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1. 发明授权

US06864280B2 γ-Tocotrienol-containing diuretics 失效
标题翻译：含有γ-生育三烯酚的利尿剂
公开(公告)号：US06864280B2
公开(公告)日：2005-03-08
申请号：US10239945
申请日：2001-03-27
申请人： Osamu Igarashi , Chikako Kiyose , Hiroyuki Yoshimura , Shigehiro Yoshitake
发明人： Osamu Igarashi , Chikako Kiyose , Hiroyuki Yoshimura , Shigehiro Yoshitake
IPC分类号： A61K31/353 , A61K31/355 , A61P3/12 , A61P7/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , C07D311/72
CPC分类号： C07D311/72 , A61K31/353 , A61K31/355
摘要： The present invention provides a diuretic, sodium ion-excreting agent, medicament for preventing or treating hypertension, medicament for preventing or treating ischemic cardiac diseases, medicament for preventing or treating congestive cardiac insufficiency or medicament for preventing or treating renal diseases, which comprises γ-tocotrienol.
摘要翻译：本发明提供了一种利尿剂，钠离子排泄剂，用于预防或治疗高血压的药物，用于预防或治疗缺血性心脏病的药物，用于预防或治疗充血性心脏功能不全的药物或用于预防或治疗肾脏疾病的药物，生育三烯酚

2. 发明授权

US06780886B2 Antioxidant containing vitamin E metabolite 有权
标题翻译：含维生素E代谢物的抗氧化剂
公开(公告)号：US06780886B2
公开(公告)日：2004-08-24
申请号：US09963365
申请日：2001-09-27
申请人： Kazuo Kondo , Osamu Igarashi , Chikako Kiyose , Hiroyuki Yoshimura , Shigehiro Yoshitake
发明人： Kazuo Kondo , Osamu Igarashi , Chikako Kiyose , Hiroyuki Yoshimura , Shigehiro Yoshitake
IPC分类号： A61K31352
CPC分类号： A61K31/355 , A61K31/353 , Y10S514/824
摘要： The present invention provides a method of preventing or treating a disease caused by oxidation in vivo by administering a pharmacologically effective amount of at least one compound selected from the group consisting of: (1) 2,5,7,8-tetramethyl-2-(&bgr;-carboxyethyl)-6-hydroxychromane; and (2) 2,7, 8-trimethyl-2-(&bgr;-carboxyethyl)-6-hydroxychromane. Further, it provides use of a compound selected from the group consisting of (3) &agr;-tocopherol, (4) &agr;-tocotrienol, (5) &ggr;-tocopherol and (6) &ggr;-tocotrienol for generation in vivo of any of the above compounds (1) and (2) to treat a disease caused by oxidated low density lipoprotein (LDL).
摘要翻译：本发明提供一种通过施用药理学有效量的至少一种选自下组的化合物来预防或治疗由体内氧化引起的疾病的方法：（1）2,5,7,8-四甲基-2- （β-羧乙基）-6-羟基苯并二氢吡喃; 和（2）2,7,8-三甲基-2-（β-羧乙基）-6-羟基苯并二氢吡喃。此外，其提供了使用选自（3）α-生育酚，（4）α-生育三烯酚，（5）γ-生育酚和（6）γ-生育三烯酚的化合物，用于在上述任一种中产生化合物（1）和（2）治疗由氧化低密度脂蛋白（LDL）引起的疾病。

3. 发明授权

US08767204B2 Spectrophotometer 有权
标题翻译：分光光度计
公开(公告)号：US08767204B2
公开(公告)日：2014-07-01
申请号：US13493736
申请日：2012-06-11
申请人： Toshiro Kimura , Hiroyuki Yoshimura
发明人： Toshiro Kimura , Hiroyuki Yoshimura
IPC分类号： G01J3/42 , G01J3/08 , G01J3/02
CPC分类号： G01J3/08 , G01J3/027 , G01J3/42
摘要： A spectrophotometer 10 includes built-in detector 24 and external detector 32. When a mountable/removable optical path switcher 23a is installed in a specimen chamber 23, measurement based on detection signals from built-in detector 24 is replaced by measurement based on detection signals from external detector 32. The spectrophotometer further includes a measurement data threshold-value storage unit 51 that stores threshold value T for measurement data from built-in detector 24 or external detector 32, and a light-receiving detector recognition unit 52 that recognizes which detector is able to receive the measuring light beam based on the results of a comparison between threshold value T and measurement data from built-in detector 24 or external detector 32 while the measuring light beam is being introduced into specimen chamber 23.
摘要翻译：分光光度计10包括内置检测器24和外部检测器32.当将可安装/可拆卸光路切换器23a安装在样本室23中时，基于来自内置检测器24的检测信号的测量被基于检测信号分光光度计还包括测量数据阈值存储单元51，其存储来自内置检测器24或外部检测器32的测量数据的阈值T，以及光接收检测器识别单元52，其识别哪个检测器能够基于来自内置检测器24或外部检测器32的阈值T与测量数据之间的比较结果同时测量光束被引入到样本室23中而接收测量光束。

4. 发明授权

US07061702B2 Master disk device for transferring magnetic patterns to both sides of a magnetic recording medium, and alignment device therefor and alignment method thereof 失效
标题翻译：用于将磁图案转印到磁记录介质的两侧的主磁盘装置及其对准装置及其对准方法
公开(公告)号：US07061702B2
公开(公告)日：2006-06-13
申请号：US10714815
申请日：2003-11-17
申请人： Hiroyuki Yoshimura , Kiminori Sato
发明人： Hiroyuki Yoshimura , Kiminori Sato
IPC分类号： G11B5/86
CPC分类号： G11B5/82 , G11B5/865
摘要： To enable alignment of a magnetic pattern of a pair of master disks and a magnetic recording medium, each of the master disks has at least a pair of alignment marks disposed outside the region of the magnetic pattern. The master disks can be optically transparent or semi-transparent. The master disks can be aligned while the alignment marks are externally observed.
摘要翻译：为了能够对准一对母盘和磁记录介质的磁性图案，每个主盘具有至少一对设置在磁图案的区域外的对准标记。主盘可以是光学透明的或半透明的。可以对准主盘，同时外部观察对准标记。

5. 发明授权

US06630463B2 Heterocycle-containing carboxylic acid derivative and drug containing the same 失效
标题翻译：含有杂环的羧酸衍生物和含有它们的药物
公开(公告)号：US06630463B2
公开(公告)日：2003-10-07
申请号：US09910068
申请日：2001-07-23
申请人： Kouichi Kikuchi , Katsuya Tagami , Hiroyuki Yoshimura , Shigeki Hibi , Mitsuo Nagai , Shinya Abe , Makoto Okita , Takayuki Hida , Seiko Higashi , Naoki Tokuhara , Seiichi Kobayashi
发明人： Kouichi Kikuchi , Katsuya Tagami , Hiroyuki Yoshimura , Shigeki Hibi , Mitsuo Nagai , Shinya Abe , Makoto Okita , Takayuki Hida , Seiko Higashi , Naoki Tokuhara , Seiichi Kobayashi
IPC分类号： A61K31404
CPC分类号： C07D401/04 , C07D209/14 , C07D231/12 , C07D241/24 , C07D241/44 , C07D249/10 , C07D401/14 , C07D403/04 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a substituent, B represents, for example, a heteroarylene group, a —CONH— group or a group represented by the formula —CR6═CR7— in which R6 and R7 represents H, a lower alkyl group or the like, D represents an arylene group, a heteroarylene group or the like, n1 stands for 0 or 1, M represents, for example, a hydroxyl group or a lower alkoxy group; or a physiologically acceptable salt thereof. As a retinoic-related compound replacing retinoic acid, it permits the provision of a preventive and/or therapeutic for various diseases.
摘要翻译：描述了由下式（I）表示的含杂环羧酸衍生物：其中A表示例如含有至少一个氮原子并且可以具有取代基的杂芳基，B表示例如亚杂芳基 -CONH-基或由式-CR 6 = CR 7表示的基团，其中R 6和R 7表示H，低级烷基等，D表示亚芳基基团，亚杂芳基等，n1表示0或1，M表示例如羟基或低级烷氧基; 或其生理上可接受的盐。作为视黄酸相关化合物代替视黄酸，它允许为各种疾病提供预防和/或治疗。

6. 发明授权

US5728952A Vibration measuring instrument 失效
标题翻译：振动测量仪
公开(公告)号：US5728952A
公开(公告)日：1998-03-17
申请号：US525466
申请日：1995-09-08
申请人： Hironobu Yao , Hiroyuki Yoshimura , Masato Takahashi , Michihiko Tsuruoka , Iwao Matsumoto , Masakazu Kawakami , Keita Okawa
发明人： Hironobu Yao , Hiroyuki Yoshimura , Masato Takahashi , Michihiko Tsuruoka , Iwao Matsumoto , Masakazu Kawakami , Keita Okawa
IPC分类号： G01F1/84 , G01N9/00
CPC分类号： G01F1/8418 , G01F1/8427 , G01F1/8431 , G01F1/8436 , G01F1/849 , G01N9/002
摘要： The precision of phase difference obtained by a phase difference calculating unit is improved by correction through outputs of a frequency ratio calculating unit and a temperature calculating unit considering that the phase or time difference of each output signal of a vibration sensor indicating the mass flow or density of a fluid is a function of the temperature and axial force on a measurement pipe, or that the axial force is a function of the ratio between two resonant frequencies.
摘要翻译：考虑到表示质量流量或密度的振动传感器的每个输出信号的相位或时间差，通过频率比计算单元和温度计算单元的输出进行校正来提高通过相位差计算单元获得的相位差的精度流体是测量管上的温度和轴向力的函数，或轴向力是两个谐振频率之间的比值的函数。

7. 发明授权

US5578603A Aminobenzoic acid derivatives 失效
标题翻译：氨基苯甲酸衍生物
公开(公告)号：US5578603A
公开(公告)日：1996-11-26
申请号：US337480
申请日：1994-11-08
申请人： Shuhei Miyazawa , Shigeki Hibi , Hiroyuki Yoshimura , Takashi Mori , Yorihisa Hoshino , Mitsuo Nagai , Kouichi Kikuchi , Hisashi Shibata , Kazuo Hirota , Takashi Yamanaka , Isao Yamatsu , Masanori Mizuno
发明人： Shuhei Miyazawa , Shigeki Hibi , Hiroyuki Yoshimura , Takashi Mori , Yorihisa Hoshino , Mitsuo Nagai , Kouichi Kikuchi , Hisashi Shibata , Kazuo Hirota , Takashi Yamanaka , Isao Yamatsu , Masanori Mizuno
IPC分类号： A61K31/46 , A61P1/00 , A61P1/08 , A61P25/20 , A61P43/00 , C07C229/60 , C07C229/64 , C07D451/04 , C07D451/12 , C07D405/10
CPC分类号： C07D451/04
摘要： An aminobenzoic acid derivative represented by the following formulas (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group; R.sup.3 represents a halogen atom; X represents --O-- or --N--; and A represents an oxygen or sulfur atom.
摘要翻译：由下列通式（I-2）或（I-3）表示的氨基苯甲酸衍生物或其药理学上可接受的盐以良好的平衡活性比表现出5-羟色胺拮抗作用和乙酰胆碱释放促进活性，作为胃肠道不明确投诉患者的药物：（I-2）和（I-3）其中R1表示诸如炔基或氰基烷基的基团; R2表示氨基或酰氨基等基团。 R3表示卤原子; X表示-O-或-N-; A表示氧或硫原子。

8. 发明授权

US5482937A 1,4-diazepine derivative and its pharmaceutical use 失效
标题翻译： 1,4-二氮杂衍生物及其药物用途
公开(公告)号：US5482937A
公开(公告)日：1996-01-09
申请号：US318971
申请日：1994-10-06
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , C07F9/6561 , A61K31/55
CPC分类号： C07D495/14 , C07F9/6561
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are useful in the pharmaceutical field, especially in treating allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译：以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐可用于制药领域，特别是用于治疗过敏性疾病。其中R1和R2是氢或烷基，R3是氢或卤素，R4是氢或烷基，X是-OCO-，Y是环烷基，环烷基烷基，炔基等。

9. 发明授权

US5476864A Glycerin derivative and its pharmacological use 失效
公开(公告)号：US5476864A
公开(公告)日：1995-12-19
申请号：US129302
申请日：1993-11-10
申请人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , A61K31/44 , C07D213/02
CPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
摘要： A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##

10. 发明授权

US5468740A 1,4-diazepine derivative and its pharmaceutical use 失效
标题翻译： 1,4-二氮杂衍生物及其药物用途
公开(公告)号：US5468740A
公开(公告)日：1995-11-21
申请号：US386533
申请日：1995-02-10
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , C07F9/6561 , A61K31/675 , C07F9/00
CPC分类号： C07D495/14 , C07F9/6561
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译：公开了以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐，尤其适用于过敏性疾病。其中R 1和R 2是氢或烷基，R 3是氢或卤素，R 4是氢或烷基，X是-OCO - ， - NHCO-，-CO-或其它，Y是环烷基，环烷基烷基，炔基等。

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