.3 and mean particle diameters of 250-610 microns.
摘要翻译：用于制备基本上具有式2Na 2 CO 3·3H 2 O 2的过碳酸钠的方法，该方法特别适合于使用普通碳酸钠，该方法包括使60-80％过氧化氢与碳酸钠一水合物或含有约75-90％的碳酸钠; 由此获得的产品，特别是具有优异的耐冲击性和耐磨性，有效密度为0.61-0.92g / cm 3，平均粒径为250-610微米的过碳酸盐产品。

10. 发明授权

US07968746B2 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases 有权
标题翻译： 4-（对醌基）-2-羟基丁酰胺衍生物用于治疗线粒体疾病
公开(公告)号：US07968746B2
公开(公告)日：2011-06-28
申请号：US12264838
申请日：2008-11-04
申请人： Orion D. Jankowski , Kieron E. Wesson , Paul Mollard , William D. Shrader
发明人： Orion D. Jankowski , Kieron E. Wesson , Paul Mollard , William D. Shrader
IPC分类号： C07C233/00
CPC分类号： C07C235/80 , C07C235/78 , C07C317/28 , C07C2601/02 , C07C2601/16 , C07D207/26 , C07D207/27 , C07D211/46 , C07D213/40 , C07D213/50 , C07D233/61 , C07D265/30 , C07D295/116 , C07D295/13 , C07D295/185 , C07D295/192 , C07D311/66
摘要： Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, and stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 4-(p-quinolyl)-2-hydroxybutanamide derivatives. Methods and compounds useful in treating other disorders such as amyotrophic lateral sclerosis (ALS), Huntington's disease, Parkinson's disease, and pervasive developmental disorders such as autism are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
摘要翻译：还公开了治疗或抑制线粒体疾病如弗里德里希共济失调（FRDA），Leber氏遗传性视神经病变（LHON），线粒体肌病，脑病，乳酸脱落和中风（MELAS），Kearns-Sayre综合征（KSS）的方法作为可用于本发明方法的化合物，例如4-（对 - 喹啉基）-2-羟基丁酰胺衍生物。还公开了可用于治疗其他疾病如肌萎缩性侧索硬化（ALS），亨廷顿氏病，帕金森病和普遍发育障碍如自闭症的方法和化合物。还公开了可用于评估受试者的代谢状态和治疗功效的能量生物标志物。还公开了调节，归一化或增强能量生物标志物的方法以及可用于这些方法的化合物。

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