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1. 发明授权

US4530836A Peptide 失效
标题翻译：肽
公开(公告)号：US4530836A
公开(公告)日：1985-07-23
申请号：US611538
申请日：1984-05-17
申请人： Noboru Yanaihara , Nobuo Sugiura , Kazuhisa Kashimoto
发明人： Noboru Yanaihara , Nobuo Sugiura , Kazuhisa Kashimoto
IPC分类号： A61K38/00 , C07K5/097 , C07K5/103 , C07K14/595 , A61K37/00 , C07C103/52
CPC分类号： C07K5/0821 , C07K14/5955 , C07K5/1013 , A61K38/00
摘要： Novel peptides represented by the following formulaR.sub.1 --A--B--C--D--Trp--Met--Y (1)wherein; R.sub.1 denotes pGlu, X--R.sub.2 --CO--, X being carboxyl or amino and R.sub.2 being lower alkylene of 1-6 carbon atoms, or ##STR1## A denotes Asp, Ala, or merely a chemical bond; B denotes Tyr(SO.sub.3 H) or Phe(NHSO.sub.3 H); C denotes Met or merely a chemical bond; D denotes Gly, D--Ala, or D--Trp; and Y denotes NH.sub.2, Asp--NH.sub.2, or Asp--Phe--NH.sub.2 ; with the proviso that Y is NH.sub.2 or Asp--NH.sub.2 when R.sub.1 is pGlu, HOOC--R.sub.2 --CO--, or ##STR2## B is Tyr(SO.sub.3 H), C is Met, and D is Gly, and pharmacologically acceptable salts thereof.
摘要翻译：由下式R1-A-B-C-D-Trp-Met-Y（1）表示的新肽，其中： R1表示pGlu，X-R2-CO-，X为羧基或氨基，R2为1-6个碳原子的低级亚烷基，或表示Asp，Ala或仅为化学键; B表示Tyr（SO3H）或Phe（NHSO3H）; C表示Met或仅仅是化学键; D表示Gly，D-Ala或D-Trp; Y表示NH2，Asp-NH2或Asp-Phe-NH2; 条件是当R1为pGlu时，Y为NH2或Asp-NH2，HOOC-R2-CO-或B为Tyr（SO3H），C为Met，D为Gly，以及其药理学上可接受的盐。

2. 再颁专利

USRE32534E Peptides, process for preparing the same and psychodepressant compositions containing the same 失效
标题翻译：肽，制备相同的方法和含有它们的心理抑制剂组合物
公开(公告)号：USRE32534E
公开(公告)日：1987-10-27
申请号：US816071
申请日：1986-01-03
申请人： Noboru Yanaihara , Nobuo Sugiura , Takashi Hiyama
发明人： Noboru Yanaihara , Nobuo Sugiura , Takashi Hiyama
IPC分类号： A61K38/00 , C07K5/072 , C07K14/595
CPC分类号： C07K14/595 , C07K5/06113 , A61K38/00
摘要： This invention provides a peptide represented by the formulaR--Tyr(SO.sub.3 H)--Met--Gly--Trp--Met--Asp--W--NH.sub.2wherein R is HOOC--A--CO--Asp-- (wherein A is lower alkylene), pGlu--Asp--, HOOC--A--CO-- (wherein A is lower alkylene) or ##STR1## and W is Phe or N.sup..alpha. -lower alkyl-Phe, or a salt thereof, process for preparing the peptide and psychodepressant composition containing the peptide.The peptides of the invention are useful as psychodepressant drug, and especially effective for curing schizophrenia.

3. 发明授权

US4517180A Peptides, process for preparing the same and psychodepressant compositions containing the same 失效
标题翻译：肽，制备相同的方法和含有它们的心理抑制剂组合物
公开(公告)号：US4517180A
公开(公告)日：1985-05-14
申请号：US545994
申请日：1983-10-27
申请人： Noboru Yanaihara , Nobuo Sugiura , Takashi Hiyama
发明人： Noboru Yanaihara , Nobuo Sugiura , Takashi Hiyama
IPC分类号： A61K38/00 , C07K5/072 , C07K14/595 , A61K37/00 , C07C103/52
CPC分类号： C07K14/595 , C07K5/06113 , A61K38/00
摘要： This invention provides a peptide represented by the formulaR--Tyr(SO.sub.3 H)--Met--Gly--Trp--Met--Asp--W--NH.sub.2wherein R is HOOC--A--CO--Asp-- (wherein A is lower alkylene), pGlu--Asp--, HOOC--A--CO-- (wherein A is lower alkylene) or ##STR1## and W is Phe or N.sup..alpha. -lower alkyl-Phe, or a salt thereof, process for preparing the peptide and psychodepressant composition containing the peptide.The peptides of the invention are useful as psychodepressant drug, and especially effective for curing schizophrenia.
摘要翻译：本发明提供由式R-Tyr（SO3H）-Met-Gly-Trp-Met-Asp-W-NH2表示的肽，其中R是HOOC-A-CO-Asp-（其中A是低级亚烷基），pGlu- Asp-，HOOC-A-CO-（其中A为低级亚烷基）或W为Phe或Nα - 低级烷基-Phe，或其盐，制备含有该肽的肽和精神抑郁剂组合物的方法。本发明的肽可用作精神抑郁药物，并且对于治疗精神分裂症尤其有效。

4. 发明授权

US4330466A Process for the production of cholecystokinin-pancreozymin C-terminal peptide amide sulfate esters 失效
标题翻译：缩胆囊素 - 胰酶酶C端肽酰胺硫酸酯的制备方法
公开(公告)号：US4330466A
公开(公告)日：1982-05-18
申请号：US217187
申请日：1980-12-16
申请人： Noboru Yanaihara , Nobuo Sugiura
发明人： Noboru Yanaihara , Nobuo Sugiura
IPC分类号： C07K7/06 , C07C231/00 , C07K1/113 , C07C103/52
CPC分类号： C07K7/06 , Y02P20/55
摘要： A novel process for the production of cholecystokininpancreozymin C-terminal peptide amide sulfate esters in a high yield and through a simple operation is described. A protected peptide amide is reacted with sulfur trioxide-pyridine complex and resulting protected piptide amide sulfate ester is then isolated in the form of its calcium salt. Thereafter, the protecting groups and calcium are removed. Sulfuric acid resulting from unreacted sulfur trioxide-pyridine complex may be precipitated and easily removed in the form of calcium sulfate.
摘要翻译：描述了一种用于以高产率和通过简单操作生产胆囊收缩胰蛋白酶C末端肽酰胺硫酸酯的新方法。保护的肽酰胺与三氧化硫 - 吡啶络合物反应，然后以其钙盐的形式分离得到的保护的肽肽酰胺硫酸酯。此后，除去保护基和钙。由未反应的三氧化硫 - 吡啶络合物产生的硫酸可以沉淀并容易地以硫酸钙的形式除去。

5. 发明申请

US20090233336A1 PROCESS FOR PRODUCING CHONDROITIN 审中-公开
标题翻译：生产氯苯醌的方法
公开(公告)号：US20090233336A1
公开(公告)日：2009-09-17
申请号：US12094208
申请日：2006-11-16
申请人： Nobuo Sugiura , Satoshi Shimokata , Koji Kimata
发明人： Nobuo Sugiura , Satoshi Shimokata , Koji Kimata
IPC分类号： C12P19/04
CPC分类号： C12P19/26
摘要： A method for producing a chondroitin (CH) with a desired sugar chain length; a method for producing a fraction containing a CH with a substantially single sugar chain length; etc. There is provided a method for producing a CH with desired sugar chain length, comprising alternately performing the steps (a) allowing a receptor substrate having a glucuronic acid residue at its non-reducing end (when this step is performed after the step (b), sugar chain obtained by the step (b)), an N-acetylgalactosamine donor and an N-acetylgalactosamine transferase to coexist in a reaction system and (b) allowing a receptor substrate having an N-acetylgalactosamine residue at its non-reducing end (when this step is performed after the step (a), sugar chain obtained by the step (a)), a glucuronic acid donor and a glucuronic acid transferase to coexist in a reaction system.
摘要翻译：一种制备具有所需糖链长度的软骨素（CH）的方法; 一种生产含有基本上单一糖链长度的CH的级分的方法; 提供了一种制备具有期望的糖链长度的CH的方法，其包括交替地执行以下步骤：（a）允许在其非还原末端具有葡萄糖醛酸残基的受体底物（步骤后步骤 b），通过步骤（b）获得的糖链），N-乙酰半乳糖胺供体和N-乙酰半乳糖胺转移酶共存于反应体系中，和（b）在其不还原条件下使具有N-乙酰半乳糖胺残基的受体底物（步骤（a）后的步骤，通过步骤（a）获得的糖链），葡萄糖醛酸供体和葡糖醛酸转移酶共存于反应体系中。

6. 发明授权

US5733892A Metastasis inhibitor composition comprising a phospholipid-linked glycosaminoglycan and method for inhibiting metastasis employing the same 失效
标题翻译：包含磷脂连接的糖胺聚糖的转移抑制剂组合物和使用其的抑制转移的方法
公开(公告)号：US5733892A
公开(公告)日：1998-03-31
申请号：US469930
申请日：1995-06-06
申请人： Katsukiyo Sakurai , Nobuo Sugiura , Koji Kimata , Sakaru Suzuki
发明人： Katsukiyo Sakurai , Nobuo Sugiura , Koji Kimata , Sakaru Suzuki
IPC分类号： C08B37/00 , A61K31/715 , C07H1/00
CPC分类号： A61K47/48053 , C08B37/0063
摘要： This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their excellent function to inhibit adhesion of cancer cells to blood vessel endothelial cells and extracellular matrix. This phospholipid- or lipid-linked glycosaminoglycan can be produced for example by: cleaving and oxidizing reducing terminal group of glycosaminoglycan, and allowing an aldehyde group or a lactone compound of the thus-formed derivative or a carboxyl group in the glycosaminoglycan chain to react with a primary amino group of a phospholipid; or linking a glycosaminoglycan derivative to a phospholipid or a lipid by allowing a primary amino group of the derivative to react with a carboxyl group of the phospholipid or lipid. This phospholipid- or lipid-linked glycosaminoglycan is useful as a metastasis inhibitor because it has no toxicity.
摘要翻译：本发明涉及通过将糖胺聚糖与磷脂或脂质连接而制备的化合物，由于其具有抑制癌细胞对血管内皮细胞和细胞外基质的粘附的优异功能，预期其具有抑制转移的药理作用。这种磷脂或脂质连接的糖胺聚糖可以例如通过以下方式制备：将糖胺聚糖的还原端基进行切割和氧化，并使得糖胺聚糖链中由此形成的衍生物或羧基的醛基或内酯化合物与磷脂的伯氨基; 或通过使该衍生物的伯氨基与磷脂或脂质的羧基反应来将糖胺聚糖衍生物与磷脂或脂质连接。这种磷脂或脂质连接的糖胺聚糖可用作转移抑制因子，因为它没有毒性。

7. 发明申请

US20100068759A1 MODIFIED CHONDROITIN SYNTHASE POLYPEPTIDE AND CRYSTAL THEREOF 有权
标题翻译：改性的合成酶聚合酶及其结晶
公开(公告)号：US20100068759A1
公开(公告)日：2010-03-18
申请号：US12304487
申请日：2007-06-12
申请人： Yoshimitsu Kakuta , Takuo Osawa , Nobuo Sugiura , Koji Kimata
发明人： Yoshimitsu Kakuta , Takuo Osawa , Nobuo Sugiura , Koji Kimata
IPC分类号： C12P21/06 , C12P19/04 , C12N9/10 , C07H21/04
CPC分类号： C12Y204/01175 , C12N9/1051 , C12P19/26
摘要： Disclosed are: (A) a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, or (B) a polypeptide comprising an amino acid sequence of SEQ ID NO:2 including deletion, substitution or addition of one or several amino acid residues and having chondroitin synthase activity; a nucleic acid encoding the polypeptide; a method for producing the polypeptide, comprising at least the steps of: (1) expressing the nucleic acid to produce the polypeptide; and (2) collecting the polypeptide produced in the step (1); and a crystal of the polypeptide. The crystal may be a monoclinic or tetragonal crystal.
摘要翻译：公开了：（A）由SEQ ID NO：2的氨基酸序列组成的多肽，或（B）包含SEQ ID NO：2的氨基酸序列的多肽，包括缺失，取代或添加一个或几个氨基酸残留并具有软骨素合成酶活性; 编码该多肽的核酸; 一种生产多肽的方法，至少包括以下步骤：（1）表达所述核酸以产生所述多肽; 和（2）收集步骤（1）中产生的多肽; 和多肽的晶体。该晶体可以是单斜晶体或四方晶体。

8. 发明授权

US07598068B2 Chondroitin polymerase and DNA encoding the same 有权
标题翻译：软骨素聚合酶和DNA编码相同
公开(公告)号：US07598068B2
公开(公告)日：2009-10-06
申请号：US10216289
申请日：2002-08-12
申请人： Toshio Ninomiya , Nobuo Sugiura , Koji Kimata
发明人： Toshio Ninomiya , Nobuo Sugiura , Koji Kimata
IPC分类号： C12N9/24 , C12N9/04 , C07K14/00
CPC分类号： C12N9/1051 , C12P19/18
摘要： A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase.
摘要翻译：具有这样性质的软骨素聚合酶分别将GlcUA和GalNAc交替地转移到来自GlcUA供体和GalNAc供体的糖链的非还原末端等; 以及生产软骨素聚合酶的方法。

9. 发明申请

US20070015249A1 Chondroitin polymerase and DNA encoding the same 有权
标题翻译：软骨素聚合酶和DNA编码相同
公开(公告)号：US20070015249A1
公开(公告)日：2007-01-18
申请号：US11484752
申请日：2006-07-12
申请人： Toshio Ninomiya , Nobuo Sugiura , Koji Kimata
发明人： Toshio Ninomiya , Nobuo Sugiura , Koji Kimata
IPC分类号： C12P21/06 , C07H21/04 , C08B37/00 , C12N9/24 , C12N1/21 , C12N15/74
CPC分类号： C12N9/1051 , C12P19/18
摘要： A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase.
摘要翻译：具有这样性质的软骨素聚合酶分别将GlcUA和GalNAc交替地转移到来自GlcUA供体和GalNAc供体的糖链的非还原末端等; 以及生产软骨素聚合酶的方法。

10. 发明授权

US5464942A Phospholipid- or lipid-linked glycosaminoglycan and process for producing the same 失效
标题翻译：磷脂或脂质连接的糖胺聚糖及其制备方法
公开(公告)号：US5464942A
公开(公告)日：1995-11-07
申请号：US847065
申请日：1991-03-24
申请人： Katsukiyo Sakurai , Nobuo Sugiura , Koji Kimata , Sakaru Suzuki
发明人： Katsukiyo Sakurai , Nobuo Sugiura , Koji Kimata , Sakaru Suzuki
IPC分类号： C08B37/00 , A61K31/725 , C08B37/10
CPC分类号： A61K47/48053 , C08B37/0063
摘要： This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their excellent function to inhibit adhesion of cancer cells to blood vessel endothelial cells and extracellular matrix. This phospholipid- or lipid-linked glycosaminoglycan can be produced for example by: cleaving and oxidizing reducing terminal group of glycosaminoglycan, and allowing an aldehyde group or a lactone compound of the thus-formed derivative or a carboxyl group in the glycosaminoglycan chain to react with a primary amino group of a phospholipid; or linking a glycosaminoglycan derivative to a phospholipid or a lipid by allowing a primary amino group of the derivative to react with a carboxyl group of the phospholipid or lipid. This phospholipid- or lipid-linked glycosaminoglycan is useful as a metastasis inhibitor because it has no toxicity.
摘要翻译： PCT No.PCT / JP91 / 00995 Sec。 371日期：1992年3月24日 102（e）1992年3月24日PCT PCT 1991年7月24日PCT公布。出版物WO92 / 01720 本发明涉及通过将糖胺聚糖与磷脂或脂质连接而制备的化合物，其预期具有抑制转移的药理作用，因为其具有抑制癌细胞对血管内皮细胞和细胞外的粘附的优异功能矩阵。这种磷脂或脂质连接的糖胺聚糖可以例如通过以下方式制备：将糖胺聚糖的还原端基进行切割和氧化，并使得糖胺聚糖链中由此形成的衍生物或羧基的醛基或内酯化合物与磷脂的伯氨基; 或通过使该衍生物的伯氨基与磷脂或脂质的羧基反应来将糖胺聚糖衍生物与磷脂或脂质连接。这种磷脂或脂质连接的糖胺聚糖可用作转移抑制因子，因为它没有毒性。

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