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1. 发明申请

US20110212030A1 Nucleic Acid Ligand Complexes 有权
标题翻译：核酸配体配合物
公开(公告)号：US20110212030A1
公开(公告)日：2011-09-01
申请号：US12624314
申请日：2009-11-23
申请人： Larry Gold , Paul Schmidt , Nebojsa Janjic
发明人： Larry Gold , Paul Schmidt , Nebojsa Janjic
IPC分类号： A61K49/10
CPC分类号： A61K9/1271 , A61K9/1272 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N15/115 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12Q1/37 , C12Q1/6811 , C40B40/00 , F02B2075/027 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/76 , G01N2333/163 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/96433 , G01N2333/96455 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , C12Q2541/101 , C12Q2563/161
摘要： This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound by identifying a nucleic acid ligand by SELEX methodology and associating the nucleic acid ligand with a lipophilic compound or a non-immunogenic, high molecular weight compound. The invention further discloses complexes comprising one or more nucleic acid ligands in association with a lipophilic compound or non-immunogenic, high molecular weight compound.
摘要翻译：本发明公开了一种由核酸配体和亲脂性化合物或非免疫原性高分子量化合物组成的治疗或诊断复合物的方法，其通过使用SELEX方法鉴定核酸配体并将核酸配体与亲脂性化合物或非免疫原性的高分子量化合物。本发明进一步公开了包含与亲脂性化合物或非免疫原性高分子量化合物结合的一种或多种核酸配体的复合物。

2. 发明授权

US06962784B2 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes 失效
标题翻译：血管内皮生长因子（VEGF）核酸配体复合物
公开(公告)号：US06962784B2
公开(公告)日：2005-11-08
申请号：US10205009
申请日：2002-07-25
申请人： Nebojsa Janjic , Larry Gold , Paul Schmidt , Chandra Vargeese , Michael Willis
发明人： Nebojsa Janjic , Larry Gold , Paul Schmidt , Chandra Vargeese , Michael Willis
IPC分类号： A61K31/70 , A61K38/00 , A61K47/48 , C07H21/00 , C07K14/52 , C12N15/115 , C12N15/88 , C12Q1/68 , C07H21/04 , C12P16/34
CPC分类号： A61K31/70 , A61K38/00 , A61K47/544 , A61K47/60 , C07H21/00 , C07K14/52 , C12N15/115 , C12N15/88 , C12N2310/3515
摘要： This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.
摘要翻译：本发明公开了一种通过SELEX方法鉴定VEGF核酸配体并将VEGF核酸配体与非 - 免疫原性，高分子量化合物或非亲和性化合物组合的复合物，免疫原性，高分子量化合物或亲脂性化合物。本发明进一步公开了包含与非免疫原性，高分子量化合物或亲脂性化合物结合的一种或多种VEGF核酸配体的复合物。本发明还包括含有VEGF核酸配体或复合物的脂质构建体及其制备方法。

3. 发明申请

US20050048521A1 Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligands 有权
标题翻译：通过与核酸配体竞争来测定与核酸分子结合的非核酸分子
公开(公告)号：US20050048521A1
公开(公告)日：2005-03-03
申请号：US10746565
申请日：2003-12-24
申请人： Nebojsa Janjic , Larry Gold
发明人： Nebojsa Janjic , Larry Gold
IPC分类号： G01N33/50 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00 , G01N33/543
CPC分类号： G01N33/53 , C12Q1/6811 , Y10S530/812 , C12Q2545/107 , C12Q2565/518
摘要： A competitive binding assay is used to determine whether a non-nucleic acid molecule from a library of non-nucleic acid molecules binds to a target. The non-nucleic acid molecule competes with a labeled nucleic acid ligand for binding to the target which may be immobilized. Detecting displacement of labeled nucleic acid ligand from a complex of the labeled nucleic acid ligand and the target determines binding of the non-nucleic acid molecule to the target. The nucleic acid ligand may be immobilized and contacted with a labeled target to form a complex. Adding a non-nucleic acid molecule to the complex displaces labeled target from the complex, and detecting displacement of the labeled target determines binding of the non-nucleic acid molecule to the target. Labeled nucleic acid ligand or labeled target displaced from or remaining in the complex can be detected for detecting displacement. Nucleic acid ligands that bind to the target are identified by the SELEX method. The assay provides a high throughput screening method for determining whether a non-nucleic acid molecule binds to a target.
摘要翻译：使用竞争性结合测定来确定非核酸分子的文库中的非核酸分子是否与靶标结合。非核酸分子与标记的核酸配体竞争结合靶，其可以被固定化。检测标记的核酸配体从标记的核酸配体和靶的复合物的置换确定非核酸分子与靶标的结合。核酸配体可以被固定化并与标记的靶接触以形成复合物。向复合物中加入非核酸分子从复合物置换标记的靶，并且检测标记的靶的置换确定非核酸分子与靶的结合。可以检测标记的核酸配体或从复合物中残留的残留的标记的靶标，以检测位移。通过SELEX法鉴定与靶标结合的核酸配体。该测定提供了用于确定非核酸分子是否结合靶的高通量筛选方法。

4. 发明授权

US06759392B1 High affinity RNA ligands of basic fibroblast growth factor 失效
标题翻译：碱性成纤维细胞生长因子的高亲和力RNA配体
公开(公告)号：US06759392B1
公开(公告)日：2004-07-06
申请号：US08442423
申请日：1995-05-16
申请人： Nebojsa Janjic , Larry Gold
发明人： Nebojsa Janjic , Larry Gold
IPC分类号： A01N4304
CPC分类号： C12N15/115 , A61K47/547 , A61K47/549 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N15/1136 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12Q1/37 , C12Q1/6811 , C40B40/00 , F02B2075/027 , G01N33/5008 , G01N33/5041 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/76 , G01N2333/16 , G01N2333/163 , G01N2333/503 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/96433 , G01N2333/96436 , G01N2333/96455 , G01N2333/96486 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , C12Q2525/101
摘要： Methods are described for the identification and preparation of nucleic acid ligand solutions to basic fibroblast growth factor (bFGF). Included in the invention are nucleic acid ligands to bFGF which are inhibitors of bFGF and 2′-amino-modified RNA ligands to bFGF.
摘要翻译：描述了用于鉴定和制备碱性成纤维细胞生长因子（bFGF）的核酸配体溶液的方法。本发明中包括bFGF的核酸配体，其是bFGF的抑制剂和bFGF的2'-氨基修饰的RNA配体。

5. 发明授权

US06426335B1 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes 有权
标题翻译：血管内皮生长因子（VEGF）核酸配体复合物
公开(公告)号：US06426335B1
公开(公告)日：2002-07-30
申请号：US09254968
申请日：2000-03-13
申请人： Nebojsa Janjic , Larry Gold , Paul Schmidt , Chandra Vargeese , Michael Willis
发明人： Nebojsa Janjic , Larry Gold , Paul Schmidt , Chandra Vargeese , Michael Willis
IPC分类号： A61K3170
CPC分类号： A61K31/70 , A61K38/00 , A61K47/544 , A61K47/60 , C07H21/00 , C07K14/52 , C12N15/115 , C12N15/88 , C12N2310/3515
摘要： This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.
摘要翻译：本发明公开了一种通过SELEX方法鉴定VEGF核酸配体并将VEGF核酸配体与非 - 免疫原性，高分子量化合物或非亲和性化合物组合的复合物，免疫原性，高分子量化合物或亲脂性化合物。本发明进一步公开了包含与非免疫原性，高分子量化合物或亲脂性化合物结合的一种或多种VEGF核酸配体的复合物。本发明还包括含有VEGF核酸配体或复合物的脂质构建体及其制备方法。

6. 发明授权

US5849479A High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF) 失效
公开(公告)号：US5849479A
公开(公告)日：1998-12-15
申请号：US233012
申请日：1994-04-25
申请人： Nebojsa Janjic , Larry Gold
发明人： Nebojsa Janjic , Larry Gold
IPC分类号： A61K38/00 , C07B61/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K7/22 , C07K14/00 , C07K14/16 , C07K14/72 , C12N9/12 , C12N15/10 , C12N15/115 , C12Q1/37 , C12Q1/68 , C12Q1/70 , F02B75/02 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/569 , G01N33/68 , G01N33/76 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： A61K47/48092 , A61K47/48076 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C07K14/005 , C07K14/72 , C07K7/22 , C12N15/1048 , C12N15/115 , C12N9/1276 , C12Q1/37 , C12Q1/6811 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/6842 , G01N33/76 , A61K38/00 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12N2740/16222 , C40B40/00 , F02B2075/027 , G01N2333/16 , G01N2333/163 , G01N2333/503 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/918 , G01N2333/96433 , G01N2333/96436 , G01N2333/96455 , G01N2333/96486 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976
摘要： Methods are described for the identification and preparation of nucleic acid ligand ligands to vascular endothelial growth factor (VEGF). Included in the invention are specific RNA ligands to VEGF identified by the SELEX method.

7. 发明授权

US5668264A High affinity PDGF nucleic acid ligands 失效
公开(公告)号：US5668264A
公开(公告)日：1997-09-16
申请号：US479783
申请日：1995-06-07
申请人： Nebojsa Janjic , Larry Gold
发明人： Nebojsa Janjic , Larry Gold
IPC分类号： C07B61/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K14/47 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/52 , C12N9/12 , C12N15/10 , C12N15/115 , C12Q1/37 , C12Q1/68 , C12Q1/70 , F02B75/02 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/569 , G01N33/68 , G01N33/76 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： A61K47/48092 , A61K47/48076 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C07K14/47 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/52 , C12N15/1048 , C12N15/115 , C12N9/1276 , C12Q1/37 , C12Q1/6811 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/6842 , G01N33/76 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C40B40/00 , F02B2075/027 , G01N2333/16 , G01N2333/163 , G01N2333/503 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/96433 , G01N2333/96436 , G01N2333/96455 , G01N2333/96486 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976
摘要： Methods are described for the identification and preparation of high-affinity nucleic acid ligands to PDGF. Included in the invention are specific ssDNA and RNA ligands to PDGF identified by the SELEX method.

8. 发明申请

US20130116150A1 Lung Cancer Biomarkers and Uses Thereof 审中-公开
标题翻译：肺癌生物标志物及其用途
公开(公告)号：US20130116150A1
公开(公告)日：2013-05-09
申请号：US13808751
申请日：2011-07-11
申请人： Sheri Wilcox , Deborah Ayers , Nebojsa Janjic , Larry Gold , Michael Riel-Mehan , Thale Jarvis
发明人： Sheri Wilcox , Deborah Ayers , Nebojsa Janjic , Larry Gold , Michael Riel-Mehan , Thale Jarvis
IPC分类号： G01N33/68 , G06F19/10 , C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , G01N33/57423 , G16B20/00 , G16B25/00 , G16B40/00 , G16B99/00
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 18, Table 20, or Table 21, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.
摘要翻译：本申请包括用于肺癌的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。在一个方面，该应用提供可以单独使用或以各种组合使用以诊断肺癌或允许肺结节的鉴别诊断为良性或恶性的生物标志物。在另一方面，提供了用于诊断个体中的肺癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表18中提供的生物标志物组的至少一种生物标志物的生物标记值，表20或表21，其中基于所述至少一种生物标记值将个体分类为具有肺癌或确定患有肺癌的个体的可能性。

9. 发明授权

US07879993B2 Platelet derived growth factor (PDGF) nucleic acid ligand complexes 有权
标题翻译：血小板衍生生长因子（PDGF）核酸配体复合物
公开(公告)号：US07879993B2
公开(公告)日：2011-02-01
申请号：US11832411
申请日：2007-08-01
申请人： Nebojsa Janjic , Larry Gold
发明人： Nebojsa Janjic , Larry Gold
IPC分类号： C07H21/04
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/544 , A61K47/60 , A61K2039/505 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/52 , C12N15/1136 , C12N15/115 , C12N2310/13 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2310/3515 , C12Q1/6811 , C40B30/04 , C12N2310/3521
摘要： This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF Nucleic Acid Ligand by SELEX methodology and associating the PDGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more PDGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a PDGF Nucleic Acid Ligand or Complex and methods for making the same.
摘要翻译：本发明公开了通过SELEX方法鉴定PDGF核酸配体来制备由PDGF核酸配体和非免疫原性，高分子量化合物或亲脂性化合物组成的复合物的方法，并将PDGF核酸配体与非 - 免疫原性，高分子量化合物或亲脂性化合物。本发明还公开了包含一种或多种与非免疫原性，高分子量化合物或亲脂性化合物结合的PDGF核酸配体的复合物。本发明还包括包含PDGF核酸配体或复合物的脂质构建体及其制备方法。

10. 发明申请

US20100029922A1 Platelet Derived Growth Factor (PDGF) Nucleic Acid Ligand Complexes 有权
标题翻译：血小板衍生生长因子（PDGF）核酸配体配合物
公开(公告)号：US20100029922A1
公开(公告)日：2010-02-04
申请号：US12512780
申请日：2009-07-30
申请人： Nebojsa Janjic , Larry Gold
发明人： Nebojsa Janjic , Larry Gold
IPC分类号： C12N15/12
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/544 , A61K47/60 , A61K2039/505 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/52 , C12N15/1136 , C12N15/115 , C12N2310/13 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2310/3515 , C12Q1/6811 , C40B30/04 , C12N2310/3521
摘要： This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF Nucleic Acid Ligand by SELEX methodology and associating the PDGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more PDGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a PDGF Nucleic Acid Ligand or Complex and methods for making the same.
摘要翻译：本发明公开了通过SELEX方法鉴定PDGF核酸配体来制备由PDGF核酸配体和非免疫原性，高分子量化合物或亲脂性化合物组成的复合物的方法，并将PDGF核酸配体与非 - 免疫原性，高分子量化合物或亲脂性化合物。本发明还公开了包含一种或多种与非免疫原性，高分子量化合物或亲脂性化合物结合的PDGF核酸配体的复合物。本发明还包括包含PDGF核酸配体或复合物的脂质构建体及其制备方法。

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