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1. 发明申请

US20070053934A1 Polyvalent multimeric composition containing active polypeptides, pharmaceutical compositions and methods of using the same 审中-公开
标题翻译：含有活性多肽的多价多聚体组合物，药物组合物及其使用方法
公开(公告)号：US20070053934A1
公开(公告)日：2007-03-08
申请号：US11510493
申请日：2006-08-25
申请人： Neville Kallenbach , Daniel Malamud , Zhigang Liu , William Abrams , Paramjit Arora
发明人： Neville Kallenbach , Daniel Malamud , Zhigang Liu , William Abrams , Paramjit Arora
IPC分类号： A61K31/70 , A61K39/12 , A01N43/04
CPC分类号： C12N7/00 , A61K38/1709 , A61K47/58 , A61K47/595 , C07K14/47 , C07K14/4723 , C07K14/705 , C12N2740/16061
摘要： The invention is directed to compositions comprising polyvalent complexes containing a biocompatible polymer backbone to which is attached a plurality of monomeric anti-microbial peptides and to methods for using such complexes to stabilize anti-microbial peptides for treating or preventing a disease or condition resulting from infection with a microbe. Multivalent derivatives of existing antimicrobial peptides in which several peptides are covalently linked have been investigated. The resulting construct may contain up to 30 or more units, and exhibits a significant enhancement of anti-microbial effect relative to the free peptides: on the order of a ten fold improvement in effectiveness, suggesting that higher multimerization can indeed lead to more effective agents. The invention is also directed to the use of such complexes for delivery of anti-viral peptides, in particular, peptides and peptide fragments obtained from salivary agglutinin protein (gp-340) for use in treating or preventing infection with HIV.
摘要翻译：本发明涉及包含含有多个单体抗微生物肽的生物相容性聚合物骨架的多价复合物的组合物，以及使用这些复合物来稳定抗微生物肽以治疗或预防感染引起的疾病或病症的方法用微生物。已经研究了几种肽共价连接的现有抗微生物肽的多价衍生物。所得构建体可以含有多达30个或更多个单元，并且相对于游离肽显示出显着增强的抗微生物效应：有效性提高十倍，这表明更高的多聚化确实会导致更有效的试剂。本发明还涉及这种复合物用于递送抗病毒肽，特别是从用于治疗或预防HIV感染的唾液凝集素蛋白（gp-340）获得的肽和肽片段的用途。

2. 发明授权

US06287605B1 Compositions and methods useful in treatment and prevention of HIV-1 infection 有权
标题翻译：用于治疗和预防HIV-1感染的组合物和方法
公开(公告)号：US06287605B1
公开(公告)日：2001-09-11
申请号：US09293758
申请日：1999-04-16
申请人： Daniel Malamud , Thandavarayan Nagashunmugam , Harvey M. Friedman , William Abrams , Earl J. Bergey
发明人： Daniel Malamud , Thandavarayan Nagashunmugam , Harvey M. Friedman , William Abrams , Earl J. Bergey
IPC分类号： A61K3537
CPC分类号： A61L2/0082 , A61K31/70 , A61K38/1709 , A61K45/06 , Y10S435/975
摘要： The invention includes compositions comprising substantially purified salivary glycoproteins and carbohydrate ligands thereof which are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies and kits useful in the treatment and prevention of HIV-1 infection.
摘要翻译：本发明包括可用于治疗和预防HIV-1感染的方法的基本上纯化的唾液糖蛋白及其碳水化合物配体的组合物。本发明还包括用于治疗和预防HIV-1感染的方法，包括将本发明的组合物与人类患者接触。另外，本发明包括可用于治疗和预防HIV-1感染的抗体和试剂盒。

3. 发明授权

US09409166B2 Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications 有权
标题翻译：用于细胞裂解，核酸分离纯化和核酸扩增相关应用的综合PCR反应器
公开(公告)号：US09409166B2
公开(公告)日：2016-08-09
申请号：US12331508
申请日：2008-12-10
申请人： Michael G Mauk , Haim H Bau , Daniel Malamud , William Abrams
发明人： Michael G Mauk , Haim H Bau , Daniel Malamud , William Abrams
IPC分类号： B01L3/00 , B01L7/00
CPC分类号： B01L3/5027 , B01J2219/00529 , B01J2219/00608 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L7/52 , B01L2200/12 , B01L2200/16 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2400/0655 , B01L2400/0677
摘要： Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.
摘要翻译：公开了能够在单个容器内进行聚合酶链反应的集成器件。还公开了样品分析的相关方法。

4. 发明申请

US20090186357A1 Integrated PCR Reactor for Cell Lysis, Nucleic Acid Isolation and Purification, and Nucleic Acid Amplication Related Applications 有权
标题翻译：用于细胞裂解的综合PCR反应器，核酸分离和纯化以及核酸扩增相关应用
公开(公告)号：US20090186357A1
公开(公告)日：2009-07-23
申请号：US12331508
申请日：2008-12-10
申请人： Michael G. Mauk , Haim H. Bau , Daniel Malamud , William Abrams
发明人： Michael G. Mauk , Haim H. Bau , Daniel Malamud , William Abrams
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/5027 , B01J2219/00529 , B01J2219/00608 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L7/52 , B01L2200/12 , B01L2200/16 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2400/0655 , B01L2400/0677
摘要： Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.
摘要翻译：公开了能够在单个容器内进行聚合酶链反应的集成器件。还公开了样品分析的相关方法。

5. 发明申请

US20080280285A1 Systems and Methods For Testing using Microfluidic Chips 审中-公开
标题翻译：使用微流控芯片进行测试的系统和方法
公开(公告)号：US20080280285A1
公开(公告)日：2008-11-13
申请号：US11937975
申请日：2007-11-09
申请人： Zongyuan G. Chen , Jing Wang , Michael Mauk , Haim H. Bau , Daniel Malamud , William Abrams , Raymond Niedbala , Hendrikus Johannes Tanke , Paul L.A.M. Corstjens
发明人： Zongyuan G. Chen , Jing Wang , Michael Mauk , Haim H. Bau , Daniel Malamud , William Abrams , Raymond Niedbala , Hendrikus Johannes Tanke , Paul L.A.M. Corstjens
IPC分类号： C12Q1/70 , B01J19/00 , C12M1/40 , C12Q1/04 , C12Q1/68 , C12P19/34 , C12M1/34 , G01N30/00 , C12M1/33 , G01N33/536 , G01N33/00
CPC分类号： G01N35/00029 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/10 , B01L2200/141 , B01L2200/143 , B01L2300/022 , B01L2300/0864 , B01L2300/1822 , B01L2400/0415 , B01L2400/0487 , B01L2400/0605 , B01L2400/0633 , B01L2400/0672 , B01L2400/0677 , B01L2400/0688 , G01N2035/00158 , Y10T436/143333
摘要： Disclosed are methods, devices and systems for biological and chemical sample processing using microfluidic chips. The disclosed microfluidic chips contain at least two detection zones for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens to determine their presence in the sample. Systems are also described comprising a cassette having at least one port and a sample inlet in fluid communication with a detection zone for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens, or mixtures thereof, if present, in a sample. Methods for concurrent testing of at least two of RNA, DNA, antibody, and antigen in a sample are also described, as are methods for testing for pre-selected pathogens and microfluidic methods.
摘要翻译：公开了使用微流控芯片的生物和化学样品处理的方法，装置和系统。所公开的微流控芯片包含至少两个用于与预先选择的RNA序列，DNA序列，抗体或抗原相互作用的检测区域，以确定它们在样品中的存在。还描述了系统，其包括具有至少一个端口的盒和与检测区流体连通的样品入口，用于与样品中预先选择的RNA序列，DNA序列，抗体或抗原或其混合物（如果存在）相互作用。还描述了样品中至少两种RNA，DNA，抗体和抗原的同时测试方法，以及用于测试预先选择的病原体和微流体方法的方法。

6. 发明申请

US20140162244A1 ISOTHERMAL NUCLEIC ACID AMPLIFICATION REACTOR WITH INTEGRATED SOLID STATE MEMBRANE 有权
标题翻译：具有集成固态膜的同位素核酸放大反应器
公开(公告)号：US20140162244A1
公开(公告)日：2014-06-12
申请号：US14001347
申请日：2012-02-15
申请人： Haim H. Bau , William R. Abrams , Eran Geva , Michael G. Mauk , Changchun Liu , Daniel Malamud , Xianbo Ceiu
发明人： Haim H. Bau , William R. Abrams , Eran Geva , Michael G. Mauk , Changchun Liu , Daniel Malamud , Xianbo Ceiu
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6844 , B01L3/5023 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/026 , B01L2200/10 , B01L2300/0663 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1827 , B01L2300/1855 , B01L2300/1861 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q1/6806 , C12Q1/703 , C12Q2537/101
摘要： Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
摘要翻译：提供了适于分离，扩增和检测可能存在于生物样品中的核酸的装置。在一些实施方案中，这些装置可以在单个室中分离，扩增和检测核酸。在其他实施方案中，所述装置适于分离和扩增反应室中的核酸，此后可将核酸传递至可渗透的介质，例如横向流动条，其中用户可以标记和检测核酸。

7. 发明授权

US5928195A Remote control drug delivery device 失效
标题翻译：远程控制药物输送装置
公开(公告)号：US5928195A
公开(公告)日：1999-07-27
申请号：US123299
申请日：1998-07-28
申请人： Daniel Malamud , Mitchell Litt , Benjamin L. Lewis
发明人： Daniel Malamud , Mitchell Litt , Benjamin L. Lewis
IPC分类号： A61M5/145 , A61M5/155
CPC分类号： A61M5/14593
摘要： A remotely controlled drug delivery device administers a dose of a drug, agent or microbicide using a gas pressure delivery system. The device stores multiple doses of the drug or agent. A toroid shaped housing includes three chambers, a gas chamber containing a pressurized gas, a drug storage chamber containing the drug or agent, and an expandable chamber for delivering the drug from the drug storage. The device includes an electronic controller for opening a valve connecting the gas chamber to the expandable chamber for a predetermined period of time in order to deliver a predetermined dose of the drug. The controller communicates with a remote control device via radio frequency. The remote control device sends a signal to the controller, which causes a dose to be delivered. The controller returns a signal to the remote control device indicating that the dose has been delivered and a signal indicating when the device needs to be removed for maintenance. The device may be used in any body cavity to deliver any desired type of drug.
摘要翻译：远程控制的药物递送装置使用气体压力输送系统施用一定剂量的药物，药剂或杀微生物剂。该装置储存多剂量的药物或药剂。环形壳体包括三个室，包含加压气体的气室，容纳药物或试剂的药物储存室，以及用于从药物储存器输送药物的可扩张室。该装置包括电子控制器，用于打开将气体室连接到可膨胀腔室一段预定时间段的阀门，以便递送预定剂量的药物。控制器通过无线电频率与遥控设备进行通信。遥控装置向控制器发送一个信号，这导致一个剂量被传送。控制器向远程控制装置返回一个信号，指示已经发送了剂量，并且指示何时需要将设备移除以进行维护的信号。该装置可以用于任何体腔以递送任何所需类型的药物。

8. 发明授权

US06297278B1 Method for inactivating sexually transmitted enveloped viruses 失效
标题翻译：灭活性传播包膜病毒的方法
公开(公告)号：US06297278B1
公开(公告)日：2001-10-02
申请号：US08223096
申请日：1994-04-04
申请人： Edwin B. Michaels , Daniel Malamud
发明人： Edwin B. Michaels , Daniel Malamud
IPC分类号： A01N3730
CPC分类号： A01N33/24 , A01N37/20 , A01N37/44 , A01N37/46 , A61K9/0034 , A61K31/14 , A61K31/185 , A61K31/195 , A61K31/205 , A61K31/415 , A61L2/0088 , A61L31/16 , A61L2300/204 , A61L2300/208 , A61L2300/408 , A61L2300/45 , A61L2300/452 , Y02A50/463 , Y10S514/843 , Y10S514/934 , A01N2300/00 , A61K2300/00 , A01N43/50 , A01N41/04 , A61K31/13 , A61K31/16
摘要： There is provided methods for inhibiting the activity of enveloped viruses, treatment of viral infections and method inactivating sperm. There is provided articles for use in these methods.
摘要翻译：提供了抑制包膜病毒活性，治疗病毒感染和方法灭活精子的方法。提供了用于这些方法的文章。

9. 发明授权

US5314917A Method for inactivating enveloped viruses and sperm 失效
标题翻译：灭活包膜病毒和精子的方法
公开(公告)号：US5314917A
公开(公告)日：1994-05-24
申请号：US673784
申请日：1991-03-22
申请人： Edwin B. Michaels , Daniel Malamud
发明人： Edwin B. Michaels , Daniel Malamud
IPC分类号： A61K31/14 , A01N33/24 , A01N37/20 , A01N37/44 , A01N37/46 , A61F6/02 , A61F6/04 , A61K9/00 , A61K31/131 , A61K31/133 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/205 , A61K31/415 , A61K31/4172 , A61L2/00 , A61L31/16 , A61P15/00 , A61P15/16 , A61P15/18 , A61P31/12 , A61P31/18 , A61K31/13
CPC分类号： A01N33/24 , A01N37/20 , A01N37/44 , A01N37/46 , A61K31/14 , A61K31/185 , A61K31/195 , A61K31/205 , A61K31/415 , A61K9/0034 , A61L2/0088 , A61L31/16 , A61L2300/204 , A61L2300/208 , A61L2300/408 , A61L2300/45 , A61L2300/452 , Y10S514/843 , Y10S514/934
摘要： There is provided methods for inhibiting the activity of enveloped viruses, treatment of viral infections and method inactiviting sperm. There is provided articles for use in these methods.
摘要翻译：提供了抑制包膜病毒活性，治疗病毒感染和方法使精子失活的方法。提供了用于这些方法的文章。

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