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1. 发明授权

US08821570B2 Adjustable annuloplasty ring with subcutaneous activation port 有权
标题翻译：可调节瓣环成形术与皮下激活口
公开(公告)号：US08821570B2
公开(公告)日：2014-09-02
申请号：US13386331
申请日：2010-07-20
申请人： Jeffrey P. DuMontelle , Maurice Buchbinder , Samuel M. Shaolian , Ninh H. Dang , Paul A. Molloy , Ross Tsukashima , Brian C. Gray , Daniel C. Anderson
发明人： Jeffrey P. DuMontelle , Maurice Buchbinder , Samuel M. Shaolian , Ninh H. Dang , Paul A. Molloy , Ross Tsukashima , Brian C. Gray , Daniel C. Anderson
IPC分类号： A61F2/24 , A61L27/50
CPC分类号： A61L27/50 , A61F2/2445 , A61F2210/0023 , A61F2210/0033 , A61F2250/001 , A61L27/507
摘要： Annuloplasty rings are employed to treat heart valve defects, such as regurgitation. Synching the heart tissue to the ring restores the valve opening to its approximate original size and operating efficiency. Adjustable annuloplasty rings allow for a proper degree of synching both during open heart surgery and over the patient's lifetime. A subcutaneous port may be coupled to an adjustable annuloplasty ring such that an external activation energy generator can be used to heat the adjustable annuloplasty ring and thereby adjust the size of the annuloplasty ring.
摘要翻译：使用瓣环成形术来治疗心脏瓣膜缺损，例如反流。将心脏组织同步到环将瓣膜开口恢复到其近似的原始尺寸和操作效率。可调环形成形术环允许在心脏开放心脏手术期间和患者生命周期内均匀适应程度的同步。皮下端口可以联接到可调节瓣环成形术环，使得外部激活能量发生器可以用于加热可调节瓣环成形术环，从而调节瓣环成形术环的尺寸。

2. 发明申请

US20120197392A1 ADJUSTABLE ANNULOPLASTY RING WITH SUBCUTANEOUS ACTIVATION PORT 有权
标题翻译：可调节ANNULOPLASTY环与辅助活动端口
公开(公告)号：US20120197392A1
公开(公告)日：2012-08-02
申请号：US13386331
申请日：2010-07-20
申请人： Jeffrey P. DuMontelle , Maurice Buchbinder , Samuel M. Shaolian , Ninh H. Dang , Paul A. Molloy , Ross Tsukashima , Brian C. Gray , Daniel C. Anderson
发明人： Jeffrey P. DuMontelle , Maurice Buchbinder , Samuel M. Shaolian , Ninh H. Dang , Paul A. Molloy , Ross Tsukashima , Brian C. Gray , Daniel C. Anderson
IPC分类号： A61F2/24
CPC分类号： A61L27/50 , A61F2/2445 , A61F2210/0023 , A61F2210/0033 , A61F2250/001 , A61L27/507
摘要： Annuloplasty rings are employed to treat heart valve defects, such as regurgitation. Synching the heart tissue to the ring restores the valve opening to its approximate original size and operating efficiency. Adjustable annuloplasty rings allow for a proper degree of synching both during open heart surgery and over the patient's lifetime. A subcutaneous port may be coupled to an adjustable annuloplasty ring such that an external activation energy generator can be used to heat the adjustable annuloplasty ring and thereby adjust the size of the annuloplasty ring.
摘要翻译：使用瓣环成形术来治疗心脏瓣膜缺损，例如反流。将心脏组织同步到环将瓣膜开口恢复到其近似的原始尺寸和操作效率。可调环形成形术环允许在心脏开放心脏手术期间和患者生命周期内均匀适应程度的同步。皮下端口可以联接到可调节瓣环成形术环，使得外部激活能量发生器可以用于加热可调节瓣环成形术环，从而调节瓣环成形术环的尺寸。

3. 发明申请

US20110313516A1 PERCUTANEOUS MAGNETIC CATHETER 审中-公开
公开(公告)号：US20110313516A1
公开(公告)日：2011-12-22
申请号：US13148743
申请日：2010-02-12
申请人： Ninh H. Dang , Samuel M. Shaolian , Ross Tsukashima , Daniel C. Anderson
发明人： Ninh H. Dang , Samuel M. Shaolian , Ross Tsukashima , Daniel C. Anderson
IPC分类号： A61F2/24
CPC分类号： A61M25/0082 , A61F2/2445 , A61F2/2448 , A61F2/2466 , A61F2210/009 , A61F2250/0004 , A61M25/0127
摘要： A percutaneous magnetic catheter may be used to position one or more magnetic components near a magnetically driven prosthesis in a patient's heart in order to adjust the magnetically driven prosthesis. In certain embodiments, the one or more magnetic components are rotatable. Rotation of the one or more magnetic components cause variations in a magnetic field. Variations in the magnetic field may be utilized to adjust the size or shape of a magnetically driven prosthesis. In this way, a magnetically driven prosthesis may be adjusted after a patient has recovered from a surgery in which the magnetically driven prosthesis was implanted. Further, a magnetically driven prosthesis may be adjusted based upon progression of a heart condition.
摘要翻译：可以使用经皮磁导管将一个或多个磁性部件定位在患者心脏内的磁驱动假体附近，以便调整磁驱动假体。在某些实施例中，一个或多个磁性部件是可旋转的。一个或多个磁性部件的旋转导致磁场的变化。可以利用磁场的变化来调节磁力驱动假体的尺寸或形状。以这种方式，可以在患者从其中植入有磁性驱动的假体的手术中恢复之后调节磁力驱动的假体。此外，可以基于心脏状况的进展来调整磁驱动假体。

4. 发明申请

US20090248148A1 SYSTEMS AND METHODS FOR ADJUSTING AN ANNULOPLASTY RING WITH AN INTEGRATED MAGNETIC DRIVE 审中-公开
标题翻译：用于调整具有集成磁力驱动器的ANNULOPLASTY环的系统和方法
公开(公告)号：US20090248148A1
公开(公告)日：2009-10-01
申请号：US12411107
申请日：2009-03-25
申请人： Samuel M. Shaolian , Scott L. Pool , Ross Tsukashima , Daniel C. Anderson
发明人： Samuel M. Shaolian , Scott L. Pool , Ross Tsukashima , Daniel C. Anderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2442 , A61F2/2445 , A61F2/2448 , A61F2210/009 , A61F2250/0001 , A61F2250/0004
摘要： Systems and methods treat a heart valve using a magnetically adjustable annuloplasty ring attached to or near a cardiac valve annulus. A changing magnetic field may be used to selectively increase or decrease a circumference of, or otherwise modify the shape of, the implanted annuloplasty ring. The adjustable annuloplasty ring includes a tubular body member, one or more adjustable members, and an internal magnet within the tubular body member. The tubular body member and the one or more adjustable members form a ring shape. The internal magnet is configured to rotate in response to a rotating external magnetic field. The internal magnet is coupled to the one or more adjustable members to change a dimension of the ring shape as the internal magnet rotates. A system for treating a heart valve may include an external adjustment device having one or more external magnets to generate the rotating external magnetic field.
摘要翻译：系统和方法使用附接到心脏瓣膜环上或附近的磁性可调节瓣环成形术来治疗心脏瓣膜。可以使用变化的磁场来选择性地增加或减少植入的瓣膜成形术环的周长或以其他方式改变植入的瓣膜成形术环的形状。可调环形成形术环包括管状本体构件，一个或多个可调节构件以及管状本体构件内的内部磁体。管状本体构件和一个或多个可调节构件形成环形。内部磁体构造为响应于旋转的外部磁场而旋转。内部磁体联接到一个或多个可调节构件，以在内部磁体旋转时改变环形的尺寸。用于治疗心脏瓣膜的系统可以包括具有一个或多个外部磁体以产生旋转外部磁场的外部调节装置。

5. 发明申请

US20110237872A1 DYNAMIC HEART HARNESS 审中-公开
标题翻译：动态心脏线束
公开(公告)号：US20110237872A1
公开(公告)日：2011-09-29
申请号：US13063736
申请日：2009-09-24
申请人： Samuel M. Shaolian , Ross Tsukashima , Scott L. Pool
发明人： Samuel M. Shaolian , Ross Tsukashima , Scott L. Pool
IPC分类号： A61F2/00
CPC分类号： A61F2/2481 , A61N2/06
摘要： A reversibly adjustable heart harness is configured to surround at least a portion of a heart and to provide a compressive force to the heart during at least a portion of a cardiac cycle. The heart harness includes a plurality of wires forming a mesh structure, and one or more tensioning motors connected to the mesh structure. The one or more tensioning motors are configured to selectively increase or reduce tension in the mesh structure to readjust the compressive force provided that the heart harness provides to the heart.
摘要翻译：可逆调节的心脏线束构造成围绕心脏的至少一部分并且在心脏周期的至少一部分期间向心脏提供压缩力。心形线束包括多个形成网状结构的线，以及连接到网状结构的一个或多个张紧马达。一个或多个张紧马达构造成选择性地增加或减小网状结构中的张力，以重新调整心脏线束提供给心脏的压缩力。

6. 发明授权

US08518107B2 Percutaneous transcatheter repair of heart valves 有权
标题翻译：心脏瓣膜经皮经导管修复
公开(公告)号：US08518107B2
公开(公告)日：2013-08-27
申请号：US13198582
申请日：2011-08-04
申请人： Ross Tsukashima , Samuel M. Shaolian , Maurice Buchbinder , Brian C. Gray , Victor S. Packham , Hung H. Cao
发明人： Ross Tsukashima , Samuel M. Shaolian , Maurice Buchbinder , Brian C. Gray , Victor S. Packham , Hung H. Cao
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61F2/2442 , A61F2/2445 , A61F2/2448 , A61F2210/0014 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2250/0004 , A61F2250/001 , A61F2250/0067 , A61F2250/0096
摘要： Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow member including a plurality of segments. Adjacent segments cooperate with one another to change the outer hollow member from an elongate insertion geometry to an annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the outer hollow member. The internal anchor member includes a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. The internal anchor member is configured to move the plurality of anchors with respect to a plurality of windows in the outer hollow member to selectively deploy the plurality of anchors through the respective windows.
摘要翻译：提供装置，系统和方法用于通过经皮经导管递送和瓣膜成形术环固定到心脏瓣膜来修复心脏瓣膜。瓣膜成形术环包括包括多个段的外部中空构件。相邻的部分彼此协作以将外部空心构件从细长插入几何形状改变为环形可操作的几何形状。瓣膜成形术环还包括至少部分地位于外部中空构件内部的内部锚定构件。内部锚固构件包括构造成将瓣环成形术环附接到心脏瓣膜环的组织的多个锚固件。内部锚固构件被构造成相对于外部中空构件中的多个窗口移动多个锚固件，以选择性地将多个锚定件展开通过相应的窗口。

7. 发明申请

US20120123531A1 PERCUTANEOUS TRANSCATHETER REPAIR OF HEART VALVES 有权
标题翻译： PERCUTANEOUS TRANSCATHETER维修心脏瓣膜
公开(公告)号：US20120123531A1
公开(公告)日：2012-05-17
申请号：US13198582
申请日：2011-08-04
申请人： Ross Tsukashima , Samuel M. Shaolian , Maurice Buchbinder , Brian C. Gray , Victor S. Packham , Hung H. Cao
发明人： Ross Tsukashima , Samuel M. Shaolian , Maurice Buchbinder , Brian C. Gray , Victor S. Packham , Hung H. Cao
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61F2/2442 , A61F2/2445 , A61F2/2448 , A61F2210/0014 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2250/0004 , A61F2250/001 , A61F2250/0067 , A61F2250/0096
摘要： Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow member including a plurality of segments. Adjacent segments cooperate with one another to change the outer hollow member from an elongate insertion geometry to an annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the outer hollow member. The internal anchor member includes a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. The internal anchor member is configured to move the plurality of anchors with respect to a plurality of windows in the outer hollow member to selectively deploy the plurality of anchors through the respective windows.
摘要翻译：提供装置，系统和方法用于通过经皮经导管递送和瓣膜成形术环固定到心脏瓣膜来修复心脏瓣膜。瓣膜成形术环包括包括多个段的外部中空构件。相邻的部分彼此协作以将外部空心构件从细长插入几何形状改变为环形可操作的几何形状。瓣膜成形术环还包括至少部分地位于外部中空构件内部的内部锚定构件。内部锚固构件包括构造成将瓣环成形术环附接到心脏瓣膜环的组织的多个锚固件。内部锚固构件被构造成相对于外部中空构件中的多个窗口移动多个锚固件，以选择性地将多个锚定件展开通过相应的窗口。

8. 发明申请

US20110218622A1 INDUCTION ACTIVATION OF ADJUSTABLE ANNULOPLASTY RINGS AND OTHER IMPLANTABLE DEVICES 审中-公开
标题翻译：可调节性静脉环和其他可植入装置的诱导激活
公开(公告)号：US20110218622A1
公开(公告)日：2011-09-08
申请号：US13040657
申请日：2011-03-04
申请人： Samuel M. Shaolian , Ross Tsukashima , Brian C. Gray , Donald P. Kannenberg
发明人： Samuel M. Shaolian , Ross Tsukashima , Brian C. Gray , Donald P. Kannenberg
IPC分类号： A61F2/24 , A61B17/00
CPC分类号： A61B17/00 , A61F2/24
摘要： Systems and methods to adjust an adjustable medical device that is implanted subcutaneously within the body of a patient. The adjustable medical device is coupled to an adjustment mechanism configured to, when powered, effect a desired adjustment to the adjustable medical device. The adjustment mechanism is electrically coupled to a receiving coil configured to resonate at a desired frequency such that an electric current induced in the receiving coil powers the adjustment mechanism. An induction activation system is configured to utilize magnetic resonance to wirelessly activate the adjustable medical device assembly, from outside the patient's body, through a skin barrier of the patient. The induction activation system comprises a power source and a delivery coil. The power source creates an alternating electrical signal. The delivery coil is electrically coupled to the power source and configured to resonate in response to the alternating electrical signal created by the power source, and thereby generate a resonating magnetic field. The delivery coil is tuned to have a resonant frequency that is the same as a frequency of the alternating electrical signal created by the power source. The receiving coil can also be tuned to resonate at the resonant frequency of the delivery coil. When the delivery coil is positioned near the patient's body, such that the receiving coil is within the magnetic field generated by the delivery coil, an electric current is induced in the receiving coil to drive the adjustment mechanism and thereby effect an adjustment of the adjustable medical device.
摘要翻译：用于调整可植入在患者体内皮下的可调节医疗装置的系统和方法。可调节医疗装置联接到调节机构，该调节机构被配置为在被供电时对可调节的医疗装置进行期望的调整。调节机构电耦合到接收线圈，该接收线圈被配置为以期望的频率谐振，使得在接收线圈中感应的电流为调节机构供电。感应激活系统被配置为利用磁共振来从患者身体外部通过患者的皮肤屏障无线地激活可调节的医疗装置组件。感应激活系统包括电源和输送线圈。电源产生交流电信号。输送线圈电耦合到电源并且被配置为响应于由电源产生的交流电信号而谐振，从而产生谐振磁场。传送线圈被调谐为具有与由电源产生的交流电信号的频率相同的谐振频率。接收线圈也可以被调谐以在输送线圈的谐振频率处共振。当输送线圈位于患者身体附近时，使得接收线圈处于由输送线圈产生的磁场内，在接收线圈中感应出电流以驱动调节机构，从而实现可调医疗设备。

9. 发明申请

US20110230961A1 DYNAMICALLY ADJUSTABLE ANNULOPLASTY RING AND PAPILLARY MUSCLE REPOSITIONING SUTURE 审中-公开
标题翻译：动态可调节的静脉环和毛细血管肌肉回顾
公开(公告)号：US20110230961A1
公开(公告)日：2011-09-22
申请号：US12985066
申请日：2011-01-05
申请人： Frank Langer , Hans-Joachim Schäfers , Samuel M. Shaolian , Paul A. Molloy , Ross Tsukashima
发明人： Frank Langer , Hans-Joachim Schäfers , Samuel M. Shaolian , Paul A. Molloy , Ross Tsukashima
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2457 , A61F2210/009 , A61F2250/0001 , A61F2250/001
摘要： A system for treating a cardiac valve includes an adjustable annuloplasty ring configured to attach to or near a cardiac valve annulus. The system also includes a suture comprising a first end coupled to the annuloplasty ring. A second end of the suture is configured to be anchored to a papillary muscle. Selectively adjusting the annuloplasty ring adjusts a tension of the suture to reposition the papillary muscle.
摘要翻译：用于治疗心脏瓣膜的系统包括被配置为附接到心脏瓣膜环或靠近心脏瓣膜环的可调环形成形术环。该系统还包括缝合线，其包括联接到瓣环成形术环的第一端。缝合线的第二端构造成锚定到乳头肌。选择性地调节瓣环成形术环调节缝合线的张力以重新定位乳头肌。

10. 发明授权

US08262878B2 Controlled activation pH sensor 失效
标题翻译：控制活化pH传感器
公开(公告)号：US08262878B2
公开(公告)日：2012-09-11
申请号：US11881021
申请日：2007-07-25
申请人： Erich H. Wolf , Charles Bankert , Ross Tsukashima , Elmer Custodio
发明人： Erich H. Wolf , Charles Bankert , Ross Tsukashima , Elmer Custodio
IPC分类号： G01N27/414
CPC分类号： G01N27/4035
摘要： The present invention pertains to a means of combining and configuring specific hydrophilic and dielectric materials in such a way as to allow an antimony/reference electrode pH sensor to be packaged and stored dry yet become fully hydrated to an activated state after exposure to aqueous liquids. The sensor is packaged and stored dry to maintain component stability and minimize component degradation. When the user removes the sensor from the package and the sensor tip is submerged in a hydration (ion conduction) media or solution, the hydrophilic coating along with the impregnated reference wick, absorb the fluid to create an electrolytic gel inside the reference wick, which activates the pH sensor.
摘要翻译：本发明涉及一种组合和配置特定的亲水和介电材料的方法，其方法是允许锑/参比电极pH传感器在暴露于含水液体之后被干燥而被充分水合至活化状态。传感器被包装并储存干燥，以保持部件的稳定性并最大程度降低部件的退化。当使用者从传感器中取出传感器并将传感器尖端浸没在水合（离子传导）介质或溶液中时，亲水涂层与浸渍的参考油芯一起吸收流体，以在参考油芯内部产生电解凝胶，激活pH传感器。

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