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1. 发明授权

US07846674B2 Assessing rheumatoid arthritis by measuring anti-CCP and interleukin 6 有权
标题翻译：通过测量抗CCP和白细胞介素6评估类风湿关节炎
公开(公告)号：US07846674B2
公开(公告)日：2010-12-07
申请号：US11472069
申请日：2006-06-21
申请人： Norbert Wild , Viet Peter Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Viet Peter Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N33/6869
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and interleukin 6 and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and interleukin 6 and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and interleukin 6 in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。该方法例如通过分析生物化学标记实施，包括在样品中测量抗CCP和白细胞介素6的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和白细胞介素6一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和白介素6的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

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