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1. 发明授权

US06210942B1 Recombinant pinoresinol/lariciresinol reductase, recombinant dirigent protein, and methods of use 有权
标题翻译：重组苯并辛醇/椴树醇还原酶，重组蛋白质和重组蛋白质，以及使用方法
公开(公告)号：US06210942B1
公开(公告)日：2001-04-03
申请号：US09475316
申请日：1999-12-30
申请人： Norman G. Lewis , Laurence B. Davin , Albena T. Dinkova-Kostova , Masayuki Fujita , David R. Gang , Simo Sarkanen , Joshua D. Ford
发明人： Norman G. Lewis , Laurence B. Davin , Albena T. Dinkova-Kostova , Masayuki Fujita , David R. Gang , Simo Sarkanen , Joshua D. Ford
IPC分类号： C12N900
CPC分类号： C12N9/0004 , C07K14/415 , C12N15/8243 , C12P7/22 , C12P17/04
摘要： Dirigent proteins and pinoresinol/lariciresinol reductases have been isolated, together with cDNAs encoding dirigent proteins and pinoresinol/lariciresinol reductases. Accordingly, isolated DNA sequences are provided which code for the expression of dirigent proteins and pinoresinol/lariciresinol reductases. In other aspects, replicable recombinant cloning vehicles are provided which code for dirigent proteins or pinoresinol/lariciresinol reductases or for a base sequence sufficiently complementary to at least a portion of dirigent protein or pinoresinol/lariciresinol reductase DNA or RNA to enable hybridization therewith. In yet other aspects, modified host cells are provided that have been transformed, transfected, infected and/or injected with a recombinant cloning vehicle and/or DNA sequence encoding dirigent protein or pinoresinol/lariciresinol reductase. Thus, systems and methods are provided for the recombinant expression of dirigent proteins and/or pinoresinol/lariciresinol reductases.
摘要翻译：已经分离了多种蛋白质和pinoresinol / lariciresinol还原酶，以及编码dibigent蛋白质和pinoresinol / lariciresinol还原酶的cDNA。因此，提供了分离的DNA序列，其编码dirigent蛋白质和pinoresinol / lariciresinol还原酶的表达。在其他方面，提供可复制的重组克隆载体，其编码dirigent蛋白质或pinoresinol / lariciresinol还原酶或与至少一部分dirigent蛋白质或pinoresinol / lariciresinol还原酶DNA或RNA充分互补的碱基序列，以使其能够进行杂交。在另外的方面，提供已经用编码dirigent蛋白质或pinoresinol / lariciresinol还原酶的重组克隆载体和/或DNA序列转化，转染，感染和/或注射的修饰的宿主细胞。因此，提供了用于重组表达dirigent蛋白质和/或pinoresinol / lariciresinol还原酶的系统和方法。

2. 发明授权

US06635459B1 Nucleotide sequences encoding pinoresinol/lariciresinol reductase proteins and their methods of use 有权
标题翻译：编码尖晶石醇/拉辛啶醇还原酶蛋白的核苷酸序列及其使用方法
公开(公告)号：US06635459B1
公开(公告)日：2003-10-21
申请号：US09704640
申请日：2000-11-02
申请人： Norman G. Lewis , Laurence B. Davin , Albena T. Dinkova-Kostova , Masayuki Fujita , David R. Gang , Simo Sarkanen , Joshua D. Ford
发明人： Norman G. Lewis , Laurence B. Davin , Albena T. Dinkova-Kostova , Masayuki Fujita , David R. Gang , Simo Sarkanen , Joshua D. Ford
IPC分类号： C12N904
CPC分类号： C12N9/0004 , C07K14/415 , C12N15/8243 , C12P7/22 , C12P17/04
摘要： Dirigent proteins and pinoresinol/lariciresinol reductases have been isolated, together with cDNAs encoding dirigent proteins and pinoresinol/lariciresinol reductases. Accordingly, isolated DNA sequences are provided from source species Forsythia intermedia, Thuja plicata, Tsuga heterophylla, Eucommia ulmoides, Linum usitatissimum, and Schisandra chinensis, which code for the expression of dirigent proteins and pinoresinol/lariciresinol reductases. In other aspects, replicable recombinant cloning vehicles are provided which code for dirigent proteins or pinoresinol/lariciresinol reductases or for a base sequence sufficiently complementary to at least a portion of dirigent protein or pinoresinol/lariciresinol reductase DNA or RNA to enable hybridization therewith. In yet other aspects, modified host cells are provided that have been transformed, transfected, infected and/or injected with a recombinant cloning vehicle and/or DNA sequence encoding dirigent protein or pinoresinol/lariciresinol reductase. Thus, systems and methods are provided for the recombinant expression of dirigent proteins and/or pinoresinol/lariciresinol reductases.
摘要翻译：已经分离了多种蛋白质和pinoresinol / lariciresinol还原酶，以及编码dibigent蛋白质和pinoresinol / lariciresinol还原酶的cDNA。因此，分离的DNA序列从源物种连翘，中华of藜，紫穗槐，杜仲，杜鹃花，中国五味子等提供，代表了dirigent蛋白质和pinoresinol / lariciresinol还原酶的表达。在其他方面，提供可复制的重组克隆载体，其编码dirigent蛋白质或pinoresinol / lariciresinol还原酶或与至少一部分dirigent蛋白质或pinoresinol / lariciresinol还原酶DNA或RNA充分互补的碱基序列，以使其能够进行杂交。在另外的方面，提供已经用编码dirigent蛋白质或pinoresinol / lariciresinol还原酶的重组克隆载体和/或DNA序列转化，转染，感染和/或注射的修饰的宿主细胞。因此，提供了用于重组表达dirigent蛋白质和/或pinoresinol / lariciresinol还原酶的系统和方法。

3. 发明申请

US20120258060A1 METHODS FOR PROTECTING THE SKIN FROM RADIATION INSULTS 审中-公开
标题翻译：保护皮肤免受辐射绝缘的方法
公开(公告)号：US20120258060A1
公开(公告)日：2012-10-11
申请号：US13528448
申请日：2012-06-20
申请人： Paul Talalay , Albena T. Dinkova-Kostova
发明人： Paul Talalay , Albena T. Dinkova-Kostova
IPC分类号： A61K31/26 , A61K31/7028 , A61P17/16 , A61K31/66
CPC分类号： A61K31/26
摘要： The present invention relates to methods and compositions for the protection of skin and mucous membranes from undesirable side effects of ionizing radiation in a patient undergoing ionizing radiation therapy. In particular, the application describes compositions and methods comprising the topical use of Nrf2 inducers.
摘要翻译：本发明涉及用于保护皮肤和粘膜免受经历电离辐射治疗的患者中电离辐射的不良副作用的方法和组合物。特别地，本申请描述了包含Nrf2诱导剂的局部使用的组合物和方法。

4. 发明申请

US20090247477A1 Methods of suppressing uv light-induced skin carcinogenesis 审中-公开
标题翻译：抑制紫外光诱导皮肤癌发生的方法
公开(公告)号：US20090247477A1
公开(公告)日：2009-10-01
申请号：US11919430
申请日：2006-04-27
申请人： Paul Talalay , Albena T. Dinkova-Kostova
发明人： Paul Talalay , Albena T. Dinkova-Kostova
IPC分类号： A61K31/7004 , A61K31/13 , A61P35/00
CPC分类号： A61K31/095
摘要： Administration of the isothiocyanate protects against UV light-induced skin carcinogenesis. In particular, topical application or dietary administration of isothiocyanate sulforaphane after exposure to UV radiation provides effective protection against skin tumor formation. Sulforaphane analogs and glucosinolates also can be employed. Lotions useful for suppressing UV light-induced skin carcinogenesis also are provided.
摘要翻译：异硫氰酸盐的施用可防止紫外光诱导的皮肤癌发生。特别地，在暴露于紫外线辐射后局部施用或异烟肼异硫氰酸酯萝卜硫素的饮食给予有效的防止皮肤肿瘤形成的保护。也可以使用萝卜硫烷类似物和硫代葡萄糖苷。还提供了用于抑制UV光诱导的皮肤致癌作用的乳液。

5. 发明授权

US07407986B2 Prevention and treatment of oxidative stress disorders by glutathione and phase II detoxification enzymes 有权
标题翻译：预防和治疗谷胱甘肽和II期解毒酶的氧化应激障碍
公开(公告)号：US07407986B2
公开(公告)日：2008-08-05
申请号：US10499196
申请日：2002-12-18
申请人： Xiangqun Gao , Albena T. Dinkova-Kostova , Paul Talalay
发明人： Xiangqun Gao , Albena T. Dinkova-Kostova , Paul Talalay
IPC分类号： A01N47/40
CPC分类号： A61K31/7024 , A61K31/00 , A61K31/26
摘要： The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracellular levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracellular levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.
摘要翻译：本发明一般涉及通过施用药物有效量的提高动物组织中细胞内谷胱甘肽含量或细胞内水平的至少一种II期解毒酶的化合物来治疗氧化应激障碍的领域。本发明还涉及通过施用药物有效量的提高受试者中的谷胱甘肽的细胞内水平或细胞内水平的至少一种II期解毒酶的化合物来保护受试者免受氧化应激障碍的领域。本发明还涉及可用于治疗氧化应激障碍的药物组合物。

6. 发明授权

US08303949B2 Prevention and treatment of oxidative stress disorders by glutathione and phase II detoxification enzymes 有权
标题翻译：预防和治疗谷胱甘肽和II期解毒酶的氧化应激障碍
公开(公告)号：US08303949B2
公开(公告)日：2012-11-06
申请号：US12179986
申请日：2008-07-25
申请人： Xiangqun Gao , Albena T. Dinkova-Kostova , Paul Talalay
发明人： Xiangqun Gao , Albena T. Dinkova-Kostova , Paul Talalay
IPC分类号： A61K38/44
CPC分类号： A61K31/7024 , A61K31/00 , A61K31/26
摘要： The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.
摘要翻译：本发明一般涉及通过施用药物有效量的在动物组织中升高谷胱甘肽的细胞内水平或至少一种II期解毒酶的细胞内水平的化合物来治疗氧化应激障碍的领域。本发明还涉及通过施用药物有效量的提高受试者中至少一种II型解毒酶的谷胱甘肽的细胞内水平或细胞内水平的化合物来保护受试者免受氧化应激障碍的领域。本发明还涉及可用于治疗氧化应激障碍的药物组合物。

7. 发明申请

US20090017002A1 PREVENTION AND TREATMENT OF OXIDATIVE STRESS DISORDERS BY GLUTATHIONE AND PHASE II DETOXIFICATION ENZYMES 有权
标题翻译：氧化应激障碍预防和治疗谷胱甘肽和二期脱氧酶
公开(公告)号：US20090017002A1
公开(公告)日：2009-01-15
申请号：US12179986
申请日：2008-07-25
申请人： Xiangqun Gao , Albena T. Dinkova-Kostova , Paul Talalay
发明人： Xiangqun Gao , Albena T. Dinkova-Kostova , Paul Talalay
IPC分类号： A61K38/44 , A61K31/27 , A61K38/45 , A61K38/43 , A61P25/28
CPC分类号： A61K31/7024 , A61K31/00 , A61K31/26
摘要： The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.
摘要翻译：本发明一般涉及通过施用药物有效量的在动物组织中升高谷胱甘肽的细胞内水平或至少一种II期解毒酶的细胞内水平的化合物来治疗氧化应激障碍的领域。本发明还涉及通过施用药物有效量的提高受试者中至少一种II型解毒酶的谷胱甘肽的细胞内水平或细胞内水平的化合物来保护受试者免受氧化应激障碍的领域。本发明还涉及可用于治疗氧化应激障碍的药物组合物。

8. 发明申请

US20110014137A1 METHODS FOR PROTECTING THE SKIN FROM RADIATION INSULTS 审中-公开
标题翻译：保护皮肤免受辐射绝缘的方法
公开(公告)号：US20110014137A1
公开(公告)日：2011-01-20
申请号：US12761551
申请日：2010-04-16
申请人： Paul Talalay , Albena T. Dinkova-Kostova
发明人： Paul Talalay , Albena T. Dinkova-Kostova
IPC分类号： A61K31/26 , A61K31/7028 , A61Q17/04 , A61P17/16 , A61P7/10 , A61P29/00 , A61P1/04 , A61P17/00 , A61P35/00
CPC分类号： A61K31/26
摘要： The present invention relates to methods and compositions for the protection of skin and mucous membranes from undesirable side effects of ionizing radiation in a patient undergoing ionizing radiation therapy. In particular, the application describes compositions and methods comprising the topical use of Nrf2 inducers.
摘要翻译：本发明涉及用于保护皮肤和粘膜免受经历电离辐射治疗的患者中电离辐射的不良副作用的方法和组合物。特别地，本申请描述了包含Nrf2诱导剂的局部使用的组合物和方法。

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