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1. 发明申请

US20110212465A1 ARMET AS A MARKER FOR CANCER 有权
标题翻译： ARMET作为癌症的标记
公开(公告)号：US20110212465A1
公开(公告)日：2011-09-01
申请号：US13103123
申请日：2011-05-09
申请人： Markus Roessler , Johann Karl , Julia Riedlinger , Ingo Lindner , Michael Tacke
发明人： Markus Roessler , Johann Karl , Julia Riedlinger , Ingo Lindner , Michael Tacke
IPC分类号： G01N33/68 , G01N33/566
CPC分类号： G01N33/57488 , G01N33/57423 , G01N33/57484 , G01N2333/475 , G01N2800/52
摘要： Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=ARMET) as a universal marker of different cancer types. ARMET aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are, e.g., breast, ovary, cervix, head and neck, endometrium, melanoma, bladder, kidney, pancreas, prostate, esophagus, stomach or bile duct cancer. Further disclosed is a method for assessing cancer from a liquid sample, derived from an individual by measuring ARMET in the sample. Measurement of ARMET can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
摘要翻译：披露了一种有助于评估癌症的方法。更具体地公开了在早期肿瘤蛋白（= ARMET）中转移的精氨酸富集作为不同癌症类型的通用标记物的用途。 ARMET有助于评估肺或肺癌（LC）或结肠癌，例如非小细胞肺癌（NSCLC）或结肠直肠癌（CRC），但也可能是其他特定类型的癌症。这些特定的癌症类型是例如乳腺，卵巢，子宫颈，头颈部，子宫内膜，黑素瘤，膀胱，肾，胰腺，前列腺，食管，胃或胆管癌。进一步公开了一种通过测量样品中的ARMET从个体获得的来自液体样品的癌症的方法。例如，可以将ARMET的测量用于癌症的早期检测或用于进行手术的患者的监视。

2. 发明申请

US20110097756A1 APEX AS A MARKER FOR LUNG CANCER 审中-公开
标题翻译： APEX作为肺癌标志物
公开(公告)号：US20110097756A1
公开(公告)日：2011-04-28
申请号：US12556879
申请日：2009-09-10
申请人： Marie-Luise Hagmann , Johann Karl , Julia Kloeckner , Markus Roessler , Michael Tacke , Michael Thierolf
发明人： Marie-Luise Hagmann , Johann Karl , Julia Kloeckner , Markus Roessler , Michael Tacke , Michael Thierolf
IPC分类号： C12Q1/44
CPC分类号： G01N33/57423 , G01N33/57488 , G01N2333/988
摘要： The present invention relates to the assessment of lung cancer. It discloses the use of protein AP endonuclease (APEX) in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample derived from an individual by measuring APEX in the sample. Measurement of APEX can, e.g., be used in the early detection or in the follow-up of patients with lung cancer.
摘要翻译：本发明涉及肺癌的评估。它公开了蛋白质AP内切核酸酶（APEX）在肺癌评估中的应用。它还涉及一种通过测量样品中的APEX，通过使用来自个体的液体样品在体外评估肺癌的方法。 APEX的测量可以例如用于肺癌患者的早期检测或随访。

3. 发明授权

US07785821B2 Measurement of nicotinamde N-methyl transferase in diagnosis of lung cancer 有权
标题翻译：测定烟碱甲氨基转移酶诊断肺癌
公开(公告)号：US07785821B2
公开(公告)日：2010-08-31
申请号：US12362584
申请日：2009-01-30
申请人： Wolfgang Rollinger , Marie Luise Hagmann , Johann Karl , Theresa Kott , Markus Roessler , Michael Tacke
发明人： Wolfgang Rollinger , Marie Luise Hagmann , Johann Karl , Theresa Kott , Markus Roessler , Michael Tacke
IPC分类号： C12Q1/48
CPC分类号： G01N33/57423 , C12Q1/48 , G01N2333/4742 , G01N2333/91011 , G01N2333/98
摘要： The present invention relates to the assessment of lung cancer. It discloses the use of protein NNMT in the assessment of lung cancer. It also relates to a method for assessing lung cancer by measuring NNMT in vitro in a liquid sample derived from an individual. Measurement of NNMT can, e.g., be used in the early detection or in the follow-up of patients with lung cancer.
摘要翻译：本发明涉及肺癌的评估。它公开了在评估肺癌中使用蛋白质NNMT。它还涉及通过在来自个体的液体样品中体外测量NNMT来评估肺癌的方法。 NNMT的测定可以例如用于肺癌患者的早期检测或随访。

4. 发明申请

US20090263841A1 USE OF NNMT AS A MARKER FOR LUNG CANCER 有权
标题翻译：使用NNMT作为肺癌标记
公开(公告)号：US20090263841A1
公开(公告)日：2009-10-22
申请号：US12362584
申请日：2009-01-30
申请人： Wolfgang Rollinger , Marie_Luise Hagmann , Johann Karl , Theresa Kott , Markus Roessler , Michael Tacke
发明人： Wolfgang Rollinger , Marie_Luise Hagmann , Johann Karl , Theresa Kott , Markus Roessler , Michael Tacke
IPC分类号： C12Q1/48
CPC分类号： G01N33/57423 , C12Q1/48 , G01N2333/4742 , G01N2333/91011 , G01N2333/98
摘要： The present invention relates to the assessment of lung cancer. It discloses the use of protein NNMT in the assessment of lung cancer. It also relates to a method for assessing lung cancer by measuring NNMT in vitro in a liquid sample derived from an individual. Measurement of NNMT can, e.g., be used in the early detection or in the follow-up of patients with lung cancer.
摘要翻译：本发明涉及肺癌的评估。它公开了在评估肺癌中使用蛋白质NNMT。它还涉及通过在来自个体的液体样品中体外测量NNMT来评估肺癌的方法。 NNMT的测定可以例如用于肺癌患者的早期检测或随访。

5. 发明申请

US20070218510A1 Use of protein PSA3 as a marker for colorectal cancer 审中-公开
标题翻译：使用蛋白质PSA3作为结肠直肠癌的标志物
公开(公告)号：US20070218510A1
公开(公告)日：2007-09-20
申请号：US11348865
申请日：2006-02-07
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/95
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein proteasome subunit alpha 3 (PSA3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSA3 in said sample. Measurement of PSA3 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质蛋白酶体亚单位α3（PSA3）在结肠直肠癌诊断中的应用。本发明涉及通过测量所述样品中的PSA3从来自个体的液体样品诊断结肠直肠癌的方法。 PSA3的测定可以例如用于结肠直肠癌的早期检测或诊断。

6. 发明申请

US20070184498A1 Protein RS15A as a marker for colorectal cancer 审中-公开
标题翻译：蛋白质RS15A作为结肠直肠癌的标志物
公开(公告)号：US20070184498A1
公开(公告)日：2007-08-09
申请号：US11640520
申请日：2006-12-15
申请人： Michael Tacke , Marie-Luise Hagmann , Johann Karl , Michael Pfeffer , Herbert Andres , Michael Thierolf , Norbert Wild , Werner Zolg
发明人： Michael Tacke , Marie-Luise Hagmann , Johann Karl , Michael Pfeffer , Herbert Andres , Michael Thierolf , Norbert Wild , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein RS15A (ribosomal protein S15a) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring RS15A in said sample. Measurement of RS15A can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质RS15A（核糖体蛋白S15a）在结直肠癌诊断中的应用。本发明涉及通过在所述样品中测量RS15A从个体衍生的来自液体样品的结肠直肠癌诊断方法。 RS15A的测定可以例如用于结肠直肠癌的早期检测或诊断。

7. 发明申请

US20070161062A1 Protein CBP2 as a marker for colorectal cancer 审中-公开
标题翻译：蛋白质CBP2作为结肠直肠癌的标志物
公开(公告)号：US20070161062A1
公开(公告)日：2007-07-12
申请号：US11640511
申请日：2006-12-15
申请人： Michael Tacke , Marie-Luise Hagmann , Johann Karl , Stefan Palme , Michael Pfeffer , Wolfgang Rollinger , Michael Thierolf , Werner Zolg
发明人： Michael Tacke , Marie-Luise Hagmann , Johann Karl , Stefan Palme , Michael Pfeffer , Wolfgang Rollinger , Michael Thierolf , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/8121
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein CBP2 (collagen-binding protein 2) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring CBP2 in said sample. Measurement of CBP2 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质CBP2（胶原结合蛋白2）在结肠直肠癌诊断中的应用。它涉及通过测量所述样品中的CBP2从来自个体的液体样品诊断结肠直肠癌的方法。 CBP2的测定可以例如用于结肠直肠癌的早期检测或诊断。

8. 发明授权

US07205118B2 Nicotinamide N-methyltransferase as a marker for colorectal cancer 有权
标题翻译：烟酰胺N-甲基转移酶作为结肠直肠癌的标志物
公开(公告)号：US07205118B2
公开(公告)日：2007-04-17
申请号：US11152765
申请日：2005-06-14
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Theresa Kott , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Theresa Kott , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/57419 , C12Q1/48
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of the protein nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质烟酰胺N-甲基转移酶（NNMT）在结肠直肠癌诊断中的应用。本发明涉及通过在所述样品中测量NNMT从个体衍生的液体样品中诊断结肠直肠癌的方法。 NNMT的测定可以例如用于结肠直肠癌的早期检测或诊断。

9. 发明申请

US20060188950A1 Use of protein spee as a marker for colorectal cancer 审中-公开
标题翻译：使用蛋白质spee作为结肠直肠癌的标志物
公开(公告)号：US20060188950A1
公开(公告)日：2006-08-24
申请号：US11348932
申请日：2006-02-07
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/91171
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein SPEE (sperrnidine synthase) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring SPEE in said sample. Measurement of SPEE can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质SPEE（精氨酸合酶）在结肠直肠癌诊断中的应用。本发明涉及一种通过测量所述样品中的SPEE从来自个体的液体样品诊断结肠直肠癌的方法。 SPEE的测量可以例如用于结肠直肠癌的早期检测或诊断。

10. 发明授权

US5804150A Process for treating gold-containing sulfide ores 失效
标题翻译：处理含金硫化矿的方法
公开(公告)号：US5804150A
公开(公告)日：1998-09-08
申请号：US805409
申请日：1997-02-24
申请人： Michael Tacke , Walter Pierson , Eberhard Stolarski
发明人： Michael Tacke , Walter Pierson , Eberhard Stolarski
IPC分类号： C22B1/02 , C22B1/10 , C22B11/00 , C22B1/00 , C22B3/00
CPC分类号： C22B11/04 , C22B1/02
摘要： The ore which contains gold and at least one of the metals silver, copper, nickel, zinc or iron is calcined at temperatures in the range from 500.degree. to 900.degree. C. with the addition of oxygen-containing gas, thereby producing a metal-oxide-containing solids mixture and a SO.sub.2 -containing exhaust gas. The SO.sub.2 containing exhaust gas is brought in contact with aqueous solution, thereby producing a sulfite-containing solution. The solids mixture from the calcination is cooled to temperatures in the range from 50.degree. to 300.degree. C. and is stirred up with the sulfite-containing solution. Metal oxides are dissolved, and a sulfate-containing solution os formed. In a first separating zone, the sulfate-containing solution is separated from the solids, and either the solids are supplied to a gold leaching or the sulfate-containing solution is subjected to a further treatment for the separation of nonferrous metals.
摘要翻译：含有金和银，铜，镍，锌或铁中的至少一种金属的矿石在加入含氧气体的同时在500-900℃的温度下煅烧，含氧化物的固体混合物和含SO 2的废气。使含SO 2的废气与水溶液接触，从而产生含亚硫酸盐的溶液。将来自煅烧的固体混合物冷却至50℃至300℃的温度，并与含亚硫酸盐的溶液一起搅拌。溶解金属氧化物，形成含硫酸盐溶液。在第一分离区中，将含硫酸盐的溶液与固体分离，并将固体供应至金浸出，或者将含硫酸盐溶液进一步处理以分离有色金属。

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