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1. 发明申请

US20100215632A1 BIOMARKERS OF SIRTUIN ACTIVITY AND METHODS OF USE THEREOF 审中-公开
标题翻译： SIRTUIN活性的生物标记及其使用方法
公开(公告)号：US20100215632A1
公开(公告)日：2010-08-26
申请号：US12450252
申请日：2008-03-19
申请人： Olivier Boss , Siva Worcester , Andre Iffland , Jesse Smith , Jill Milne , Michael Jirousek
发明人： Olivier Boss , Siva Worcester , Andre Iffland , Jesse Smith , Jill Milne , Michael Jirousek
IPC分类号： A61K38/43 , C12Q1/44 , C12Q1/68 , C12Q1/02
CPC分类号： G01N33/6893 , C12Q1/34
摘要： Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods for identifying compounds that modulate the activity of a sirtuin protein using one or more sirtuin biomarkers.
摘要翻译：提供了用于监测受试者中的沉默调节蛋白调节的方法，例如在用沉默调节蛋白调节化合物治疗期间。所述方法涉及确定来自受试者的生物样品中一种或多种沉默调节蛋白的生物标志物的表达水平。还提供了用于鉴定使用一种或多种沉默调节蛋白的生物标志物来调节沉默调节蛋白的活性的化合物的方法。

2. 发明授权

US08304206B2 Mass spectrometry assays for identifying compounds that activate deacetylases 有权
标题翻译：用于鉴定激活脱乙酰酶的化合物的质谱测定
公开(公告)号：US08304206B2
公开(公告)日：2012-11-06
申请号：US12085839
申请日：2006-12-01
申请人： Jesse Smith , Jill Milne , Amy Lynch , David Carney , Andre Iffland , Olivier Boss
发明人： Jesse Smith , Jill Milne , Amy Lynch , David Carney , Andre Iffland , Olivier Boss
IPC分类号： C12Q1/34
CPC分类号： G01N33/6851 , C12Q1/25 , G01N33/6842 , G01N2333/98
摘要： Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods utilize mass spectrometry for determining the acetylation state of a substrate peptide. The methods may also be used to identify compounds that modulate the activity of a protein having acetyltransferase or deacetylase activity. In some embodiments, a compound that modulates a deacetylase is an activator of the deacetylase.
摘要翻译：提供了用于测定调节蛋白质底物的乙酰化状态的蛋白质的活性的方法。该方法可用于测定乙酰转移酶活性和脱乙酰酶活性。该方法利用质谱法测定底物肽的乙酰化状态。该方法还可用于鉴定调节具有乙酰转移酶或脱乙酰酶活性的蛋白质的活性的化合物。在一些实施方案中，调节脱乙酰酶的化合物是脱乙酰酶的活化剂。

3. 发明申请

US20090221020A1 Mass Spectrometry Assays for Acetyltransferase/Deacetylase Activity 有权
标题翻译：乙酰转移酶/脱乙酰酶活性的质谱检测
公开(公告)号：US20090221020A1
公开(公告)日：2009-09-03
申请号：US12085839
申请日：2006-12-01
申请人： Jesse Smith , Jill Milne , Amy Lynch , David Carney , Andre Iffland , Olivier Boss
发明人： Jesse Smith , Jill Milne , Amy Lynch , David Carney , Andre Iffland , Olivier Boss
IPC分类号： C12Q1/02 , C12Q1/00
CPC分类号： G01N33/6851 , C12Q1/25 , G01N33/6842 , G01N2333/98
摘要： Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods utilize mass spectrometry for determining the acetylation state of a substrate peptide. The methods may also be used to identify compounds that modulate the activity of a protein having acetyltransferase or deacetylase activity.
摘要翻译：提供了用于测定调节蛋白质底物的乙酰化状态的蛋白质的活性的方法。该方法可用于测定乙酰转移酶活性和脱乙酰酶活性。该方法利用质谱法测定底物肽的乙酰化状态。该方法还可用于鉴定调节具有乙酰转移酶或脱乙酰酶活性的蛋白质的活性的化合物。

4. 发明申请

US20050199650A1 Bulk bag discharging system assembly 审中-公开
标题翻译：散装袋排放系统组装
公开(公告)号：US20050199650A1
公开(公告)日：2005-09-15
申请号：US11118986
申请日：2005-04-29
申请人： Scott Nyhof , Jesse Smith , Thomas Hofman , Robert Meirick
发明人： Scott Nyhof , Jesse Smith , Thomas Hofman , Robert Meirick
IPC分类号： B65B69/00 , B66C1/22 , B66C19/00 , B65D35/56
CPC分类号： B65B69/0091 , B66C1/226 , B66C19/00
摘要： A material container discharge assembly including a main frame assembly; a spout access chamber engaging the main frame assembly; at least two independently movable material container impactors engaged to the main frame assembly and adapted to engage a material container when the material container is positioned within the main frame assembly and above the spout access chamber; and wherein the material container impactors include a conditioning frame.
摘要翻译：一种材料容器排放组件，包括主框架组件; 与主框架组件接合的喷口进入室; 至少两个可独立移动的材料容器冲击器，其接合到所述主框架组件，并且当所述材料容器定位在所述主框架组件内并且在所述喷口存取室上方时适于接合材料容器; 并且其中所述材料容器冲击器包括调节框架。

5. 发明授权

US08333655B2 Methods of receiving electronic wagers in a wagering game via a handheld electronic wager input device 有权
标题翻译：通过手持电子投注装置在投注游戏中接收电子投注的方法
公开(公告)号：US08333655B2
公开(公告)日：2012-12-18
申请号：US13000933
申请日：2009-07-10
申请人： Mark B. Gagner , Timothy T. Gronkowski , Paul M. Lesley , Timothy C. Loose , Jim Motyl , James M. Rasmussen , Victor T. Shi , Alfred Thomas , Jesse Smith
发明人： Mark B. Gagner , Timothy T. Gronkowski , Paul M. Lesley , Timothy C. Loose , Jim Motyl , James M. Rasmussen , Victor T. Shi , Alfred Thomas , Jesse Smith
IPC分类号： A63F9/24
CPC分类号： G07F17/3258 , G07F17/32 , G07F17/3202 , G07F17/3206 , G07F17/3209 , G07F17/3218 , G07F17/3244 , G07F17/3272 , G07F17/34
摘要： A gaming system for conducting a multi-player wagering game includes a multi-touch table surface that is touched by a handheld electronic wager input device (EWID) carried by a player for placing wagers on a wagering game displayed on the multi-touch table surface. Each EWID carried by a player has an associated unique identification code, linked to the respective player's account. Players indicate an amount to be wagered by touching the EWID to designated wager amount areas, then place the wager by touching the EWID to a designated wagering area. Because each EWID is uniquely associable with distinct player accounts, the gaming system can support any number of players placing wagers. The funds remain safe in the player account and no funds are stored on the EWID. Only the identification code is detected, which is compared with the associated player account before allowing that player to place wagers.
摘要翻译：用于进行多玩家投注游戏的游戏系统包括由玩家携带的手持电子下注输入装置（EWID）触摸的多点触控表面，用于将下注放置在多点触控桌面上显示的投注游戏。播放器携带的每个EWID具有相关联的唯一识别码，链接到相应玩家的帐户。玩家通过触摸EWID到指定的赌注金额区域来指示要下注的金额，然后通过触摸EWID将赌注下注到指定的投注区域。因为每个EWID与独特的玩家账户唯一关联，所以游戏系统可以支持任何数量的玩家投下赌注。资金在玩家帐户中保持安全，EWID上没有资金存储。只有识别码被检测到，在允许该玩家进行下注之前将其与相关的玩家帐户进行比较。

6. 发明申请

US20100030578A1 SYSTEM AND METHOD FOR COLLABORATIVE SHOPPING, BUSINESS AND ENTERTAINMENT 审中-公开
标题翻译：协同购物，商务和娱乐的系统与方法
公开(公告)号：US20100030578A1
公开(公告)日：2010-02-04
申请号：US12409074
申请日：2009-03-23
申请人： M.A. Sami Siddique , Abida Raouf , Abdul Aziz Raouf , Jesse Smith
发明人： M.A. Sami Siddique , Abida Raouf , Abdul Aziz Raouf , Jesse Smith
IPC分类号： G06Q30/00 , G06Q10/00 , G06Q20/00 , G06Q50/00 , G06F3/048 , G06F15/16
CPC分类号： G06Q10/0637 , G06Q20/12 , G06Q20/204 , G06Q20/40 , G06Q30/02 , G06Q30/06 , G06Q30/0601 , G06Q40/12 , G06Q50/24 , G06T15/02 , G06T17/00 , G16H10/60 , H04W4/00
摘要： The methods and systems described herein relate to online methods of collaboration in community environments. The methods and systems are related to an online apparel modeling system that allows users to have three-dimensional models of their physical profile created. Users may purchase various goods and/or services and collaborate with other users in the online environment.
摘要翻译：本文所述的方法和系统涉及社区环境中的在线协作方法。这些方法和系统与在线服装建模系统相关，允许用户创建其物理轮廓的三维模型。用户可以购买各种商品和/或服务，并与在线环境中的其他用户协作。

7. 发明申请

US20090286210A1 Methods and Systems for Providing Interactive Content 审中-公开
标题翻译：提供互动内容的方法和系统
公开(公告)号：US20090286210A1
公开(公告)日：2009-11-19
申请号：US12355071
申请日：2009-01-16
申请人： Kimberly Spreen , Jesse Smith , Kevin Huang , Mary Frances Jones
发明人： Kimberly Spreen , Jesse Smith , Kevin Huang , Mary Frances Jones
IPC分类号： G09B21/00
CPC分类号： G09B21/009
摘要： Embodiments of the invention provide an interactive system that can receive input and present content in an interactive manner.
摘要翻译：本发明的实施例提供了可以以交互方式接收输入和呈现内容的交互式系统。

8. 发明申请

US20060140755A1 Gas turbine engine blade tip clearance apparatus and method 有权
标题翻译：燃气轮机发动机叶片间隙装置及方法
公开(公告)号：US20060140755A1
公开(公告)日：2006-06-29
申请号：US11025435
申请日：2004-12-29
申请人： Frederick Schwarz , Robert Perkinson , Jesse Smith
发明人： Frederick Schwarz , Robert Perkinson , Jesse Smith
IPC分类号： F01D11/08
CPC分类号： F01D11/22 , F01D11/122 , F04D29/052 , F05D2260/403 , F16C23/06 , F16C2360/23
摘要： A gas turbine engine is provided that includes one or more rotor assemblies, one or more shroud segments, and an actuator. The rotor assemblies are rotatable around an axially extending rotational axis, and each rotor assembly has a plurality of blades. Each blade has a blade tip. The one or more shroud segments each has a blade seal surface disposed radially outside of the one or more rotor assemblies. The blade tips and blade seal surfaces (collectively referred to as the blade seal surface) have mating conical geometries and a clearance distance extending between the blade tips and blade seal surface. The blade tips and blade seal surface are disposed at an angle relative to the axial centerline of the engine, which angle is greater than zero. The actuator is selectively operable to axially move one or both of the shroud segments and rotor assemblies relative to the other of the shroud segments and rotor assemblies to alter the clearance distance.
摘要翻译：提供了一种燃气涡轮发动机，其包括一个或多个转子组件，一个或多个护罩段和致动器。转子组件可围绕轴向延伸的旋转轴线旋转，并且每个转子组件具有多个叶片。每个叶片都有一个叶片尖端。一个或多个护罩段各自具有设置在一个或多个转子组件的径向外侧的叶片密封表面。叶片尖端和叶片密封表面（统称为叶片密封表面）具有匹配的圆锥形几何形状和在叶片尖端和叶片密封表面之间延伸的间隙距离。叶片尖端和叶片密封表面相对于发动机的轴向中心线成角度设置，该角度大于零。致动器可选择性地可操作以相对于护罩段和转子组件中的另一个轴向移动护罩段和转子组件中的一个或两个，以改变间隙距离。

9. 发明申请

US20050241728A1 Bulk bag filling system 失效
标题翻译：散装袋灌装系统
公开(公告)号：US20050241728A1
公开(公告)日：2005-11-03
申请号：US11119872
申请日：2005-05-02
申请人： Scott Nyhof , Jesse Smith
发明人： Scott Nyhof , Jesse Smith
IPC分类号： B65B1/04 , B65B43/54
CPC分类号： B65B1/04 , B65B43/54
摘要： A bulk bag filling system includes a frame having a base, a fill carriage coupled to the frame and a rotary carriage. The fill carriage is alignable with a fill port for receiving a bulk material. The rotary carriage includes a plurality of bag loop hangers for receiving bag loops of a bag to be filled. The rotary carriage is movably coupled to the fill carriage and a spout, for receiving a neck of the bag to be filled, extends through the rotary carriage. The spout is alignable with the fill port.
摘要翻译：散装袋填充系统包括具有基座的框架，联接到框架的填充托架和旋转托架。填充托架可与用于接收散装材料的填充口对齐。旋转托架包括多个用于接收待填充袋的袋环的袋环吊架。旋转托架可移动地联接到填充托架，并且用于接收要填充的袋的颈部的出口延伸穿过旋转托架。喷嘴可与填充口对齐。

10. 发明授权

US10002337B2 Method for collaborative shopping 有权
公开(公告)号：US10002337B2
公开(公告)日：2018-06-19
申请号：US13612593
申请日：2012-09-12
申请人： M. A. Sami Siddique , Abida Raouf , Abdul Aziz Raouf , Jesse Smith
发明人： M. A. Sami Siddique , Abida Raouf , Abdul Aziz Raouf , Jesse Smith
IPC分类号： G06Q30/00 , G06Q10/06 , G06Q20/12 , G06Q20/20 , G06Q20/40 , G06Q30/02 , G06Q30/06 , G06Q50/24 , G06T15/02 , G06T17/00 , G06Q40/00
CPC分类号： G06Q10/0637 , G06Q20/12 , G06Q20/204 , G06Q20/40 , G06Q30/02 , G06Q30/06 , G06Q30/0601 , G06Q40/12 , G06Q50/24 , G06T15/02 , G06T17/00 , G16H10/60 , H04W4/00
摘要： The methods and systems described herein relate to online methods of collaboration in community environments. The methods and systems are related to an online apparel modeling system that allows users to have three-dimensional models of their physical profile created. Users may purchase various goods and/or services and collaborate with other users in the online environment.

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