专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09995740B2 Method of determining temperature and method of detecting a target peptide 有权
公开(公告)号：US09995740B2
公开(公告)日：2018-06-12
申请号：US15079139
申请日：2016-03-24
申请人： SYSMEX CORPORATION
发明人： Rena Tsuruoka , Yukiko Miura
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , G01N33/542 , G01N1/44 , G01N21/64 , G01N21/76
CPC分类号： G01N33/542 , G01N1/44 , G01N21/6428 , G01N21/763 , G01N2021/6417 , G01N2021/6432 , G01N2021/6441 , G01N2333/76
摘要： Disclosed is a method of determining whether a temperature of a sample has reached a predetermined temperature. The method comprises the steps of: mixing an albumin-containing sample with a peptide reagent comprising a peptide for temperature determination; heating the mixture; detecting an optical change of the mixture; and determining whether the temperature of the mixture has reached the predetermined temperature based on the detection result of the optical change. In the method, a dissociation constant (Kd) of binding of the peptide for temperature determination to albumin is 500 μM or more, and the peptide for temperature determination comprises a first labeling substance and a second labeling substance.

2. 发明申请

US20170241996A1 ELECTROCHEMICAL BIOSENSOR AND A METHOD OF SENSING ALBUMIN AND ITS COMPLEXES 审中-公开
公开(公告)号：US20170241996A1
公开(公告)日：2017-08-24
申请号：US15509460
申请日：2015-09-01
申请人： INDIAN INSTITUTE OF SCIENCE
发明人： Vinay Kumar , Navakanta Bhat
IPC分类号： G01N33/543 , G01N27/327 , G01N33/68
CPC分类号： G01N33/5438 , G01N27/327 , G01N27/3277 , G01N33/566 , G01N33/6827 , G01N2333/76 , G01N2333/765
摘要： An electrochemically active device for collecting and retaining a biological sample with a bioanalyte, the device provided with at least a two-electrode member and an albumin-binding and an electrochemically active receptor in chemical contact with the two-electrode members and the biological sample. The present invention also provides a point-of-care biosensor with the device of the present invention and a method for measuring a bioanalyte in a biological sample. The device, point-of-care biosensor and the method of the present invention facilitate accurate measurements concentrations of urine albumin, human serum albumin (HSA), glycated albumin (GA) and methemalbumin (MHA) by determining redox current values in reduced volumes of biological samples.

3. 发明申请

US20170146507A1 METHOD FOR DETECTING ALBUMIN BASED ON COLORIMETRIC ASSAY AND SYSTEM THEREOF 有权
公开(公告)号：US20170146507A1
公开(公告)日：2017-05-25
申请号：US14985986
申请日：2015-12-31
申请人： NATIONAL CHUNG CHENG UNIVERSITY
发明人： SHAU-CHUN WANG , TEH-SHENG LAI , TING-CHOU CHANG
IPC分类号： G01N33/487 , G01N21/25 , B01D61/46 , G01N27/447 , B01D61/44
CPC分类号： G01N33/487 , B01D61/44 , B01D61/46 , B01D2311/02 , B01D2311/2623 , B01D2311/2684 , B01L3/50 , G01N1/4005 , G01N21/251 , G01N21/554 , G01N27/44721 , G01N27/44791 , G01N33/6827 , G01N2001/4011 , G01N2201/0221 , G01N2201/12 , G01N2333/76
摘要： A method for detecting albumin based on a colorimetric assay and a system thereof are disclosed. Gold nanoparticles are added into the sample preparing device having a sample without spectroscopic tags, wherein the sample without spectroscopic tags is formed as the alkaline solution to avoid the interference substances adhering on the gold nanoparticles. The gold nanoparticles are concentrated by using the microfluidic concentrator with the circular ion exchange membrane by applying an external electric field across two electrodes. The image of the concentrated gold nanoparticles is captured by the image capturing device for measuring the saturation intensities of the image, wherein there is a relation between the saturation intensities and the concentration of the albumin in the sample without spectroscopic tags. The concentration of the albumin of the sample without spectroscopic tags is obtained by the relation and the measured saturation intensities.

4. 发明申请

US20160202271A1 TEST PAPER FOR DETECTION OF DIABETIC NEPHROPATHY 审中-公开
标题翻译：用于检测糖尿病性肾病的试纸
公开(公告)号：US20160202271A1
公开(公告)日：2016-07-14
申请号：US14655748
申请日：2014-08-20
申请人： SHENZHEN LEADMED MEDICAL TECHNOLOGY COMPANY LIMITED
发明人： Peng Yue , Jinyuan Zhou , Weiwei Sheng
IPC分类号： G01N33/68 , G01N21/78
CPC分类号： G01N33/6893 , G01N21/78 , G01N33/54306 , G01N2021/752 , G01N2021/757 , G01N2021/7759 , G01N2021/7763 , G01N2035/00118 , G01N2333/4713 , G01N2333/76 , G01N2800/042 , G01N2800/347
摘要： Disclosed is a test paper for detection of diabetic nephropathy, which includes a water-absorbing filter paper, a glass fiber membrane and a NC membrane, all of which are stacked successively from top to bottom. The test paper has a T1 testing region, a T2 testing region and a T3 reference region arranged along a transverse direction; the NC membrane is coated by urinary microalbumin antibodies in the T1 testing region, is coated by urinary haptoglobin antibodies in the T2 testing region and is coated by mouse anti-human IgG antibodies in the T3 reference region; and the glass fiber membrane is coated by urinary microalbumin labeled with colloidal gold in the T1 testing region, is coated by urinary haptoglobin labeled with colloidal gold in the T2 testing region and is coated by mouse anti-human IgG albumen labeled with colloidal gold in the T3 reference region.
摘要翻译：公开了一种用于检测糖尿病肾病的试纸，其包括吸水滤纸，玻璃纤维膜和NC膜，所有这些都从上到下依次层叠。测试纸具有沿横向布置的T1测试区域，T2测试区域和T3参考区域; NC膜在T1测试区域用尿微量白蛋白抗体包被，在T2测试区域用尿触珠蛋白抗体包被，并在T3参考区域用小鼠抗人IgG抗体包被; 玻璃纤维膜在T1测试区域用胶体金标记的尿微量白蛋白涂覆，在T2测试区域用胶体金标记的尿触珠蛋白包被，并用胶体金标记的小鼠抗人IgG白蛋白 T3参考区域。

5. 发明申请

US20160168235A1 TRANSTHYRETIN AMYLOID-SELECTIVE AND POLYREACTIVE CATABODIES 审中-公开
标题翻译：紫杉醇选择性和聚合物制品
公开(公告)号：US20160168235A1
公开(公告)日：2016-06-16
申请号：US14906125
申请日：2014-07-21
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： Sudhir Paul , Yasuhiro Nishiyama , Stephanie Planque
IPC分类号： C07K16/18 , G01N33/68 , C07K14/47
CPC分类号： C07K16/18 , C07K14/47 , C12N9/0002 , C12Q1/37 , G01N33/6854 , G01N33/6893 , G01N2333/76 , G01N2800/28 , G01N2800/325 , G01N2800/7047
摘要： The present invention provides transthyretin amyloid-selective and polyreactive catabodies and method of use thereof.
摘要翻译：本发明提供了转甲状腺素蛋白淀粉样蛋白选择性和多反应性多囊虫病及其使用方法。

6. 发明申请

US20160097780A1 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于诊断阿尔茨海默病的方法和组合物
公开(公告)号：US20160097780A1
公开(公告)日：2016-04-07
申请号：US14777718
申请日：2014-03-04
申请人： RANDOX TEORANTA
发明人： Peter Fitzgerald , Ivan McConnell , John Lamont , Ciaran Richardson
IPC分类号： G01N33/68 , G06F19/24 , C12Q1/68
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2333/47 , G01N2333/4716 , G01N2333/76 , G01N2333/775 , G01N2333/81 , G01N2333/8121 , G01N2333/912 , G01N2800/2821 , G16B40/00
摘要： The present invention relates to methods for the diagnosis of subjects that have or are at risk of having Alzheimer's disease (AD). In particular the present invention identifies individuals who have or are at risk of having AD through measurement of the levels of Afamin in combination with at least one other biomarker such as Alpha-1-antichymotrypsin, Alpha-2-macroglobulin, ApoB100, Complement C5, Serine threonine protein kinase TBK1 or Complement C3 in a fluid sample taken from a subject. Furthermore, genotype (Apolipoprotein E or glutathione S-transferase Omega) may also be taken into consideration and used within classification algorithms to determine the probability of a subject having or being at risk of having AD.
摘要翻译：本发明涉及诊断患有阿尔茨海默病（AD）或有阿尔兹海默病（AD）风险的受试者的方法。特别地，本发明通过与至少一种其它生物标志物如α-1-抗胰凝乳蛋白酶，α-2-巨球蛋白，ApoB100，补体C5的测量结合来测量具有或有风险患有AD的个体，来自受试者的流体样品中的丝氨酸苏氨酸蛋白激酶TBK1或补体C3。此外，还可以考虑基因型（载脂蛋白E或谷胱甘肽S-转移酶Omega）并在分类算法中使用，以确定受试者具有或具有AD风险的概率。

7. 发明申请

US20140106390A1 BIOMARKERS FOR THE TREATMENT OF MULTIPLE MYELOMA 审中-公开
标题翻译：用于治疗多发性骨髓瘤的生物标志物
公开(公告)号：US20140106390A1
公开(公告)日：2014-04-17
申请号：US14112474
申请日：2012-04-17
申请人： Mohamed Zaki , Christian Jacques
发明人： Mohamed Zaki , Christian Jacques
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/56972 , G01N33/56977 , G01N33/57426 , G01N33/57488 , G01N33/57496 , G01N33/6854 , G01N33/70 , G01N33/721 , G01N33/9493 , G01N2333/70539 , G01N2333/76 , G01N2333/765 , G01N2333/805 , G01N2800/52 , G01N2800/60
摘要： Provided herein are the biomarkers for predicting or monitoring the efficacy of a treatment for multiple myeloma. The use of certain M-protein or other protein levels as biomarkers to predict whether a multiple myeloma treatment is likely to be successful is also provided. Further, the analysis of these biomarkers can be used to monitor progress of treatment effectiveness and patient compliance in multiple myeloma patients who are receiving treatment.
摘要翻译：本文提供了用于预测或监测多发性骨髓瘤治疗功效的生物标志物。还提供使用某些M蛋白或其他蛋白质水平作为生物标志物来预测多发性骨髓瘤治疗是否可能成功。此外，这些生物标志物的分析可用于监测接受治疗的多发性骨髓瘤患者的治疗效果和患者依从性的进展。

8. 发明申请

US20130096837A1 AUTOMATED BLOOD ANALYZER 审中-公开
标题翻译：自动血液分析仪
公开(公告)号：US20130096837A1
公开(公告)日：2013-04-18
申请号：US13416953
申请日：2012-03-09
申请人： Joseph FELDSCHUH , Jonathan FELDSCHUH
发明人： Joseph FELDSCHUH , Jonathan FELDSCHUH
IPC分类号： G06F19/10
CPC分类号： A61B5/02755 , A61B5/1427 , A61B5/14546 , A61B5/15003 , A61B5/155 , A61B5/157 , G01N33/6827 , G01N2333/76 , G16B99/00
摘要： An automated blood analyzer that analyzes blood of a living being including one or more sample carriers that hold samples of blood of a living being, each sample having been withdrawn from the living being at a different point in time after the living being was injected with radio-labeled albumin, means for calculating a set of data points representing blood volume of the living being at the one or more points in time after the living being was injected with the radio-labeled albumin based on detected counts of the radio-labeled albumin in the samples of blood, wherein the automated blood analyzer uses the set of data points for further analysis of the blood of the living being, and a quality control module that at least one of calibrates the means for calculating or verifies that the means for calculating operates within predetermined parameters.
摘要翻译：一种自动血液分析仪，其对生活中的血液进行分析，所述血液分析装置包括一个或多个样本载体，所述样本载体保持生物血液样本，每个样本已经在生活之后的不同时间点从生物体中撤出，标记的白蛋白，用于计算一组数据点，用于根据检测到的放射性标记的白蛋白的计数，计算一组数据点，所述数据点表示在生物体内的一个或多个时间点的生物体积被放射性标记的白蛋白血液样本，其中所述自动血液分析仪使用所述数据点集合来进一步分析所述生物的血液;以及质量控制模块，所述质量控制模块至少一个校准用于计算或验证所述计算装置运行的装置在预定参数内。

9. 发明授权

US07951528B2 Use of transthyretin as a biomarker for colorectal adenoma and/or carcinoma; method for detection and test system 有权
标题翻译：使用转甲状腺素蛋白作为结肠直肠腺瘤和/或癌的生物标志物; 检测和测试系统的方法
公开(公告)号：US07951528B2
公开(公告)日：2011-05-31
申请号：US11660070
申请日：2004-08-13
申请人： Hartmut Juhl , Kerstin David
发明人： Hartmut Juhl , Kerstin David
IPC分类号： C12Q1/00
CPC分类号： G01N33/57419 , G01N33/57488 , G01N33/78 , G01N2333/76 , G01N2800/52
摘要： The invention is directed to a method for detecting colorectal adenoma and/or colorectal carcinoma comprising the steps: a) providing an isolated sample material which has been taken from an individual, b) determining the level of transthyretin in said isolated sample material, and c) comparing the determined level of transthyretin with a reference value. The invention is further directed to a method for discriminating between colorectal adenoma and colorectal carcinoma as well as to a method for monitoring the course of colorectal adenoma and/or colorectal carcinoma and/or the treatment of colorectal adenoma and/or colorectal carcinoma. Moreover, the invention is directed to a test system and an array for use in these methods. Furthermore, the invention is directed to the use of transthyretin as a biomarker for a detection of colorectal adenoma and/or colorectal carcinoma in an individual.
摘要翻译：本发明涉及一种用于检测结肠直肠腺瘤和/或结肠直肠癌的方法，包括以下步骤：a）提供从个体获取的分离的样品材料，b）确定所述分离的样品材料中转甲状腺素蛋白的水平，c ）将确定的转甲状腺素蛋白水平与参考值进行比较。本发明还涉及用于区分结肠直肠腺瘤和结肠直肠癌的方法以及用于监测结肠直肠腺瘤和/或结肠直肠癌的过程和/或治疗结直肠腺瘤和/或结肠直肠癌的方法。此外，本发明涉及一种用于这些方法的测试系统和阵列。此外，本发明涉及转甲状腺素蛋白作为生物标志物用于检测个体中结肠直肠腺瘤和/或结肠直肠癌的用途。

10. 发明申请

US20100292149A1 Modulation of the Neuroendocrine System as a Therapy for Motor Neuron Disease 审中-公开
标题翻译：神经内分泌系统作为运动神经元疾病治疗的调节
公开(公告)号：US20100292149A1
公开(公告)日：2010-11-18
申请号：US12508908
申请日：2009-07-24
申请人： Robert P. Bowser
发明人： Robert P. Bowser
IPC分类号： A61K38/11 , A61K38/17 , A61K31/7105 , A61P25/28 , A61K38/31 , G01N33/53 , G01N33/00
CPC分类号： A61K38/31 , A61K38/095 , A61K38/1709 , A61K38/22 , A61K38/2271 , A61K38/57 , A61K48/00 , G01N33/6896 , G01N2333/76 , G01N2333/8139 , G01N2800/28 , Y10T436/143333 , Y10T436/24 , Y10T436/25
摘要： The invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject. The method comprises administering to the nervous system of the subject a composition comprising a thyroxine protein or a therapeutic fragment or pharmacologic mimic thereof and a pharmaceutically acceptable carrier. The invention also provides a method for treating ALS in a subject that comprises administering to the subject a transthyretin protein, 7B2 protein, a cystatin C protein, a neuroendocrine protein, a cysteine protease inhibitor, or an inhibitor of an enzyme that processes a 7B2 protein. In addition, the invention provides methods for determining the susceptibility of a subject to developing ALS and for determining the progression of ALS in a subject.
摘要翻译：本发明提供了一种用于治疗受试者的肌萎缩性侧索硬化症（ALS）的方法。该方法包括对受试者的神经系统施用包含甲状腺素蛋白或其治疗片段或其药理学模拟物和药学上可接受的载体的组合物。本发明还提供了一种治疗受试者的ALS的方法，其包括对受试者施用转甲状腺素蛋白，7B2蛋白，半胱氨酸蛋白酶抑制蛋白C蛋白，神经内分泌蛋白，半胱氨酸蛋白酶抑制剂或处理7B2蛋白的酶的抑制剂。此外，本发明提供了确定受试者对发展中的ALS的敏感性和确定受试者中ALS进展的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式