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1. 发明授权

US08960808B2 Underwater miner cutter head, underwater miner, and underwater mining system 有权
标题翻译：水下矿工刀头，水下矿工和水下采矿系统
公开(公告)号：US08960808B2
公开(公告)日：2015-02-24
申请号：US13635492
申请日：2011-05-09
申请人： Norihide Wakita , Futoshi Sameshima , Hiroyuki Odaka
发明人： Norihide Wakita , Futoshi Sameshima , Hiroyuki Odaka
IPC分类号： E02F3/92 , E02F3/24 , E02F3/88 , E02F3/20 , E21C50/00
CPC分类号： E02F3/246 , E02F3/205 , E02F3/8866 , E02F3/9237 , E02F3/9268 , E21C50/00
摘要： Provided is an underwater miner cutter head (20) attached to an underwater miner disposed on a seabed and configured to excavate the seabed, the cutter head including cylindrical cutter drums (21) disposed on respective sides defining a regular polygon in plan view, having bits (26) on the outer circumferential surfaces thereof, and configured to rotate around corresponding first rotational axes by first driving sources; and an intake (28) disposed at a center part of the regular polygon and configured to receive muck excavated with the bits (26), wherein rotating directions of the cutter drums (21) are set such that the bits (26) sequentially move toward the intake (28).
摘要翻译：本发明提供了一种安装在海床上并被构造成挖掘海底的水下矿工的水下矿工切割头（20），该切割头包括设置在平面图中限定正多边形的相应侧上的圆柱形切割滚筒（21）（26），并且构造成通过第一驱动源围绕对应的第一旋转轴线旋转; 以及设置在所述正多边形的中心部分并且被配置为接收用所述钻头（26）挖掘的钻屑的进气口（28），其中所述切割器滚筒（21）的旋转方向被设定为使得所述钻头（26）顺序地朝向摄入量（28）。

2. 发明申请

US20130038113A1 UNDERWATER MINER CUTTER HEAD, UNDERWATER MINER, AND UNDERWATER MINING SYSTEM 有权
标题翻译：水下矿工切割头，水下矿物和水下采矿系统
公开(公告)号：US20130038113A1
公开(公告)日：2013-02-14
申请号：US13635492
申请日：2011-05-09
申请人： Norihide Wakita , Futoshi Sameshima , Hiroyuki Odaka
发明人： Norihide Wakita , Futoshi Sameshima , Hiroyuki Odaka
IPC分类号： E21C50/00 , E02F3/92
CPC分类号： E02F3/246 , E02F3/205 , E02F3/8866 , E02F3/9237 , E02F3/9268 , E21C50/00
摘要： Provided is an underwater miner cutter head (20) attached to an underwater miner disposed on a seabed and configured to excavate the seabed, the cutter head including cylindrical cutter drums (21) disposed on respective sides defining a regular polygon in plan view, having bits (26) on the outer circumferential surfaces thereof, and configured to rotate around corresponding first rotational axes by first driving sources; and an intake (28) disposed at a center part of the regular polygon and configured to receive muck excavated with the bits (26), wherein rotating directions of the cutter drums (21) are set such that the bits (26) sequentially move toward the intake (28).
摘要翻译：本发明提供了一种安装在海床上并被构造成挖掘海底的水下矿工的水下矿工切割头（20），该切割头包括设置在平面图中限定正多边形的相应侧上的圆柱形切割滚筒（21）（26），并且构造成通过第一驱动源围绕对应的第一旋转轴线旋转; 以及设置在所述正多边形的中心部分并且被配置为接收用所述钻头（26）挖掘的钻屑的进气口（28），其中所述切割器滚筒（21）的旋转方向被设定为使得所述钻头（26）顺序地朝向摄入量（28）。

3. 发明申请

US20060135578A1 Five-membered heterocyclic compounds 失效
标题翻译：五元杂环化合物
公开(公告)号：US20060135578A1
公开(公告)日：2006-06-22
申请号：US10527426
申请日：2003-09-09
申请人： Yu Momose , Nobuyuki Takakura , Tsuyoshi Maekawa , Hiroyuki Odaka , Hiroyuki Kimura
发明人： Yu Momose , Nobuyuki Takakura , Tsuyoshi Maekawa , Hiroyuki Odaka , Hiroyuki Kimura
IPC分类号： A61K31/422 , C07D413/14
CPC分类号： C07D263/32 , C07F9/6558 , C07F9/65583
摘要： The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1- or -Z1-(CH2)n— (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, —PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.
摘要翻译：本发明提供由下式表示的化合物：其中R 1是任选取代的5元杂环基; X，Y和V相同或不同，各自为键，氧原子，硫原子等; Q为碳原子数为1〜20的二价烃基; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - - - - - - - - 1 - （CH 2）（n为0〜8的整数，Z 1为键，氧原子，硫原子等）; n为0〜8的整数。环B是任选进一步具有1至3个取代基的含氮杂环; W是碳原子数为1〜20的键或二价烃基; R 2是氢原子，氰基，-PO（OR 9）（OR 10）（R 10） SUP＆gt;和R 10相同或不同，各自为氢原子或任选取代的烃基，R 9和R 10为任选地键合以形成任选取代的环）等，或其盐，其具有优异的脂肪组织重量减少作用，降血糖作用和降血脂作用，并且其可用作预防或治疗肥胖症，糖尿病，高脂血症，葡萄糖耐量降低，高血压等。

4. 发明申请

US20050142065A1 Screening method 审中-公开
标题翻译：筛选方法
公开(公告)号：US20050142065A1
公开(公告)日：2005-06-30
申请号：US10512237
申请日：2003-04-24
申请人： Koki Kato , Yasutaka Nagisa , Hiroyuki Odaka
发明人： Koki Kato , Yasutaka Nagisa , Hiroyuki Odaka
IPC分类号： A61P3/10 , A61P43/00 , G01N33/50 , G01N33/72 , A61K49/00 , A01K67/027
CPC分类号： G01N33/723 , G01N33/5088 , G01N2800/042
摘要： The present invention provides a method of screening for an agent for the treatment of human diabetes mellitus, which comprises administering a test compound to a diabetes mellitus model non-human mammal, and selecting a compound that causes a decrease of not less than 0.5% in a glycated hemoglobin value after administration.
摘要翻译：本发明提供一种筛选人类糖尿病治疗药物的方法，该方法包括将试验化合物给予非人类哺乳动物糖尿病模型，并选择引起不少于0.5％的化合物给药后糖化血红蛋白值。

5. 发明授权

US06911459B2 Pharmaceutical composition 失效
标题翻译：药物组成
公开(公告)号：US06911459B2
公开(公告)日：2005-06-28
申请号：US10462793
申请日：2003-06-17
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： A61K45/06 , A61K9/20 , A61K9/48 , A61K31/00 , A61K31/133 , A61K31/155 , A61K31/18 , A61K31/33 , A61K31/41 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/52 , A61K31/64 , A61K31/70 , A61K31/702 , A61P3/08 , A61P3/10 , A61P5/50 , A61P43/00 , C07D233/54 , C07D263/44 , C07D277/20 , C07D277/34 , C07D401/02
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.
摘要翻译：药物组合物，其包含胰岛素敏感性增强剂与其它作用机制中与增强剂不同的抗糖尿病药物组合，其对糖尿病性高血糖症具有有效的抑制作用，并且可用于预防和治疗糖尿病。

6. 发明授权

US06545009B1 Retinoid-related receptor function regulating agent 失效
标题翻译：类视黄醇相关受体功能调节剂
公开(公告)号：US06545009B1
公开(公告)日：2003-04-08
申请号：US09720644
申请日：2000-12-28
申请人： Yasuo Sugiyama , Yu Momose , Hiroyuki Kimura , Junichi Sakamoto , Hiroyuki Odaka
发明人： Yasuo Sugiyama , Yu Momose , Hiroyuki Kimura , Junichi Sakamoto , Hiroyuki Odaka
IPC分类号： A61K31435
CPC分类号： C07D413/04 , C07D263/32 , C07D277/30 , C07D417/04
摘要： 1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be useful for preventing or treating diabetes, preventing or treating hyperlipidemia, preventing or treating impaired glucose tolerance (IGT) or for preventing transition from impaired glucose tolerance to diabetes.
摘要翻译：公开了1,3-唑衍生物，其药物组合物和调节具有1,3-唑衍生物的类视黄醇相关受体功能的方法。这种调节可用于预防或治疗糖尿病，预防或治疗高脂血症，预防或治疗葡萄糖耐量异常（IGT）或预防糖耐量受损转变为糖尿病。

7. 发明授权

US06303640B1 Pharmaceutical composition 有权
公开(公告)号：US06303640B1
公开(公告)日：2001-10-16
申请号：US09605704
申请日：2000-06-29
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： C07D40102
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

8. 发明授权

US06251924B1 Pharmaceutical composition 有权
标题翻译：药物组成
公开(公告)号：US06251924B1
公开(公告)日：2001-06-26
申请号：US09618635
申请日：2000-07-18
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： C07D40102
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in he mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.
摘要翻译：药物组合物，其包含胰岛素敏感性增强剂与其作用机制不同于其它抗糖尿病药物，其对糖尿病性高血糖症具有有效的抑制作用，并且可用于预防和治疗糖尿病。

9. 发明授权

US06214848B1 Pharmaceutical composition 有权
公开(公告)号：US06214848B1
公开(公告)日：2001-04-10
申请号：US09302508
申请日：1999-04-30
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： C07D40102
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

10. 发明授权

US6150384A Pharmaceutical composition 有权
公开(公告)号：US6150384A
公开(公告)日：2000-11-21
申请号：US303493
申请日：1999-04-30
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： A61K45/06 , A61K9/20 , A61K9/48 , A61K31/00 , A61K31/133 , A61K31/155 , A61K31/18 , A61K31/33 , A61K31/41 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/52 , A61K31/64 , A61K31/70 , A61K31/702 , A61P3/08 , A61P3/10 , A61P5/50 , A61P43/00 , C07D233/54 , C07D263/44 , C07D277/20 , C07D277/34 , C07D401/02 , A61K31/42
CPC分类号： A61K9/2018 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/52 , A61K31/64 , A61K31/70 , A61K45/06 , A61K9/2054 , A61K9/4858 , Y10S514/866
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

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