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1. 发明授权

US4315988A Thermophilic collagenases, thermophilic bacteria capable of producing thermophilic collagenases, and process for producing said collagenases 失效
标题翻译：嗜热胶原酶，能够产生嗜热胶原酶的嗜热细菌，以及生产所述胶原酶的方法
公开(公告)号：US4315988A
公开(公告)日：1982-02-16
申请号：US25748
申请日：1979-03-30
申请人： Naoto Miwa , Yoshiro Masuda , Seiichi Kawarabuki , Toshiyuki Sai , Takao Saito
发明人： Naoto Miwa , Yoshiro Masuda , Seiichi Kawarabuki , Toshiyuki Sai , Takao Saito
IPC分类号： C12N9/48 , A61K38/00 , C12N9/54 , C12N1/20
CPC分类号： C12N9/54 , A61K38/00 , Y10S435/832
摘要： This invention relates to a process for producing collagenase, which comprises aerobically cultivating a collagenase-producing bacterium belonging to the genus Bacillus, and recovering collagenase from the culture broth.This invention also provides a thermophilic bacterium of the genus Bacillus which has the ability to produce collagenase and which grows at a temperature of 42.degree. to 74.degree. C. and a pH of 5.0 to 9.0 and a novel thermophilic collagenase which does not substantially lose collagenase activity even when maintained for 1 hour at a temperature of 60.degree. C. in the presence of a calcium ion at a pH in the range of 6.5 to 8.5, and which has a molecular weight, determined by gel filtration, between those of cytochrome C and ovalbumin.
摘要翻译：本发明涉及一种生产胶原酶的方法，其包括有条不紊地培养属于芽孢杆菌属的胶原酶生产菌，并从培养液中回收胶原酶。本发明还提供了芽孢杆菌属的嗜热细菌，其具有生产胶原酶的能力，并且在42℃至74℃的温度和5.0至9.0的pH下生长，并且基本上不损失胶原酶的新型嗜热胶原酶即使在pH为6.5〜8.5的钙离子存在下，在60℃的温度下保持1小时，并且通过凝胶过滤测定分子量，细胞色素C 和卵清蛋白。

2. 发明授权

US4352881A Method of measuring creatine kinase activity 失效
标题翻译：测定肌酸激酶活性的方法
公开(公告)号：US4352881A
公开(公告)日：1982-10-05
申请号：US302868
申请日：1981-09-16
申请人： Masanobu Inagawa , Toshiyuki Sai , Seiichi Kawarabuki , Naoto Miwa
发明人： Masanobu Inagawa , Toshiyuki Sai , Seiichi Kawarabuki , Naoto Miwa
IPC分类号： G01N33/70 , C12Q1/32 , C12Q1/48 , C12Q1/50 , G01N33/72
CPC分类号： C12Q1/32 , C12Q1/50
摘要： A method and composition for use therein for measuring the activity of creatine kinase (hereinafter referred to as "CK") having good storage stability is disclosed. More particularly, a composition for measurement of CK activity which comprises as main components phosphoglycerate kinase (hereinafter referred to a "PGK") which catalyzes the following reaction 2 and glyceraldehyde-3-phosphate dehydrogenase (hereinafter referred to as "GAPDH") which catalyzes the following reaction 3. Reaction 1 is catalyzed by the creatine kinase.Reaction 1Creatinephosphate+Adenosine-5'-diphosphate (hereinafter referred to as "ADP").revreaction.Creatine+Adenosine-5'-triphosphate (hereinafter referred to as "ATP")Reaction 2ATP+3-Phosphoglycerate.revreaction.ADP+1,3-DiphosphoglycerateReaction 31,3-Diphosphoglycerate+Reduce .beta.-nicotinamideadenine dinucleotide (hereinafter referred to as "NADH").revreaction.Glyceraldehyde-3-phosphate+.beta.-nicotinamideadenine dinucleotide (hereinafter referred to as "NAD")+Inorganic phoshate
摘要翻译：公开了一种用于测量具有良好储存稳定性的肌酸激酶（以下称为“CK”）活性的方法和组合物。更具体地，涉及用于测定CK活性的组合物，其包含催化以下反应的磷酸甘油酸激酶（以下称为“PGK”）和催化下列反应的甘油醛-3-磷酸脱氢酶（以下称为“GAPDH”）的主要成分以下反应3.反应1由肌酸激酶催化。反应1磷酸肌酸+腺苷-5'-二磷酸（以下称为“ADP”） - >肌酸+腺苷-5'-三磷酸（以下称为“ATP”）反应2 ATP + 3-磷酸甘油 - -ADP + 1,3-二磷酸甘油酸反应3 1,3-二磷酸甘油酸+减少β-烟酰胺腺苷二核苷酸（以下简称“NADH”） - > - - 甘油醛-3-磷酸+β-烟酰胺腺嘌呤二核苷酸

3. 发明授权

US6055972A Air fuel ratio control apparatus having air-fuel ratio control point switching function 失效
标题翻译：具有空燃比控制点切换功能的空燃比控制装置
公开(公告)号：US6055972A
公开(公告)日：2000-05-02
申请号：US886063
申请日：1997-06-30
申请人： Masaya Fujimoto , Minoru Ohta , Makoto Nakae , Isao Watanabe , Naoto Miwa , Hiromi Sano , Masahiro Shibata
发明人： Masaya Fujimoto , Minoru Ohta , Makoto Nakae , Isao Watanabe , Naoto Miwa , Hiromi Sano , Masahiro Shibata
IPC分类号： G01N27/406 , G01N27/416 , F02D41/30
CPC分类号： G01N27/4067
摘要： An air-fuel ratio sensor of a limit current type is used for an air-fuel ratio feedback control. When the air-fuel ratio sensor is in a semi-activated state, the air-fuel ratio sensor is driven into an electromotive force generating mode by a current externally applied thereto thereby to shift an electromotive force changing point so that an air-fuel ratio at which the electromotive force changes stepwisely is shifted from the stoichiometric ratio point to a lean zone. When the air-fuel ratio sensor is in a completely activated state, the air-fuel ratio sensor is applied with a voltage to produce a limit current varying with an air-fuel ratio so that a feedback control is performed based on the advanced control theory by using a linear current output characteristics.
摘要翻译：用于空燃比反馈控制的极限电流型的空燃比传感器。当空燃比传感器处于半激活状态时，通过外部施加的电流将空燃比传感器驱动成电动势产生模式，从而使电动势变化点移动，使得空燃比传感器的空燃比电动势逐步变化的位置从化学计量比点偏移到贫带。当空燃比传感器处于完全启动状态时，空燃比传感器被施加电压以产生随空燃比变化的极限电流，从而基于先进控制理论进行反馈控制通过使用线性电流输出特性。

4. 发明授权

US5900129A Oxygen concentration sensor 失效
标题翻译：氧浓度传感器
公开(公告)号：US5900129A
公开(公告)日：1999-05-04
申请号：US659642
申请日：1996-06-06
申请人： Nobuyuki Tsuji , Takashi Kojima , Isao Watanabe , Masahiro Hamaya , Minoru Ohta , Naoto Miwa
发明人： Nobuyuki Tsuji , Takashi Kojima , Isao Watanabe , Masahiro Hamaya , Minoru Ohta , Naoto Miwa
IPC分类号： G01N27/409 , G01N27/407 , G01N27/26
CPC分类号： G01N27/4078 , G01N27/4062 , G01N27/407
摘要： An oxygen concentration sensor having excellent sealing performance between a lead wire and a lead wire insertion hole includes a sensor element disposed insertedly into a housing, protective covers disposed at an end portion of the housing, lead wires inserted into the protective covers, and an elastic insulating member disposed inside the protective covers and having a lead wire insertion hole for inserting the lead wires. The lead wire insertion hole in the elastic insulating member has a rib protruding in the radial direction. The elastic insulating member is caulked and fixed by the protective covers.
摘要翻译：具有导线和引线插入孔之间密封性能优异的氧浓度传感器包括插入壳体中的传感器元件，设置在壳体的端部的保护盖，插入保护盖中的引线和弹性绝缘构件，其设置在所述保护盖内部并且具有用于插入所述引线的引线插入孔。弹性绝缘构件中的引线插入孔具有沿径向突出的肋。弹性绝缘构件被保护罩铆接固定。

5. 发明授权

US5766672A Method of manufacturing an oxygen concentration detector element 失效
标题翻译：氧浓度检测元件的制造方法
公开(公告)号：US5766672A
公开(公告)日：1998-06-16
申请号：US704927
申请日：1996-08-28
申请人： Yasumichi Hotta , Hiromi Sano , Namitsugu Fujii , Naoto Miwa
发明人： Yasumichi Hotta , Hiromi Sano , Namitsugu Fujii , Naoto Miwa
IPC分类号： G01N27/409 , G01N27/407 , B05D5/12
CPC分类号： G01N27/4075
摘要： An oxygen concentration detector element 2 includes a cup-shaped solid electrolyte 20 with an inside chamber 25 opened at one end and closed at the other end. An external electrode 21 is formed on an outer surface of solid electrolyte 20 by dipping solid electrolyte 20 in first chemical plating liquid 81, while an internal electrode 22 is formed on an inner surface of solid electrolyte 20 by introducing second chemical plating liquid 82 into inside chamber 25. First, in an injecting step, an injection needle 11 is inserted into inside chamber 25 and second chemical plating liquid 82 is introduced into inside chamber 25 via injection needle 11, and then injection needle 11 is pulled out of inside chamber 25. Next, in a plating step, internal electrode 22 is formed on the inner surface of inside chamber 25 using second chemical plating liquid 82. Then, in a discharging step, residual second chemical plating liquid 82 is discharged from inside chamber 25.
摘要翻译：氧浓度检测元件2包括杯状固体电解质20，其内侧室25在一端开口并在另一端封闭。通过在第一化学镀液81中浸渍固体电解质20而在固体电解质20的外表面上形成外部电极21，而在固体电解质20的内表面上形成内部电极22，通过将第二化学镀液82引入到内部电极首先，在注射步骤中，将注入针11插入内部腔25中，并且将第二化学镀液82经由注射针11引入到内部腔25内，然后将注射针11从内部腔25中拉出。接着，在电镀工序中，使用第二化学镀液82在内部室25的内表面上形成内部电极22.然后，在排出工序中，残留的第二化学镀液82从内部室25排出。

6. 发明授权

US5766434A Oxygen concentration detecting device and method for fabricating the same 失效
标题翻译：氧浓度检测装置及其制造方法
公开(公告)号：US5766434A
公开(公告)日：1998-06-16
申请号：US797652
申请日：1997-01-31
申请人： Namitsugu Fujii , Hiromi Sano , Yasumichi Hotta , Naoto Miwa , Motoaki Satou
发明人： Namitsugu Fujii , Hiromi Sano , Yasumichi Hotta , Naoto Miwa , Motoaki Satou
IPC分类号： G01N27/407 , G01N27/26
CPC分类号： G01N27/4075 , G01N27/4077
摘要： An oxygen concentration detecting device comprises a solid electrolyte body, inner and outer electrodes formed on the opposite sides of the solid electrolyte body, and a protective layer formed on the outer electrode and comprised of coarse particles and fine particles mutually bonded through an inorganic binder while substantially keeping the original forms of the both types of particles. A ratio of an average particle size, RB, of the coarse particles to an average particle size, RA, of the fine particles of 30:1 or above, and a content, WA, of the fine particles in the protective layer based on the total content, W, of the content, WA, of the fine particles and the content, WB, of the coarse particles on the weight basis is in the range of 15 to 80 %. A method for fabricating the detecting device having such a protective layer as set out above is also described.
摘要翻译：氧浓度检测装置包括固体电解质体，形成在固体电解质体的相对侧的内部和外部电极，以及形成在外部电极上的保护层，其由通过无机粘合剂相互粘合的粗粒子和微粒组成，基本保持两种类型颗粒的原始形式。基于上述保护层中的微粒的粗粒子的平均粒径RB与微粒的平均粒径RA（30:1以上）和含量WA的比例粗颗粒的含量W W，微粒的含量W和重量的含量WB在15〜80％的范围内。还描述了制造具有上述保护层的检测装置的方法。

7. 发明授权

US4685437A Intake air heater for internal combustion engine with perforated plate heater element partially traversing air passage 失效
标题翻译：具有穿孔板加热器元件的内燃机的进气加热器部分穿过空气通道
公开(公告)号：US4685437A
公开(公告)日：1987-08-11
申请号：US772904
申请日：1985-09-05
申请人： Toshiaki Tanaka , Hitoshi Niwa , Hirokatsu Mukai , Naoto Miwa , Akio Nara , Etsuji Nomura , Makoto Hori , Koichi Hasegawa , Hiroshi Noguchi
发明人： Toshiaki Tanaka , Hitoshi Niwa , Hirokatsu Mukai , Naoto Miwa , Akio Nara , Etsuji Nomura , Makoto Hori , Koichi Hasegawa , Hiroshi Noguchi
IPC分类号： F02B3/06 , F02M29/04 , F02M31/13 , F02M31/12
CPC分类号： F02M31/13 , F02M29/04 , F02B3/06 , Y02T10/126
摘要： An air heater for heating intake air for an internal combustion engine only in cold start or further warming up operation, having a frame which defines an opening for passing air therethrough, and at least one heater element in the shape of a perforated plate such as a lattice or honeycomb plate supported by the frame so as to traverse only a part of the opening area of the air passage opening, while leaving a substantial part of the opening area free as untraversed by the heater element.
摘要翻译：一种空气加热器，其仅在冷启动或进一步预热操作中为内燃机的进气供暖，其具有限定用于使空气通过的开口的框架，以及至少一个多孔板形状的加热元件，例如格架或蜂窝板由框架支撑，以便只穿过空气通道开口的开口区域的一部分，同时使打开区域的大部分自由未被加热器元件拉开。

8. 发明授权

US06951601B1 Oxygen concentration detector 失效
标题翻译：氧浓度检测仪
公开(公告)号：US06951601B1
公开(公告)日：2005-10-04
申请号：US08838910
申请日：1997-04-11
申请人： Akio Tanaka , Naoto Miwa , Toshitaka Saito , Hiromi Sano , Kazunori Suzuki , Masaya Fujimoto
发明人： Akio Tanaka , Naoto Miwa , Toshitaka Saito , Hiromi Sano , Kazunori Suzuki , Masaya Fujimoto
IPC分类号： G01N27/41 , G01N27/406 , G01N27/407 , G01N27/409
CPC分类号： G01N27/4075 , G01N27/4067
摘要： The oxygen concentration detector of the present invention includes a sensor element having a solid electrolyte and having an external electrode and an internal electrode provided on the external surface and the internal surface, respectively, and a heater provided adjacent to the internal surface of the sensor element, in which a high-emissivity layer consisting of a material having a high emissivity is provided on the internal surface of the sensor element and/or the surface of the heater.
摘要翻译：本发明的氧浓度检测器具有固体电解质的传感器元件，分别具有设置在外表面和内表面上的外部电极和内部电极，以及设置在传感器元件的内表面附近的加热器其中在传感器元件的内表面和/或加热器的表面上设置由具有高发射率的材料构成的高发射率层。

9. 发明授权

US06372194B1 MRI contrast media recognizing minor environmental changes 失效
标题翻译： MRI造影剂识别轻微的环境变化
公开(公告)号：US06372194B1
公开(公告)日：2002-04-16
申请号：US09381176
申请日：1999-09-17
申请人： Toshihiro Akaike , Masahito Mikawa , Atsushi Maruyama , Naoto Miwa
发明人： Toshihiro Akaike , Masahito Mikawa , Atsushi Maruyama , Naoto Miwa
IPC分类号： A61B5055
CPC分类号： A61K49/085 , A61K49/12 , A61K49/128
摘要： This relates to a contrast medium containing a complex of a gadolinium (Gd) type contrast agent and a polymer. More particularly, the contrast medium wherein the polymer capable of phase transit in response to environmental changes, particularly, pH, light or temperature, to develop a different water solubility, and a method for imaging by the use of this contrast medium. By binding a polymer responsive to microenvironmental changes with a Gd type MRI contrast agent, on-off switching of MRI imaging capability is enabled, wherein imaging occurs only on the target sites. Consequently, a highly specific MRI contrast medium can be obtained, whereby a highly specific MRI diagnosis is made possible, wherein only the target sites such as a tumor and a particular site are imaged and otherwise at the site where imaging is not necessary.
摘要翻译：这涉及含有钆（Gd）型造影剂和聚合物的复合物的造影剂。更具体地，其中响应于环境变化，特别是pH，光或温度而相转移的聚合物以形成不同的水溶性的造影剂，以及通过使用该造影剂进行成像的方法。通过用Gd型MRI造影剂结合响应于微环境变化的聚合物，能够进行MRI成像能力的开 - 关切换，其中成像仅在靶位点上发生。因此，可以获得高度特异性的MRI造影剂，由此可以进行高度特异性的MRI诊断，其中只有目标部位如肿瘤和特定部位成像，否则在不需要成像的部位进行成像。

10. 发明授权

US5935399A Air-fuel ratio sensor 失效
标题翻译：空燃比传感器
公开(公告)号：US5935399A
公开(公告)日：1999-08-10
申请号：US792737
申请日：1997-01-31
申请人： Akio Tanaka , Naoto Miwa , Hiromi Sano , Toshitaka Saito , Katsuhiro Ishikawa
发明人： Akio Tanaka , Naoto Miwa , Hiromi Sano , Toshitaka Saito , Katsuhiro Ishikawa
IPC分类号： G01N27/407
CPC分类号： G01N27/4075
摘要： An air-fuel ratio sensing element comprises a cup-shaped solid electrolyte with one end opened and the other end closed, an external electrode provided on an outer wall surface of the solid electrolyte so as to be exposed to measured gas, and an internal electrode provided on an inner wall surface of the solid electrolyte in a confronting relationship to the external electrode. A first insulating layer, made of a gas-permeable and nonconductive porous material, is provided on the external electrode at least in a region used for detecting of an air-fuel ratio. A second insulating layer is provided outside the first insulating layer and, a heater layer as provided between the first insulating layer and the second insulating layer.
摘要翻译：空燃比检测元件包括一端敞开而另一端闭合的杯形固体电解质，设置在固体电解质的外壁表面上以暴露于测量气体的外部电极，以及内部电极以与外部电极相对的关系设置在固体电解质的内壁表面上。至少在用于检测空燃比的区域中，在外部电极上设置由透气且不导电的多孔材料制成的第一绝缘层。第二绝缘层设置在第一绝缘层的外侧，以及设置在第一绝缘层和第二绝缘层之间的加热器层。

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