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1. 发明授权

US07300510B2 Goniochromatic bright pigments 失效
标题翻译：光亮色素
公开(公告)号：US07300510B2
公开(公告)日：2007-11-27
申请号：US10510962
申请日：2003-05-08
申请人： Oliver Seeger , Norbert Mronga , Rainer Henning , Raimund Schmid
发明人： Oliver Seeger , Norbert Mronga , Rainer Henning , Raimund Schmid
IPC分类号： C04B14/00 , C04B14/04
CPC分类号： C09C1/0015 , C01P2004/20 , C01P2004/84 , C09C2200/1054 , C09C2200/402 , C09C2200/408 , C09C2200/409
摘要： Goniochromatic luster pigments comprising at least one dielectric low-refractive interference-colored layer which includes a polar organic solvent which can interact with the layer material via functional groups.
摘要翻译：包含至少一个电介质低折射干涉着色层的色度光泽颜料，其包括可通过官能团与层材料相互作用的极性有机溶剂。

2. 发明申请

US20050223940A1 Goniochromatic bright pigments 失效
标题翻译：光亮色素
公开(公告)号：US20050223940A1
公开(公告)日：2005-10-13
申请号：US10510962
申请日：2003-05-08
申请人： Oliver Seeger , Norbert Mronga , Rainer Henning , Raimund Schmid
发明人： Oliver Seeger , Norbert Mronga , Rainer Henning , Raimund Schmid
IPC分类号： C09C1/00 , C09D11/00
CPC分类号： C09C1/0015 , C01P2004/20 , C01P2004/84 , C09C2200/1054 , C09C2200/402 , C09C2200/408 , C09C2200/409
摘要： Goniochromatic luster pigments comprising at least one dielectric low-refractive interference-colored layer which includes a polar organic solvent which can interact with the layer material via functional groups.
摘要翻译：包含至少一个电介质低折射干涉着色层的色度光泽颜料，其包括可通过官能团与层材料相互作用的极性有机溶剂。

3. 发明授权

US10174213B2 Coating system 有权
公开(公告)号：US10174213B2
公开(公告)日：2019-01-08
申请号：US14344775
申请日：2012-09-14
申请人： Juliane Kruesemann , Thomas Frey , Rainer Henning , Annegret Pietsch , Claudia Sierakowski , Tom Landuydt
发明人： Juliane Kruesemann , Thomas Frey , Rainer Henning , Annegret Pietsch , Claudia Sierakowski , Tom Landuydt
IPC分类号： C09D7/00 , C09D101/14 , C09D123/06 , C09D5/33 , C09D5/02 , C09D5/00 , C09D7/41 , C09D7/61
摘要： A coating formed on a substrate is provided which coating comprises (a) an organic NIR-transparent pigment and/or an inorganic NIR-reflective pigment; (b) a dye having a transmittance of at least 75% in the range of from 700 to 2500 nm; and (c) optionally an effect pigment; wherein said coating exhibits a total solar reflectance (TSR) of (i) ≥40%, if 60

4. 发明授权

US07897574B2 Pharmaceutical composition for treating haemorrhagic shock and its consecutive symptoms 失效
标题翻译：用于治疗出血性休克及其连续症状的药物组合物
公开(公告)号：US07897574B2
公开(公告)日：2011-03-01
申请号：US12158670
申请日：2006-11-10
申请人： Peter Petzelbauer , Rainer Henning
发明人： Peter Petzelbauer , Rainer Henning
IPC分类号： A61K38/36
CPC分类号： A61K38/16 , Y02A50/411
摘要： The invention is concerned with the use of a peptide comprising the N-terminal sequence Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro-Ala- Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg (SEQ ID NO: 1) or any allelic variant or derivative of said peptide possessing the biological property of matching the inducible VE-cadherin binding motif on the Bβ-chain (i.e. Bβ15-42) of human fibrin for the preparation of a pharmaceutical preparation for the treatment of shock, more specifically of hemorrhagic shock.
摘要翻译：本发明涉及使用包含N-末端序列Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro- （SEQ ID NO：1）或具有与诱导型VE-钙粘蛋白结合基序匹配的生物学特性的所述肽的任何等位基因变体或衍生物（Pro-Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg 在人类纤维蛋白的B＆bgr-chain（即B＆Bgr; 15-42）上制备用于治疗休克的药物制剂，更具体地说是出血性休克。

5. 发明申请

US20100267615A1 METHODS FOR TREATMENT AND/OR PREVENTION OF A DISEASE ASSOCIATED WITH VASCULAR LEAK 审中-公开
标题翻译：治疗和/或预防与血管通透相关的疾病的方法
公开(公告)号：US20100267615A1
公开(公告)日：2010-10-21
申请号：US12793388
申请日：2010-06-03
申请人： Peter Petzelbauer , Rainer Henning , Sonja Reingruber , Waltraud Pasteiner , Marion Gröger
发明人： Peter Petzelbauer , Rainer Henning , Sonja Reingruber , Waltraud Pasteiner , Marion Gröger
IPC分类号： A61K38/16 , A61P5/00 , A61P11/06 , A61P35/00 , A61P27/06 , A61P27/02 , A61P3/10
CPC分类号： G01N33/5064 , G01N33/5088 , G01N2400/50 , G01N2800/328
摘要： The present invention is directed to methods for treatment and/or prevention of a disease associated with vascular leak in a patient comprising administering to the patient an effective amount of SEQ ID NO: 1.
摘要翻译：本发明涉及用于治疗和/或预防与患者血管渗漏相关的疾病的方法，其包括向患者施用有效量的SEQ ID NO：1。

7. 发明申请

US20080004220A1 PEPTIDES AND PEPTIDE DERIVATIVES, THE PRODUCTION THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：肽和肽衍生物，其生产方式，因为它们用于制备治疗和/或预防性活性药物组合物
公开(公告)号：US20080004220A1
公开(公告)日：2008-01-03
申请号：US11678538
申请日：2007-02-23
申请人： Peter Petzelbauer , Rainer Henning , Sonja Reingruber
发明人： Peter Petzelbauer , Rainer Henning , Sonja Reingruber
IPC分类号： A61K38/16 , A61P29/00 , C07K14/00
CPC分类号： C07K14/75
摘要： The invention relates to peptides and peptide derivatives of the following general Formulas Ia and Ib as well as in particular anti-inflammatory drugs containing these peptides.
摘要翻译：本发明涉及以下通式Ia和Ib的肽和肽衍生物，特别是含有这些肽的抗炎药。

8. 发明授权

US5604251A Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors 失效
标题翻译：咪唑衍生物与联苯基磺酰脲或联苯基磺酰氨基酸侧链及其作为血管紧张素II受体的用途
公开(公告)号：US5604251A
公开(公告)日：1997-02-18
申请号：US479561
申请日：1995-06-07
申请人： Holger Heitsch , Rainer Henning , Adalbert Wagner , Hermann Gerhards , Reinhard Becker , Bernward Sch olkens
发明人： Holger Heitsch , Rainer Henning , Adalbert Wagner , Hermann Gerhards , Reinhard Becker , Bernward Sch olkens
IPC分类号： A61K31/415 , A61K31/4164 , A61K31/64 , A61P9/10 , A61P9/12 , C07D233/84 , C07D233/86 , C07D233/90 , A61K31/505 , A61K31/42 , C07D403/12 , C07D403/14
CPC分类号： C07D233/84 , C07D233/90
摘要： Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their useCompounds of the formula (I) ##STR1## in which R.sup.1 is, for example, ethyl,R.sup.2 is, for example, methyl,n is, for example, zero,R.sup.3 is, for example, COOH, andR.sup.4 is, for example, SO.sub.2 NHCONHCH.sub.3are highly active antagonists of angiotensin II receptors.
摘要翻译：咪唑衍生物与联苯基磺酰脲或联苯磺酰氨基甲酸酯侧链，其制备方法及用途式（I）化合物其中R 1为例如甲基，R 2为例如甲基，n为例如为0，R3为例如COOH，R4为例如SO2NHCONHCH3，为血管紧张素II受体的高效拮抗剂。

9. 发明授权

US5360791A Renin-inhibiting aminodiol derivatives 失效
标题翻译：肾素抑制性氨基二醇衍生物
公开(公告)号：US5360791A
公开(公告)日：1994-11-01
申请号：US1221
申请日：1993-01-06
申请人： Rainer Henning , Hansjorg Urbach , Dieter Ruppert , Bernward Scholkens
发明人： Rainer Henning , Hansjorg Urbach , Dieter Ruppert , Bernward Scholkens
IPC分类号： A61K38/00 , C07D401/12 , C07K5/02 , C07K5/065 , A61K37/02 , C07K5/08
CPC分类号： C07D401/12 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/06078 , A61K38/00
摘要： The invention relates to compounds of the formula I ##STR1## in which A denotes a radical of the formula II ##STR2## in which E denotes a CH.sub.2 group or an NR.sup.9 radical,G denotes a radical from the group comprising S, SO, SO.sub.2, O, CO, CS or a direct bond,B denotes an amino acid,D denotes a heterocycle andR.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.9 are defined in the description, and their salts.The invention in addition relates to a process for the preparation of the compounds of the formula I and their use as pharmaceuticals.
摘要翻译：本发明涉及式I的化合物，其中A表示式II的基团，其中E表示CH 2基团或NR 9基团，G表示包括S，SO的基团，SO 2，O，CO，CS或直接键，B表示氨基酸，D表示杂环，R 1，R 2，R 3，R 4，R 5，R 6和R 9在说明书中定义，及其盐。本发明还涉及制备式I化合物及其作为药物的用途的方法。

10. 发明授权

US4999370A Compounds with a psychotropic action, agents containing them, and the use thereof for the treatment and prophylaxis of disorders of the central nervous system 失效
标题翻译：具有精神作用的化合物，含有它们的药剂及其用于治疗和预防中枢神经系统疾病的用途
公开(公告)号：US4999370A
公开(公告)日：1991-03-12
申请号：US301297
申请日：1989-01-25
申请人： Wolfgang Ruger , Hansjorg Urbach , Rainer Henning , Jens Stechl , Patricia Usinger , Franz Hock
发明人： Wolfgang Ruger , Hansjorg Urbach , Rainer Henning , Jens Stechl , Patricia Usinger , Franz Hock
IPC分类号： C12N9/99 , A61K31/55 , A61K38/00 , A61K38/55 , A61K45/06 , A61P25/18 , A61P25/20 , C07D223/10 , C07D223/16 , C07D471/04 , C07D487/04 , C07D513/04 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07K14/81 , C07D209/02 , A61K31/40
CPC分类号： C07K5/0222 , A61K38/005
摘要： Compounds with a psychotropic action, agents containing them, and the use thereof for the treatment and prophylaxis of disorders of the central nervous system.The invention relates to the use of angiotensin converting enzyme inhibitors as pharmaceuticals with a psychotropic, especially anxiolytic, action, to agents containing them, and to the use thereof for the treatment or prophylaxis of disorders of the central nervous system, especially of anxiety states.The invention also relates to new compounds of the formula ##STR1## in which R.sup.2 denotes hydrogen or ethyl, and R.sup.3 denotes n-octyl, to processes for the preparation thereof, to agents containing them, and to the use thereof as pharmaceuticals.
摘要翻译：具有精神作用的化合物，含有它们的药剂及其用于治疗和预防中枢神经系统疾病的用途。本发明涉及血管紧张素转换酶抑制剂作为具有精神药物，特别是抗焦虑作用的药物对含有它们的药物的用途，以及其用于治疗或预防中枢神经系统疾病，特别是焦虑状态的用途。本发明还涉及式IMA的新化合物，其中R2表示氢或乙基，R3表示正辛基，其制备方法，含有它们的试剂，以及作为药物的用途。

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