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1. 发明申请

US20120244568A1 LABEL-FREE RIGID CELL ASSAY METHOD 审中-公开
标题翻译：无标签电池测试方法
公开(公告)号：US20120244568A1
公开(公告)日：2012-09-27
申请号：US13357969
申请日：2012-01-25
申请人： Fang Lai , Guangshan Li , Anping Liu , Jinlin Peng
发明人： Fang Lai , Guangshan Li , Anping Liu , Jinlin Peng
IPC分类号： C12Q1/02
CPC分类号： G01N21/553
摘要： A label-free cell assay method including: culturing rigid cells in a buffer, the rigid cells having a diameter of about 3 to about 7 micrometers; depositing the rigid cells on the surface of a sensor system; and detecting the rigid cells with the sensor when exposed to two or more wavelengths of light having two or more penetration depths, as defined herein. Also disclosed are assay methods for contacting the rigid cells with a substance and determining the response of the contacted rigid cells to the substance, such as a drug candidate or modulator compound, as defined herein.
摘要翻译：无标记细胞测定方法，包括：在缓冲液中培养刚性细胞，刚性细胞具有约3至约7微米的直径; 将刚性电池沉积在传感器系统的表面上; 并且当暴露于具有两个或更多个穿透深度的两个或更多个波长的光，如本文所定义时，用传感器检测刚性单元。还公开了用于使刚性细胞与物质接触并测定接触的刚性细胞对如本文所定义的药物候选物或调节剂化合物的物质的反应的测定方法。

2. 发明授权

US08163561B2 Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors 失效
标题翻译：基于表面等离子体共振传感器的生物实体深度解析感测方法
公开(公告)号：US08163561B2
公开(公告)日：2012-04-24
申请号：US12627463
申请日：2009-11-30
申请人： Norman Henry Fontaine , Joydeep Lahiri , Guangshan Li , Anping Liu , Jinlin Peng
发明人： Norman Henry Fontaine , Joydeep Lahiri , Guangshan Li , Anping Liu , Jinlin Peng
IPC分类号： G01N21/00
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

3. 发明申请

US20110171746A1 Variable Penetration Depth Biosensor Methods 失效
标题翻译：可变穿透深度生物传感器方法
公开(公告)号：US20110171746A1
公开(公告)日：2011-07-14
申请号：US12627463
申请日：2009-11-30
申请人： Norman Henry Fontaine , Joydeep Lahiri , Guangshan Li , Anping Liu , Jinlin Peng
发明人： Norman Henry Fontaine , Joydeep Lahiri , Guangshan Li , Anping Liu , Jinlin Peng
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

4. 发明授权

US08243276B2 Variable penetration depth biosensor 失效
标题翻译：可变穿透深度生物传感器
公开(公告)号：US08243276B2
公开(公告)日：2012-08-14
申请号：US12627515
申请日：2009-11-30
申请人： James Gregory Couillard , Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng , Donnell Thaddeus Walton
发明人： James Gregory Couillard , Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng , Donnell Thaddeus Walton
IPC分类号： G01N21/00
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

5. 发明申请

US20120133943A1 Systems And Methods For Multi-Wavelength SPR Biosensing With Reduced Chromatic Aberration 审中-公开
标题翻译：具有减少色差的多波长SPR生物传感系统和方法
公开(公告)号：US20120133943A1
公开(公告)日：2012-05-31
申请号：US12955421
申请日：2010-11-29
申请人： Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng
发明人： Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed.
摘要翻译：公开了用于使用两个或更多个波长并且具有降低的色差来感测表面等离子体共振（SPR）生物传感器的系统和方法。该系统包括在两个或更多波长处具有色差的波束形成光学系统。光源系统分别提供两个或多个波长的光，每个波长的光从与波束形成光学系统不同的距离提供。选择不同的距离以减少或消除色差对SPR生物传感器芯片上焦点形成的不利影响。还公开了一种用于使用具有不同波长的不同光照射SPR生物传感器的照明系统。

6. 发明申请

US20110128546A1 Variable Penetration Depth Biosensor 失效
标题翻译：可变穿透深度生物传感器
公开(公告)号：US20110128546A1
公开(公告)日：2011-06-02
申请号：US12627515
申请日：2009-11-30
申请人： James Gregory Couillard , Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng , Donnell Thaddeus Walton
发明人： James Gregory Couillard , Norman Henry Fontaine , Guangshan Li , Anping Liu , Jinlin Peng , Donnell Thaddeus Walton
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

7. 发明申请

US20070048747A1 Methods for assaying analytes 审中-公开
标题翻译：测定分析物的方法
公开(公告)号：US20070048747A1
公开(公告)日：2007-03-01
申请号：US11219049
申请日：2005-09-01
申请人： Thomas Leslie , Guangshan Li , Jeffrey Lynn , Jinlin Peng
发明人： Thomas Leslie , Guangshan Li , Jeffrey Lynn , Jinlin Peng
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00 , G01N33/50
CPC分类号： G01N33/54393 , G01N33/543
摘要： Described herein are methods for assaying analytes.
摘要翻译：本文描述了用于测定分析物的方法。

8. 发明申请

US20050009204A1 Multiplexed binding assays for receptor arrays 审中-公开
标题翻译：受体阵列的多重结合测定
公开(公告)号：US20050009204A1
公开(公告)日：2005-01-13
申请号：US10639718
申请日：2003-08-12
申请人： Ye Fang , Yulong Hong , Joydeep Lahiri , Fang Lai , Jinlin Peng , Brian Webb , Ann Ferrie
发明人： Ye Fang , Yulong Hong , Joydeep Lahiri , Fang Lai , Jinlin Peng , Brian Webb , Ann Ferrie
IPC分类号： C40B30/04 , G01N33/68 , G01N33/74 , G01N33/543
CPC分类号： C40B30/04 , G01N33/74 , G01N2333/726
摘要： A thematic microarray and methods for multiplexed binding assays using a cocktail solution of labeled ligands in the presence or absence of a target compound is provided. The methods enables researchers to screening compounds against multiple targets using a microarray format.
摘要翻译：提供了一种专题微阵列和在存在或不存在目标化合物的情况下使用标记配体的混合溶液进行多重结合测定的方法。这些方法使研究人员可以使用微阵列格式来筛选多个靶点的化合物。

9. 发明授权

US07604984B2 Spatially scanned optical reader system and method for using same 失效
标题翻译：空间扫描光学阅读器系统及其使用方法
公开(公告)号：US07604984B2
公开(公告)日：2009-10-20
申请号：US11027547
申请日：2004-12-29
申请人： Anthony G. Frutos , Jacques Gollier , Jinlin Peng , Garrett A. Piech , Michael B. Webb
发明人： Anthony G. Frutos , Jacques Gollier , Jinlin Peng , Garrett A. Piech , Michael B. Webb
IPC分类号： C12M1/34 , G01N21/00 , G01N21/01 , G01J3/00 , G01J3/28 , G02B6/00 , G02B6/34 , G02B26/08 , G02F1/07
CPC分类号： G01N21/253 , G01N21/554 , G01N21/7743
摘要： An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). The light source outputs an optical beam which is scanned across a moving biosensor and while this is happening the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data which is a function of a position (and possibly time) on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength (peak position) or resonant angle which indicates whether or not a biomolecular binding event occurred on the biosensor. Several other uses of the raw data are also described herein.
摘要翻译：本文描述了一种光学阅读器系统，其使用扫描的光束来询问生物传感器以确定生物分子结合事件是否在生物传感器的表面上发生。在一个实施例中，光学读取器系统包括光源，检测器和处理器（例如，计算机，DSP）。光源输出沿着移动的生物传感器扫描的光束，并且当发生这种情况时，检测器收集从生物传感器反射的光束。计算机处理所收集的光束并记录所生成的原始光谱或角度数据，该数据是生物传感器上的位置（可能是时间）的函数。然后，处理器可以分析原始数据以创建谐振波长（峰值位置）或共振角的空间图，其指示生物传感器上是否发生生物分子结合事件。这里还描述了原始数据的几种其他用途。

10. 发明申请

US20090186776A1 Microcolumn-platform based array for high-throughput analysis 审中-公开
标题翻译：用于高通量分析的基于微柱平台的阵列
公开(公告)号：US20090186776A1
公开(公告)日：2009-07-23
申请号：US12137918
申请日：2008-06-12
申请人： Brian L. Webb , Jinlin Peng , Michael D. Brady , Mircea Despa , Keith A. Horn , Joydeep Lahiri , David M. Root , James B. Stamatoff , Po Ki Yuen
发明人： Brian L. Webb , Jinlin Peng , Michael D. Brady , Mircea Despa , Keith A. Horn , Joydeep Lahiri , David M. Root , James B. Stamatoff , Po Ki Yuen
IPC分类号： C40B30/10 , C40B60/12
CPC分类号： B01L3/50853 , B01J2219/00317 , B01J2219/00504 , B01J2219/00511 , B01J2219/00585 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00662 , B01J2219/00707 , B01L3/5025 , B01L2200/025 , B01L2200/026 , B01L2300/046 , B01L2300/0636 , B01L2300/0829 , C12Q1/6837 , C40B60/14 , G01N33/54366 , G01N33/54373 , G01N33/54386 , G01N35/028
摘要： A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.
摘要翻译：提供了用于进行生物或化学分析的装置和方法。该装置包括从支撑板突出的三维微柱阵列。每个微柱具有远离支撑板的相对平面的第一表面。多个不同生物材料的阵列可以附接到第一表面。该装置与现有的微量滴定板结合使用可以提高使用微阵列进行结合测定的高通量能力。

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