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    • 1. 发明申请
    • NOVEL PHARMACEUTICAL COMPOSITION FOR TREATING NOCICEPTIVE PAIN
    • 用于治疗疼痛的新型药物组合物
    • US20110152268A1
    • 2011-06-23
    • US13061219
    • 2009-09-10
    • Nobuaki TakeshitaFusako NishigakiToshiaki AokiSeiji TamuraKazumi KikuchiAkio Kuroda
    • Nobuaki TakeshitaFusako NishigakiToshiaki AokiSeiji TamuraKazumi KikuchiAkio Kuroda
    • A61K31/5375C07D265/30A61P29/00
    • C07D265/30A61K31/5375
    • The present invention relates to a pharmaceutical composition for treating nociceptive pain, containing a morpholine derivative or a pharmaceutically acceptable salt thereof, as an active ingredient. The present invention is useful in providing an excellent pharmaceutical composition for treating nociceptive pain. In addition, the present invention is particularly useful in providing a pharmaceutical composition for treating pain accompanying a disease selected from the group consisting of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, spondylosis deformans, gouty arthritis, juvenile arthritis, scapulohumeral periarthritis, and cervical syndrome, lumbago, lumbago accompanying spondylosis deformans, menalgia, pain and tumentia after inflammation, operation or injury, pain after odontectomy, and cancer pain. In addition, the present invention is particularly useful for alleviating pain in a damaged cartilage region, and is particularly useful for osteoarthritis in which NSAIDs are not effective.
    • 本发明涉及用于治疗伤害性疼痛的药物组合物,其含有吗啉衍生物或其药学上可接受的盐作为活性成分。 本发明可用于提供用于治疗伤害性疼痛的优异药物组合物。 此外,本发明特别可用于提供用于治疗伴随选自以下的疾病的药物组合物:选自类风湿性关节炎,类风湿性脊椎炎,骨关节炎,变形性椎关节强硬症,痛风性关节炎,幼年型关节炎,肩周炎性关节炎和子宫颈综合征, 腰痛,腰痛伴椎关节僵硬,麻痹症,炎症,手术或损伤后疼痛,咽后切除术后的疼痛,以及癌症疼痛。 此外,本发明特别可用于缓解软骨损伤区域的疼痛,特别适用于NSAIDs无效的骨关节炎。
    • 2. 发明申请
    • NOVEL PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DIABETIC NEUROPATHY
    • 新型预防和/或治疗糖尿病神经病变药物
    • US20100113451A1
    • 2010-05-06
    • US12530745
    • 2008-03-14
    • Toshiaki AokiNobuhito MuraiSeiji TamuraHiroko YamamotoNozomu Hamakawa
    • Toshiaki AokiNobuhito MuraiSeiji TamuraHiroko YamamotoNozomu Hamakawa
    • A61K31/5375A61P25/00
    • C07D265/30A61K31/5375
    • The present invention relates to an agent for preventing and/or treating diabetic neuropathy comprising a 2-[(substituted-inden-7-yloxy)methyl]morpholine of the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The invention is useful for providing an excellent agent for preventing and/or treating diabetic neuropathy, and particularly useful for providing an agent for preventing and/or treating diabetic motor neuropathy (such as muscle weakness disorder (such as muscle weakness disorder with inability to walk independently)), diabetic sensory neuropathy (such as paresthesia (such as vibration perception abnormality), allodynia, hypoesthesia (such as numbness of extremities or cold sensation), or pain), or diabetic autonomic neuropathy (such as stool abnormality (such as constipation or diarrhea), urination disorder, impotence, orthostatic hypotension, sudomotor dysfunction, abnormal heart rate variability, or delayed gastric emptying). Further, the invention is particularly useful for providing an agent for improving pathophysiology of diabetic neuropathy.
    • 本发明涉及用于预防和/或治疗糖尿病性神经病变的药剂,其包含式(I)的2 - [(取代 - 茚-7-基氧基)甲基]吗啉或其药学上可接受的盐作为活性成分。 本发明可用于提供用于预防和/或治疗糖尿病性神经病变的优异剂,特别可用于提供用于预防和/或治疗糖尿病运动神经病变(如肌肉无力障碍(例如无力行走的肌肉无力障碍) 独立)),糖尿病感觉神经病变(如感觉异常(如振动感知异常),异常性疼痛,麻醉(如四肢麻木或感冒)或疼痛)或糖尿病性自主神经病变(如便秘便秘) 或腹泻),排尿障碍,阳ence,直立性低血压,苏体功能障碍,异常心率变异性或延迟胃排空)。 此外,本发明特别可用于提供改善糖尿病性神经病变病理生理学的药剂。
    • 3. 发明授权
    • Tired Roller
    • 累了滚子
    • US06105707A
    • 2000-08-22
    • US37028
    • 1998-03-09
    • Seiji TamuraMorio OshinaTsuyoshi Takayama
    • Seiji TamuraMorio OshinaTsuyoshi Takayama
    • E01C19/27B60K17/00
    • E01C19/27
    • A tired roller is provided with a prime mover and a speed change unit of the HST type. The speed change unit includes an HST hydraulic pump of the variable displacement type driven by the prime mover and an HST hydraulic motor driven by pressure oil from the hydraulic pump, and can change a rotational speed of the hydraulic motor by varying a delivery rate of pressure oil from the hydraulic pump. Rotation of the hydraulic motor is therefore transmitted at a lower speed to a drive-axle tire train. A propeller shaft is connected to the hydraulic motor without interposition of any speed reduction mechanism, so that the propeller shaft is rotated at a high speed with a low torque. This has made it possible to form the propeller shaft smaller in diameter and hence to arrange it in a narrow space between tires in the drive-axle tire train. Further, the rotation of the hydraulic motor is reduced in speed at an output side of the propeller shaft, thereby making it possible to transmit the rotation in a state increased in rotating torque to the drive-axle tire train.
    • 一个疲劳的滚轮设有原动机和HST型变速单元。 变速单元包括由原动机驱动的可变排量型的HST液压泵和由液压泵由压力油驱动的HST液压马达,并且可以通过改变液压马达的转速来改变压力的输送速率 油从液压泵。 因此,液压马达的旋转以较低的速度传递到驱动轮轮胎列车。 螺旋桨轴连接到液压马达而不插入任何减速机构,使得传动轴以低扭矩高速旋转。 这使得可以形成直径更小的传动轴,并且因此将其布置在驱动轮轮胎列车中的轮胎之间的狭窄空间中。 此外,液压马达的旋转在传动轴的输出侧的速度降低,从而可以将旋转扭矩增大的旋转传递到驱动轴轮胎列。
    • 4. 发明授权
    • Robot apparatus and control method thereof
    • 机器人装置及其控制方法
    • US07761184B2
    • 2010-07-20
    • US10805708
    • 2004-03-22
    • Tomohisa MoridairaSeiji Tamura
    • Tomohisa MoridairaSeiji Tamura
    • G06F19/00G05B19/04G05B19/418
    • G06N3/008B25J9/1674G05B2219/39082G05B2219/39088G05B2219/39094
    • A robot apparatus capable of offering significantly improved safety and a control method thereof by detecting a safety level status and a safety level of the safety level status and then, in response, taking prescribed countermeasures. In addition, in a movable robot apparatus and its control method, a safety level status detecting means for detecting a safety level status and a control means for performing a control process so as to implement prescribed countermeasures depending on the position of the safety level status detected by the safety level status detecting means are provided. Further, in a robot apparatus and its control method, a safety level involving an object and movable parts is detected when the object is detected, and the movable parts are moved so as to mitigate or avoid the danger based on the detected safety level and a determined action.
    • 一种能够通过检测安全等级状态和安全等级状态的安全级别而提供显着改善的安全性的机器人装置及其控制方法,然后作为响应,采取规定的对策。 此外,在可动机器人装置及其控制方法中,安全级状态检测装置用于检测安全等级状态,以及控制装置,用于执行控制处理,以便根据检测到的安全等级状态的位置实现规定的对策 由安全等级状态检测装置提供。 此外,在机器人装置及其控制方法中,当检测到物体时检测到涉及物体和可移动部件的安全等级,并且移动可移动部件以便基于检测到的安全等级来减轻或避免危险,并且 确定行动。
    • 6. 发明授权
    • Method for manufacturing a diaphragm for a gasmeter
    • 制造气量计隔膜的方法
    • US5422064A
    • 1995-06-06
    • US221559
    • 1994-04-01
    • Seiji Tamura
    • Seiji Tamura
    • G01F3/22B29C33/40
    • G01F3/225
    • This method for forming a measuring diaphragm which measures the volume of a passing gas with high accuracy and has a prolonged service life because the diaphragm moves completely in the same way to both sides of the measuring vessel in which it is fixed. The measuring diaphragm when produced in quantity has an undulating structure of high uniformity and variation in quality of the diaphragm is small. The method of preparation of the measuring diaphragm includes providing each of a pair of molds with a flat part at the center and providing a multiplicity of grooves and ribs at the periphery parallel to an edge of the central part; placing the grooves and ribs in such a way that the grooves of one mold fit the ribs of the other mold, such that the depth of a groove on a mold is larger than the height of a rib on the other mold which fits the groove; pressing an elastomer composite sheet material between the molds, such that one side of the pressed elastomer composite sheet material is pressed to the surface of the ribs of the mold and fixed there with tension and the other side of the elastomer composite sheet material is out in contact with the surface of the grooves of the mold; and then heating the elastomer composite sheet material to crosslink the elastomers composite sheet and to form a desired shape.
    • 该方法用于形成测量膜片,该测量膜片由于膜片以与固定的测量容器的两侧完全相同的方式完全测量高通量气体并且具有延长的使用寿命。 量产时的测量膜片具有高度均匀的起伏结构,并且膜片质量的变化小。 测量膜的制备方法包括:在一对模具中设置一个平坦部分,并在平行于中心部分边缘的边缘处提供多个凹槽和肋; 以这样的方式放置槽和肋,使得一个模具的凹槽与另一个模具的肋条配合,使得模具上的凹槽的深度大于在另一个模具上适合槽的肋的高度; 在模具之间挤压弹性体复合片材,使得压制的弹性体复合片材的一面被压到模具的肋表面并且在其上固定,并且弹性体复合片材的另一侧在 与模具槽的表面接触; 然后加热弹性体复合片材以使弹性体复合片材交联并形成所需的形状。
    • 7. 发明授权
    • Hydraulic circuit system for civil engineering and architectural
machinery
    • 土木工程及建筑机械液压回路系统
    • US4614475A
    • 1986-09-30
    • US737884
    • 1985-05-28
    • Seiji TamuraToshimichi IkedaToichi Hirata
    • Seiji TamuraToshimichi IkedaToichi Hirata
    • E02F9/22F02F3/00
    • E02F9/2239E02F9/2292Y10S37/902
    • A hydraulic circuit system for civil engineering and architectural machinery having at least first and second hydraulic pumps, a plurality of actuators driven by hydraulic fluid from said pumps, and a plurality of directional control valves for controlling the direction and flow rate of the hydraulic fluid supplied from the pumps to the actuators. In the directional control valves, a first boom directional control valve and one of right and left travelling directional control valves are connected to the first pump in parallel with each other, a swing directional control valve, an arm directional control valve and a second boom directional control valve are connected to the second pump in parallel with one another, and the other of the right and left travelling directional control valve is connected in tandem to the swing, arm and second boom directional control valves at a location downstream thereof. A connecting line is provided for communication between an inlet port of the one travelling directional control valve and an inlet port of the other travelling directional control valve.
    • 一种用于土木工程和建筑机械的液压回路系统,其具有至少第一和第二液压泵,由所述泵的液压流体驱动的多个致动器以及用于控制供应的液压流体的方向和流量的多个方向控制阀 从泵到执行器。 在方向控制阀中,第一起重臂方向控制阀和左右行驶方向控制阀中的一个彼此并联连接到第一泵,摆动方向控制阀,臂方向控制阀和第二起重臂定向 控制阀彼此并联连接到第二泵,并且左右行进方向控制阀中的另一个与其下游位置的摆臂,臂和第二起重臂方向控制阀串联连接。 连接线设置在一个行进方向控制阀的入口与另一行进方向控制阀的入口之间的连通。
    • 8. 发明授权
    • Honeycomb structure
    • 蜂窝结构
    • US08685885B2
    • 2014-04-01
    • US13090262
    • 2011-04-20
    • Seiji TamuraMasaya SatoShigeaki Goto
    • Seiji TamuraMasaya SatoShigeaki Goto
    • B01J23/02B32B3/12
    • B01D46/2466C04B28/24C04B35/565C04B37/005C04B38/0006C04B38/0016C04B2111/00793C04B2111/0081C04B2235/3418C04B2235/3826C04B2235/5224C04B2237/062C04B2237/365C04B14/324C04B14/4625C04B24/383C04B38/0019C04B38/0054C04B38/0074
    • A honeycomb structure includes a ceramic block including honeycomb fired bodies. The honeycomb fired bodies include an assembly including a plurality of substantially quadrangular-cross-section units which are combined with one another with an adhesive layer interposed between the plurality of substantially quadrangular-cross-section units. A peripheral face of the assembly of substantially quadrangular-cross-section units has a concave portion and a convex portion formed in a substantially step-shaped pattern. At least one substantially triangular-cross-section unit has an outer wall on a periphery portion of the at least one substantially triangular-cross-section unit. The at least one substantially triangular-cross-section unit is fit in the concave portion with the adhesive layer interposed between the at least one substantially triangular-cross-section unit and the concave portion. A sealing material layer is provided on a peripheral face of the ceramic block. The sealing material layer has partially different thickness.
    • 蜂窝结构体包括具有蜂窝烧制体的陶瓷块。 蜂窝烧制体包括一组合件,该组件包括多个大致四边形横截面单元,它们彼此组合,并且夹在多个基本四边形横截面单元之间的粘合剂层。 大致四边形横截面单元的组件的外周面具有形成为大致阶梯形图案的凹部和凸部。 至少一个基本上三角形的横截面单元在至少一个基本上三角形横截面单元的周边部分上具有外壁。 所述至少一个基本上为三角形的截面单元装配在所述凹部中,所述粘合剂层插入在所述至少一个基本上三角形横截面单元和所述凹部之间。 密封材料层设置在陶瓷块的周面上。 密封材料层具有部分不同的厚度。