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1. 发明授权

US09476102B2 Isothermal nucleic acid amplification reactor with integrated solid state membrane 有权
标题翻译：具有集成固态膜的等温核酸扩增反应器
公开(公告)号：US09476102B2
公开(公告)日：2016-10-25
申请号：US14001347
申请日：2012-02-15
申请人： Haim H. Bau , William R. Abrams , Eran Geva , Michael G. Mauk , Changchun Liu , Daneil Malamud , Xianbo Ceiu
发明人： Haim H. Bau , William R. Abrams , Eran Geva , Michael G. Mauk , Changchun Liu , Daneil Malamud , Xianbo Ceiu
IPC分类号： C12Q1/70 , C12M1/00 , C12Q1/68 , B01L3/00
CPC分类号： C12Q1/6844 , B01L3/5023 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/026 , B01L2200/10 , B01L2300/0663 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1827 , B01L2300/1855 , B01L2300/1861 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q1/6806 , C12Q1/703 , C12Q2537/101
摘要： Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
摘要翻译：提供了适于分离，扩增和检测可能存在于生物样品中的核酸的装置。在一些实施方案中，这些装置可以在单个室中分离，扩增和检测核酸。在其他实施方案中，所述装置适于分离和扩增反应室中的核酸，此后可将核酸传递至可渗透的介质，例如横向流动条，其中用户可以标记和检测核酸。

2. 发明授权

US4751645A Method for sonic analysis of an anomaly in a seafloor topographic representation 失效
标题翻译：海底地形表征异常声波分析方法
公开(公告)号：US4751645A
公开(公告)日：1988-06-14
申请号：US896132
申请日：1986-08-12
申请人： William R. Abrams , John Spruance
发明人： William R. Abrams , John Spruance
IPC分类号： G01S7/60 , G01S15/89
CPC分类号： G01S15/8902 , G01S7/60
摘要： A method for sonic analyzation on-line and in real time or off-line in post processing of a topographic representation of a seafloor to provide the latitude and longitude of an object producing a corresponding anomaly appearance identified in a topographic respresentation generated from a side scan sonar tow fish includes in the on-line, real time analyzation the steps of sequentially touching the tip of a sonic digitizer stylus to a point on the line representation of the seafloor laterally opposite the appearance of the anomaly; to the leading edge and the trailing edge of the anomaly and to the tip of an acoustic shadow of the anomaly appearance; and, if length is desired, to the top and bottom edges of the anomaly appearance. A computer includes a set of instructions to calculate the desired information and is coupled to a host computer associated with a vessel which tows the sonar tow fish along a course covering an area of interest of the seafloor. The computer receives the position, speed and heading of the tow fish at each point contacted by the stylus tip and calculates the latitude and longitude, height, length and width of the corresponding object. In the off-line post processing mode the stylus tip is touched to a calibration point prior to the anomaly analysis and to a fix mark immediately before and after an identified anomaly and inputting the latitude and longitude associated with the respective fix marks. The remaining steps in the post processing mode are similar to the on-line, real time analysis.
摘要翻译：一种用于在海底地形表征的后处理中在线和实时或离线进行声波分析的方法，以提供物体的纬度和经度，产生在从侧扫产生的地形表示中识别的相应的异常外观声纳拖曳鱼包括在线实时分析步骤，将声波数字化仪触针的尖端顺序地接触到与异常外观横向相反的海底线上的一点上; 到异常的前缘和后缘以及异常外观的声影的尖端; 并且如果需要长度，则到异常外观的顶部和底部边缘。计算机包括一组用于计算所需信息的指令，并且耦合到与沿着覆盖海底感兴趣区域的路线拖动声纳丝束的船舶相关联的主计算机。计算机接收由触笔尖接触的每个点处的拖曳鱼的位置，速度和方向，并计算相应对象的纬度和经度，高度，长度和宽度。在离线后处理模式中，在异常分析之前，触针尖被触摸到校准点，并且紧接在所识别的异常之前和之后，并且输入与相应固定标记相关联的纬度和经度。后处理模式中的其余步骤类似于在线实时分析。

3. 发明申请

US20140162244A1 ISOTHERMAL NUCLEIC ACID AMPLIFICATION REACTOR WITH INTEGRATED SOLID STATE MEMBRANE 有权
标题翻译：具有集成固态膜的同位素核酸放大反应器
公开(公告)号：US20140162244A1
公开(公告)日：2014-06-12
申请号：US14001347
申请日：2012-02-15
申请人： Haim H. Bau , William R. Abrams , Eran Geva , Michael G. Mauk , Changchun Liu , Daniel Malamud , Xianbo Ceiu
发明人： Haim H. Bau , William R. Abrams , Eran Geva , Michael G. Mauk , Changchun Liu , Daniel Malamud , Xianbo Ceiu
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6844 , B01L3/5023 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/026 , B01L2200/10 , B01L2300/0663 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1827 , B01L2300/1855 , B01L2300/1861 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q1/6806 , C12Q1/703 , C12Q2537/101
摘要： Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
摘要翻译：提供了适于分离，扩增和检测可能存在于生物样品中的核酸的装置。在一些实施方案中，这些装置可以在单个室中分离，扩增和检测核酸。在其他实施方案中，所述装置适于分离和扩增反应室中的核酸，此后可将核酸传递至可渗透的介质，例如横向流动条，其中用户可以标记和检测核酸。

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