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1. 发明授权

US5006553A Agent for improving reduced functions of organs caused by inhibited blood circulation 失效
标题翻译：改善由血液循环受阻引起的器官功能降低的药剂
公开(公告)号：US5006553A
公开(公告)日：1991-04-09
申请号：US555829
申请日：1990-07-23
申请人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
发明人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention provides (1) an agent for improving the reduced functions of organs caused by inhibited blood circulation, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) ##STR1## wherein R.sub.1 to R.sub.3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ (Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for improving the reduced functions of organs caused by inhibited blood circulation, characterized by administering, in need of such treatment, an effective amount of an organogermanium compound represented by the above formula (I).
摘要翻译：本发明提供（1）一种用于改善由抑制血液循环引起的功能降低的药剂，其特征在于，含有式（I）表示的有机锗化合物作为有效成分，其中R1至 R3各自为氢原子，低级烷基如甲基，乙基等可以相同或不同，或取代或未取代的苯基，X为羟基，O-低级烷基，氨基或O-Y +（Y是金属如钠，钾等，或含碱性基团的化合物如溶菌酶，碱性氨基酸等），和（2）一种改善功能降低的方法其特征在于，在需要这种治疗的情况下施用有效量的由上述式（I）表示的有机锗化合物。

2. 发明授权

US4919917A Agent for reducing nephrotoxicity caused by cyclosporin administration 失效
标题翻译：降低环孢菌素给药引起的肾毒性的药剂
公开(公告)号：US4919917A
公开(公告)日：1990-04-24
申请号：US261406
申请日：1988-10-24
申请人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
发明人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
IPC分类号： A61K31/28 , A61K38/00 , A61P13/02 , A61P15/00 , A61P37/06 , A61P43/00 , C07F7/30
CPC分类号： C07F7/30 , Y10S514/922
摘要： The present invention provides (1) an agent for reducing the nephrotoxicity caused by cyclosporin administration, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) ##STR1## wherein R.sub.1 to R.sub.3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ (Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for reducing the nephrotoxicity caused by cyclosporin administration, characterized by administering, in need of such treatment, an effective amount of an organogermanium compound represented by the above formula (I).
摘要翻译：本发明提供（1）一种降低由环孢菌素给药引起的肾毒性的药剂，其特征在于，含有式（I）表示的有机锗化合物作为有效成分，其中R1〜R3各自为氢原子，可以相同或不同的甲基，乙基等的低级烷基或取代或未取代的苯基，X是羟基，O-低级烷基，氨基或O -Y +（Y是钠，钾等金属或溶菌酶，碱性氨基酸等碱性化合物），（2）降低环孢菌素给药引起的肾毒性的方法，其特征在于，在需要这种治疗的情况下施用有效量的由上式（I）表示的有机锗化合物。

3. 发明授权

US4956272A Organogermanium containing solution for washing and storing separated organs 失效
标题翻译：含有机硅的溶液用于洗涤和储存分离的器官
公开(公告)号：US4956272A
公开(公告)日：1990-09-11
申请号：US261628
申请日：1988-10-24
申请人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
发明人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
IPC分类号： A01N1/02 , A01N55/02
CPC分类号： A01N55/02 , A01N1/02 , A01N1/0226
摘要： The present invention provides (1) a solution for washing and storing separated organs, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) ##STR1## wherein R.sub.1 to R.sub.3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ (Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for washing and storing separated organs with a solution containing, as an effective component, an organogermanium compound represented by the formula (I).
摘要翻译：本发明提供（1）洗涤和储存分离的器官的溶液，其特征在于含有式（I）表示的有机锗化合物作为有效成分，其中R1至R3各自为氢原子，可以相同或不同的甲基，乙基等的低级烷基或取代或未取代的苯基，X是羟基，O-低级烷基，氨基或O-Y + （Y是钠，钾等金属或溶菌酶，碱性氨基酸等含碱性化合物的化合物），和（2）将分离的器官与含有作为有效成分，由式（I）表示的有机锗化合物。

4. 发明授权

US5631648A Signal compression or expansion circuit for mobile communication 失效
标题翻译：用于移动通信的信号压缩或扩展电路
公开(公告)号：US5631648A
公开(公告)日：1997-05-20
申请号：US353615
申请日：1994-12-12
申请人： Takaaki Yamada , Kazuo Kumano , Kazuhiro Takeda
发明人： Takaaki Yamada , Kazuo Kumano , Kazuhiro Takeda
IPC分类号： H03G7/08 , H03G7/00 , H03G11/00 , H04B1/64 , H03M1/88
CPC分类号： H04B1/64
摘要： A signal-processing circuit adapted for signal compression and expansion performed in the transmitter and receiver of mobile communication equipment. The signal-processing circuit comprises a multiplication type D/A converter to which an analog signal is applied, a level detector circuit that detects the level of the analog signal, and an A/D converter. The D/A converter converts the analog input signal into an analog output signal having an amplitude corresponding to digital control data. The A/D converter digitizes the output signal from the level detector circuit and supplies it as said digital control data to the D/A converter. These circuits can be fabricated from CMOS circuits.
摘要翻译：一种适于在移动通信设备的发射机和接收机中执行的信号压缩和扩展的信号处理电路。该信号处理电路包括一个乘法型D / A转换器，一个模拟信号被施加到其上，一个电平检测电路检测模拟信号的电平，一个A / D转换器。 D / A转换器将模拟输入信号转换成具有对应于数字控制数据的振幅的模拟输出信号。 A / D转换器对来自电平检测器电路的输出信号进行数字化，并将其作为数字控制数据提供给D / A转换器。这些电路可以由CMOS电路制造。

5. 发明授权

US06074359A Method and apparatus for a tidal oscillating pulse peritoneal dialysis 失效
标题翻译：用于潮波振荡脉冲腹膜透析的方法和装置
公开(公告)号：US06074359A
公开(公告)日：2000-06-13
申请号：US420896
申请日：1995-04-11
申请人： Prakash R. Keshaviah , Jim Ebben , Paul Emerson , Kazuo Kumano
发明人： Prakash R. Keshaviah , Jim Ebben , Paul Emerson , Kazuo Kumano
IPC分类号： A61H23/00 , A61M1/14 , A61M1/16 , A61M1/28 , A61M37/00 , A61M1/00
CPC分类号： A61M1/28 , A61M1/281 , A61M1/288 , A61H23/00 , A61M1/1694 , A61M2205/12 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , A61M37/0092
摘要： An improved peritoneal dialysis method and system is provided. The method utilizes a tidal oscillating pulse peritoneal dialysis system. To this end, a system for providing peritoneal dialysis to a patient is provided. The system comprises a single catheter that is placed in the patient, a reservoir of dialysate having a volume greater than or equal to three liters, and a single pump for pumping the dialysate from the reservoir into and out of the patient.
摘要翻译：提供了一种改进的腹膜透析方法和系统。该方法利用潮波振荡脉冲腹膜透析系统。为此，提供了一种用于向患者提供腹膜透析的系统。该系统包括放置在患者体内的单个导管，具有大于或等于3升体积的透析液储存器和用于将透析液从储存器泵入和流出患者的单个泵。

6. 发明授权

US5929706A Automatic gain control method and device 失效
标题翻译：自动增益控制方法及装置
公开(公告)号：US5929706A
公开(公告)日：1999-07-27
申请号：US843251
申请日：1997-04-14
申请人： Tsutomu Haruta , Kazuo Kumano
发明人： Tsutomu Haruta , Kazuo Kumano
IPC分类号： H03M1/18 , H03G1/00 , H03G3/00 , H03G3/30
CPC分类号： H03G3/001 , H03G1/0088
摘要： An automatic gain control method and device capable of maintaining the gain within a predetermined proper range by first amplifying an input analog signal from a microphone or the like, then sampling the amplified analog signal while comparing the voltage thereof with a predetermined reference voltage, and when the number of times that the voltage of the amplified analog signal is higher than the reference voltage exceeds a predetermined number of times, varying the gain of the amplified analog signal stepwise in response to every excess beyond the predetermined number of times. Consequently it becomes possible to eliminate the necessity of an input amplifier of a sufficient bandwidth and an A-D converter, hence realizing manufacture of an improved device composed of a single-chip CMOS integrated circuit, with further advantages of minimizing the number of required component parts, reducing the production processes, achieving a higher integration density and lowering the power consumption.
摘要翻译：一种自动增益控制方法和装置，其能够通过首先放大来自麦克风等的输入模拟信号来将增益保持在预定的适当范围内，然后对放大的模拟信号进行采样，同时将其电压与预定参考电压进行比较，放大的模拟信号的电压高于参考电压的次数超过预定次数，响应于每超过预定次数而逐步改变放大的模拟信号的增益。因此，可以消除足够带宽的输入放大器和AD转换器的必要性，从而实现由单芯片CMOS集成电路构成的改进器件的制造，具有最小化所需部件数量的进一步优点，减少生产过程，实现更高的集成密度和降低功耗。

7. 发明授权

US6030766A Organ preservation composition comprising nicaraven and methods of use 失效
标题翻译：器官保存组合物，包括尼姑和使用方法
公开(公告)号：US6030766A
公开(公告)日：2000-02-29
申请号：US976580
申请日：1997-11-24
申请人： Yoshihiko Masaki , Kazuo Kumano
发明人： Yoshihiko Masaki , Kazuo Kumano
IPC分类号： A01N1/00 , A01N1/02 , A61K31/44 , A61K31/455 , A01N43/40
CPC分类号： A01N1/0221 , A01N1/00 , A01N1/02 , A61K31/44 , A61K31/455
摘要： An organ preservative or protective that are characterized by containing (.+-.)-N,N'-propylenedinicotinamide as an active ingredient. The compound not only exhibits outstanding organ preserving and protecting effects: it is also free from any significant problems with side effects and safety aspects. Hence, it is very useful as an organ preservative and protective.
摘要翻译：特征在于含有（+/-） - N，N'-丙基二烟酰胺作为活性成分的器官防腐剂或保护剂。该化合物不仅具有优异的器官保存和保护作用：对副作用和安全性方面也没有任何重大问题。因此，作为器官防腐剂和保护剂是非常有用的。

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