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1. 发明申请

US20100233731A1 DETECTION AND MEASUREMENT OF BLOOD-FEEDING ACTIVITY 有权
标题翻译：血液供应活动的检测和测量
公开(公告)号：US20100233731A1
公开(公告)日：2010-09-16
申请号：US12789757
申请日：2010-05-28
申请人： Nathan L. Smith
发明人： Nathan L. Smith
IPC分类号： G01N33/569 , C07K16/44
CPC分类号： G01N33/68 , G01N21/76 , G01N33/5308 , G01N33/72 , G01N2333/43582 , G01N2333/43586 , G01N2333/43591 , G01N2333/76
摘要： This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both.
摘要翻译：本发明提供了用于检测外壳或区域中的血液外寄生物活性的组合物和方法。组合物包含对抗原或标记物反应的试剂或试剂，因为它们出现在排泄物或其它外寄生物质中。这种标记物或抗原可以由外寄生物本身产生，或者由于其进食活性而可能被引入外寄生虫体内。本发明的方法包括从外壳或区域收集包含环境灰尘或材料的样品，并对样品进行测试以检测血液外寄生虫标志物，宿主标记物或两者的存在。

2. 发明申请

US20100111934A1 Determining Immunoglobulins In Non-Blood Body Fluids Of Neonatal Ungulates 有权
标题翻译：确定新生儿有蹄类非血体液中的免疫球蛋白
公开(公告)号：US20100111934A1
公开(公告)日：2010-05-06
申请号：US12610649
申请日：2009-11-02
申请人： Nathan L. Smith
发明人： Nathan L. Smith
IPC分类号： A61K39/395 , G01N33/68 , A61P37/00
CPC分类号： G01N33/6854
摘要： Provided is a method for determining immunoglobulins in a neonatal ungulate. The method entails obtaining a sample of oral secretions from the neonatal ungulate and measuring an amount of immunoglobulins in the sample of oral secretions. The method is faster and more convenient than previously available methods for determining immunglobulins in neonatal ungulates, such as neonatal horses and cattle.
摘要翻译：提供了一种用于测定新生儿有蹄类动物中的免疫球蛋白的方法。该方法需要从新生儿有蹄类动物获得口服分泌物样品并测量口服分泌物样品中的免疫球蛋白的量。该方法比以前可用于测定新生儿有蹄类动物中的新鲜血清的新方法如新生马和牛更方便。

3. 发明申请

US20100120071A1 DETECTION AND MEASUREMENT OF BLOOD-FEEDING ACTIVITY 有权
公开(公告)号：US20100120071A1
公开(公告)日：2010-05-13
申请号：US11494215
申请日：2006-07-27
申请人： Nathan L. Smith
发明人： Nathan L. Smith
IPC分类号： G01N33/569
CPC分类号： G01N33/68 , G01N21/76 , G01N33/5308 , G01N33/72 , G01N2333/43582 , G01N2333/43586 , G01N2333/43591 , G01N2333/76
摘要： This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both.

4. 发明授权

US4087609A Azido-triazines 失效
标题翻译：叠氮三嗪
公开(公告)号：US4087609A
公开(公告)日：1978-05-02
申请号：US741896
申请日：1976-11-15
申请人： Nathan L. Smith , Vithal J. Rajadhyaksha
发明人： Nathan L. Smith , Vithal J. Rajadhyaksha
IPC分类号： C07D251/20 , C07D251/26 , C07D251/38 , C07D251/44 , C07D403/12 , C07K1/04 , C12N11/06 , C07D251/46 , C07D251/50 , C07D251/54
CPC分类号： C07C247/00 , C07D251/20 , C07D251/26 , C07D251/38 , C07D251/44 , C07K1/042 , C12N11/06
摘要： Novel compounds having the structural formula ##STR1## where B is NR, O, S, ##STR2## or --CH.sub.2 ; (M).sub.n is a saturated or unsaturated aliphatic hydrocarbon chain; X is NR, O or S; A is SO.sub.2 R, CN, NO.sub.2 or H; Y is NR.sub.2, N.sub.3, halogen or SH; R is H and/or a lower alkyl group; D is N.sub.3 or halogen and n is 1-12.
摘要翻译：具有结构式的新型化合物，其中B为NR，O，S，IMA或-CH 2; （M）n是饱和或不饱和的脂族烃链; X为NR，O或S; A是SO2R，CN，NO2或H; Y是NR2，N3，卤素或SH; R是H和/或低级烷基; D是N 3或卤素，n是1-12。

5. 发明授权

US08597894B2 Determining immunoglobulins in non-blood body fluids of neonatal ungulates 有权
公开(公告)号：US08597894B2
公开(公告)日：2013-12-03
申请号：US12610649
申请日：2009-11-02
申请人： Nathan L. Smith
发明人： Nathan L. Smith
IPC分类号： G01N33/53
CPC分类号： G01N33/6854
摘要： Provided is a method for determining immunoglobulins in a neonatal ungulate. The method entails obtaining a sample of oral secretions from the neonatal ungulate and measuring an amount of immunoglobulins in the sample of oral secretions. The method is faster and more convenient than previously available methods for determining immunglobulins in neonatal ungulates, such as neonatal horses and cattle.

6. 发明授权

US08460890B2 Detection and measurement of blood-feeding activity 有权
标题翻译：检测和测量供血活动
公开(公告)号：US08460890B2
公开(公告)日：2013-06-11
申请号：US12789757
申请日：2010-05-28
申请人： Nathan L. Smith
发明人： Nathan L. Smith
IPC分类号： G01N33/53 , G01N33/569 , A61K39/395 , A61K35/24 , A61K35/37 , A61K35/64 , A61K39/00
CPC分类号： G01N33/68 , G01N21/76 , G01N33/5308 , G01N33/72 , G01N2333/43582 , G01N2333/43586 , G01N2333/43591 , G01N2333/76
摘要： This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both.
摘要翻译：本发明提供了用于检测外壳或区域中的血液外寄生物活性的组合物和方法。组合物包含对抗原或标记物反应的试剂或试剂，因为它们出现在排泄物或其它外寄生物质中。这种标记物或抗原可以由外寄生物本身产生，或者由于其进食活性而可能被引入外寄生虫体内。本发明的方法包括从外壳或区域收集包含环境灰尘或材料的样品，并对样品进行测试以检测血液外寄生虫标志物，宿主标记物或两者的存在。

7. 发明授权

US07727734B1 Detection and measurement of blood-feeding activity 有权
标题翻译：检测和测量供血活动
公开(公告)号：US07727734B1
公开(公告)日：2010-06-01
申请号：US11494215
申请日：2006-07-27
申请人： Nathan L. Smith
发明人： Nathan L. Smith
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , G01N21/76 , G01N33/5308 , G01N33/72 , G01N2333/43582 , G01N2333/43586 , G01N2333/43591 , G01N2333/76
摘要： This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both.
摘要翻译：本发明提供了用于检测外壳或区域中的血液外寄生物活性的组合物和方法。组合物包含对抗原或标记物反应的试剂或试剂，因为它们出现在排泄物或其它外寄生物质中。这种标记物或抗原可以由外寄生物本身产生，或者由于其进食活性而可能被引入外寄生虫体内。本发明的方法包括从外壳或区域收集包含环境灰尘或材料的样品，并对样品进行测试以检测血液外寄生虫标志物，宿主标记物或两者的存在。

8. 发明授权

US4547466A Detecting rheumatoid factor with synthetic particles having immune complexes thereon 失效
标题翻译：用其上具有免疫复合物的合成颗粒检测类风湿因子
公开(公告)号：US4547466A
公开(公告)日：1985-10-15
申请号：US499957
申请日：1983-06-01
申请人： Michael F. Turanchik , Kwok K. Yeung , Nathan L. Smith
发明人： Michael F. Turanchik , Kwok K. Yeung , Nathan L. Smith
IPC分类号： G01N33/543 , G01N33/564 , G01N33/546
CPC分类号： G01N33/54313 , G01N33/564 , G01N2800/102 , Y10S436/808
摘要： A suspension of particles such as carboxylated polystyrene latex particles are coated (as by carbodiimide coupling) with an antigen (such as chemically modified Bovine Serum Albumin). The antigen-coated particles are incubated with a gamma-globulin to the antigen (such as can be produced by immunizing rabbits) under non-agglutinating conditions. The particles having antigen/gamma-globulin immune complexes are recovered and resuspended to form a diagnostic reagent which agglutinates when mixed with human serum containing Rheumatoid Factor.
摘要翻译：将诸如羧化聚苯乙烯胶乳颗粒的颗粒的悬浮液与抗原（如化学修饰的牛血清白蛋白）一起包被（如通过碳二亚胺偶联）。将抗原包被的颗粒与γ-凝球蛋白一起在非凝集条件下与抗原（例如可以通过免疫兔产生）一起温育。回收具有抗原/γ-球蛋白免疫复合物的颗粒并重新悬浮以形成当与含有类风湿因子的人血清混合时凝集的诊断试剂。

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