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1. 发明授权

US07846674B2 Assessing rheumatoid arthritis by measuring anti-CCP and interleukin 6 有权
标题翻译：通过测量抗CCP和白细胞介素6评估类风湿关节炎
公开(公告)号：US07846674B2
公开(公告)日：2010-12-07
申请号：US11472069
申请日：2006-06-21
申请人： Norbert Wild , Viet Peter Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Viet Peter Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N33/6869
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and interleukin 6 and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and interleukin 6 and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and interleukin 6 in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。该方法例如通过分析生物化学标记实施，包括在样品中测量抗CCP和白细胞介素6的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和白细胞介素6一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和白介素6的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

2. 发明申请

US20070298518A1 Measurment of anti-CCP and serum amyloid a method to assess rheumatoid arthritis 有权
标题翻译：抗CCP和血清淀粉样蛋白的测定法评估类风湿关节炎
公开(公告)号：US20070298518A1
公开(公告)日：2007-12-27
申请号：US11509548
申请日：2006-08-24
申请人： Norbert Wild , Veit Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and serum amyloid A and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and serum amyloid A and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and serum amyloid A in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。通过分析生物化学标记可以最好地实践，包括在样品中测量抗CCP和血清淀粉样蛋白A的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和血清淀粉样蛋白A一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和血清淀粉样蛋白A的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

3. 发明申请

US20070184498A1 Protein RS15A as a marker for colorectal cancer 审中-公开
标题翻译：蛋白质RS15A作为结肠直肠癌的标志物
公开(公告)号：US20070184498A1
公开(公告)日：2007-08-09
申请号：US11640520
申请日：2006-12-15
申请人： Michael Tacke , Marie-Luise Hagmann , Johann Karl , Michael Pfeffer , Herbert Andres , Michael Thierolf , Norbert Wild , Werner Zolg
发明人： Michael Tacke , Marie-Luise Hagmann , Johann Karl , Michael Pfeffer , Herbert Andres , Michael Thierolf , Norbert Wild , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein RS15A (ribosomal protein S15a) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring RS15A in said sample. Measurement of RS15A can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质RS15A（核糖体蛋白S15a）在结直肠癌诊断中的应用。本发明涉及通过在所述样品中测量RS15A从个体衍生的来自液体样品的结肠直肠癌诊断方法。 RS15A的测定可以例如用于结肠直肠癌的早期检测或诊断。

4. 发明授权

US08062907B2 Method to assess the severity of rheumatoid arthritis by measuring anti-CCP and serum amyloid A 有权
标题翻译：通过测量抗CCP和血清淀粉样蛋白A评估类风湿关节炎的严重程度的方法
公开(公告)号：US08062907B2
公开(公告)日：2011-11-22
申请号：US13024543
申请日：2011-02-10
申请人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/564 , C07K14/47 , C07K16/18
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： Disclosed is a method for assessing a severity of rheumatoid arthritis. The method involves measuring in a patient sample a concentration of anti-cyclic citrullinated peptides (anti-CCP) and serum amyloid A, combining the concentrations determined to obtain a combined value, and comparing the combined value to a cut-off value established from a reference population. In another method, a marker selected from the group consisting of C-reactive protein (CRP), interleukin 6 (IL-6), S100 protein, osteopontin, rheumatoid factor (RF), matrix metalloprotease 1 (MMP-1), matrix metalloprotease 3 (MMP-3), hyaluronic acid, and soluble CD14 (sCD14) may also be determined along with the anti-CCP and serum amyloid A.
摘要翻译：公开了一种评估类风湿性关节炎严重程度的方法。该方法包括在患者样品中测量抗环瓜氨酸肽（抗CCP）和血清淀粉样蛋白A的浓度，将确定的浓度组合以获得组合值，并将组合值与从参考人口。在另一种方法中，选自C反应蛋白（CRP），白介素6（IL-6），S100蛋白，骨桥蛋白，类风湿因子（RF），基质金属蛋白酶1（MMP-1），基质金属蛋白酶 3（MMP-3），透明质酸和可溶性CD14（sCD14）也可以与抗CCP和血清淀粉样蛋白A一起测定。

5. 发明申请

US20110129861A1 MEASUREMENT OF ANTI-CCP AND SERUM AMYLOID A METHOD TO ASSESS RHEUMATOID ARTHRITIS 有权
标题翻译：抗CCP和血清淀粉样蛋白的测定方法评估炎症性脑膜炎
公开(公告)号：US20110129861A1
公开(公告)日：2011-06-02
申请号：US13024543
申请日：2011-02-10
申请人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and serum amyloid A and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and serum amyloid A and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and serum amyloid A in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。通过分析生物化学标记可以最好地实践，包括在样品中测量抗CCP和血清淀粉样蛋白A的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和血清淀粉样蛋白A一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和血清淀粉样蛋白A的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

6. 发明申请

US20070072237A1 Method of assessing rheumatoid arthritis by measuring rheumatoid factor and interleukin-6 审中-公开
标题翻译：通过测量类风湿因子和白细胞介素-6评估类风湿关节炎的方法
公开(公告)号：US20070072237A1
公开(公告)日：2007-03-29
申请号：US11509416
申请日：2006-08-24
申请人： Norbert Wild , Veit Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/52
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of RF and interleukin-6 and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with RF and interleukin-6 and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising RF and interleukin-6 in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。通过分析生物化学标记可以最好地实践，包括在样品中测量RF和白细胞介素-6的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善RA在本发明方法中的评估，可以与RF和白介素-6一起确定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含RF和白细胞介素-6的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

7. 发明授权

US07981693B2 Combined measurement of anti-CCP and serum amyloid A to assess rheumatoid arthritis 有权
标题翻译：联合测定抗CCP和血清淀粉样蛋白A以评估类风湿关节炎
公开(公告)号：US07981693B2
公开(公告)日：2011-07-19
申请号：US11509548
申请日：2006-08-24
申请人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/564 , C07K14/47 , C07K16/18
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and serum amyloid A and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and serum amyloid A and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and serum amyloid A in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。通过分析生物化学标记可以最好地实践，包括在样品中测量抗CCP和血清淀粉样蛋白A的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和血清淀粉样蛋白A一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和血清淀粉样蛋白A的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

8. 发明申请

US20060257951A1 Use of protein spee as a marker for breast cancer 审中-公开
标题翻译：使用蛋白质spee作为乳腺癌的标志物
公开(公告)号：US20060257951A1
公开(公告)日：2006-11-16
申请号：US11404216
申请日：2006-04-14
申请人： Gabriele Pestlin , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Norbert Wild , Werner Zolg
发明人： Gabriele Pestlin , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Norbert Wild , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N2333/91171
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of spermidine synthase (SPEE) in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring SPEE in the sample. Measurement of SPEE can, e.g., be used in the early detection or diagnosis of breast cancer.
摘要翻译：本发明涉及乳腺癌的诊断。它公开了亚精胺合酶（SPEE）在乳腺癌诊断中的应用。它涉及通过测量样品中的SPEE从来自个体的液体样品中诊断乳腺癌的方法。 SPEE的测量可以例如用于乳腺癌的早期检测或诊断。

9. 发明授权

US07566542B2 Use of protein ASC as a marker for breast cancer 失效
标题翻译：使用蛋白质ASC作为乳腺癌的标志物
公开(公告)号：US07566542B2
公开(公告)日：2009-07-28
申请号：US11404218
申请日：2006-04-14
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/53 , G01N33/574 , G01N33/48 , G01N33/536 , G01N33/537 , G01N33/577
CPC分类号： G01N33/57415
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.
摘要翻译：本发明涉及乳腺癌的诊断。它公开了蛋白质ASC在乳腺癌诊断中的应用。它涉及一种通过测量样品中的ASC从个体获得的来自液体样品的乳腺癌诊断方法。 ASC的测量可以例如用于乳腺癌的早期检测或诊断。

10. 发明申请

US20060141543A1 Cellular retinoic acid binding protein II as a marker for breast cancer 失效
公开(公告)号：US20060141543A1
公开(公告)日：2006-06-29
申请号：US11294176
申请日：2005-12-05
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57473 , G01N2333/70567
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid binding protein II in said sample. Measurement of cellular retinoic acid binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.

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