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1. 发明授权

US5788625A Method of making reconstructive SIS structure for cartilaginous elements in situ 失效
标题翻译：原位软骨元件重建SIS结构的方法
公开(公告)号：US5788625A
公开(公告)日：1998-08-04
申请号：US628773
申请日：1996-04-05
申请人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
发明人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
IPC分类号： A61L27/00 , A61B17/04 , A61B17/28 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61F2/04
CPC分类号： A61F2/3872 , A61B17/282 , A61F2/30756 , A61B17/0482 , A61B2017/00969 , A61B2017/320052 , A61F2/3094 , A61F2/40 , A61F2/4261 , A61F2/442 , A61F2002/30461 , A61F2002/30563 , A61F2002/30971 , A61F2220/0075 , A61F2240/001 , Y10S623/908
摘要： A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of a small intestine submucosa compressed and secured together and shaped to provide the multi-layered reconstructive element of the anatomical shape of the cartilaginous element to be constructed. The method of forming the reconstructive structure includes superimposing the planar layers of the small intestine compressing, securing and cutting to the desired shape. The superimposing is performed so as to maintain the layers substantially planar prior to compressing and securing. The method of reconstructing a cartilaginous element includes removing at least a portion, if not substantially all of the cartilaginous element, but leaving a seed portion, sculpturing the reconstructive structure to the anatomical shape of the cartilaginous element to be reconstructed; positioning the receptive element adjacent to the seed portion and securing it thereto. To reconstruct a joint having two bones separated by a cartilaginous material, the method includes removing any remaining portions of the cartilaginous material down to a bleeding bone site and positioning and securing the reconstructive element to the bleeding bone site. A barrier layer may be provided between the bleeding bone site and the reconstruction element. Also, a defect site without a bleeding bone site may be created and used with a reconstructive element.
摘要翻译：用于软骨元件的重建结构，其具有压缩并固定在一起并成形为提供要构造的软骨元件的解剖形状的多层重建元件的小肠粘膜下层的多个叠层。形成重建结构的方法包括将小肠的平面层压缩，固定和切割叠加到期望的形状。执行叠加以在压缩和固定之前将层保持基本上平面。重建软骨元件的方法包括去除至少一部分（如果不是基本上全部的软骨元件）但留下种子部分，将重建结构雕刻成待重建的软骨元件的解剖形状; 将接受元件定位成与种子部分相邻并将其固定到其上。为了重建具有由软骨材料分离的两个骨骼的关节，该方法包括将软骨材料的剩余部分移除到出血骨部位并将重建元件定位并固定到出血骨部位。可以在出血骨部位和重建元件之间设置阻挡层。此外，可以创建没有出血骨部位的缺损部位并与重建元件一起使用。

2. 发明授权

US06793676B2 Method of reconstructing a joint 有权
标题翻译：重建关节的方法
公开(公告)号：US06793676B2
公开(公告)日：2004-09-21
申请号：US09767346
申请日：2001-01-23
申请人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
发明人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
IPC分类号： A61F208
CPC分类号： A61F2/3872 , A61B17/0482 , A61B17/282 , A61B2017/00969 , A61B2017/320052 , A61F2/30756 , A61F2/3094 , A61F2/40 , A61F2/4261 , A61F2/442 , A61F2002/30461 , A61F2002/30563 , A61F2002/30971 , A61F2220/0075 , A61F2240/001 , Y10S623/908
摘要： A method of reconstructing a joint having two bones separated by cartilaginous material is provided. The method comprises the steps of removing a portion of the cartilaginous material to create a defect site, positioning an anatomically shaped reconstructive structure comprising multiple layers of submucosa and having a thickness of about 1 to about 12 millimeters adjacent to the defect site, and securing the reconstructive structure to the defect site. The method can further comprise the steps of positioning a barrier layer between the bleeding bone and the reconstructive structure, securing the barrier layer to the bleeding bone, and securing the reconstructive structure to the barrier layer.
摘要翻译：提供了一种重建具有由软骨材料分离的两个骨骼的关节的方法。该方法包括以下步骤：去除软骨材料的一部分以产生缺陷部位，定位包括多层粘膜下层的解剖学形状的重建结构，并且具有邻近缺损部位约1至约12毫米的厚度，重建结构到缺陷部位。该方法还可以包括以下步骤：将渗透骨与重建结构之间的阻挡层定位，将阻挡层固定到出血骨，以及将重建结构固定到阻挡层。

3. 发明授权

US06176880B1 Tissue graft construct for replacement of cartilaginous structures 失效
公开(公告)号：US06176880B1
公开(公告)日：2001-01-23
申请号：US08913771
申请日：1997-12-17
申请人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
发明人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
IPC分类号： A61F208
CPC分类号： A61F2/3872 , A61B17/0482 , A61B17/282 , A61B2017/00969 , A61B2017/320052 , A61F2/30756 , A61F2/3094 , A61F2/40 , A61F2/4261 , A61F2/442 , A61F2002/30461 , A61F2002/30563 , A61F2002/30971 , A61F2220/0075 , A61F2240/001 , Y10S623/908
摘要： A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of intestinal submucosa tissue compressed and secured together and shaped to provide a reconstructive structure having the anatomical shape of the cartilaginous element to be reconstructed is described. The method of forming the reconstructive structure includes superimposing the planar layers of the intestinal submucosa tissue, securing the layers to form a multi-layered structure and cutting the resulting multi-layered structure to the desired shape.

4. 发明授权

US5922028A Multi-layered SIS tissue graft construct for replacement of cartilaginous elements in situ 失效
标题翻译：用于替代原位软骨元件的多层SIS组织移植物构建体
公开(公告)号：US5922028A
公开(公告)日：1999-07-13
申请号：US951327
申请日：1997-10-16
申请人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
发明人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
IPC分类号： A61L27/00 , A61B17/04 , A61B17/28 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61F2/08
CPC分类号： A61F2/3872 , A61B17/282 , A61F2/30756 , A61B17/0482 , A61B2017/00969 , A61B2017/320052 , A61F2/3094 , A61F2/40 , A61F2/4261 , A61F2/442 , A61F2002/30461 , A61F2002/30563 , A61F2002/30971 , A61F2220/0075 , A61F2240/001 , Y10S623/908
摘要： A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of a small intestine submucosa compressed and secured together and shaped to provide the multilayered reconstructive element of the anatomical shape of the cartilaginous element to be constructed. The method of forming the reconstructive structure includes superimposing the planar layers of the small intestine compressing, securing and cutting to the desired shape. The superimposing is performed so as to maintain the layers substantially planar prior to compressing and securing. The method of reconstructing a cartilaginous element includes removing at least a portion, if not substantially all of the cartilaginous element, but leaving a seed portion, sculpturing the reconstructive structure to the anatomical shape of the cartilaginous element to be reconstructed; positioning the receptive element adjacent to the seed portion and securing it thereto. To reconstruct a joint having two bones separated by a cartilaginous material, the method includes removing any remaining portions of the cartilaginous material down to a bleeding bone site and positioning and securing the reconstructive element to the bleeding bone site. A barrier layer may be provided between the bleeding bone site and the reconstruction element. Also, a defect site without a bleeding bone site may be created and used with a reconstructive element.
摘要翻译：用于软骨元件的重建结构，其具有压缩并固定在一起并成形为提供要构建的软骨元件的解剖形状的多层重建元件的小肠粘膜下层的多个叠层。形成重建结构的方法包括将小肠的平面层压缩，固定和切割叠加到期望的形状。执行叠加以在压缩和固定之前将层保持基本上平面。重建软骨元件的方法包括去除至少一部分（如果不是基本上全部的软骨元件）但留下种子部分，将重建结构雕刻成待重建的软骨元件的解剖形状; 将接受元件定位成与种子部分相邻并将其固定到其上。为了重建具有由软骨材料分离的两个骨骼的关节，该方法包括将软骨材料的剩余部分移除到出血骨部位并将重建元件定位并固定到出血骨部位。可以在出血骨部位和重建元件之间设置阻挡层。此外，可以创建没有出血骨部位的缺损部位并与重建元件一起使用。

5. 发明授权

US08361467B2 Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权
标题翻译：将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节
公开(公告)号：US08361467B2
公开(公告)日：2013-01-29
申请号：US10630227
申请日：2003-07-30
申请人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
发明人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K39/395 , A61K39/00 , A61K38/18
CPC分类号： A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要： The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译：本发明涉及向患病关节中透射施用高特异性拮抗剂，所述高特异性拮抗剂选自：i）促炎白细胞介素的抑制剂; ii）TNF-α合成抑制剂; iii）膜结合TNF-α的抑制剂; iv）TNF-α的天然受体的抑制剂; v）NO合酶抑制剂，vi）PLA2酶抑制剂; vii）抗增殖剂; viii）抗氧化剂; ix）选自EPO模拟肽，EPO模拟物，IGF-I，IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂，和x）MMP的抑制剂; 和xi）p38激酶的抑制剂。

6. 发明授权

US07361195B2 Cartilage repair apparatus and method 有权
标题翻译：软骨修复装置及方法
公开(公告)号：US07361195B2
公开(公告)日：2008-04-22
申请号：US10195347
申请日：2002-07-15
申请人： Herbert E. Schwartz , Prasanna Malaviya , Mark J. Pelo , Pamela L. Plouhar
发明人： Herbert E. Schwartz , Prasanna Malaviya , Mark J. Pelo , Pamela L. Plouhar
IPC分类号： A61F2/28
CPC分类号： A61L27/3886 , A61B2017/0641 , A61B2017/0646 , A61B2017/0647 , A61F2/0063 , A61F2/0811 , A61F2/30749 , A61F2/30756 , A61F2/3872 , A61F2002/30294 , A61F2002/30299 , A61F2002/30579 , A61F2002/30751 , A61F2002/30766 , A61F2230/0091 , A61F2230/0093 , A61L27/3629 , A61L27/3633 , A61L27/3654 , A61L27/3683 , A61L27/3852 , A61L2430/06
摘要： An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.
摘要翻译：用于修复和再生软骨的矫形装置包括构造成定位在形成在软骨中的孔中的栓塞和构造成支撑插塞的锚固件。塞子和锚固体中的一个或两个可以由天然存在的细胞外基质如小肠粘膜下层形成。还公开了一种软骨修复和再生的方法。

7. 发明授权

US07160333B2 Reinforced small intestinal submucosa 有权
标题翻译：加强小肠粘膜下层
公开(公告)号：US07160333B2
公开(公告)日：2007-01-09
申请号：US10656345
申请日：2003-09-05
申请人： Pamela L. Plouhar , Prasanna Malaviya , Joe W. Ferguson , Mora C. Melican
发明人： Pamela L. Plouhar , Prasanna Malaviya , Joe W. Ferguson , Mora C. Melican
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61F2/0063 , A61F2/08 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3641 , A61L27/40 , C08L67/04
摘要： Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.
摘要翻译：提供了用于软组织附着，加强或构造的生物假体装置。该装置包括一片天然存在的细胞外基质和与天然存在的细胞外基质部分相连的一片合成网。

8. 发明授权

US06638312B2 Reinforced small intestinal submucosa (SIS) 有权
公开(公告)号：US06638312B2
公开(公告)日：2003-10-28
申请号：US09918116
申请日：2001-07-30
申请人： Pamela L. Plouhar , Prasanna Malaviya , Joe W. Ferguson , Mora C. Melican
发明人： Pamela L. Plouhar , Prasanna Malaviya , Joe W. Ferguson , Mora C. Melican
IPC分类号： A61F202
CPC分类号： A61L27/3683 , A61F2/0063 , A61F2/08 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3641 , A61L27/40 , C08L67/04
摘要： A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the synthetic portion comprises one or more rows of fibers or mesh positioned between layers of the small intestine submucosa.

9. 发明授权

US07201917B2 Porous delivery scaffold and method 有权
标题翻译：多孔递送支架和方法
公开(公告)号：US07201917B2
公开(公告)日：2007-04-10
申请号：US10195633
申请日：2002-07-15
申请人： Prasanna Malaviya , Herbert E. Schwartz , Pamela L. Plouhar , Janine M. Orban
发明人： Prasanna Malaviya , Herbert E. Schwartz , Pamela L. Plouhar , Janine M. Orban
IPC分类号： A61K45/00 , C12N5/02
CPC分类号： A61L27/3843 , A61B17/064 , A61B17/0642 , A61B2017/0646 , A61F2/0063 , A61F2/0811 , A61F2/30749 , A61F2/3872 , A61F2002/30294 , A61F2002/30751 , A61F2002/30766 , A61F2230/0091 , A61L27/18 , A61L27/3604 , A61L27/3633 , A61L27/3687 , A61L27/3691 , A61L27/54 , A61L27/56 , A61L31/005 , A61L2300/252 , A61L2300/412 , A61L2300/602 , A61L2300/64 , A61L2430/06 , C08L67/04
摘要： A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. The scaffold may further comprise biological agents that promote tissue repair and healing. Porous implantable scaffolds fabricated by such a method are also disclosed.
摘要翻译：制造用于修复受损或患病组织的可植入支架的方法包括将细胞外基质材料块悬浮在液体中的步骤。细胞外基质材料和液体形成质量。随后将液体排出，以便在质量块中形成空隙。支架还可包含促进组织修复和愈合的生物制剂。还公开了通过这种方法制造的多孔可植入支架。

10. 发明授权

US08025896B2 Porous extracellular matrix scaffold and method 有权
标题翻译：多孔细胞外基质支架及方法
公开(公告)号：US08025896B2
公开(公告)日：2011-09-27
申请号：US10195354
申请日：2002-07-15
申请人： Prasanna Malaviya , Herbert E. Schwartz , Pamela L. Plouhar , Mark J. Pelo
发明人： Prasanna Malaviya , Herbert E. Schwartz , Pamela L. Plouhar , Mark J. Pelo
IPC分类号： A61F2/00
CPC分类号： A61L27/3691 , A61B2017/0646 , A61F2/0063 , A61F2/0811 , A61F2/30749 , A61F2/3872 , A61F2002/30294 , A61F2002/30751 , A61F2002/30766 , A61F2230/0091 , A61L27/3604 , A61L27/3633 , A61L27/365 , A61L27/3654 , A61L27/3683 , A61L27/3847 , A61L27/3852 , A61L27/56 , A61L31/005 , A61L2430/06
摘要： A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. Porous implantable scaffolds fabricated by such a method are also disclosed.
摘要翻译：制造用于修复受损或患病组织的可植入支架的方法包括将细胞外基质材料块悬浮在液体中的步骤。细胞外基质材料和液体形成质量。随后将液体排出，以便在质量块中形成空隙。还公开了通过这种方法制造的多孔可植入支架。

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