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1. 发明授权

US06981961B1 Needleless syringe comprising an injector with nested elements 有权
标题翻译：无针注射器包括具有嵌套元件的注射器
公开(公告)号：US06981961B1
公开(公告)日：2006-01-03
申请号：US10018133
申请日：2000-06-30
申请人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Claude Mikler
发明人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Claude Mikler
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/3007 , A61M5/3134
摘要： The invention concerns the field of needleless syringes for injecting an active principle for therapeutic purposes. More particularly, it concerns a needleless syringe for injecting an active principle (7) initially set between an injector (1, 10) comprising at least an injection nozzle, said injector being contacted with the skin, and a wall (8) mobile under the effect of a propelling system (9) pressurizing and expelling the active principle through the injector located at the syringe downstream end (2). In order to produce nozzles in a considerable injector thickness and to control the jet coherence distance, said injector (1, 10) comprises at least two elements (3, 4) whereof the contact surfaces (30, 40, 40′) are oriented towards the skin, at least a groove (31, 41, 41′) forming an injection nozzle in the assembly of said elements.
摘要翻译：本发明涉及用于注射用于治疗目的的活性成分的无针注射器领域。更具体地，涉及一种无针注射器，用于注射初始设置在包括至少一个注射喷嘴的喷射器（1,10）之间的有源原理（7），所述喷射器与皮肤接触，以及在所述喷射器推进系统（9）通过位于注射器下游端（2）处的喷射器加压和排出活性物质的作用。为了产生相当注射器厚度的喷嘴并且控制射流相干距离，所述喷射器（1,10）包括至少两个元件（3,4），其中接触表面（30,40,40'）朝向所述皮肤至少在所述元件的组件中形成喷嘴的凹槽（31,41,41'）。

2. 发明授权

US06623446B1 Needleless syringe comprising an injector with stacked elements 有权
标题翻译：无针注射器包括具有堆叠元件的注射器
公开(公告)号：US06623446B1
公开(公告)日：2003-09-23
申请号：US10018223
申请日：2001-12-18
申请人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Denis Roller
发明人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Denis Roller
IPC分类号： A61M530
CPC分类号： A61M5/30 , A61M5/3007 , A61M5/3134
摘要： The invention concerns the technical field of needleless syringes for injecting an active principle for therapeutic purposes. More particularly, it concerns a needleless syringe for injecting an active principle (7, 70) initially set between an injector (1, 10) comprising at least an injection nozzle (50, 50′, 60′) contacted with the skin and a wall (8) mobile under the effect of a propelling system (9) pressurizing and expelling the active principle through the injector located at the downstream end (2, 20) of the syringe. In order to produce nozzles passing through a considerable injector thickness and to control the jet coherence distance, said injector (1, 10) comprises a support (3, 21) with at least a housing (4, 40) wherein are stacked plates (51, 61, 91, 51′, 71′, 91′, 52, 92) each comprising an equal number of orifices aligned to form at least a nozzle (50, 50′, 60′) through the stack.
摘要翻译：本发明涉及用于注射用于治疗目的的活性成分的无针注射器的技术领域。更具体地，涉及一种无针注射器，其用于注射初始设置在至少包括与皮肤接触的注射喷嘴（50,50'，60'）的喷射器（1,10）之间的有源原理（7,70）（8）在推进系统（9）的作用下移动，所述推进系统（9）通过位于所述注射器的下游端（2,20）处的所述喷射器对所述有效原理进行加压和排出。为了产生通过相当的喷射器厚度并且控制射流相干距离的喷嘴，所述喷射器（1,10）包括具有至少一个壳体（4,40）的支撑件（3,21），所述壳体是叠置的板（51），61,91,51'，71'，91'，52,92），每个孔包括相等数量的孔，其对齐以形成通过所述堆叠的至少一个喷嘴（50,50'，60'）。

3. 发明授权

US06610028B1 Needless syringe provided with a piezoelectric triggering system 有权
标题翻译：无需注射器配有压电触发系统
公开(公告)号：US06610028B1
公开(公告)日：2003-08-26
申请号：US10018356
申请日：2002-02-04
申请人： Patrick Alexandre , Bernard Brouquieres , Claude Mikler , Louis Simonet
发明人： Patrick Alexandre , Bernard Brouquieres , Claude Mikler , Louis Simonet
IPC分类号： A61M530
CPC分类号： A61M5/30 , A61M5/2046 , A61M2005/2013
摘要： The invention concerns the technical field of needleless syringes for injecting an active principle through the skin. More particularly, the invention concerns a needleless syringe provided with a piezoelectric crystal and a triggering device comprising a triggering member and impacting means and, on a triggering device particularly adapted to needleless syringes. The invention is mainly characterized in that the impacting means comprises a latch maintained under elastic stress by being blocked against a stop element and the triggering member is capable of moving the latch to release it, so that it is urged to strike the piezoelectric crystal. Then, the crystal produces an electric arc designed to initiate a pyrotechnic charge whereof the combustion gases will help to expel the active principle contained in the syringe.
摘要翻译：本发明涉及用于通过皮肤注射活性成分的无针注射器的技术领域。更具体地说，本发明涉及一种设置有压电晶体的无针注射器和包括触发元件和冲击装置的触发装置，以及特别适用于无针注射器的触发装置。本发明的主要特征在于，冲击装置包括通过阻挡止动元件而保持在弹性应力下的闩锁，并且触发构件能够移动闩锁以将其释放，从而被迫使其撞击压电晶体。然后，晶体产生电弧，用于启动烟火充电，其中燃烧气体将有助于排出包含在注射器中的活性原理。

4. 发明授权

US07513885B2 Needleless syringe with membrane isolating a multiple duct injector 有权
标题翻译：无针注射器，隔膜隔离多管道注射器
公开(公告)号：US07513885B2
公开(公告)日：2009-04-07
申请号：US10849145
申请日：2004-05-20
申请人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Philippe Gautier
发明人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Philippe Gautier
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2046 , A61M5/286 , A61M5/3007 , A61M2005/3118
摘要： The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurized for injection.
摘要翻译：本发明涉及具有多个管道的注射器的无针注射器领域。需要解决的问题是喷射器与液体活性成分的长期兼容性。为此目的，注射器（1）包括圆柱形容器（2），其在其上游部分处由能够被驱动装置（70）移动的封闭元件（3）封闭，并且在其下游部分由注射器（4）封闭）包括至少一个注射管道，并且所述贮存器固定到注射器的主体（8），所述注射器使得与活性成分兼容的膜片（5）将其与注射器（4）和所述的当注射加压时，隔膜可以被液体（6）通过。

5. 发明授权

US07156822B2 Needleless syringe with membrane isolating a multiple duct injector 有权
标题翻译：无针注射器，隔膜隔离多管道注射器
公开(公告)号：US07156822B2
公开(公告)日：2007-01-02
申请号：US10849017
申请日：2004-05-20
申请人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Philippe Gautier
发明人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Philippe Gautier
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2046 , A61M5/286 , A61M5/3007 , A61M2005/3118
摘要： The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurised for injection.
摘要翻译：本发明涉及具有多个管道的注射器的无针注射器领域。需要解决的问题是喷射器与液体活性成分的长期兼容性。为此目的，注射器（1）包括圆柱形容器（2），其在其上游部分处由能够被驱动装置（70）移动的封闭元件（3）封闭，并且在其下游部分由注射器（4）封闭）包括至少一个注射管道，并且所述贮存器固定到注射器的主体（8），所述注射器使得与活性成分兼容的膜片（5）将其与注射器（4）和所述的当注射加压时，隔膜可以被液体（6）通过。

6. 发明授权

US06979310B2 Needleless syringe with membrane isolating a multiple duct injector 有权
标题翻译：无针注射器，隔膜隔离多管道注射器
公开(公告)号：US06979310B2
公开(公告)日：2005-12-27
申请号：US10258884
申请日：2001-05-29
申请人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Philippe Gautier
发明人： Alain Navelier , Patrick Alexandre , Bernard Brouquieres , Philippe Gautier
IPC分类号： A61M5/20 , A61M5/28 , A61M5/30 , A61M5/31
CPC分类号： A61M5/30 , A61M5/2046 , A61M5/286 , A61M5/3007 , A61M2005/3118
摘要： The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurized for injection.
摘要翻译：本发明涉及具有多个管道的注射器的无针注射器领域。需要解决的问题是喷射器与液体活性成分的长期兼容性。为此目的，注射器（1）包括圆柱形容器（2），其在其上游部分处由能够被驱动装置（70）移动的封闭元件（3）封闭，并且在其下游部分由注射器（4）封闭）包括至少一个注射管道，并且所述贮存器固定到注射器的本体（8），所述注射器使得与活性成分兼容的膜片（5）将其与注射器（4）和所述的当注射加压时，隔膜可以被液体（6）通过。

7. 发明授权

US07559920B2 Device for connecting an active substance container to an injection nozzle in a device used to inject said active substance 有权
标题翻译：用于将活性物质容器连接到用于注射所述活性物质的装置中的注射喷嘴的装置
公开(公告)号：US07559920B2
公开(公告)日：2009-07-14
申请号：US10553418
申请日：2004-04-15
申请人： Patrick Alexandre , Georges Baud , Bernard Brouquieres
发明人： Patrick Alexandre , Georges Baud , Bernard Brouquieres
IPC分类号： A61M5/00 , A61M5/30
CPC分类号： A61M5/30 , A61J1/062 , A61M5/24 , A61M5/3007 , A61M5/3134 , A61M2005/3117 , A61M2005/3132
摘要： The invention relates to an injection device which may or may not be equipped with a needle, comprising an injection nozzle and a tube which is intended to receive the active substance to be injected, whereby the tube is fixed to the nozzle using connecting means. The inventive device is characterized in that the aforementioned connecting means comprise at least three identical bosses which are solidly connected to the nozzle. Moreover, each of said bosses comprises an inclined part which terminates in a flange, said flange co-operating with a collar which is formed on the tube and acts as a backstop for the tube when the latter is connected to the nozzle.
摘要翻译：本发明涉及一种注射装置，其可以或可以不配备针头，该注射装置包括注射喷嘴和旨在接收待注射的活性物质的管，由此使用连接装置将管固定到喷嘴。本发明的装置的特征在于，上述连接装置包括至少三个相同的凸起，其牢固地连接到喷嘴。此外，每个所述凸台包括终止于凸缘的倾斜部分，所述凸缘与形成在管上的套环协同工作，并且当套管连接到喷嘴时用作管子的止回阀。

8. 发明授权

US07404808B2 Needleless syringe comprising an optimized injector-receptacle 有权
标题翻译：无针注射器包括优化的注射器 - 容器
公开(公告)号：US07404808B2
公开(公告)日：2008-07-29
申请号：US10546251
申请日：2004-04-09
申请人： Patrick Alexandre , Georges Baud , Bernard Brouquieres
发明人： Patrick Alexandre , Georges Baud , Bernard Brouquieres
IPC分类号： A61M5/30
CPC分类号： A61M5/3007 , A61M5/2046 , A61M5/30 , A61M2005/2013 , A61M2005/3132
摘要： The invention relates to the realm of needleless syringes used for injecting liquid active substances. Said syringe comprises a reservoir that is enclosed by means of displaceable plugs which trap the liquid. The reservoir is initially isolated from an injector-receptacle (37) which is provided with at least two peripheral injection conduits (38) that are arranged outside the receptacle (37). Said receptacle (37) encompasses a pocket bore (31) which accommodates the plug located downstream such that the optimized inlets (39) of the conduits are unobstructed. The face of the receptacle (37), which is located upstream, comprises a multilobed sealing joint (34) which is disposed parallel to and as close as possible to the edges of the bore (31) and the inlets (39). The aim of the invention is to create an injector-receptacle (37) that is optimized regarding discharging and the resistance thereof to the injection pressure.
摘要翻译：本发明涉及用于注射液体活性物质的无针注射器领域。所述注射器包括通过捕获液体的可移动塞子封闭的储存器。储存器最初与注射器 - 容器（37）隔离，所述注射器 - 容器（37）设置有布置在容器（37）外部的至少两个周边注射导管（38）。所述容器（37）包围一口袋孔（31），其容纳位于下游的塞子，使得导管的优化入口（39）畅通无阻。位于上游的容器（37）的表面包括多孔密封接头（34），其平行于并尽可能靠近孔（31）和入口（39）的边缘设置。本发明的目的是创建一种针对放电和针对注射压力的抵抗而优化的注射器 - 容器（37）。

9. 发明申请

US20060089595A1 Needleless injection device comprising means for regulating the gas pressure level in the combustion chamber 有权
标题翻译：无针注射装置包括用于调节燃烧室中的气体压力水平的装置
公开(公告)号：US20060089595A1
公开(公告)日：2006-04-27
申请号：US10547997
申请日：2004-03-18
申请人： Patrick Alexandre , Bernard Brouquieres , David Desailly
发明人： Patrick Alexandre , Bernard Brouquieres , David Desailly
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2046 , A61M5/46 , A61M5/484
摘要： The invention relates to a needleless injection device (1) comprising a body (2) which supports and/or defines a plurality of elements that form a circuit of elements. The aforementioned circuit comprises, from upstream towards downstream, an initiation device which is associated with a pyrotechnic gas generator, a receptacle (5) housing a liquid system. According to the invention, the pyrotechnic gas generator comprises a pyrotechnic charge (62) which is placed in a combustion chamber (4). The inventive device is characterised in that it comprises at least one device for regulating the gas pressure level in the combustion chamber (4).
摘要翻译：本发明涉及一种无针注射装置（1），其包括主体（2），其支撑和/或限定形成元件电路的多个元件。上述电路从上游到下游包括与烟火气体发生器相关联的启动装置，容纳液体系统的容器（5）。根据本发明，烟火气体发生器包括放置在燃烧室（4）中的烟火装置（62）。本发明的装置的特征在于它包括用于调节燃烧室（4）中的气体压力水平的至少一个装置。

10. 发明授权

US07559917B2 Needleless syringe functioning by compression of the reservoir containing the liquid active principle 有权
标题翻译：无针注射器通过压缩含有液体活性成分的储存器而起作用
公开(公告)号：US07559917B2
公开(公告)日：2009-07-14
申请号：US10332487
申请日：2001-07-27
申请人： Patrick Alexandre , Bernard Brouquieres , Bernard Pech
发明人： Patrick Alexandre , Bernard Brouquieres , Bernard Pech
IPC分类号： A61M37/00
CPC分类号： A61M5/30 , A61M5/2046 , A61M5/286 , A61M5/3007 , A61M5/31511 , A61M2005/3104
摘要： The invention concerns the field of pre-filled and disposable needleless syringes, operating with a gas generator and used for intradermal, subcutaneous and intramuscular injections of a liquid active principle for therapeutic purposes in human and veterinary medicine. Said injection device (1) is mainly characterized in that it has a free pressuring space (26) around the reservoir (20) of the active principle (17) so that the gases produced by the gas generator (4) instantly penetrate said pressurizing space (26), compressing said reservoir (20) just before causing the plunger to move (18) to expel the liquid active principle (17). During said displacement, the reservoir (20) is subjected to a state of equal pressure.
摘要翻译：本发明涉及预充填和一次性无针注射器的领域，其与气体发生器一起操作，并用于人和兽医学中用于治疗目的的液体活性成分的皮内，皮下和肌内注射。所述注射装置（1）的主要特征在于其在有源原理（17）的储存器（20）周围具有自由的加压空间（26），使得由气体发生器（4）产生的气体立即穿过所述加压空间（26），在使柱塞移动（18）之前压缩所述储存器（20）以排出液体活性成分（17）。在所述位移期间，储存器（20）经受相等压力的状态。

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