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1. 发明授权

US08163561B2 Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors 失效
标题翻译：基于表面等离子体共振传感器的生物实体深度解析感测方法
公开(公告)号：US08163561B2
公开(公告)日：2012-04-24
申请号：US12627463
申请日：2009-11-30
申请人： Norman Henry Fontaine , Joydeep Lahiri , Guangshan Li , Anping Liu , Jinlin Peng
发明人： Norman Henry Fontaine , Joydeep Lahiri , Guangshan Li , Anping Liu , Jinlin Peng
IPC分类号： G01N21/00
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

2. 发明申请

US20110171746A1 Variable Penetration Depth Biosensor Methods 失效
标题翻译：可变穿透深度生物传感器方法
公开(公告)号：US20110171746A1
公开(公告)日：2011-07-14
申请号：US12627463
申请日：2009-11-30
申请人： Norman Henry Fontaine , Joydeep Lahiri , Guangshan Li , Anping Liu , Jinlin Peng
发明人： Norman Henry Fontaine , Joydeep Lahiri , Guangshan Li , Anping Liu , Jinlin Peng
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

3. 发明授权

US08243276B2 Variable penetration depth biosensor 失效
标题翻译：可变穿透深度生物传感器
公开(公告)号：US08243276B2
公开(公告)日：2012-08-14
申请号：US12627515
申请日：2009-11-30
申请人： James Gregory Couillard , Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng , Donnell Thaddeus Walton
发明人： James Gregory Couillard , Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng , Donnell Thaddeus Walton
IPC分类号： G01N21/00
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

4. 发明申请

US20120133943A1 Systems And Methods For Multi-Wavelength SPR Biosensing With Reduced Chromatic Aberration 审中-公开
标题翻译：具有减少色差的多波长SPR生物传感系统和方法
公开(公告)号：US20120133943A1
公开(公告)日：2012-05-31
申请号：US12955421
申请日：2010-11-29
申请人： Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng
发明人： Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed.
摘要翻译：公开了用于使用两个或更多个波长并且具有降低的色差来感测表面等离子体共振（SPR）生物传感器的系统和方法。该系统包括在两个或更多波长处具有色差的波束形成光学系统。光源系统分别提供两个或多个波长的光，每个波长的光从与波束形成光学系统不同的距离提供。选择不同的距离以减少或消除色差对SPR生物传感器芯片上焦点形成的不利影响。还公开了一种用于使用具有不同波长的不同光照射SPR生物传感器的照明系统。

5. 发明申请

US20110128546A1 Variable Penetration Depth Biosensor 失效
标题翻译：可变穿透深度生物传感器
公开(公告)号：US20110128546A1
公开(公告)日：2011-06-02
申请号：US12627515
申请日：2009-11-30
申请人： James Gregory Couillard , Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng , Donnell Thaddeus Walton
发明人： James Gregory Couillard , Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng , Donnell Thaddeus Walton
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

6. 发明申请

US20120244568A1 LABEL-FREE RIGID CELL ASSAY METHOD 审中-公开
标题翻译：无标签电池测试方法
公开(公告)号：US20120244568A1
公开(公告)日：2012-09-27
申请号：US13357969
申请日：2012-01-25
申请人： Fang Lai , Guangshan Li , Anping Liu , Jinlin Peng
发明人： Fang Lai , Guangshan Li , Anping Liu , Jinlin Peng
IPC分类号： C12Q1/02
CPC分类号： G01N21/553
摘要： A label-free cell assay method including: culturing rigid cells in a buffer, the rigid cells having a diameter of about 3 to about 7 micrometers; depositing the rigid cells on the surface of a sensor system; and detecting the rigid cells with the sensor when exposed to two or more wavelengths of light having two or more penetration depths, as defined herein. Also disclosed are assay methods for contacting the rigid cells with a substance and determining the response of the contacted rigid cells to the substance, such as a drug candidate or modulator compound, as defined herein.
摘要翻译：无标记细胞测定方法，包括：在缓冲液中培养刚性细胞，刚性细胞具有约3至约7微米的直径; 将刚性电池沉积在传感器系统的表面上; 并且当暴露于具有两个或更多个穿透深度的两个或更多个波长的光，如本文所定义时，用传感器检测刚性单元。还公开了用于使刚性细胞与物质接触并测定接触的刚性细胞对如本文所定义的药物候选物或调节剂化合物的物质的反应的测定方法。

7. 发明授权

US09290406B2 Method for producing optical fiber having controlled perturbations 有权
标题翻译：具有受控扰动的光纤的制造方法
公开(公告)号：US09290406B2
公开(公告)日：2016-03-22
申请号：US13587091
申请日：2012-08-16
申请人： Xin Chen , Charles Frederick Laing , Ming-Jun Li , Anping Liu , Eric John Mozdy , Joseph Doull Thaler
发明人： Xin Chen , Charles Frederick Laing , Ming-Jun Li , Anping Liu , Eric John Mozdy , Joseph Doull Thaler
IPC分类号： C03B37/025 , C03B37/027
CPC分类号： C03B37/02745 , C03B37/02763 , C03B2203/06 , C03B2203/18 , C03B2203/20 , Y02P40/57
摘要： A method for producing an optical fiber is provided. The method includes the steps of drawing an optical fiber from a heated glass source in a furnace and introducing index perturbations to the optical fiber via a plurality of perturbation sources arranged at a plurality of different azimuthal locations. The index perturbations are introduced synchronously at different locations along the axial length of the fiber by the plurality of perturbation sources in a generally helical pattern on the outside surface of the fiber in one embodiment. According to another embodiment, the index perturbations are introduced by the plurality of perturbation sources at different frequencies.
摘要翻译：提供一种光纤的制造方法。该方法包括以下步骤：在炉中从加热的玻璃源中拉出光纤，并且通过布置在多个不同方位位置处的多个扰动源将折射率扰动引入光纤。在一个实施例中，通过多个扰动源以纤维的外表面上的大致螺旋图案沿着纤维的轴向长度在不同位置同时引入折射率扰动。根据另一实施例，索引扰动由多个扰动源以不同的频率引入。

8. 发明授权

US08797642B2 Large mode area optical fiber 有权
标题翻译：大模光区域光纤
公开(公告)号：US08797642B2
公开(公告)日：2014-08-05
申请号：US12669664
申请日：2008-07-16
申请人： Xin Chen , Joohyun Koh , Ming-Jun Li , Anping Liu
发明人： Xin Chen , Joohyun Koh , Ming-Jun Li , Anping Liu
IPC分类号： G02B6/036 , H04B10/17
CPC分类号： G02B6/14 , G02B6/024 , G02B6/03644 , G02B6/03661 , G02B6/03688 , H01S3/06708 , H01S3/06712 , H01S3/06729 , H01S3/08045 , H01S3/094007
摘要： A large-mode-area (LMA) optical fiber (10) that operates as a single-mode optical fiber. The optical fiber includes a core region (20) surrounded by an inner cladding (32), which in turn is surrounded by an outer cladding (40). The inner cladding includes at least one up-doped ring region (32R1). The ring region is configured to form a large attenuation differential between the higher-order modes and the fundamental mode so only that the fundamental mode remains traveling in the optical fiber. If necessary, the optical fiber can include a bend (10B) having a select “resonant” bend diameter (DB) that increases the relative attenuation of the fundamental and higher-order modes. The optical fiber supports an effective mode field diameter (MFD) of up to 40 μm to 50 μm. As a result, detrimental non-linear effects are suppressed, which allows the optical fiber to carry substantially more optical power than conventional LMA optical fibers. The LMA optical fiber is thus eminently suited for a number of optical-fiber-based applications calling for high optical power, such as fiber lasers and pump sources for wavelength conversion.
摘要翻译：作为单模光纤工作的大模（LMA）光纤（10）。光纤包括由内包层（32）包围的芯区域（20），该内部区域又由外包层（40）围绕。内包层包括至少一个上掺杂环区（32R1）。环形区域被配置为在高阶模式和基模之间形成大的衰减差分，从而仅使基本模式保持在光纤中行进。如果需要，光纤可以包括具有选择的“共振”弯曲直径（DB）的弯曲（10B），该弯曲直径（DB）增加了基极和高阶模的相对衰减。光纤支持高达40μm至50μm的有效模场直径（MFD）。结果，抑制了有害的非线性效应，这使得光纤比传统的LMA光纤承载更多的光功率。因此，LMA光纤非常适合于需要高光功率的多个基于光纤的应用，例如用于波长转换的光纤激光器和泵浦光源。

9. 发明授权

US08472763B1 Spectral beam combination of laser beams 有权
标题翻译：激光束的光束组合
公开(公告)号：US08472763B1
公开(公告)日：2013-06-25
申请号：US13043342
申请日：2011-03-08
申请人： Anping Liu , Eric C. Honea , Charles A. Lemaire , Roy D. Mead , Christopher D. Brooks , Andrew J. W. Brown , Charles E. Hamilton , Thomas H. Loftus , Fabio Di Teodoro
发明人： Anping Liu , Eric C. Honea , Charles A. Lemaire , Roy D. Mead , Christopher D. Brooks , Andrew J. W. Brown , Charles E. Hamilton , Thomas H. Loftus , Fabio Di Teodoro
IPC分类号： G02B6/34 , G02B6/26 , G02B4/42
CPC分类号： G02B6/3853 , C03B37/10 , G02B6/02328 , G02B6/02347 , G02B6/02376 , G02B6/02385 , G02B6/3826 , H01S3/005 , H01S3/0064 , H01S3/0078 , H01S3/06704 , H01S3/06708 , H01S3/06729 , H01S3/06741 , H01S3/06745 , H01S3/06754 , H01S3/06758 , H01S3/094007
摘要： A method and apparatus use a photonic-crystal fiber having a very large core while maintaining a single transverse mode. In some fiber lasers and amplifiers having large cores problems exist related to energy being generated at multiple-modes (i.e., polygamy), and of mode hopping (i.e., promiscuity) due to limited control of energy levels and fluctuations. The problems of multiple-modes and mode hopping result from the use of large-diameter waveguides, and are addressed by the invention. This is especially true in lasers using large amounts of energy (i.e., lasers in the one-megawatt or more range). By using multiple small waveguides in parallel, large amounts of energy can be passed through a laser, but with better control such that the aforementioned problems can be reduced. An additional advantage is that the polarization of the light can be maintained better than by using a single fiber core.
摘要翻译：一种方法和装置使用具有非常大核心的光子晶体光纤，同时保持单个横向模式。在一些光纤激光器和具有大的核心问题的放大器存在与在多模式（即一夫多妻制）下产生的能量以及由于能量水平和波动的有限控制而导致的模式跳变（即，混乱）有关的问题。使用大直径波导导致多模和跳频的问题，并由本发明解决。在使用大量能量的激光器（即，1兆瓦或更大范围的激光器）中尤其如此。通过平行地使用多个小波导，可以将大量能量通过激光器，但是具有更好的控制，从而可以减少上述问题。另外的优点是可以比通过使用单个纤芯更好地保持光的偏振。

10. 发明授权

US07539381B2 Low bend loss coated optical fiber 有权
标题翻译：低折射损耗涂层光纤
公开(公告)号：US07539381B2
公开(公告)日：2009-05-26
申请号：US11801896
申请日：2007-05-11
申请人： Xin Chen , Joohyun Koh , Ming-Jun Li , Anping Liu , Jianguo Wang
发明人： Xin Chen , Joohyun Koh , Ming-Jun Li , Anping Liu , Jianguo Wang
IPC分类号： G02B6/02
CPC分类号： C03C25/106 , G02B6/02395 , G02B6/03683
摘要： An optical fiber includes a core and a cladding, said cladding having a refractive index nc a first coating directly contacting the cladding of said fiber, said coating having a thickness of less than 10 microns, said coating having a refractive index delta %=100×(ni2−nc2)/2ni2 less than −1 percent. In another aspect, an optical fiber includes a core and a cladding, said cladding having a refractive index nc, a first coating directly contacting the cladding of said fiber, said fiber comprising a glass diameter less than 100 microns, said coating having a thickness of at least 8 microns, said coating having a refractive index delta %=100×(ni2−nc2)/2ni2 less than −1 percent.
摘要翻译：光纤包括芯和包层，所述包层具有折射率nc，第一涂层直接接触所述纤维的包层，所述涂层的厚度小于10微米，所述涂层具有折射率δ％= 100×（ ni2-nc2）/ 2ni2小于-1％。在另一方面，光纤包括芯和包层，所述包层具有折射率nc，直接接触所述纤维包层的第一涂层，所述纤维包含小于100微米的玻璃直径，所述涂层的厚度为至少8微米，所述涂层具有小于-1％的折射率Δ％= 100×（ni2-nc2）/ 2ni2。

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