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1. 发明授权

US06294692B1 Process for producing N-formylleucine of high purity 失效
标题翻译：生产高纯度N-甲酰基亮氨酸的方法
公开(公告)号：US06294692B1
公开(公告)日：2001-09-25
申请号：US09460991
申请日：1999-12-15
申请人： Patricia Hussenet , Philippe Le Goff , Gérard Sennyey , Charles-Henry Vincent
发明人： Patricia Hussenet , Philippe Le Goff , Gérard Sennyey , Charles-Henry Vincent
IPC分类号： C07C22908
CPC分类号： C07C231/08
摘要： A process for producing N-formylleucine includes reacting leucine with formamide, precipitating the N-formylleucine, once the reaction is complete, at a temperature of approximately 0° to 40° C., by mixing the reaction medium with water and an acid, so that the final pH of the mixture is approximately 2 to 3, wherein the amount of water used in between approximately 1.5 and 5 parts per part by weight of starting formamide.
摘要翻译：生产N-甲酰基亮氨酸的方法包括使亮氨酸与甲酰胺反应，一旦反应完成，通过将反应介质与水和酸混合，在约0℃至40℃的温度下沉淀N-甲酰基亮氨酸，因此混合物的最终pH为约2至3，其中使用的水的量在约1.5至5重量份的起始甲酰胺之间。

2. 发明授权

US5648537A Process for the synthesis of substituted carbodiimides 失效
标题翻译：用于合成取代的碳二亚胺的方法
公开(公告)号：US5648537A
公开(公告)日：1997-07-15
申请号：US584944
申请日：1996-01-16
申请人： Patricia Hussenet , Philippe Le Goff , Gerard Sennyey
发明人： Patricia Hussenet , Philippe Le Goff , Gerard Sennyey
IPC分类号： C07C267/00
CPC分类号： C07C267/00
摘要： The invention relates to a new process for the synthesis of a disubstituted carbodiimide, including a first stage of phosgenation of an N,N'-disubstituted urea in an organic solvent medium.After this first stage ammonia is added to the reaction mixture without preliminary isolation of any intermediate compound.The process is simple, relatively inexpensive and the yield is high.Disubstituted carbodiimides are organic synthesis intermediates used especially in pharmaceutical chemistry as coupling agents in peptide synthesis.
摘要翻译：本发明涉及用于合成二取代碳二亚胺的新方法，包括在有机溶剂介质中N，N'-二取代脲的光气化的第一阶段。在第一阶段之后，将氨加入到反应混合物中，而不预先分离任何中间体化合物。该方法简单，成本较低，产量高。二取代的碳二亚胺是在药物化学中特别用作肽合成中的偶联剂的有机合成中间体。

3. 发明授权

US06702965B2 Method of forming a porous composite product, in particular with a high specific surface 有权
标题翻译：形成多孔复合制品的方法，特别是具有高比表面积的方法
公开(公告)号：US06702965B2
公开(公告)日：2004-03-09
申请号：US09957573
申请日：2001-09-20
申请人： Jean-François Penneau , François Capitaine , Philippe Le Goff
发明人： Jean-François Penneau , François Capitaine , Philippe Le Goff
IPC分类号： B29C6720
CPC分类号： B01D67/003 , B01D69/02 , B01D69/141 , B01D2323/10 , B01D2323/12 , B01J20/20 , B01J20/26 , B01J20/28014 , B01J20/28026 , B01J20/2803 , B01J20/28033 , B01J20/28057 , B01J20/28078 , B29C47/0004 , B29C47/0021 , C08J9/0066 , C08J9/26 , C08J2201/046 , C08L71/02 , C25B11/035 , H01G11/38 , H01G11/86 , H01M4/00 , H01M4/8605 , H01M4/96 , Y02E60/13 , Y10T428/249953 , Y10T428/249978 , Y10T428/249986 , C08L2666/04
摘要： A process for the preparation of a porous composite product. The process steps are forming a homogeneous mixture having one or more insoluble polymers, one or more soluble or calcinable polymers and one or more fillers, in particular with a high specific surface; extruding the mixture to form an extruded precursor product; removing the soluble or calcinable polymer or polymers from the extruded precursor product, in order to form pores, and recovering the porous composite product.
摘要翻译：一种制备多孔复合制品的方法。方法步骤是形成具有一种或多种不溶性聚合物，一种或多种可溶或可煅烧聚合物和一种或多种填料，特别是具有高比表面积的均匀混合物; 挤出混合物以形成挤出的前体产物; 从挤出的前体产物中除去可溶或可煅烧的聚合物或聚合物，以形成孔隙，并回收多孔复合材料产品。

4. 发明申请

US20080288062A1 DEVICE FOR SHRINKING OR REINFORCING THE VALVULAR ORIFICES OF THE HEART 审中-公开
标题翻译：用于收缩或加强心脏瓣膜的装置
公开(公告)号：US20080288062A1
公开(公告)日：2008-11-20
申请号：US11934095
申请日：2007-11-02
申请人： Raymond Andrieu , Philippe Le Goff , Afksendiyos Kalangos
发明人： Raymond Andrieu , Philippe Le Goff , Afksendiyos Kalangos
IPC分类号： A61F2/24
CPC分类号： A61B17/06166 , A61B2017/00004 , A61B2017/00783 , A61B2017/06057 , A61F2/2445 , A61F2002/30062 , A61F2210/0004 , A61L31/148
摘要： A device for shrinking and/or reinforcing the heart valve orifices includes a thick link (1) made of a bioresorbable, soft and curved material. It is secured at one of its ends to at least a thin yarn (3) whereof the end is fixed to a curved needle.
摘要翻译：用于收缩和/或加强心脏瓣膜孔的装置包括由生物可再吸收的柔软和弯曲的材料制成的厚连接件（1）。它的一端固定在至少一条细纱（3）上，其端部固定在弯曲的针上。

5. 发明申请

US20110238019A1 RESORBABLE INTRA-URETHRAL PROSTHESIS 失效
标题翻译：可持续的内部预测
公开(公告)号：US20110238019A1
公开(公告)日：2011-09-29
申请号：US12513405
申请日：2006-11-06
申请人： Raymond Andrieu , Philippe Le Goff , Milan Krajicek , Vaclav Vomacka
发明人： Raymond Andrieu , Philippe Le Goff , Milan Krajicek , Vaclav Vomacka
IPC分类号： A61M25/00
CPC分类号： A61F2/04 , A61F2002/047 , A61F2210/0004 , A61F2250/0039
摘要： The device made in a resorbable material intended to be placed in urethra for Treatment of stricture has the shape of a tube (1), the wall of which has offices (2).
摘要翻译：用于放置在尿道中用于治疗狭窄的可再吸收材料的装置具有管（1）的形状，其壁具有办公室（2）。

6. 发明申请

US20090299129A1 RECOVERABLE INTRA-UTERINE SYSTEM 有权
标题翻译：可恢复的内脏系统
公开(公告)号：US20090299129A1
公开(公告)日：2009-12-03
申请号：US12374290
申请日：2007-06-26
申请人： Pascal Mock , Nicolas Bouche , Philippe Le Goff
发明人： Pascal Mock , Nicolas Bouche , Philippe Le Goff
IPC分类号： A61B17/435 , A61B17/43
CPC分类号： A61F6/144 , A61B17/43 , A61B17/435
摘要： The recoverable intra-uterine system comprises a housing capable of containing one or a plurality of elements selected from among the group comprising an embryo, male and/or female gametes, a fertilized oocyte, and unfertilized ovum and a combination of these elements, the housing having along an axis a distal end and a proximal end, and a device for holding the recoverable intra-uterine device in the uterus. The holding device is arranged at the proximal end of the housing and includes at least one holding arm in the uterine cavity capable of taking at least two positions: —one free position in which at least one holding arm is separated from the axis; and —a retracted position in which at least one holding arm is substantially parallel to the axis. Use in medically assisted reproduction techniques.
摘要翻译：可恢复的子宫内系统包括能够包含选自包括胚，雄和/或雌配子，受精卵母细胞和未受精卵的组中的一种或多种元件的壳体和这些元件的组合，所述壳体沿着轴线具有远端和近端，以及用于将可恢复的子宫内装置保持在子宫中的装置。保持装置设置在壳体的近端处，并且在子宫腔中包括至少一个保持臂，其能够至少采取两个位置： - 一个自由位置，其中至少一个保持臂与轴线分离; 和 - 至少一个保持臂基本上平行于所述轴线的缩回位置。用于医疗辅助生殖技术。

7. 发明授权

US5386057A Process for the preparation of acyl isocyanates 失效
标题翻译：酰基异氰酸酯的制备方法
公开(公告)号：US5386057A
公开(公告)日：1995-01-31
申请号：US100177
申请日：1993-08-02
申请人： Philippe Le Goff , Daniele Dewilde , Noriyuki Tsuboniwa , Satoshi Urano
发明人： Philippe Le Goff , Daniele Dewilde , Noriyuki Tsuboniwa , Satoshi Urano
IPC分类号： C07B43/10 , C07C263/10 , C07C265/12 , C07C265/16 , C07C275/16 , C07C249/00
CPC分类号： C07C263/10 , C07C2101/14
摘要： The invention concerns a process for the preparation of acyl isocyanates which consists of reacting oxalyl chloride with a salt selected from the group consisting of hydrohalides and sulphates of carboxamides and/or carbamates, unsubstituted on nitrogen, then heating the reaction mixture at a temperature between 30.degree. and 150.degree. C. The process is suitable for preparation of acyl isocyanates with excellent yields in easy to control operational conditions.
摘要翻译：本发明涉及一种制备酰基异氰酸酯的方法，该方法由草酰氯与选自由氮取代的羧酰胺和/或氨基甲酸酯的氢卤酸盐和硫酸盐组成的组中反应的盐组成，然后在30℃的温度下加热反应混合物 DEG和150℃。该方法适用于在易于控制操作条件下具有优异产率的酰基异氰酸酯的制备。

8. 发明申请

US20130110452A1 PERMANENT SYSTEM FOR 3D LOCATION OF AN INDIVIDUAL MOVING INSIDE A BUILDING 审中-公开
标题翻译：用于建筑物内个人移动的三维位置的永久系统
公开(公告)号：US20130110452A1
公开(公告)日：2013-05-02
申请号：US13695462
申请日：2011-04-13
申请人： Philippe Le Goff , Catherine Hugel-Le Goff , Raymond Andrieu
发明人： Philippe Le Goff , Catherine Hugel-Le Goff , Raymond Andrieu
IPC分类号： G01C22/00 , G06F15/00
CPC分类号： G01C22/006 , G01C21/20 , G06F15/00
摘要： A system for accurately locating and positioning a person moving or standing still inside a hostile or severely damaged environment. For a person walking through any given environment, the location system continuously provides coordinates for positioning the person within the environment relative to the entry point thereof. The location system uses the morphological data of the person and integrates the person's movement in real time by acquiring features of the person's pace as the result of simultaneously combining the angles formed by the ankles, knees and hips of the person when walking, measured by electrogoniometers and interpreted according to a developed calculation method. The location system outdoes other existing solutions for locating a person in a difficult environment, such as, inside an underground building, partially collapsed and filled with opaque smoke, without the risk of faulty measurements, since it does not track by waves or by any vision-based system.
摘要翻译：一个准确定位和定位移动或站立在敌对或严重受损环境中的人的系统。对于通过任何给定环境的人来说，定位系统连续提供相对于其入口点在环境中定位人的坐标。定位系统使用人的形态学数据，通过获取人的脚步的特征，通过同步组合步行时由人的脚踝，膝盖和臀部形成的角度，通过电子计量器测量，实时整合人的运动并根据开发的计算方法进行解释。定位系统超出了其他现有的解决方案，用于将人们置于困难的环境中，例如在地下建筑物内部，部分塌陷并充满不透明的烟雾，而不会有不正确的测量的风险，因为它不会被波浪或任何视觉追踪的系统。

9. 发明申请

US20110152495A1 METHOD FOR MOULDING POLY(1,4-DIOXANONE) 审中-公开
标题翻译：聚（1,4-二氧杂环己烷）
公开(公告)号：US20110152495A1
公开(公告)日：2011-06-23
申请号：US13001865
申请日：2008-06-30
申请人： Philippe Le Goff , Raymond Andrieu
发明人： Philippe Le Goff , Raymond Andrieu
IPC分类号： A61L31/06 , B29C45/72 , C08G63/664
CPC分类号： B29C45/0001 , A61B17/122 , A61L31/06 , B29K2995/006 , C08L67/04
摘要： A method of moulding a bioresorbable polymer for producing a bioresorbable medical device includes the following successive steps: (a) heating a poly(1,4-dioxanone) in the absence of any solvent of this polymer to a mass temperature between 145° C. and 165° C., (b) injection moulding the molten mass obtained in step (a) in a mould which is at a temperature of 80° C. to 115° C. lower than the mass temperature of the poly(1,4-dioxanone), (c) cooling the mould until solidification of the mass of poly(1,4-dioxanone), and (d) removing the thus obtained part from the mould. Also described is a moulded part which can be obtained by such a method as well as a medical device containing such a part.
摘要翻译：一种生产可再生的可再生聚合物的生产可生物再吸收的医疗器械的方法包括以下连续步骤：（a）在不存在该聚合物溶剂的情况下加热聚（1,4-二恶烷酮）至145℃ 和165℃，（b）将在步骤（a）中获得的熔融物质注入模具中，该模具的温度低于聚（1,4）的质量温度为80℃至115℃ 二恶烷酮），（c）冷却模具直至聚（1,4-二恶烷酮）团块固化，和（d）从模具中除去所得部分。还描述了可以通过这种方法获得的模制部件以及包含这种部件的医疗装置。

10. 发明授权

US07384686B2 Porous composite product in particular with a high specific surface preparation process and electrode formed of a porous composite film for an electro-chemical assembly 有权
标题翻译：多孔复合产品，特别是具有高比表面处理工艺和由用于电化学组装的多孔复合膜形成的电极
公开(公告)号：US07384686B2
公开(公告)日：2008-06-10
申请号：US10390422
申请日：2003-03-17
申请人： Jean-François Penneau , François Capitaine , Philippe Le Goff
发明人： Jean-François Penneau , François Capitaine , Philippe Le Goff
IPC分类号： B32B5/22 , H01G9/058 , H01M4/60
CPC分类号： B01D67/003 , B01D69/02 , B01D69/141 , B01D2323/10 , B01D2323/12 , B01J20/20 , B01J20/26 , B01J20/28014 , B01J20/28026 , B01J20/2803 , B01J20/28033 , B01J20/28057 , B01J20/28078 , B29C47/0004 , B29C47/0021 , C08J9/0066 , C08J9/26 , C08J2201/046 , C08L71/02 , C25B11/035 , H01G11/38 , H01G11/86 , H01M4/00 , H01M4/8605 , H01M4/96 , Y02E60/13 , Y10T428/249953 , Y10T428/249978 , Y10T428/249986 , C08L2666/04
摘要： A porous composite product in the form of a film with a high specific surface. Used in a wide range of electrochemical products especially in the field of selective membranes, packaging or catalysis. The porous composite product has a high homogeneity in the distribution of the filler and a continuous structure. The product is capable of being obtained by extrusion.
摘要翻译：具有高比表面积的薄膜形式的多孔复合产品。用于广泛的电化学产品，特别是在选择性膜，包装或催化领域。多孔复合材料在填料分布方面具有高均匀性，并具有连续的结构。该产品能够通过挤出获得。

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