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1. 发明授权

US07198953B2 Method of using a reference control composition for measurement of nucleated red blood cells 有权
标题翻译：使用参照对照组合物测定有核红细胞的方法
公开(公告)号：US07198953B2
公开(公告)日：2007-04-03
申请号：US10960370
申请日：2004-10-07
申请人： Nery Ortiz , Jing Li , Yi Li , Sandra Socarras
发明人： Nery Ortiz , Jing Li , Yi Li , Sandra Socarras
IPC分类号： G01N33/48 , G01N31/00
CPC分类号： G01N33/96 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2496/05 , Y10T436/101666
摘要： Methods of using a reference control composition containing a nucleated red blood cell component for measurement of nucleated red blood cells are disclosed. The nucleated red blood cell component is made of stabilized or processed nucleated blood cells which have impedance and optical properties simulating the impedance and optical properties of human nucleated red blood cells under a blood lysing condition as measured by a specific measurement. The methods include mixing the reference control composition with a lytic reagent, and analyzing the control sample mixture on a flow cytometric instrument by impedance, impedance and optical measurement, or DC impedance and a multi-dimensional measurement of light scatter, radio frequency and a second DC impedance; and reporting the simulated nucleated red blood cells in the reference control composition.
摘要翻译：公开了使用含有核红细胞成分的参照对照组合物测定有核红细胞的方法。有核红细胞成分由稳定或加工的有核血细胞制成，其具有模拟通过特异性测量测量的血液裂解条件下的人核红细胞的阻抗和光学性质的阻抗和光学性质。所述方法包括将参考对照组合物与裂解试剂混合，并通过阻抗，阻抗和光学测量或DC阻抗和光散射，射频和第二次的多维测量在流式细胞仪上分析对照样品混合物直流阻抗; 并报告参考对照组合物中的模拟有核红细胞。

2. 发明申请

US20050079623A1 Method of using a reference control composition for measurement of nucleated red blood cells 有权
标题翻译：使用参照对照组合物测定有核红细胞的方法
公开(公告)号：US20050079623A1
公开(公告)日：2005-04-14
申请号：US10960370
申请日：2004-10-07
申请人： Nery Ortiz , Jing Li , Yi Li , Sandra Socarras
发明人： Nery Ortiz , Jing Li , Yi Li , Sandra Socarras
IPC分类号： G01N33/48 , G01N33/96
CPC分类号： G01N33/96 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2496/05 , Y10T436/101666
摘要： Methods of using a reference control composition containing a nucleated red blood cell component for measurement of nucleated red blood cells are disclosed. The nucleated red blood cell component is made of stabilized or processed nucleated blood cells which have impedance and optical properties simulating the impedance and optical properties of human nucleated red blood cells under a blood lysing condition as measured by a specific measurement. The methods include mixing the reference control composition with a lytic reagent, and analyzing the control sample mixture on a flow cytometric instrument by impedance, impedance and optical measurement, or DC impedance and a multi-dimensional measurement of light scatter, radio frequency and a second DC impedance; and reporting the simulated nucleated red blood cells in the reference control composition.
摘要翻译：公开了使用含有核红细胞成分的参照对照组合物测定有核红细胞的方法。有核红细胞成分由稳定或加工的有核血细胞制成，其具有模拟通过特异性测量测量的血液裂解条件下的人核红细胞的阻抗和光学性质的阻抗和光学性质。所述方法包括将参考对照组合物与裂解试剂混合，并通过阻抗，阻抗和光学测量或DC阻抗和光散射，射频和第二次的多维测量在流式细胞仪上分析对照样品混合物直流阻抗; 并报告参考对照组合物中的模拟有核红细胞。

3. 发明授权

US07135341B2 Reference control containing a nucleated red blood cell component 有权
标题翻译：含有核红细胞成分的参照对照
公开(公告)号：US07135341B2
公开(公告)日：2006-11-14
申请号：US11094644
申请日：2005-03-30
申请人： Nery Ortiz , Sandra Socarras
发明人： Nery Ortiz , Sandra Socarras
IPC分类号： G01N31/00
CPC分类号： G01N33/96 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： A method of making a reference control containing a nucleated red blood cell component includes providing a blood cell containing a nucleus; treating the blood cell with a treatment solution to alter a nucleus property from a natural value to a target value suitable for simulating nucleated red blood cells on a blood analyzer; and suspending treated blood cell in a suspension medium to form a reference control. The method also includes integrating the nucleated red blood cell component with white blood cell, red blood cell, platelet and reticulocyte components. Further disclosed is a cell treatment composition for altering a nucleus property, which includes a conditioning component, a lytic component for permeating cell membrane, and a fixing component for preserving the cell nucleus. Also disclosed is a method of using the reference control for measurement of nucleated red blood cells on a blood analyzer.
摘要翻译：制备含有核红细胞成分的参照对照的方法包括提供含有核的血细胞; 用处理溶液处理血细胞以将核性质从天然值改变为适合于在血液分析仪上模拟有核红细胞的目标值; 并将经处理的血细胞悬浮在悬浮介质中以形成参照对照。该方法还包括将有核红细胞成分与白细胞，红细胞，血小板和网织红细胞成分相结合。进一步公开了用于改变核性质的细胞处理组合物，其包括调理组分，用于渗透细胞膜的溶解组分和用于保留细胞核的固定组分。还公开了在血液分析仪上使用用于测量有核红细胞的参考对照的方法。

4. 发明授权

US07354767B2 Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells 有权
标题翻译：含有由无核血细胞制成的有核红细胞成分的参照对照组合物
公开(公告)号：US07354767B2
公开(公告)日：2008-04-08
申请号：US11377171
申请日：2006-03-16
申请人： Nery Ortiz , Theodore J. Gerula , Sandra Socarras
发明人： Nery Ortiz , Theodore J. Gerula , Sandra Socarras
IPC分类号： G01N33/48 , G01N31/00
CPC分类号： G01N33/96 , G01N15/1012 , G01N15/12 , G01N15/147 , G01N2015/1037 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/2525
摘要： A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell component made of fixed non-nucleated blood cells and a suspension medium. The non-nucleated blood cell has a natural cell size substantially similar to a size of nucleus of said nucleated red blood cell of said blood sample. The nucleated red blood cell component can be made of equine, ovine, bovine, feline, canine, or porcine red blood cells; and it is substantially free of nucleic acid. The reference control composition can further include a white blood cell component, a red blood cell component, a platelet component, a reticulocyte component, or combinations thereof. Further disclosed are the methods of using the reference control composition for measurement of nucleated red blood cells on a blood analyzer.
摘要翻译：公开了含有有核红细胞成分的参照对照组合物及其制造方法。参考对照组合物包含由固定的无核血细胞和悬浮介质制成的有核红细胞成分。非成核血细胞具有与所述血液样品的所述有核红细胞的核的大小基本相似的天然细胞大小。有核红细胞成分可以由马，羊，牛，猫，犬或猪红细胞组成; 并且其基本上不含核酸。参考对照组合物还可包含白细胞成分，红细胞成分，血小板成分，网状细胞成分或其组合。还公开了使用参考对照组合物测量血液分析仪上的有核红细胞的方法。

5. 发明申请

US20070072298A1 Reference Control Containing a Nucleated Red Blood Cell Component 有权
标题翻译：含有核红细胞成分的参考对照
公开(公告)号：US20070072298A1
公开(公告)日：2007-03-29
申请号：US11554098
申请日：2006-10-30
申请人： Nery Ortiz , Sandra Socarras
发明人： Nery Ortiz , Sandra Socarras
IPC分类号： G01N31/00
CPC分类号： G01N33/96 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： A method of making a reference control containing a nucleated red blood cell component includes providing a blood cell containing a nucleus; treating the blood cell with a treatment solution to alter a nucleus property from a natural value to a target value suitable for simulating nucleated red blood cells on a blood analyzer; and suspending treated blood cell in a suspension medium to form a reference control. The method also includes integrating the nucleated red blood cell component with white blood cell, red blood cell, platelet and reticulocyte components. Further disclosed is a cell treatment composition for altering a nucleus property, which includes a conditioning component, a lytic component for permeating cell membrane, and a fixing component for preserving the cell nucleus. Also disclosed is a method of using the reference control for measurement of nucleated red blood cells on a blood analyzer.
摘要翻译：制备含有核红细胞成分的参照对照的方法包括提供含有核的血细胞; 用处理溶液处理血细胞以将核性质从天然值改变为适合于在血液分析仪上模拟有核红细胞的目标值; 并将经处理的血细胞悬浮在悬浮介质中以形成参照对照。该方法还包括将有核红细胞成分与白细胞，红细胞，血小板和网织红细胞成分相结合。进一步公开了用于改变核性质的细胞处理组合物，其包括调理组分，用于渗透细胞膜的溶解组分和用于保留细胞核的固定组分。还公开了在血液分析仪上使用用于测量有核红细胞的参考对照的方法。

6. 发明授权

US07285417B2 Reference control containing a nucleated red blood cell component 有权
标题翻译：含有核红细胞成分的参照对照
公开(公告)号：US07285417B2
公开(公告)日：2007-10-23
申请号：US11554098
申请日：2006-10-30
申请人： Nery Ortiz , Sandra Socarras
发明人： Nery Ortiz , Sandra Socarras
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N33/96 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： A method of making a reference control containing a nucleated red blood cell component includes providing a blood cell containing a nucleus; treating the blood cell with a treatment solution to alter a nucleus property from a natural value to a target value suitable for simulating nucleated red blood cells on a blood analyzer; and suspending treated blood cell in a suspension medium to form a reference control. The method also includes integrating the nucleated red blood cell component with white blood cell, red blood cell, platelet and reticulocyte components. Further disclosed is a cell treatment composition for altering a nucleus property, which includes a conditioning component, a lytic component for permeating cell membrane, and a fixing component for preserving the cell nucleus. Also disclosed is a method of using the reference control for measurement of nucleated red blood cells on a blood analyzer.
摘要翻译：制备含有核红细胞成分的参照对照的方法包括提供含有核的血细胞; 用处理溶液处理血细胞以将核性质从天然值改变为适合于在血液分析仪上模拟有核红细胞的目标值; 并将经处理的血细胞悬浮在悬浮介质中以形成参照对照。该方法还包括将有核红细胞成分与白细胞，红细胞，血小板和网织红细胞成分相结合。进一步公开了用于改变核性质的细胞处理组合物，其包括调理组分，用于渗透细胞膜的溶解组分和用于保留细胞核的固定组分。还公开了在血液分析仪上使用用于测量有核红细胞的参考对照的方法。

7. 发明申请

US20070218558A1 Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells 有权
标题翻译：含有由无核血细胞制成的有核红细胞成分的参照对照组合物
公开(公告)号：US20070218558A1
公开(公告)日：2007-09-20
申请号：US11377171
申请日：2006-03-16
申请人： Nery Ortiz , Theodore Gerula , Sandra Socarras
发明人： Nery Ortiz , Theodore Gerula , Sandra Socarras
IPC分类号： G01N33/48
CPC分类号： G01N33/96 , G01N15/1012 , G01N15/12 , G01N15/147 , G01N2015/1037 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/2525
摘要： A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell component made of fixed non-nucleated blood cells and a suspension medium. The non-nucleated blood cell has a natural cell size substantially similar to a size of nucleus of said nucleated red blood cell of said blood sample. The nucleated red blood cell component can be made of equine, ovine, bovine, feline, canine, or porcine red blood cells; and it is substantially free of nucleic acid. The reference control composition can further include a white blood cell component, a red blood cell component, a platelet component, a reticulocyte component, or combinations thereof. Further disclosed are the methods of using the reference control composition for measurement of nucleated red blood cells on a blood analyzer.
摘要翻译：公开了含有有核红细胞成分的参照对照组合物及其制造方法。参考对照组合物包含由固定的无核血细胞和悬浮介质制成的有核红细胞成分。非成核血细胞具有与所述血液样品的所述有核红细胞的核的大小基本相似的天然细胞大小。有核红细胞成分可以由马，羊，牛，猫，犬或猪红细胞组成; 并且其基本上不含核酸。参考对照组合物还可包含白细胞成分，红细胞成分，血小板成分，网状细胞成分或其组合。还公开了使用参考对照组合物测量血液分析仪上的有核红细胞的方法。

8. 发明申请

US20050227359A1 Reference control containing a nucleated red blood cell component 有权
标题翻译：含有核红细胞成分的参照对照
公开(公告)号：US20050227359A1
公开(公告)日：2005-10-13
申请号：US11094644
申请日：2005-03-30
申请人： Nery Ortiz , Sandra Socarras
发明人： Nery Ortiz , Sandra Socarras
IPC分类号： G01N31/00 , G01N33/48 , G01N33/96
CPC分类号： G01N33/96 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： A method of making a reference control containing a nucleated red blood cell component includes providing a blood cell containing a nucleus; treating the blood cell with a treatment solution to alter a nucleus property from a natural value to a target value suitable for simulating nucleated red blood cells on a blood analyzer; and suspending treated blood cell in a suspension medium to form a reference control. The method also includes integrating the nucleated red blood cell component with white blood cell, red blood cell, platelet and reticulocyte components. Further disclosed is a cell treatment composition for altering a nucleus property, which includes a conditioning component, a lytic component for permeating cell membrane, and a fixing component for preserving the cell nucleus. Also disclosed is a method of using the reference control for measurement of nucleated red blood cells on a blood analyzer.
摘要翻译：制备含有核红细胞成分的参照对照的方法包括提供含有核的血细胞; 用处理溶液处理血细胞以将核性质从天然值改变为适合于在血液分析仪上模拟有核红细胞的目标值; 并将经处理的血细胞悬浮在悬浮介质中以形成参照对照。该方法还包括将有核红细胞成分与白细胞，红细胞，血小板和网织红细胞成分相结合。进一步公开了用于改变核性质的细胞处理组合物，其包括调理组分，用于渗透细胞膜的溶解组分和用于保留细胞核的固定组分。还公开了在血液分析仪上使用用于测量有核红细胞的参考对照的方法。

9. 发明授权

US06692968B2 Apparatus and method for sample purification and analysis 失效
标题翻译：样品纯化和分析的装置和方法
公开(公告)号：US06692968B2
公开(公告)日：2004-02-17
申请号：US09957234
申请日：2001-09-20
申请人： Alexander Burshteyn , John W. Joubran , Nazle Kuylen , Frank J. Lucas , Carlos L. Aparicio , Michael L. Bell , Ravinder Gupta , Maria Elena Insausti , Jack D. McNeal , Paul W. Price , Sandra Socarras
发明人： Alexander Burshteyn , John W. Joubran , Nazle Kuylen , Frank J. Lucas , Carlos L. Aparicio , Michael L. Bell , Ravinder Gupta , Maria Elena Insausti , Jack D. McNeal , Paul W. Price , Sandra Socarras
IPC分类号： G01N134
CPC分类号： G01N1/4077 , B01D61/147 , B01D61/18 , B01D61/20 , B01D63/02 , Y10T436/25375 , Y10T436/255
摘要： A method for utilizing a filtration device for removing interferants from a test sample containing a mixture of a composition of interest and interferants in an automated apparatus is disclosed. The filtration device includes a microporous hollow fiber membrane having a plurality of pores sized to retain the composition of interest while allowing smaller diameter interferants to pass through the membrane.
摘要翻译：公开了一种在自动化设备中利用过滤装置从含有感兴趣组合物和干扰物的混合物的测试样品中除去干扰物的方法。过滤装置包括具有多个孔的微孔中空纤维膜，其尺寸适于保持感兴趣的组合物，同时允许较小直径的干燥剂通过膜。

10. 发明申请

US20120034640A1 Isotonic Buffered Composition and Method that Enables Counting of Cells 有权
标题翻译：等渗缓冲组合物和使细胞计数的方法
公开(公告)号：US20120034640A1
公开(公告)日：2012-02-09
申请号：US12853046
申请日：2010-08-09
申请人： Wayne Goldson , Sandra Socarras
发明人： Wayne Goldson , Sandra Socarras
IPC分类号： C12Q1/02
CPC分类号： C12Q1/06 , G01N33/5002
摘要： The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million of formaldehyde over the course of one year. Methods for using the compositions are also described.
摘要翻译：本发明公开了用于使用液体体积计量的自动细胞分析仪中的多用途计量流体/漂洗剂。组合物含有螯合剂，电离盐，任选的稳定离子，缓冲液，非溶血性表面活性剂和任选的抗微生物剂。有利地，组合物在一年的时间内产生少于百万分之一百万的甲醛。还描述了使用组合物的方法。

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