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    • 1. 发明授权
    • Fully hydraulic steering
    • 全液压转向
    • US06971472B2
    • 2005-12-06
    • US10727905
    • 2003-12-04
    • Ove PedersenBjarne Schmidt
    • Ove PedersenBjarne Schmidt
    • B62D5/09B62D5/093B62D5/32B62D5/06
    • B62D5/091B62D5/093B62D5/32
    • The invention concerns a fully hydraulic steering with a steering member, a steering unit that can be activated by the steering member, said steering unit comprising a supply connection arrangement (P, T) with a pressure connection (P) and a tank connection (T), and a working connection arrangement (L, R) with two working connections (L, R), and a steering motor, which is connected with the working connection arrangement (L, R). It is endeavored to increase the possibilities of steering. For this purpose, it is ensured that an auxiliary force operated steering valve is arranged in parallel to the steering unit between the supply connection arrangement (P, T) and the working connection arrangement (L, R).
    • 本发明涉及一种具有转向构件的全液压转向装置,一种可由转向构件启动的转向装置,所述转向装置包括具有压力连接(P)和油箱连接(T)的供应连接装置(P,T) )和与工作连接装置(L,R)连接的具有两个工作连接(L,R)和转向马达的工作连接装置(L,R)。 努力提高转向的可能性。 为此,确保辅助力操作转向阀与供给连接装置(P,T)和工作连接装置(L,R)之间的转向单元平行布置。
    • 2. 发明授权
    • Phenyl derivatives containing an acidic group, their preparation and their use as chloride channel blockers
    • US06417393B1
    • 2002-07-09
    • US09194083
    • 1999-01-22
    • Palle ChristophersenOve Pedersen
    • Palle ChristophersenOve Pedersen
    • C07C24100
    • C07C311/47A61K31/155A61K31/17C07C233/55C07C271/58C07C275/40C07C275/42C07C309/51C07C311/08C07C311/21C07C311/60C07C335/22
    • The present patent application relates to compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein one of R1, R2 and R3 is a non-cyclic acidic group having a pKa value below 8 or a group which is in vivo convertible to such a group; R4, R5 and the other two of the substituents R1, R2 and R3 are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amnino, and aryl, aralkyl, arylamino, aryloxy, aryl—CO—, or heteroaryl, wherein the aryl and heteroaryl groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or R3 and R4 or R4 and R5 together form a fused 4- to 7-membered carbocyclic ring which may be unsaturated, or partially or fully saturated, while the other substituents R1, R2, R3, R4 and R5 are as defined above; Y is —CO—, —CS—, —SO2—, or —C(═N—R8)—, wherein R8 is hydrogen, alkyl, or cyano; X is —NH—, —CH2—NH—, or —SO2—NH—; Z is NR6, O, —CH═CH—, —C═C—, —N═CH—, or —CH═N—; wherein R6 is hydrogen, or alkyl; R11, R12, R13, R14 and R15 are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, —NHSO2—R7, —COOR7, —SO2N(R7)2, —SO2OR7 and —CO—R7, wherein R7 is hydrogen alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl or aralkyl; and aryl, aralkyl, arylamino, aryloxy, aryl-CO—, or heteroaryl, wherein the aryl and heteroaryl groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or one of R11 and R12, R12 and R13, R13 and R14 or R14 and R15 together form a fused 4- to 7-membered carbocyclic ring which may be unsaturated, or partially or fully saturated, while the other substituents R11, R12, R13, R14 and R15 are as defined above. The compounds are useful for the treatment of diseases and disorders responsive to the blockage of chloride channels.