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1. 发明授权

US07674576B2 Semen extender composition and methods for manufacturing and using 有权
公开(公告)号：US07674576B2
公开(公告)日：2010-03-09
申请号：US10044796
申请日：2002-01-11
申请人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
发明人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
IPC分类号： A01N1/02 , A61B17/43
CPC分类号： A01N1/02 , A01N1/0226
摘要： A semen extender composition is provided. The semen extender composition includes a sperm cell protecting amount of phospholipid, an effective amount of surfactant to reduce ice crystal formation during freezing of the composition; a carbohydrate, and a biological buffer to provide a semen extender use solution having a pH of between about 6.9 and about 7.5, and wherein the use solution exhibits an osmolality of about 250 mOsM to about 350 mOsM. Methods for manufacturing and using a semen extender composition are provided.

2. 发明申请

US20100196872A1 Semen extender composition and methods for manufacturing and using 失效
标题翻译：精液增量剂的制备和使用方法
公开(公告)号：US20100196872A1
公开(公告)日：2010-08-05
申请号：US12660978
申请日：2010-03-08
申请人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
发明人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
IPC分类号： A01N1/02 , A01P1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： A semen extender composition is provided. The semen extender composition includes a sperm cell protecting amount of phospholipid, an effective amount of surfactant to reduce ice crystal formation during freezing of the composition; a carbohydrate, and a biological buffer to provide a semen extender use solution having a pH of between about 6.9 and about 7.5, and wherein the use solution exhibits an osmolality of about 250 mOsM to about 350 mOsM. Methods for manufacturing and using a semen extender composition are provided.
摘要翻译：提供精液延长剂组合物。精液延长剂组合物包括精子细胞保护量的磷脂，有效量的表面活性剂以减少组合物冷冻期间的冰晶形成; 碳水化合物和生物缓冲液，以提供pH为约6.9至约7.5的精液增量剂使用溶液，并且其中所述使用溶液的重量克分子渗透浓度为约250mOsM至约350mOsM。提供了制造和使用精液延伸剂组合物的方法。

3. 发明授权

US08435730B2 Semen extender composition and methods for manufacturing and using 失效
公开(公告)号：US08435730B2
公开(公告)日：2013-05-07
申请号：US12660978
申请日：2010-03-08
申请人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
发明人： Naida M. Loskutoff , Jennifer Rohr , Richard B. Lomneth , David G. Wood , Elizabeth Crichton
IPC分类号： A01N1/02 , A61B17/43
CPC分类号： A01N1/02 , A01N1/0226
摘要： A semen extender composition is provided. The semen extender composition includes a sperm cell protecting amount of phospholipid, an effective amount of surfactant to reduce ice crystal formation during freezing of the composition; a carbohydrate, and a biological buffer to provide a semen extender use solution having a pH of between about 6.9 and about 7.5, and wherein the use solution exhibits an osmolality of about 250 mOsM to about 350 mOsM. Methods for manufacturing and using a semen extender composition are provided.

4. 发明授权

US07838256B2 Assay and kit for drug efflux transporter activity 失效
标题翻译：药物流出物转运蛋白活性测定和试剂盒
公开(公告)号：US07838256B2
公开(公告)日：2010-11-23
申请号：US11678209
申请日：2007-02-23
申请人： Donald W. Miller , Corbin J. Bachmeier , Richard B. Lomneth
发明人： Donald W. Miller , Corbin J. Bachmeier , Richard B. Lomneth
IPC分类号： G01N33/53 , C40B30/04
CPC分类号： G01N33/542 , G01N2500/10 , G01N2800/44
摘要： The present invention relates to high-throughput cell-based assays for real-time monitoring of multi-resistant drug protein activity. The present invention is an improvement over existing assays in that in addition to a fluorescent drug efflux probe as an indicator of MDR protein activity, the instant assays provide an o-tolidine-based dye for quenching extracellular fluorescence of the probe.
摘要翻译：本发明涉及用于实时监测多重耐药性蛋白质活性的高通量的基于细胞的测定法。本发明是对现有测定的改进，因为除了作为MDR蛋白活性的指示剂的荧光药物外排探针之外，本发明提供了一种用于猝灭探针的细胞外荧光的邻甲苯胺染料。

5. 发明申请

US20080206781A1 Assay and kit for drug efflux transporter activity 失效
标题翻译：药物流出物转运蛋白活性测定和试剂盒
公开(公告)号：US20080206781A1
公开(公告)日：2008-08-28
申请号：US11678209
申请日：2007-02-23
申请人： Donald W. Miller , Corbin J. Bachmeier , Richard B. Lomneth
发明人： Donald W. Miller , Corbin J. Bachmeier , Richard B. Lomneth
IPC分类号： G01N33/53
CPC分类号： G01N33/542 , G01N2500/10 , G01N2800/44
摘要： The present invention relates to high-throughput cell-based assays for real-time monitoring of multi-resistant drug protein activity. The present invention is an improvement over existing assays in that in addition to a fluorescent drug efflux probe as an indicator of MDR protein activity, the instant assays provide an o-tolidine-based dye for quenching extracellular fluorescence of the probe.
摘要翻译：本发明涉及用于实时监测多重耐药性蛋白质活性的高通量的基于细胞的测定法。本发明是对现有测定的改进，因为除了作为MDR蛋白活性的指示剂的荧光药物外排探针之外，本发明提供了一种用于猝灭探针的细胞外荧光的邻甲苯胺染料。

6. 发明授权

US4388339A Margarine and method for making same 失效
标题翻译：人造黄油及其制作方法
公开(公告)号：US4388339A
公开(公告)日：1983-06-14
申请号：US318163
申请日：1981-11-04
申请人： Richard B. Lomneth , Daniel R. Blair , Gary L. Parnell , Bernard Y. Tao
发明人： Richard B. Lomneth , Daniel R. Blair , Gary L. Parnell , Bernard Y. Tao
IPC分类号： A23D7/00 , A23D7/02 , C11B7/00 , A23D3/00 , A23D5/00
CPC分类号： A23D7/001 , A23D7/02 , C11B7/0075
摘要： A margarine or other emulsified spread and methods for making these are disclosed. A water-in-oil emulsion is formed by mixing an aqueous base with an oil phase containing a margarine fat which comprises a soft oil and a structural fat having a unique melting profile and triglyceride composition. The emulsion is chilled to a temperature of from about 15.degree. F. (-9.degree. C.) to about 45.degree. F. (7.degree. C.) over a time period of at least about 0.5 minutes. The chilled emulsion is then crystallized over a time period of at least about 3 minutes. Due to heat generated during crystallization, the crystallized emulsion is preferably chilled further to a temperature of from about 15.degree. F. (-9.degree. C.) to about 40.degree. F. (4.degree. C.) over a time period of at least about 0.2 minutes. For stick-type products, the combination of chilling the emulsion to cooler temperatures together with longer residence times for crystallization provides spreads having sufficient viscosity to form stick-type products with conventional margarine equipment. This emulsified spread is characterized by a slump grade of at least 8 after one hour at 80.degree. F. and a Hot Probe value of at least about 11.3 (.degree.F./6 sec.).
摘要翻译：公开了人造黄油或其它乳化扩散剂及其制备方法。通过将水性基质与含有人造奶油的油相混合形成油包水乳液，所述人造奶油包含软油和具有独特熔融曲线和甘油三酯组成的结构脂肪。将乳液在至少约0.5分钟的时间内冷却至约15°F（-9℃）至约45°F（7℃）的温度。然后将冷冻的乳液在至少约3分钟的时间内结晶。由于结晶期间产生的热量，结晶的乳液优选在至少约15°F（-9℃）至约40°F（4℃）的温度下进一步冷却至少约0.2分钟。对于棒状产品，将乳液冷却至较冷的温度以及更长的停留时间用于结晶的组合提供了具有足够粘度的涂料以形成具有常规人造黄油设备的棒状产品。该乳化扩散的特征在于80℃下1小时后的坍落度等级至少为8，热探头值至少为11.3（°F / 6秒）。

7. 发明授权

US4390561A Margarine oil product 失效
标题翻译：人造黄油产品
公开(公告)号：US4390561A
公开(公告)日：1983-06-28
申请号：US318162
申请日：1981-11-04
申请人： Daniel R. Blair , Richard B. Lomneth , Robert L. Prosise , Bernard Y. Tao
发明人： Daniel R. Blair , Richard B. Lomneth , Robert L. Prosise , Bernard Y. Tao
IPC分类号： A23D7/00 , A23D7/02 , C11B7/00 , A23D5/00
CPC分类号： C11B7/0075 , A23D7/001 , A23D7/02
摘要： A margarine oil product useful for margarines and other emulsified spreads, especially stick-type products is disclosed. The margarine oil product comprises a soft oil and a particular structural fat, and is characterized by solid fat content and fatty acid composition. The structural fat used to make it has a unique triglyceride composition in terms of positional isomers and Fatty Acid Composition. The important positional isomers are the SSS, SOS, SSO and SOO/SLS triglycerides, wherein S=palmitic or stearic acid, O=oleic acid, and L=linoleic acid. The weight ratios of palmitic to stearic acid (P:St) and oleic to linoleic (O:L) acid residues attached to the glycerides are important.
摘要翻译：公开了用于人造黄油和其它乳化扩散剂的人造黄油产品，特别是棒状产品。人造黄油产品包括软油和特定结构脂肪，其特征在于固体脂肪含量和脂肪酸组成。用于制造它的结构性脂肪在位置异构体和脂肪酸组成方面具有独特的甘油三酯组成。重要的位置异构体是SSS，SOS，SSO和SOO / SLS甘油三酸酯，其中S =棕榈酸或硬脂酸，O =油酸，L =亚油酸。与甘油酯连接的棕榈酸与硬脂酸（P：St）和油酸与亚油酸（O：L）酸残基的重量比是重要的。

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