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1. 发明授权

US6007835A Transdermal matrix system 失效
标题翻译：透皮基质系统
公开(公告)号：US6007835A
公开(公告)日：1999-12-28
申请号：US43726
申请日：1998-03-26
申请人： Chantal Bon-Lapillonne , Daniel Dhuique-Mayer , Claude Mikler
发明人： Chantal Bon-Lapillonne , Daniel Dhuique-Mayer , Claude Mikler
IPC分类号： A61K9/70 , A61K38/24
CPC分类号： A61K9/7053 , A61K9/7076
摘要： A novel transdermal system for the percutaneous delivery of a hormone, including a carrier and an adhesive matrix, is disclosed. The matrix includes (a) 20-50 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer, (b) 30-60 parts by weight of a tackifyier resin, (c) 4-25 parts by weight of propylene glycol laurate, (d) 2-10 parts by weight of a compound selected from N-alkyl-2-pyrrolidones, wherein the alkyl group is a C.sub.4-- C.sub.15 group, (e) 0.01-2 parts by weight of a stabilizing agent, (f) 0.1-12 parts by weight of at least one hormone selected from the group consisting of oestrogenic and progestogenic components, and (g) 1-12 parts by weight of a vinyl acetate/N-vinyl-2-pyrrolidone copolymer. A method for preparing said system and the therapeutical use thereof are also disclosed.
摘要翻译： PCT No.PCT / FR96 / 01496 Sec。 371日期：1998年3月26日 102（e）1998年3月26日PCT PCT 1996年9月25日PCT公布。公开号WO97 / 11689 日本1997年4月3日公开了一种用于经皮输送激素的新型透皮系统，包括载体和粘合剂基质。该基质包括（a）20-50重量份的聚（苯乙烯 - 异戊二烯 - 苯乙烯）三嵌段共聚物，（b）30-60重量份的增粘树脂，（c）4-25重量份丙烯二醇月桂酸酯，（d）2-10重量份选自N-烷基-2-吡咯烷酮的化合物，其中烷基是C 4 -C 15基团，（e）0.01-2重量份的稳定剂，（f）0.1-12重量份选自雌激素和孕激素成分的至少一种激素，和（g）1-12重量份的乙酸乙烯酯/ N-乙烯基-2-吡咯烷酮共聚物。还公开了一种制备该系统及其治疗用途的方法。

2. 发明授权

US5580572A Styrene-isoprene-styrene copolymer-based transdermal matrix system for the administration of an oestrogen and/or a progestogen 失效
标题翻译：用于施用雌激素和/或孕激素的苯乙烯 - 异戊二烯 - 苯乙烯共聚物基透皮基质体系
公开(公告)号：US5580572A
公开(公告)日：1996-12-03
申请号：US413216
申请日：1995-03-28
申请人： Claude Mikler , Laurent Liorzou , Daniel Dhuique-Mayer
发明人： Claude Mikler , Laurent Liorzou , Daniel Dhuique-Mayer
IPC分类号： A61L15/10 , A61F13/02 , A61K9/70 , A61K31/165 , A61K31/40 , A61K31/565 , A61K31/57 , A61K47/16 , A61K47/22 , A61K47/32 , A61K47/34 , A61P5/00 , A61F13/00
CPC分类号： A61K9/7053 , A61K9/7076 , Y10S514/946 , Y10S514/947
摘要： This invention is concerned with a new transdermal matrix system for the percutaneous administration of a hormone, said matrix system, which has a support and a self-adhesive matrix, comprising a matrix containing:(a) 20 to 42 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer,(b) 35 to 55 parts by weight of a tackifying resin.(c) 5 to 25 parts by weight of a plasticizing agent selected from the group consisting of oleic alcohol, peglicol 5-oleate, propyleneglycol laurate or a polypropoxyl ether of cetyl alcohol,(d) 5 to 15 parts by weight of at least one compound selected from the group consisting of:crotamiton, andN-substituted 2-pyrrolidones of formula I, ##STR1## wherein R represents a (C.sub.1 -C.sub.15)-alkyl, cyclohexyl or 2-hydroxyethyl group,(e) 0,01 to 1 part by weight of a stabilizing agent and,(f) 0,1 to 5 parts by weight of a hormone selected from the group consisting of oestrogen components, progestogen components and mixtures thereof.It also relates to a method for prepararing said system.No figure.
摘要翻译：本发明涉及用于经皮给药激素的新的透皮基质体系，所述基质体系具有支持体和自粘性基质，其包含基质，其包含：（a）20至42重量份的聚（苯乙烯 - 异戊二烯 - 苯乙烯）三嵌段共聚物，（b）35〜55重量份增粘树脂。（c）5至25重量份选自油酸醇，焦油醇5-油酸酯，丙二醇月桂酸酯或鲸蜡醇的聚丙氧基醚的增塑剂，（d）5至15重量份的至少一种选自以下的化合物：克罗他米通和式I的N-取代的2-吡咯烷酮，其中R表示（C 1 -C 15） - 烷基，环己基或2-羟乙基，（e）0 ，0.1至1重量份的稳定剂，和（f）0.1至5重量份的选自雌激素组分，孕激素成分及其混合物的激素。它还涉及一种用于制作所述系统的方法。没有数字

3. 发明授权

US5718913A Reservoir which can be impregnated with a solution of active principle, for an iontophoretic device for transdermal delivery of medicinal products and method of manufacture of such a resevoir 失效
标题翻译：可以用活性成分溶液浸渍的储存器，用于医药产品透皮递送的离子电渗装置和制造这种储存器的方法
公开(公告)号：US5718913A
公开(公告)日：1998-02-17
申请号：US600916
申请日：1996-02-26
申请人： Daniel Dhuique-Mayer , Laurent Liorzou
发明人： Daniel Dhuique-Mayer , Laurent Liorzou
IPC分类号： A61N1/30 , A61F13/00
CPC分类号： A61N1/0448
摘要： The reservoir loaded with a divided material which can be impregnated with the solution of active principle, comprises a) a support sheet (1) made of a cavitied material which is permeable to the solution and capable of contributing to the mechanical strength of the reservoir b) a layer (3) of particles of the impregnatable material and c) a substrative layer (2) interposed between one face of the support sheet (1) and the layer of particles (3) in order to hold the latter on the support sheet (1), this substrative layer (2) consisting of a substance which is miscible with the solution of active principle.
摘要翻译： PCT No.PCT / FR94 / 00974。 371日期1996年2月26日 102（e）日期1996年2月26日PCT 1994年8月3日PCT PCT。公开号WO95 / 06496 日期1995年3月9日装载有可以浸渍有效原理溶液的分割材料的储存器包括a）由空腔材料制成的支撑片（1），该空穴材料对溶液是可渗透的并且能够有助于机械储存器的强度b）可浸渍材料的颗粒层（3）和c）插入在支撑片材（1）的一个表面和颗粒层（3）之间的底层（2），以便保持后者在支撑片（1）上，该底层（2）由与活性成分的溶液混溶的物质组成。

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