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1. 发明授权

US07261702B1 Needleless syringe operating with an impact wave generator through a wall 有权
标题翻译：无冲击注射器通过墙壁与冲击波发生器一起操作
公开(公告)号：US07261702B1
公开(公告)日：2007-08-28
申请号：US10018469
申请日：2000-06-30
申请人： Patrick Alexandre , Pierre Brunet , Brigitte Cagnon , Claude Mikler
发明人： Patrick Alexandre , Pierre Brunet , Brigitte Cagnon , Claude Mikler
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2046 , A61M5/2053
摘要： The technical field of the invention is that of needleless syringes used for intradermal, subcutaneous or intramuscular injections of active principle for therapeutic purposes. More particularly, the invention concerns a needleless syringe (10) comprising a propelling system, the active principle and an application guide (8), mainly characterised in that the propelling system consists of an impact wave generating device (3) and the active principle is arranged in at least a blind cavity (7) of the downstream surface (6) of a barrier (4) extended by the application guide (8). Thus, the active principle is expelled in the form of streamlined jets, driven at very high speed.
摘要翻译：本发明的技术领域是用于皮内，皮下或肌内注射用于治疗目的的活性成分的无针注射器。更具体地，本发明涉及一种无针注射器（10），其包括推进系统，有源原理和应用引导件（8），其主要特征在于推进系统由冲击波产生装置（3）组成，并且有源原理是布置在由应用引导件（8）延伸的屏障（4）的下游表面（6）的至少一个盲腔（7）中。因此，积极的原则是以流线型喷气式飞机的速度被驱逐出去的。

2. 发明授权

US06981961B1 Needleless syringe comprising an injector with nested elements 有权
标题翻译：无针注射器包括具有嵌套元件的注射器
公开(公告)号：US06981961B1
公开(公告)日：2006-01-03
申请号：US10018133
申请日：2000-06-30
申请人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Claude Mikler
发明人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Claude Mikler
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/3007 , A61M5/3134
摘要： The invention concerns the field of needleless syringes for injecting an active principle for therapeutic purposes. More particularly, it concerns a needleless syringe for injecting an active principle (7) initially set between an injector (1, 10) comprising at least an injection nozzle, said injector being contacted with the skin, and a wall (8) mobile under the effect of a propelling system (9) pressurizing and expelling the active principle through the injector located at the syringe downstream end (2). In order to produce nozzles in a considerable injector thickness and to control the jet coherence distance, said injector (1, 10) comprises at least two elements (3, 4) whereof the contact surfaces (30, 40, 40′) are oriented towards the skin, at least a groove (31, 41, 41′) forming an injection nozzle in the assembly of said elements.
摘要翻译：本发明涉及用于注射用于治疗目的的活性成分的无针注射器领域。更具体地，涉及一种无针注射器，用于注射初始设置在包括至少一个注射喷嘴的喷射器（1,10）之间的有源原理（7），所述喷射器与皮肤接触，以及在所述喷射器推进系统（9）通过位于注射器下游端（2）处的喷射器加压和排出活性物质的作用。为了产生相当注射器厚度的喷嘴并且控制射流相干距离，所述喷射器（1,10）包括至少两个元件（3,4），其中接触表面（30,40,40'）朝向所述皮肤至少在所述元件的组件中形成喷嘴的凹槽（31,41,41'）。

3. 发明授权

US06610028B1 Needless syringe provided with a piezoelectric triggering system 有权
标题翻译：无需注射器配有压电触发系统
公开(公告)号：US06610028B1
公开(公告)日：2003-08-26
申请号：US10018356
申请日：2002-02-04
申请人： Patrick Alexandre , Bernard Brouquieres , Claude Mikler , Louis Simonet
发明人： Patrick Alexandre , Bernard Brouquieres , Claude Mikler , Louis Simonet
IPC分类号： A61M530
CPC分类号： A61M5/30 , A61M5/2046 , A61M2005/2013
摘要： The invention concerns the technical field of needleless syringes for injecting an active principle through the skin. More particularly, the invention concerns a needleless syringe provided with a piezoelectric crystal and a triggering device comprising a triggering member and impacting means and, on a triggering device particularly adapted to needleless syringes. The invention is mainly characterized in that the impacting means comprises a latch maintained under elastic stress by being blocked against a stop element and the triggering member is capable of moving the latch to release it, so that it is urged to strike the piezoelectric crystal. Then, the crystal produces an electric arc designed to initiate a pyrotechnic charge whereof the combustion gases will help to expel the active principle contained in the syringe.
摘要翻译：本发明涉及用于通过皮肤注射活性成分的无针注射器的技术领域。更具体地说，本发明涉及一种设置有压电晶体的无针注射器和包括触发元件和冲击装置的触发装置，以及特别适用于无针注射器的触发装置。本发明的主要特征在于，冲击装置包括通过阻挡止动元件而保持在弹性应力下的闩锁，并且触发构件能够移动闩锁以将其释放，从而被迫使其撞击压电晶体。然后，晶体产生电弧，用于启动烟火充电，其中燃烧气体将有助于排出包含在注射器中的活性原理。

4. 外观设计

USD359807S Applicator for ionophoretic transcutaneous delivery of drugs 失效
公开(公告)号：USD359807S
公开(公告)日：1995-06-27
申请号：US20522
申请日：1994-03-22
申请人： Claude Mikler , Michael Paton
设计人： Claude Mikler , Michael Paton

5. 发明授权

US06247485B1 Miniature valve for filling the reservoir of an apparatus for the transdermal administration of medicine 有权
标题翻译：用于填充用于透皮给药的装置的储存器的微型阀
公开(公告)号：US06247485B1
公开(公告)日：2001-06-19
申请号：US09285000
申请日：1999-07-20
申请人： Carole Rossi , Philippe Millot , Daniel Esteve , Claude Mikler , Eric Teillaud
发明人： Carole Rossi , Philippe Millot , Daniel Esteve , Claude Mikler , Eric Teillaud
IPC分类号： A61M500
CPC分类号： F16K99/0001 , A61M37/00 , A61M2205/0244 , F15C5/00 , F16K99/003 , F16K99/0067 , F16K2099/0074 , F16K2099/008 , F16K2099/0086 , Y10T137/1647
摘要： A miniature valve for filling the reservoir of an apparatus for the transdermal administration of a medicine including a) a substrate, b) a fuel charge arranged on the substrate opposite the passage to be opened through it, and c) an electric resistor placed in contact with the fuel charge so that the supply of this resistor with a predetermined electric energy ensures the combustion of the charge and the opening of the passage by local rupture of the substrate under the pressure of the fuel gases of the charge. The device is useful for filling a medicine reservoir for the transdermal administration medicine aided by inophoresis.
摘要翻译：一种用于填充用于经皮给药的药物的储存器的微型阀，包括：a）基底; b）布置在所述基底上的燃料电荷，所述燃料电荷与所述待通过的通道相对; c）电阻器，燃料电荷使得具有预定电能的该电阻器的供应通过在电荷的燃料气体的压力下的基板的局部破裂来确保电荷的燃烧和通道的打开。该装置可用于填充用于透皮给药药物的药物储存器，辅助通过吸气。

6. 外观设计

USD359806S Applicator for ionophoretic transcutaneous delivery of drugs 失效
公开(公告)号：USD359806S
公开(公告)日：1995-06-27
申请号：US020224
申请日：1994-03-22
申请人： Claude Mikler , Michael Paton
设计人： Claude Mikler , Michael Paton

7. 外观设计

USD343684S Applicator for electrophoretic transcutaneous delivery of drugs 失效
公开(公告)号：USD343684S
公开(公告)日：1994-01-25
申请号：US851825
申请日：1992-03-16
申请人： Michael Paton , Claude Mikler
设计人： Michael Paton , Claude Mikler

8. 发明授权

US06731987B1 Electrode for the transferring an electric current through a patient's skin 有权
标题翻译：用于通过患者皮肤转移电流的电极
公开(公告)号：US06731987B1
公开(公告)日：2004-05-04
申请号：US09831318
申请日：2002-04-25
申请人： Eric Thomas McAdams , Dao Min Zhou , Pascal Andre Nicolas Muller , Claude Mikler
发明人： Eric Thomas McAdams , Dao Min Zhou , Pascal Andre Nicolas Muller , Claude Mikler
IPC分类号： A61N104
CPC分类号： A61N1/0436 , A61N1/0452 , A61N1/0456 , A61N1/0468 , A61N1/0492
摘要： The electrode comprises a) a layer (5) which conducts electricity for the supply or the collection of an electrical current traversing the electrode, and b) a consumable electrochemical interface layer (7). According to the invention, it comprises, in addition, an intermediate layer (6) made of a chemically inert and electrically resistant material. This layer can consist of a dispersion of fine particles of carbon in a polymer binder. Application in the preparation of electrodes with increased electrochemical capacity, for an ionophoresis device for the transdermal administration of drugs or a device for the electrocicatrization of wounds.
摘要翻译：电极包括a）一层（5），其传导电力用于供应或收集穿过该电极的电流，以及b）一个可消耗的电化学界面层（7）。根据本发明，它还包括由化学惰性和电阻材料制成的中间层（6）。该层可以由聚合物粘合剂中的细颗粒的分散体组成。用于制备具有增加的电化学容量的电极，用于透皮给药药物的离子电泳装置或用于伤口电致染色的装置。

9. 发明授权

US6007835A Transdermal matrix system 失效
标题翻译：透皮基质系统
公开(公告)号：US6007835A
公开(公告)日：1999-12-28
申请号：US43726
申请日：1998-03-26
申请人： Chantal Bon-Lapillonne , Daniel Dhuique-Mayer , Claude Mikler
发明人： Chantal Bon-Lapillonne , Daniel Dhuique-Mayer , Claude Mikler
IPC分类号： A61K9/70 , A61K38/24
CPC分类号： A61K9/7053 , A61K9/7076
摘要： A novel transdermal system for the percutaneous delivery of a hormone, including a carrier and an adhesive matrix, is disclosed. The matrix includes (a) 20-50 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer, (b) 30-60 parts by weight of a tackifyier resin, (c) 4-25 parts by weight of propylene glycol laurate, (d) 2-10 parts by weight of a compound selected from N-alkyl-2-pyrrolidones, wherein the alkyl group is a C.sub.4-- C.sub.15 group, (e) 0.01-2 parts by weight of a stabilizing agent, (f) 0.1-12 parts by weight of at least one hormone selected from the group consisting of oestrogenic and progestogenic components, and (g) 1-12 parts by weight of a vinyl acetate/N-vinyl-2-pyrrolidone copolymer. A method for preparing said system and the therapeutical use thereof are also disclosed.
摘要翻译： PCT No.PCT / FR96 / 01496 Sec。 371日期：1998年3月26日 102（e）1998年3月26日PCT PCT 1996年9月25日PCT公布。公开号WO97 / 11689 日本1997年4月3日公开了一种用于经皮输送激素的新型透皮系统，包括载体和粘合剂基质。该基质包括（a）20-50重量份的聚（苯乙烯 - 异戊二烯 - 苯乙烯）三嵌段共聚物，（b）30-60重量份的增粘树脂，（c）4-25重量份丙烯二醇月桂酸酯，（d）2-10重量份选自N-烷基-2-吡咯烷酮的化合物，其中烷基是C 4 -C 15基团，（e）0.01-2重量份的稳定剂，（f）0.1-12重量份选自雌激素和孕激素成分的至少一种激素，和（g）1-12重量份的乙酸乙烯酯/ N-乙烯基-2-吡咯烷酮共聚物。还公开了一种制备该系统及其治疗用途的方法。

10. 发明授权

US5580572A Styrene-isoprene-styrene copolymer-based transdermal matrix system for the administration of an oestrogen and/or a progestogen 失效
标题翻译：用于施用雌激素和/或孕激素的苯乙烯 - 异戊二烯 - 苯乙烯共聚物基透皮基质体系
公开(公告)号：US5580572A
公开(公告)日：1996-12-03
申请号：US413216
申请日：1995-03-28
申请人： Claude Mikler , Laurent Liorzou , Daniel Dhuique-Mayer
发明人： Claude Mikler , Laurent Liorzou , Daniel Dhuique-Mayer
IPC分类号： A61L15/10 , A61F13/02 , A61K9/70 , A61K31/165 , A61K31/40 , A61K31/565 , A61K31/57 , A61K47/16 , A61K47/22 , A61K47/32 , A61K47/34 , A61P5/00 , A61F13/00
CPC分类号： A61K9/7053 , A61K9/7076 , Y10S514/946 , Y10S514/947
摘要： This invention is concerned with a new transdermal matrix system for the percutaneous administration of a hormone, said matrix system, which has a support and a self-adhesive matrix, comprising a matrix containing:(a) 20 to 42 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer,(b) 35 to 55 parts by weight of a tackifying resin.(c) 5 to 25 parts by weight of a plasticizing agent selected from the group consisting of oleic alcohol, peglicol 5-oleate, propyleneglycol laurate or a polypropoxyl ether of cetyl alcohol,(d) 5 to 15 parts by weight of at least one compound selected from the group consisting of:crotamiton, andN-substituted 2-pyrrolidones of formula I, ##STR1## wherein R represents a (C.sub.1 -C.sub.15)-alkyl, cyclohexyl or 2-hydroxyethyl group,(e) 0,01 to 1 part by weight of a stabilizing agent and,(f) 0,1 to 5 parts by weight of a hormone selected from the group consisting of oestrogen components, progestogen components and mixtures thereof.It also relates to a method for prepararing said system.No figure.
摘要翻译：本发明涉及用于经皮给药激素的新的透皮基质体系，所述基质体系具有支持体和自粘性基质，其包含基质，其包含：（a）20至42重量份的聚（苯乙烯 - 异戊二烯 - 苯乙烯）三嵌段共聚物，（b）35〜55重量份增粘树脂。（c）5至25重量份选自油酸醇，焦油醇5-油酸酯，丙二醇月桂酸酯或鲸蜡醇的聚丙氧基醚的增塑剂，（d）5至15重量份的至少一种选自以下的化合物：克罗他米通和式I的N-取代的2-吡咯烷酮，其中R表示（C 1 -C 15） - 烷基，环己基或2-羟乙基，（e）0 ，0.1至1重量份的稳定剂，和（f）0.1至5重量份的选自雌激素组分，孕激素成分及其混合物的激素。它还涉及一种用于制作所述系统的方法。没有数字

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