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    • 6. 发明申请
    • ILEAL ELECTRICAL STIMULATION
    • ILEAL电刺激
    • US20110066208A1
    • 2011-03-17
    • US12865292
    • 2009-01-30
    • Pankaj PasrichaJiande Chen
    • Pankaj PasrichaJiande Chen
    • A61N1/36
    • A61N1/36007
    • The disclosure is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways. The stimulatory electrodes are placed by laparoscopic, endoscopic or surgical means.
    • 本公开是在需要的个体中治疗肥胖症的方法,包括将远端小肠或回肠中的刺激电极定位,并且在电刺激有效的脉冲或重复脉冲列中给予电刺激,至少在 部分地,刺激远端小肠或回肠的迷走神经传入和传出活动。 迷走神经传入和传出活动的刺激导致回肠制动器的调节。 具体地说,在脉冲串中提供电刺激。 此外,描述了通过回肠电刺激治疗功能性胃肠道疾病的方法。 此外,本发明提供了一种饮食障碍的治疗方法,包括给予至少部分刺激迷走神经和交感神经通路有效的回肠电刺激。 刺激电极通过腹腔镜,内窥镜或外科手段放置。
    • 8. 发明授权
    • Gastrointestinal electrical stimulation for the treatment of pacreatitis
    • 胃肠电刺激治疗胰腺炎
    • US08326427B2
    • 2012-12-04
    • US12836377
    • 2010-07-14
    • Pankaj PasrichaJlande Chen
    • Pankaj PasrichaJlande Chen
    • A61N1/00
    • A61N1/36007A61N1/05A61N1/0517A61N1/0551
    • A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.
    • 一种预防急性胰腺炎的方法,包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。 电极通过腹腔镜,内窥镜或外科手段放置。 胃肠道刺激激活迷走神经反射。 迷走神经反射的激活是通过胃和胰腺传入的。 胃肠道刺激也激活轴突反射。 轴突反射的激活是通过脊神经的二分支。 电刺激与内窥镜手术同时进行或立即进行内镜手术。 此外,本文提供了一种防止内脏器官炎症的方法,包括将刺激电极定位在迷走神经中的下降传出物附近,有意义的个体的内脏器官,并施用有效的短脉冲电刺激重复训练 在激活烟碱受体。
    • 9. 发明申请
    • GASTROINTESTINAL ELECTRICAL STIMULATION FOR THE TREATMENT OF PANCREATITIS
    • 用于治疗胰腺炎的胃肠电刺激
    • US20110015695A1
    • 2011-01-20
    • US12836377
    • 2010-07-14
    • Pankaj PasrichaJiande Chen
    • Pankaj PasrichaJiande Chen
    • A61N1/05
    • A61N1/36007A61N1/05A61N1/0517A61N1/0551
    • A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.
    • 一种预防急性胰腺炎的方法,包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。 电极通过腹腔镜,内窥镜或外科手段放置。 胃肠道刺激激活迷走神经反射。 迷走神经反射的激活是通过胃和胰腺传入的。 胃肠道刺激也激活轴突反射。 轴突反射的激活是通过脊神经的二分支。 电刺激与内窥镜手术同时进行或立即进行内镜手术。 此外,本文提供了一种防止内脏器官炎症的方法,包括将刺激电极定位在迷走神经中的下降传出物附近,有意义的个体的内脏器官,并施用有效的短脉冲电刺激重复训练 在激活烟碱受体。