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1. 发明申请

US20120242354A1 METHOD AND APPARATUS FOR DETECTING PHASE BOUNDARIES AND CORRESPONDINGLY EQUIPPED LABORATORY DEVICE 有权
标题翻译：检测相位边界和相关实验室设备的方法和装置
公开(公告)号：US20120242354A1
公开(公告)日：2012-09-27
申请号：US13504379
申请日：2010-12-22
申请人： Nicolas Cors , Markus Schoni , Markus Wiggli , Adi Zuppiger
发明人： Nicolas Cors , Markus Schoni , Markus Wiggli , Adi Zuppiger
IPC分类号： G01N27/22 , G01R27/26
CPC分类号： G01F23/268 , G01F23/266 , G01N35/1011 , G01N2035/1025
摘要： A device for detecting a phase boundary in a liquid tank a sensor that can be advanced in the direction of the phase boundary in the liquid tank. A circuit processes an output signal of the sensor to detect a change in capacitance and has a first channel with a first filter module to filter out a first signal having a short pulse width from the output signal and a second channel having a second filter module to filter out a second signal having a greater pulse width from the output signal. A controller module with comparator module determines whether the first signal reaches a first threshold value and a processing module determines whether the second signal meets predefined second signal criteria.
摘要翻译：一种用于检测液罐中相位边界的装置，该传感器可以在液罐中的相边界方向前进。 A电路处理传感器的输出信号以检测电容的变化，并且具有第一通道与第一滤波器模块以从输出信号中滤出具有短脉冲宽度的第一信号，以及具有第二滤波器模块的第二通道从输出信号中滤出具有较大脉冲宽度的第二信号。具有比较器模块的控制器模块确定第一信号是否达到第一阈值，并且处理模块确定第二信号是否满足预定义的第二信号准则。

2. 发明授权

US09335200B2 Method and apparatus for detecting phase boundaries and correspondingly equipped laboratory device 有权
标题翻译：用于检测相位边界的方法和装置以及相应配备的实验室装置
公开(公告)号：US09335200B2
公开(公告)日：2016-05-10
申请号：US13504379
申请日：2010-12-22
申请人： Nicolas Cors , Markus Schoni , Markus Wiggli , Adi Zuppiger
发明人： Nicolas Cors , Markus Schoni , Markus Wiggli , Adi Zuppiger
IPC分类号： G01F23/26 , G01N35/10
CPC分类号： G01F23/268 , G01F23/266 , G01N35/1011 , G01N2035/1025
摘要： A device for detecting a phase boundary in a liquid tank a sensor that can be advanced in the direction of the phase boundary in the liquid tank. A circuit processes an output signal of the sensor to detect a change in capacitance and has a first channel with a first filter module to filter out a first signal having a short pulse width from the output signal and a second channel having a second filter module to filter out a second signal having a greater pulse width from the output signal. A controller module with comparator module determines whether the first signal reaches a first threshold value and a processing module determines whether the second signal meets predefined second signal criteria.
摘要翻译：一种用于检测液罐中相位边界的装置，该传感器可以在液罐中的相边界方向前进。 A电路处理传感器的输出信号以检测电容的变化，并且具有第一通道与第一滤波器模块以从输出信号中滤出具有短脉冲宽度的第一信号，以及具有第二滤波器模块的第二通道从输出信号中滤出具有较大脉冲宽度的第二信号。具有比较器模块的控制器模块确定第一信号是否达到第一阈值，并且处理模块确定第二信号是否满足预定义的第二信号准则。

3. 发明授权

US08119080B2 Interlacing pipette or dispenser tips in a liquid handling system 有权
标题翻译：在液体处理系统中将移液器或分配器尖端交错
公开(公告)号：US08119080B2
公开(公告)日：2012-02-21
申请号：US12503508
申请日：2009-07-15
申请人： Markus Wiggli , Fred Schinzel , Bronwen Forster
发明人： Markus Wiggli , Fred Schinzel , Bronwen Forster
IPC分类号： B01L3/02
CPC分类号： G01N35/1067 , Y10T436/2575
摘要： A liquid handling system has a robot manipulator for orienting pipette or dispenser tips in relation to sample containers situated in or on the system, pipette or dispenser tips, drives for moving the robot manipulator, and processors for controlling the movements and actions of the robot manipulator and/or of the pipette or dispenser tips. The system also includes at least two blocks situated on two arms of the robot manipulator, at least two of the pipette or dispenser tips being situated on each block and at an axial distance to one another. The axial distance essentially corresponds to the grid spacing of wells of a microplate. At least one of these blocks, for the alternating interlaced orientation of the pipette or dispenser tips of at least two blocks along a shared line, are individually movable at least in the X direction. A method allows the time-saving pipetting over of liquid samples between diverse sample containers, e.g., between sample tubes and microplates having 24, 96, 384, or 1536 wells.
摘要翻译：液体处理系统具有机器人操纵器，用于相对于位于系统中或系统上的样品容器定位移液管或分配器尖端，移液管或分配器尖端，用于移动机器人操纵器的驱动器和用于控制机器人操纵器的运动和动作的处理器和/或移液器或分配器尖端。系统还包括位于机器人操纵器的两个臂上的至少两个块，移液管或分配器尖端中的至少两个位于每个块上且彼此以轴向距离。轴向距离基本上对应于微板的孔的网格间距。这些块中的至少一个，用于沿着共享线路的至少两个块的移液管或分配器尖端的交替交错取向可至少在X方向上移动。一种方法允许在不同样品容器之间例如在具有24,96,384或1536个孔的样品管和微孔板之间的液体样品上的超时移液。

4. 发明申请

US20050053454A1 Device and method for transferring objects 有权
标题翻译：用于传输对象的设备和方法
公开(公告)号：US20050053454A1
公开(公告)日：2005-03-10
申请号：US10886887
申请日：2004-07-08
申请人： Markus Wiggli , Hanspeter Romer , Peter Muerset , Gregor Batliner , Fred Schinzel , Alois Oberholzer
发明人： Markus Wiggli , Hanspeter Romer , Peter Muerset , Gregor Batliner , Fred Schinzel , Alois Oberholzer
IPC分类号： G01N35/02 , G01N35/00 , G01N35/04 , B66C23/00
CPC分类号： G01N35/04 , G01N35/00732 , G01N35/0099 , G01N2035/041 , G01N2035/0415 , G01N2035/0417 , G01N2035/0424 , G01N2035/0425
摘要： A device for transferring and characterizing objects positions the object on a horizontal work field. The device includes at least one rail extending parallel to the X direction and a displacement unit, movable back and forth in the X direction, having a motorized gripping mechanism for grasping an object. A processor for controlling movements of the displacement unit and actions of the gripping mechanism is distinguished in that the displacement unit includes a carrying device, movable together therewith along the rail, for transferring objects in the X direction. The carrying device is a plate for carrying objects moved onto this carrying plate using the gripping mechanism. According to a method of the invention, objects are moved onto the plate of the carrying device, transferred in the X direction, and deposited again at a second position.
摘要翻译：用于传输和表征对象的设备将对象放置在水平工作字段上。该装置包括平行于X方向延伸的至少一个轨道和可在X方向前后移动的位移单元，具有用于抓握物体的机动夹持机构。用于控制位移单元的移动的处理器和夹持机构的动作的区别在于，位移单元包括沿着轨道一起可移动的运送装置，用于沿X方向传送物体。携带装置是用于使用夹持机构携带移动到该承载板上的物体的板。根据本发明的方法，将物体移动到携带装置的板上，在X方向上传送，并再次沉积在第二位置。

5. 发明申请

US20100179687A1 Interlacing pipette or dispenser tips in a liquid handling system 有权
标题翻译：在液体处理系统中将移液器或分配器尖端交错
公开(公告)号：US20100179687A1
公开(公告)日：2010-07-15
申请号：US12503508
申请日：2009-07-15
申请人： Markus Wiggli , Fred Schinzel , Bronwen Forster
发明人： Markus Wiggli , Fred Schinzel , Bronwen Forster
IPC分类号： G06F17/00 , B01L3/02
CPC分类号： G01N35/1067 , Y10T436/2575
摘要： A liquid handling system has a robot manipulator for orienting pipette or dispenser tips in relation to sample containers situated in or on the system, pipette or dispenser tips, drives for moving the robot manipulator, and processors for controlling the movements and actions of the robot manipulator and/or of the pipette or dispenser tips. The system also includes at least two blocks situated on two arms of the robot manipulator, at least two of the pipette or dispenser tips being situated on each block and at an axial distance to one another. The axial distance essentially corresponds to the grid spacing of wells of a microplate. At least one of these blocks, for the alternating interlaced orientation of the pipette or dispenser tips of at least two blocks along a shared line, are individually movable at least in the X direction. A method allows the time-saving pipetting over of liquid samples between diverse sample containers, e.g., between sample tubes and microplates having 24, 96, 384, or 1536 wells.
摘要翻译：液体处理系统具有机器人操纵器，用于相对于位于系统中或系统上的样品容器定位移液管或分配器尖端，移液管或分配器尖端，用于移动机器人操纵器的驱动器和用于控制机器人操纵器的运动和动作的处理器和/或移液器或分配器尖端。系统还包括位于机器人操纵器的两个臂上的至少两个块，移液管或分配器尖端中的至少两个位于每个块上且彼此以轴向距离。轴向距离基本上对应于微板的孔的网格间距。这些块中的至少一个，用于沿着共享线路的至少两个块的移液管或分配器尖端的交替交错取向可至少在X方向上移动。一种方法允许在不同样品容器之间例如在具有24,96,384或1536个孔的样品管和微孔板之间的液体样品上的超时移液。

6. 发明申请

US20070264725A1 Device and Method for Disposing Pipette Syringes in a System Used for Manipulationg Liquid Samples 有权
标题翻译：将移液器注射器置于用于操作液体样品的系统中的装置和方法
公开(公告)号：US20070264725A1
公开(公告)日：2007-11-15
申请号：US11630181
申请日：2005-05-30
申请人： Markus Wiggli , Fred Schinzel , Bronwen Forster
发明人： Markus Wiggli , Fred Schinzel , Bronwen Forster
IPC分类号： G01N1/10 , B01L3/02
CPC分类号： G01N35/1067 , Y10T436/2575
摘要： Devices (1) and methods are disclosed for situating pipette or dispenser tips (2) in a system (3) for manipulating liquid samples (4). A device (1) according to the present invention comprises: a robot manipulator (5) for orienting pipette or dispenser tips (2) in relation to sample containers (6) situated in or on the system (3); pipette or dispenser tips (2); drives for moving the robot manipulator (5); and processors for controlling the movements and actions of the robot manipulator (5) and/or of the pipette or dispenser tips (2). The device (1) according to the present invention is characterized in that it comprises at least two blocks (8, 9) situated on an arm (7) of the robot manipulator (5), on each of which at least two pipette or dispenser tips (2) are situated at an axial distance (10) to one another. The axial distance (10) essentially corresponds to the grid spacing of wells (19) of a microplate (18). At least one of these blocks (8,−9)—for the alternating interlaced orientation of the pipette or dispenser tips (2) of the two blocks (8,−9) along a shared line (12)—is implemented as individually movable in the X direction and in the Y direction. The method according to the present invention allows the time-saving pipetting over of liquid samples (4) between diverse sample containers, e.g., between sample tubes and microplates (18) having 24, 96, 384, or 1536 wells.
摘要翻译：公开了用于将移液管或分配器尖端（2）置于系统（3）中以操纵液体样品（4）的装置（1）和方法。根据本发明的装置（1）包括：机器人操纵器（5），用于相对于位于系统（3）中或系统（3）上的样品容器（6）定向移液管或分配器尖端（2）; 移液器或分配头（2）; 用于移动机器人操纵器（5）的驱动器; 以及用于控制机器人操纵器（5）和/或移液管或分配器尖端（2）的运动和动作的处理器。根据本发明的装置（1）的特征在于它包括位于机器人操纵器（5）的臂（7）上的至少两个块（8,9），其中每个块至少两个移液器或分配器尖端（2）彼此轴向距离（10）。轴向距离（10）基本上对应于微板（18）的孔（19）的网格间距。这些块（8,9）中的至少一个用于沿着共享线（12）的两个块（8,9）的移液管或分配器尖端（2）的交替交错取向被实现为可单独移动在X方向和Y方向上。根据本发明的方法允许在不同的样品容器之间，例如在具有24,96,384或1536个孔的样品管和微孔板（18）之间的液体样品（4）上进行省时的移液。

7. 发明授权

US09140367B2 Inlet valve for chamber systems and sample containers, and chamber systems and sample containers with such inlet valves 有权
标题翻译：用于室系统和样品容器的进气阀，以及具有这种入口阀的室系统和样品容器
公开(公告)号：US09140367B2
公开(公告)日：2015-09-22
申请号：US14342997
申请日：2012-08-28
申请人： Nico Birkner , Thomas Iten , Marina Knoppke , Markus Wiggli
发明人： Nico Birkner , Thomas Iten , Marina Knoppke , Markus Wiggli
IPC分类号： B01L99/00 , F16K1/32 , B01L3/00
CPC分类号： B01L3/523 , B01L3/502 , B01L3/502738 , B01L3/508 , B01L3/50825 , B01L2300/04 , B01L2300/044 , B01L2300/049 , F16K1/32 , F16K21/04
摘要： An inlet valve charges an inner chamber of a system or sample container with liquid and has a first pipetting axis, an inlet opening, it supplies liquid by a laboratory pipette that is automatically reclosed and also has a valve body with a blocking element, a pressing part and a throat, a valve space enclosing the valve body at least partly near the throat, a spring mechanism and a sealing element. The throat connects the blocking element to the pressing part and has an open passage region which opens into the liquid passage of the pressing part and into the valve space. The spring mechanism presses a sealing surface of the blocking element against the sealing element in a closed position of the valve body. The valve body can be brought to an open position by pressing the pressing part against the spring mechanism.
摘要翻译：入口阀为系统或样品容器的内腔充满液体，并具有第一移液轴线，入口开口，其通过实验室移液管供应液体，其被自动重新闭合并且还具有带有阻塞元件的阀体，按压部分和喉部，封闭阀体至少部分地靠近喉部的阀门空间，弹簧机构和密封元件。喉部将阻塞元件连接到按压部分，并且具有通向按压部分的液体通道并进入阀门空间的开放通道区域。弹簧机构在阀体的关闭位置将阻塞元件的密封表面压靠密封元件。通过将按压部件压靠在弹簧机构上，能够使阀体处于打开位置。

8. 发明授权

US07575937B2 Device and method for disposing pipette syringes in a system used for manipulating liquid samples 有权
标题翻译：在用于操作液体样品的系统中设置移液器注射器的装置和方法
公开(公告)号：US07575937B2
公开(公告)日：2009-08-18
申请号：US11630181
申请日：2005-05-30
申请人： Markus Wiggli , Fred Schinzel , Bronwen Forster
发明人： Markus Wiggli , Fred Schinzel , Bronwen Forster
IPC分类号： G01N35/10
CPC分类号： G01N35/1067 , Y10T436/2575
摘要： A device and method for situating pipette or dispenser tips in a system for manipulating liquid samples, has a robot manipulator for orienting the tips relative to sample containers, drives for moving the robot manipulator and processors for controlling movements and actions of the robot manipulator and/or the tips. At least two tips are situated at an axial distance from each another, on at least two blocks on an arm of the robot manipulator. The axial distance corresponds to a grid spacing of wells of a microplate. At least one of the blocks is individually movable in an X direction and in a Y direction. The method allows time-saving pipetting over of liquid samples between diverse sample containers, such as between sample tubes and microplates having 24, 96, 384, or 1536 wells.
摘要翻译：用于将移液管或分配器尖端定位在用于操纵液体样品的系统中的装置和方法具有用于相对于样本容器定向尖端的机器人操纵器，用于移动机器人操纵器的驱动器和用于控制机器人操纵器的运动和动作的驱动器和/ 或提示。至少两个尖端位于机器人操纵器的臂上的至少两个块上彼此轴向距离处。轴向距离对应于微板的孔的网格间距。至少一个块可以在X方向和Y方向上单独移动。该方法允许在不同样品容器之间的液体样品上进行移液，例如在样品管和具有24,96,384或1536孔的微孔板之间。

9. 发明授权

US07264432B2 Device and method for transferring objects 有权
标题翻译：用于传输对象的设备和方法
公开(公告)号：US07264432B2
公开(公告)日：2007-09-04
申请号：US10886887
申请日：2004-07-08
申请人： Markus Wiggli , Hanspeter Romer , Peter Muerset , Gregor Batliner , Fred Schinzel , Alois Oberholzer
发明人： Markus Wiggli , Hanspeter Romer , Peter Muerset , Gregor Batliner , Fred Schinzel , Alois Oberholzer
IPC分类号： B65H5/00
CPC分类号： G01N35/04 , G01N35/00732 , G01N35/0099 , G01N2035/041 , G01N2035/0415 , G01N2035/0417 , G01N2035/0424 , G01N2035/0425
摘要： A device for transferring and characterizing objects positions the object on a horizontal work field. The device includes at least one rail extending parallel to the X direction and a displacement unit, movable back and forth in the X direction, having a motorized gripping mechanism for grasping an object. A processor for controlling movements of the displacement unit and actions of the gripping mechanism is distinguished in that the displacement unit includes a carrying device, movable together therewith along the rail, for transferring objects in the X direction. The carrying device is a plate for carrying objects moved onto this carrying plate using the gripping mechanism. According to a method of the invention, objects are moved onto the plate of the carrying device, transferred in the X direction, and deposited again at a second position.
摘要翻译：用于传输和表征对象的设备将对象放置在水平工作字段上。该装置包括平行于X方向延伸的至少一个轨道和可在X方向前后移动的位移单元，具有用于抓握物体的机动夹持机构。用于控制位移单元的移动的处理器和夹持机构的动作的区别在于，位移单元包括沿着轨道一起可移动的运送装置，用于沿X方向传送物体。携带装置是用于使用夹持机构携带移动到该承载板上的物体的板。根据本发明的方法，将物体移动到携带装置的板上，在X方向上传送，并再次沉积在第二位置。

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